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Neural Regeneration Research 2021年第4期16卷 787-794页

作者： Pan Wang Hai-Juan Sui Xiao-Jia li li-na bai Jing Bi Hong Lai Department of Anatomy China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of liaoning Province Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Department of Neurobiology Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Department of Pharmacology Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina

Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury,but it remains unclear whether melatonin can also ameliorate cerebral microvascular *** models of Alzheimer’s disease were established by six intracerebroventricular injections of amyloidbeta 1–42,administered once every other ***(30 mg/kg)was intraperitoneally administered for 13 successive days,with the first dose given 24 hours prior to the first administration of amyloid-beta 1–*** ameliorated learning and memory impairments in the Morris water maze test,improved the morphology of microvessels in the cerebral cortex and hippocampus,increased microvessel density,alleviated pathological injuries of cerebral neurons,and decreased the expression of vascular endothelial growth factor and vascular endothelial growth factor receptors 1 and *** findings suggest that melatonin can improve microvessel abnormalities in the cerebral cortex and hippocampus by lowering the expression of vascular endothelial growth factor and its receptors,thereby improving the cognitive function of patients with Alzheimer’s *** study was approved by the Animal Care and Use Committee of Jinzhou Medical University,China(approval No.2019015)on December 6,2018.

关键词： Alzheimer’s disease brain central nervous system factor in vivo model pathways protein rat

First-principles study of high performance lithium/sodium storage of Ti3C2T2 nanosheets as electrode materials

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Chinese Physics B 2020年第1期29卷 398-407页

作者： li-na bai ling-Ying Kong Jing Wen Ning Ma Hong Gao Xi-Tian Zhang Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China School of Computer Science and Information Engineering Harbin Normal UniversityHarbin 150025China Department of Physics Harbin Institute of TechnologyHarbin 150001China

Ti3C2Tx nanosheet,the first synthesized MXene with high capacity performance and charge/discharge rate,has attracted increasingly attention in renewable energy storage *** performing systematic density functional theory calculations,the theoretical capacity of the intrinsic structure of single-and multi-layered Ti3C2T2(T=F or O)corresponding to M(M=li and na)atoms are *** volumetric capacity and gravimetric capacity are obtained,which are related to the stacking *** optimal ratios of capacity to structure are determined under different stacking degrees for understanding the influence of surface functional groups on energy storage *** performance can be tuned by performing surface modification and increasing the interlayer *** addition,the reason for theoretical capacity differences of M atoms is analyzed,which is attributed to difference in interaction between the M-ions and substrate and the difference in electrostatic exclusion between adsorbed *** results provide an insight into the understanding of the method of efficiently increasing the energy storage performance,which will be useful for designing and using high performance electrode materials.

关键词： density functional theory MXene electrode materials

Development of a test strip for rapid detection of lactoperoxidase in raw milk

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第8期16卷 672-679页

作者： Hong-xia CHE Bo TIAN li-na bai li-ming CHENG li-li liU Xiao-na ZHANG Zhan-mei JIANG Xiao-xi XU Key Laboratory of Dairy Science (KLDS) Ministry of Education Northeast Agricultural University

Traditional methods for detecting lactoperoxidase （LP） are complex and time-consuming, so a test strip was made based on the enzymatic reaction principle to enable quick and convenient detection of LP in raw milk. In this study 0.1 mol/L citric acid （CA）/0.2 mol/L disodium hydrogen phosphate （naP） buffer solution （pH 5.0）, 22 mmol/L 3,3＇,5,5＇-tetramethylbenzidine （TMB）, 0.6 mmol/L hydrogen peroxide （H202）, and 0.5% Tween-20 or 0.3% cetyltri- methyl ammonium bromide （CTAB） were optimal for preparing a quick, sensitive, and accurate LP test strip. The coefficient of variation （CV） of the estimated LP concentrations ranged from 2.47% to 6.72% and the minimum LP concentration detected by the test strip was 1-2 mg/L. Estimates of active LP in sixteen raw milk samples obtained using the test strip or the TMB method showed a good correlation （c=0.9776）. So the test strip provides a quick, convenient, and accurate method for detecting the LP concentration of raw milk.

关键词： Lactoperoxidase Test strip Rapid detection Raw milk 3 3' 5 5'-Tetramethylbenzidine (TMB)

Stability of β-carotene microcapsules with Maillard reaction products derived from whey protein isolate and galactose as coating materials

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第10期18卷 867-877页

作者： Zhan-mei JIANG li-na bai nan YANG Zhi-biao FENG Bo TIAN Key Laboratory of Dairy Science(KLDS) Ministry of EducationNortheast Agricultural UniversityHarbin 150030China

The stability of β-carotene microcapsules using Maillard reaction products（MRPs） derived from whey protein isolate（WPI） and galactose as coating materials, was studied under the varying environmental conditions of temperature, pH, air, incandescent light, and ultraviolet（UV） *** electron microscopy showed that microcapsules prepared by WPI-galactose MRPs displayed a smooth and less concave-convex surface and that the particle size（D_（50）） of the microcapsules made with WPI-galactose MRPs was smaller than those made with WPI-galactose *** storage stability of β-carotene microencapsulated in WPI-galactose MRPs was remarkably better than that of β-carotene microencapsulated in the WPI-galactose mixture and that of β-carotene crystal, in respect of temperature, pH, air, incandescent light, and UV light *** the storage temperature was increased from 5 to 105 ℃, the retention rate of β-carotene microcapsules significantly decreased（P〈0.05）.When p H values were increased from 1 to 12, the β-carotene retention rate of the microcapsules significantly increased and afterward *** with the retention rate of β-carotene microencapsulated in a WPI-galactose mixture, the retention rate of β-carotene microencapsulated in WPI-galactose MRPs was at a maximum between pH 8 and *** the actions of air, incandescent light, and UV light, the retention rates of β-carotene microcapsules in WPI-galactose MRPs and WPI-galactose mixture, as well as in β-carotene crystal, decreased significantly as the storage time increased（P〈0.05）.Therefore, the use of WPI-galactose MRPs as coating materials can aid in improving the storage stability of β-carotene microcapsules.

关键词： Maillard reaction products (MRPs) Whey protein isolate (WPI) β--Carotene Microcapsule Stability

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宋子文与驼峰航线

黑龙江教育学院学报 2011年第4期30卷 203-204页

作者：李佰娜辽宁师范大学历史文化旅游学院辽宁大连116029

驼峰航线是二战期间滇缅公路被切断后美国援华的唯一通道,驼峰空运关系到中国的持续抗战及抗战胜利的时间问题。在推动驼峰航线的开辟,抵制不利于驼峰航线的言论及想方设法推动驼峰航线的发展等方面,宋子文都作出了自己的贡献。

关键词：驼峰航线宋子文抗日战争

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多级孔复合分子筛加氢脱芳催化剂研究进展

天然气化工—C1化学与化工 2018年第5期43卷 126-130页

作者：石留洋李剑杨丽娜白金辽宁石油化工大学化学化工与环境学部辽宁抚顺113001

综述了微-介孔复合分子筛和介-介孔复合分子筛加氢脱芳催化剂的结构、性质及催化性能。前者研究较多,它利用了微孔分子筛的比表面积、酸性和水热稳定性优势和介孔分子筛的孔径优势,催化活性和选择性高,其中含HY的微-介孔分子筛具有很好... 详细信息

综述了微-介孔复合分子筛和介-介孔复合分子筛加氢脱芳催化剂的结构、性质及催化性能。前者研究较多,它利用了微孔分子筛的比表面积、酸性和水热稳定性优势和介孔分子筛的孔径优势,催化活性和选择性高,其中含HY的微-介孔分子筛具有很好的耐硫性。由于酸性相对较弱,后者在柴油加氢脱芳中可以兼顾柴油的十六烷值和收率。指出深入研究多级孔复合分子筛的酸性和孔道分布与其催化性能的关系是未来的研究重点。

关键词：微-介孔复合分子筛介-介孔复合分子筛催化剂加氢脱芳烃

超声乳化联合EX-PRESS引流钉植入治疗难治性开角型青光眼合并白内障

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国际眼科杂志 2019年第8期19卷 1344-1347页

作者：王友张键王晓莉柏丽娜蔡方荣中国四川省简阳市人民医院眼科

目的:观察超声乳化联合EX-PRESS引流钉植入治疗难治性开角型青光眼合并白内障的疗效。方法:选取难治性开角型青光眼合并白内障患者共66例67眼。试验组采用超声乳化吸除联合EX-PRESS引流钉植入术,对照组采用超声乳化吸除联合小梁切除术... 详细信息

目的:观察超声乳化联合EX-PRESS引流钉植入治疗难治性开角型青光眼合并白内障的疗效。方法:选取难治性开角型青光眼合并白内障患者共66例67眼。试验组采用超声乳化吸除联合EX-PRESS引流钉植入术,对照组采用超声乳化吸除联合小梁切除术。术前进行BCVA、IOP检查;观察并发症、手术时间,术后观察视力、眼压、滤过泡改变;随访时间为术后1d,1wk,1、6mo,1a。结果:试验组手术时间为23.26±2.00min,对照组手术时间为31.73±2.17min,两组间有差异(t=16.68,P<0.01)。试验组术后发生浅前房和滤过泡瘢痕化者各1眼;对照组术后发生低眼压3眼,前房出血和脉络膜脱离各1眼,滤过泡瘢痕化者5眼。滤过泡Kronfeld分型无差异(Z=-0.775,P=0.438)。两组干预因素及时间对患者术后眼压均有影响(F组间=8.67,P组间<0.01;F时间=127.58,P时间<0.01;F组间×时间=7.5,P组间×时间<0.01)。干预因素对患者术后视力无影响,两组术后视力同术前相比均有差异(F组间=0.35,P组间=0.55;F时间=34.92,P时间<0.01;F组间×时间=0.38,P组间×时间=0.86)。结论:超声乳化联合EX-PRESS引流钉植入治疗难治性开角型青光眼合并白内障安全有效、手术时间短,可作为一种常规青白联合手术方式。

关键词：超声乳化 EX-PRESS引流钉植入术难治性开角型青光眼白内障眼压并发症

Ultrasound features of congenital cytomegalovirus infection in the first trimester:A case report

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World Journal of Clinical Cases 2025年第5期13卷 30-35页

作者： Xiao-li Chen li-Qiang Zhang li-li bai Department of Ultrasound Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental *** majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening *** SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal *** ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV *** karyotyping and microarray analysis of the fetus yielded no significant *** compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her *** ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female *** five months of age,the infant presented with epilepsy and significant growth and developmental *** Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal *** research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.

关键词： Prenatal diagnosis Congenital infection Cytomegalovirus Fetal ultrasound Case report

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan bai Hui Ma Yue Zhang Jinfeng li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

ADC border effect and suppression of quantization error in the digital dynamic measurement

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Chinese Physics B 2017年第9期26卷 91-97页

作者：白丽娜刘海东周渭张勇翟鸿启崔震健赵明英谷小倩刘蓓玲黄李贝 Department of Measurement and Instrumentation Xidian University State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong University

The digital measurement and processing is an important direction in the measurement and control field. The quantization error widely existing in the digital processing is always the decisive factor that restricts the development and applications of the digital technology. In this paper, we find that the stability of the digital quantization system is obviously better than the quantization resolution. The application of a border effect in the digital quantization can greatly improve the accuracy of digital processing. Its effective precision has nothing to do with the number of quantization bits, which is only related to the stability of the quantization system. The high precision measurement results obtained in the low level quantization system with high sampling rate have an important application value for the progress in the digital measurement and processing field.

关键词： quantization error border effect digital converter(ADC)