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Acta Mathematica Sinica,English Series 2005年第6期21卷 1377-1390页

作者： Yi Wen JIANG li ming wu Department of Mathematics Military Economics Academy Wuhan 430035 P. R. China Laboratoire de Mathématiques Appliqudes CNRS UMR 6620 Universitd Blaise Pascal 63177 Aubière France Department Mathematics Wuhan University Wuhan 430072 P. R. China

All known results on large deviations of occupation measures of Markov processes are based on the assumption of （essential） irreducibility. In this paper we establish the weak＊ large deviation principle of occupation measures for any countable Markov chain with arbitrary initial measures. The new rate function that we obtain is not convex and depends on the initial measure, contrary to the （essentially） irreducible case.

关键词： Large deviations Markov processes (chains)

Poincaréand Logarithmic Sobolev Inequalities for Nearly Radial Measures

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1377-1398页

作者： Patrick CATTIAUX Arnaud GUILliN li ming wu Institut de Mathématiques de Toulouse CNRS UMR 5219UniversitéPaul Sabatier118 Route de NarbonneF-31062 Toulouse Cedex 09 Laboratoire de Mathématiques Blaise Pascal CNRS UMR 6620UniversitéClermont-AuvergneAvenue des LandaisF-63177 Aubiere

Poincaréinequality has been studied by Bobkov for radial measures,but few are known about the logarithmic Sobolev inequality in the radial *** try to fill this gap here using different methods:Bobkov's argument and super-Poincaréinequalities,direct approach via L_(1)-logarithmic Sobolev *** also give various examples where the obtained bounds are quite *** bounds obtained by Lee–Vempala in the log-concave bounded case are refined for radial measures.

关键词： Radial measure log-concave measure Poincaréinequality logarithmic Sobolev inequality super-Poincaréinequality

Logarithmic Sobolev,Isoperimetry and Transport Inequalities on Graphs

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Acta Mathematica Sinica,English Series 2016年第10期32卷 1221-1236页

作者： Yu Tao MA Ran WANG li ming wu School of Mathematical Sciences & Lab.Math.Com.Sys. Beijing Normal University School of Mathematics and Statistics Wuhan University School of Mathematical Sciences University of Science and Technology of China Institute of Applied Math. Chinese Academy of Sciences Laboratoire de Math.CNRS-UMR 6620 Université Blaise Pascal

In this paper, we study some functional inequalities （such as Poincar@ inequality, loga- rithmic Sobolev inequality, generalized Cheeger isoperimetric inequality, transportation-information inequality and transportation-entropy inequality） for reversible nearest-neighbor Markov processes on connected finite graphs by means of （random） path method. We provide estimates of the involved constants.

关键词： Graph log-Sobolev inequality isoperimetry transport inequality

Risk Assessment and Ecological Effects of Transgenic Bacillus thuringiensis Crops on Non-Target Organisms

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Journal of Integrative Plant Biology 2011年第7期53卷 520-538页

作者： Hui-lin Yu Yun-He li Kong-ming wu State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of AgriculturalSciences Beijing 100193 China

The application of recombinant DNA technology has resulted in many insect-resistant varieties by genetic engineering （GE）. Crops expressing Cry toxins derived from Bacillus thuringiensis （Bt） have been planted worldwide, and are an effective tool for pest control. However, one ecological concern regarding the potential effects of insect-resistant GE plants on non-target organisms （NTOs） has been continually debated. In the present study, we briefly summarize the data regarding the development and commercial use of transgenic Bt varieties, elaborate on the procedure and methods for assessing the non-target effects of insect-resistant GE plants, and synthetically analyze the related research results, mostly those published between 2005 and 2010. A mass of laboratory and field studies have shown that the currently available Bt crops have no direct detrimental effects on NTOs due to their narrow spectrum of activity, and Bt crops are increasing the abundance of some beneficial insects and improving the natural control of specific pests. The use of Bt crops, such as Bt maize and Bt cotton, results in significant reductions of insecticide application and clear benefits on the environment and farmer health. Consequently, Bt crops can be a useful component of integrated pest management systems to protect the crop from targeted pests.

关键词： Bt crops non-target organisms risk assessment IPM.

Determination of Pesticide Residue Cartap Using a Sensitive Fluorescent Probe

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Journal of Integrative Agriculture 2012年第11期11卷 1861-1870页

作者： JING Xu DU li-ming wu Hao wu Wen-ying CHANG Yin-xia Analytical and Testing Center Shanxi Normal University Linfen 041000 P.R.China

The insecticide cartap （CP） is non-fluorescent in aqueous solutions. This property makes its determination through direct fluorescent method difficult. In acidic medium and at room temperature, palmatine （PAL） can react with cucurbit[7]uril （CB[7]） to form stable complexes, and the fluorescence intensity of the complex is greatly enhanced. Significant quenching of the fluorescence intensity of the CB[7]-PAL complex was observed with the addition of cartap. Based on the significant quenching of the supramolecular complex fluorescence intensity, a new spectrofluorimetric method with high sensitivity and selectivity was developed to determine cartap in aqueous solution. The fluorescence quenching values （AF） showed good linear relationship with cartap concentrations from 0.009 to 2.4 ~tg mL-~ with a detection limit 0.0029 ~tg mE-x. The proposed method had been successfully applied to the determination of cartap residues in grain and vegetable with recoveries of 87.4-103%. In addition, the association constants of the complexes formed between the host and the guest were determined. The competing reaction and the supramolecular interaction mechanisms between the cartap and PAL as they fight for occupancy of the CB[7] cavity were studied using spectrofluorimetry, xH NMR and molecular modeling calculations.

关键词： cartap cucurbituril palmatine fluorescent probe

Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 117-124页

作者： li-ming wu Le-Le Zhang Xin-Hua Chen Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital Zhejiang University School of Medicine

Background: Irreversible electroporation(IRE) is a novel ablative technique for hepatobiliary and pancreatic cancers. This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobiliary and pancreatic cancers. Data sources: Studies were identified by searching Pub Med and Embase for articles published in English from database inception through July 31, 2017. For inclusion, each clinical study had to report morbidity and survival data on hepatobiliary and pancreatic cancers treated with IRE and contain at least 10 patients. Studies that met these criteria were included for analysis. Two authors assessed each clinical study for data extraction. The controversial parts were resolved through discussion with seniors. Results: A total of 24 clinical studies were included. Fourteen focused on hepatic ablation with IRE comprising 437 patients with 666 lesions of different tumor types. Two patients(0.5%) died after the IRE procedure. Morbidity of hepatic ablation with IRE ranged from 7% to 35%. Most complications were mild. Complete response for hepatic tumors was reported as 57%–97%. Ten studies with 455 patients focused on pancreatic IRE. The overall mortality of IRE in pancreatic cancer was 2%. Overall severe morbidity of IRE in pancreatic cancer ranged from 0 to 20%. The median overall survival after IRE ranged from 7 to 23 months. Patients treated with IRE combined with surgical resection showed a longer overall survival. Conclusions: IRE significantly improves the prognosis of advanced hepatobiliary and pancreatic malignances, and companied with less complications. Hence, IRE is a relatively safe and effective non-thermal ablation strategy and potentially recommended as an option for therapy of patients with hepatobiliary and pancreatic malignances.

关键词： Irreversible electroporation Hepatic cancer Pancreatic cancer

Rapid and efficient synthesis of new chiral aromatic amide molecular tweezers under solvent-free conditions using microwave

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Chinese Chemical Letters 2009年第4期20卷 397-400页

作者： Xiao Xiang Zhao Zhi Gang Zhao Xing li liu Xiu ming wu College of Chemistry and Environmental Protection Engineering Southwest University for Nationalities Chengdu 610041 China

An efficient and simple method for the synthesis of new chiral aromatic amide molecular tweezers by irradiation with microwave under solvent-free conditions has been developed. Its main advantages are short reaction t... 详细信息

关键词： Molecular tweezer Aromatic amide Microwave irradiation Molecular recognition

Hepatitis B virus reinfection after liver transplan- tation: related risk factors and perspective

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 502-508页

作者： li-ming wu Xiao Xu Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: In recent years, liver transplantation (LT) has been acknowledged as an acceptable option for patients with hepatitis B virus (HBV) related end-stage liver diseases. However, HBV reinfection is an important event affecting the long-term survival of recipients. This paper was to review the risk factors related to HBV reinfection after LT. DATA SOURCES: English literature was reviewed based on MEDliNE focusing on the potential factors related to HBV reinfection after LT. RESULTS: HBV reinfection attributes to the unfavorable prognosis after LT. Many related factors may be responsible for it, including recipent factors (ethnical background, preoperative HBV replication status, extrahepatic HBV existence status), donor factors (compromised donor liver, HLA-A, -B compatibilities), perioperative treatment (use of antiviral agents, drug resistance, virus mutation, immu-nosuppressants protocol, blood transfusion) and others. CONCLUSIONS: The successful management of HBV reinfection will only be achieved by perfect clarification of its mechanism. The new strategies include new antiviral agents, gene therapy and immune intervention, reliable use of the compromised donor livers, and so on.

关键词： hepatitis B virus reinfection liver transplantation related risk factors

MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 336-344页

作者： Jun Cheng li-ming wu Xue-Song Deng Jian wu Zhen Lv Hang-Fen Zhao Zhang Yang Yong Ni Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's Hospital Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of Medicine Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Institutes of Biomedical Sciences Fudan University School of life Science Fudan University

Background: Accumulating evidence demonstrates that microRNAs(miRNAs) play essential roles in tumorigenesis and cancer progression of hepatocellular carcinoma(HCC). Average targets of a miRNA were more than 100. And one miRNA may act in tumor via regulating several targets. The present study aimed to explore more potential targets of miR-449a by proteomics technology and further uncover the role of miR-449a in HCC ***: Technologies such as i TRAQ-based quantitative proteomic were used to investigate the effect of miR-449a on HCC. The expression of c-Met and miR-449a was detected by q RT-PCR in HCC ***-and loss-of-function experiments were performed to identify the function and potential target of miR-449a in HCC ***: In HCC, miR-449a was significantly downregulated, while c-Met was upregulated *** proteomics and luciferase reporter assay identified c-Met as a direct target of ***, miR-449a inhibited HCC growth not only by targeting CDK6 but also by suppressing cMet/Ras/Raf/ERK signaling pathway. Furthermore, the inhibition of c-Met expression with a specific siRNA significantly inhibited cells growth and deregulated the ERK pathway in ***: The tumor suppressor miR-449a suppresses HCC tumorigenesis by repressing the c-Met/ERK pathway.

关键词： Hepatocellular carcinoma miR-449a c-Met Proteomics Tumorigenesis

Endoscopic diagnosis of early-stage primary esophageal small cell carcinoma: Report of two cases

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World Journal of Clinical Cases 2021年第11期9卷 2562-2568页

作者： li-Mian Er Yan Ding Xiao-Fang Sun Wen-Qian Ma li Yuan Xiu-li Zheng Na-Na An ming-li wu Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Endoscopy People's Hospital of XingtaiXingtai 054000Hebei ProvinceChina

BACKGROUND Primary esophageal small cell carcinoma(PESCC)is a highly aggressive malignancy,and its detailed clinical behaviors have remained virtually *** of the rapid tumor progression,the diagnosis of esophageal small cell carcinoma at early stage is extremely difficult in clinical ***,only a handful of PESCC cases have been *** SUMMARY Case 1:A 62-year-old man was diagnosed with an esophageal submucosal tumor by *** ultrasonography showed a 0.8 cm low echo nodule in the muscularis *** the patient refused to undergo endoscopic resection,neoplasia was detected by endoscopy 1 year *** 2:A 68-year-old woman was diagnosed as having an esophageal submucosal tumor by endoscopy at a local *** 2 wk later,we performed endoscopic ultrasonography and found a 1 cm low echo nodule in the muscularis mucosa;the submucosal was thinner than normal but still continuous;mucosal hyperemia and erosion were found on the surface of the *** submucosal dissection(ESD)was performed and the histopathological finding showed a small cell carcinoma invading the submucosal *** Early esophageal small cell carcinoma shows submucosal infiltrating growth with a hypoechoic mass in the muscularis mucosa as diagnosed by endoscopic *** is easily misdiagnosed as submucosal *** manifestations should be identified and pathological biopsies should beemployed. ESD may be performed to provide an opportunity for early treatmentof PESCC.

关键词： Primary esophageal small cell carcinoma Early stage Endoscopic submucosal dissection Endoscopic ultrasonography Small submucosal masses Poor prognosis Case report