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Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles:Sequential Embryo Transfer or Double-blastocyst Transfer?

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Current Medical Science 2024年第1期44卷 212-222页

作者： Qiao-hang ZHAO Yu-wei SONG Jian CHEN Xiang zhou Ji-lai XIE Qiu-ping YAO Qi-yin DONG Chun FENG li-ming zhou Wei-ping FU Min JIN The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310052China Jiaxing Maternity and Child Health Care Hospital Jiaxing 314051China Huzhou Maternity and Child Care Hospital Huzhou 313002China Ningbo Women and Children's Hospital Ningbo 315000China

Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of SeET and DBT on pregnancy *** Totally,261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective *** to different embryo quality and transfer strategies,they were divided into four groups:group A,good-quality SeET(GQ-SeET,n=38 cycles);group B,poor-quality or mixed-quality SeET(PQ/MQ-SeET,n=31 cycles);group C,good-quality DBT(GQ-DBT,n=121 cycles);and group D,poor-quality or mixed-quality DBT(PQ/MQ-DBT,n=71 cycles).The main outcome,clinical pregnancy rate,was compared,and the generalized estimating equation(GEE)model was used to correct potential confounders that might impact pregnancy *** GQ-DBT achieved a significantly higher clinical pregnancy rate(aOR 2.588,95%CI 1.267–5.284,P=0.009)and live birth rate(aOR 3.082,95%CI 1.482–6.412,P=0.003)than PQ/***,the clinical pregnancy rate was significantly higher in GQ-SeET than in PQ/MQ-SeET(aOR 4.047,95%CI 1.218–13.450,P=0.023).The pregnancy outcomes of GQ-SeET were not significantly different from those of GQ-DBT,and the same results were found between PQ/MQ-SeET and PQ/*** SeET relative to DBT did not seem to improve pregnancy outcomes for RIF patients if the embryo quality was comparable between the two *** clinical pregnancy outcomes could be obtained by transferring good-quality embryos,no matter whether in SeET or *** quality plays a more important role in pregnancy outcomes for RIF patients.

关键词： recurrent implantation failure sequential embryo transfer frozen-thawed embryo transfer embryo transfer strategies

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Influence of stearic acid surface modification on flowability and agglomeration of battery grade li_(2)CO_(3)powder

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Particuology 2024年第9期92卷 263-277页

作者： ming zhou lithium Industry Center Zhejiang New Era Zhongneng Technology Co.Ltd.Shaoxing312000China

This work investigates the flow and agglomeration behaviors of battery grade li_(2)CO_(3)powder and the influence of stearic acid surface *** degree of agglomeration is directly related to the uniformity of li_(2)CO_(3)and its powder *** to the Chinese National Nonferrous Metal Industry Standard,battery grade li_(2)CO_(3)powder has D50 equal to 3–8μm which belongs to a micron-sized superfine ***,with the extension of storage time,the serious agglomeration phenomenon occurs due to the large specific surface area and rough and irregular powder *** Hausner ratio(HR)of the unmodified sample increases from 1.14 to 1.41,and the corresponding flowability is classified as good to ***,among samples with doping stearic acid,the optimum amount of it is 0.10 wt%which exhibits an extremely stable HR value from 1.14 to ***,after 156 days,the repose angle(AR)obtained for samples without surface modification and using 0.10 wt%stearic acid are calculated to be 49°and 28°,*** on the values of HR and AR,the flowability of the unmodified sample is poor while the sample modified with 0.10 wt%of stearic acid still maintain excellent powder flow ***,The liMn_(2)O_(4)cathode material synthesized from modified li_(2)CO_(3)powder with a stearic acid content of 0.10 wt%exhibits good crystallinity and comparable electrochemical performance to that prepared by commercial li_(2)CO_(3).These results indicate that stearic acid has the potential to be an ideal modifier for battery grade li_(2)CO_(3)powder that needs to be kept for a long time.

关键词： Battery grade li_(2)CO_(3)powder Flowability Surface modification Stearic acid

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Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo

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World Journal of Gastroenterology 2009年第15期15卷 1816-1820页

作者： Yun Zeng Gang liu li-ming zhou Department of Pharmacology West China Medical Center of Preclinical andForensic Medicine Sichuan University Chengdu 610041Sichuan Province China Institute of Materia Medica and Department of Pharmacology North Sichuan Medical CollegeNanchong 637007 Sichuan Province China

AIM:To investigate the inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 and its mechanism. METHODS:MTT assay was used to assess the inhibitory effect of acetylshikonin on proliferation of SGC-7901 *** osis-inducing effect was determined by flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling with Hoechst *** of mRNA and protein in Bcl-2 and Bax was analyzed by reverse transcription-polymerase chain reaction and Western *** effect of acetylshikonin on a mouse SGC-7901 model was also determined. RESULTS:Forty-eight hours after treatment with acetylshikonin,MTT assay showed that acetylshikonin inhibited the proliferation of SGC-7901 cells in a dose-dependent *** half maximal inhibitory concentration of acetylshikonin to SGC-7901 cells was 0.428±0.07 mg/*** shrinkage,nuclear pyknosis and chromatin condensation,which are the characteristics of cell apoptosis,were observed in treated SGC-7901 cells and the percentage of apoptosis increased in a dose-dependent *** downregulated the expression of Bcl-2 and up-regulated the expression of Bax in the treated SGC-7901 cells compared with the *** experiment in vivo showed that 0.5,1,and 2 mg/kg of acetylshikonin significantly inhibited the growth of tumor in the mouse SGC-7901 model,with an inhibitory rate of 25.00%-55.76%. CONCLUSION:Acetylshikonin inhibits the growth of SGC-7901 cells in vitro and in vivo by inducing cell apoptosis.

关键词： Acetylshikonin Antitumor effect SGC-7901cells Apoptosis

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Effect of Azoxystrobin on Oxygen Consumption and cyt b Gene Expression of Colletotrichum capsici from Chilli Fruits

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Agricultural Sciences in China 2009年第5期8卷 628-631页

作者： CHEN Yu JIN li-hua zhou ming-guo College of Plant Protection Nanjing Agricultural University~Key Laboratory of Monitoring and Management of Crop Diseases and PestInsects Ministry of Agriculture Nanjing 210095 P.R. China

Azoxystrobin acts as an inhibitor of electron transport by binding to the Qo center of cytochrome b （cyt b）. Resistance to azoxystrobin was usually caused by the point mutation of cyt b gene or by the induction of alternative respiration. Oxygen consumption test for mycelia of Colletotrichum capsici showed that azoxystrobin inhibited mycelial respiration within 12 h; however, as time went on, the respiration of the mycelia recovered when the mycelia were treated with azoxystrobin and salicylhydroxamic acid （SHAM, a known inhibitor of alternative respiration）, and the oxygen consumption of the mycelia could not be inhibited. Meanwhile, cytochrome b （cyt b） gene expression increased with the recovery of mycelial respiration. The increased cyt b gene expression might play a role in the development of resistance to azoxystrobin in C. capsici.

关键词： QoI fungicides gene expression chili fungal respiration azoxystrobin resistance

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live births from in vitro fertilization-embryo transfer following the administration of gonadotropin-releasing hormone agonist without gonadotropins:Two case reports

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World Journal of Clinical Cases 2023年第9期11卷 2067-2073页

作者： Mai li Ping Su li-ming zhou Reproductive Center Ningbo Women and Children’s HospitalNingbo 315000Zhejiang ProvinceChina Reproductive Center Institution of Reproductive HealthTongji Medical CollegeWuhan 430030Hubei ProvinceChina

BACKGROUND The prevalence of female infertility between the ages of 25 and 44 is 3.5%to 16.7%in developed countries and 6.9%to 9.3%in developing *** means that infertility affects one in six couples and is recognized by the World Health Organization as the fifth most serious global *** International Committee for Monitoring Assisted Reproductive Technology reported that the global total of babies born as a result of assisted reproductive technology procedures and other advanced fertility treatments is more than 8 *** in controlled ovarian hyperstimulation procedures led to crucial accomplishments in human fertility *** European Society for Human Reproduction and Embryology guideline on ovarian stimulation gave us valuable evidence-based recommendations to optimize ovarian stimulation in assisted reproductive *** ovarian stimulation protocols for in vitro fertilization(IVF)–embryo transfer are based upon the administration of gonadotropins combined with gonadotropin-releasing hormone(GnRH)analogues,either GnRH agonists(GnRHa)or *** development of ovarian cysts requires the combination of GnRHa and gonadotropins for controlled ovarian ***,in rare cases patients may develop an ovarian hyper response after administration of GnRHa *** SUMMARY Here,two case studies were *** the first case,a 33-year-old female diagnosed with polycystic ovary syndrome presented for her first IVF cycle at our reproductive *** days after triptorelin acetate was administrated(day 18 of her menstrual cycle),bilateral ovaries presented polycystic *** patient was given 5000 IU of human chorionic ***-two oocytes were obtained,and eight embryos *** blastospheres were transferred in the frozen-thawed embryo transfer cycle,and the patient was *** the second case,a 37-year-old woman presented to the reproductive center for h

关键词： Gonadotropin-releasing hormone agonist Ovarian hyperstimulation In vitro fertilization live birth Infertility Frozen-thawed embryo transfer Human chorionic gonadotropin Case report

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Optimal Timing of Business Conversion for Solvency Improvement

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 744-757页

作者： Peng li ming zhou School of Finance Nanjing University of Finance and EconomicsNanjing 210023China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China

In this paper,we study the optimal timing to convert the risk of business for an insurance company in order to improve its *** cash flow of company evolves according to a jump-diffusion *** conversion option offers the company an opportunity to transfer the jump risk business *** exchange for this option,the company needs to pay both fixed and proportional transaction *** proportional cost can also be seen as the profit loading of the jump risk *** formulated this problem as an optimal stopping *** solving this stopping problem,we find that the optimal timing of business conversion mainly depends on the profit loading of the jump risk business.A larger profit loading would make the conversion option *** fixed cost,however,only delays the optimal timing of business *** the end,numerical results are provided to illustrate the impacts of transaction costs and environmental parameters to the optimal strategies.

关键词： optimal stopping jump-diffusion process conversion option

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Synthesis and Crystal Structure of a Mn(II) Complex with Thiosemicarbazone Derivative of Pyridine-3-carbaldehyde Showing Unusual Coordination Mode of Tridentate Thiosemicarbazone

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1275-1279页

作者： li ming-Xue zhou Jing WANG Jing-Ping WANG Zi-liang Institute of Molecular and Crystal Engineering College of Chemistry and Chemical Engineering Henan University Kaifeng 475001 China

The title complex Mn（HL）4（NCS）2（CH3CH2OH）2 has been achieved via selfassembly by incorporating manganese（Ⅱ） into pyridine-3-carbaldehyde thiosemicarbazonate ligand, and characterized by elemental analysis and single-crystal X-ray diffraction study. The crystal crystallizes in triclinic, space group PI^-, with a = 8.896（2）, b = 9.530（2）, c = 14.520（4）°A, α = 87.035（4）, β= 88.112（4）, γ= 69.434（4）°, V= 1150.9（5）°A^3, Z = 1, Mr = 984.17, Dc = 1.420 g/cm^3,μ（MoKα） = 0.612 mm^-1, F（000） = 511, the final R = 0.0574 and wR = 0.1547 for 2855 observed reflections with I〉2σ（I）. The complex contains one six-coordinated manganese ion connected by two thiosemicarbazide ligands, in which the thiosemicarbazone ligand acts as a monodentate ligand and coordinates to the center metal atoms via the pyridyl nitrogen atoms, two ethanol molecules and two isothiocyanic anions to give rise to a mononuclear structure. The coordination of a potentially tridentate thiosemicarbazone in manganese（Ⅱ） complex without using its sulfur and imine nitrogen sites is unusual. Hydrogen bonds existing in the complex link the different components to stabilize the crystal structure.

关键词： crystal structure thiosemicarbazide manganese hydrogen bond

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Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： Jun-Hao zhou li-ming Tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot *** prepolymers were characterized fully by various ***,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and *** from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical ***,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their *** influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then *** composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT *** addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

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On the measurement of slip length for liquid flow over super-hydrophobic surface

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Chinese Science Bulletin 2009年第24期54卷 4560-4565页

作者： li Jian zhou ming CAI Lan YE Xia YUAN Run Center for Photon Manufacturing Science and Technology Jiangsu University Zhenjiang 212013 China

To design a surface with large slip or larger drag reduction is a pop issue in the fields of liquid transporting and body swimming. In this context, it is a crucial problem to measure the slip length for these surfaces. Here we propose a novel method by using rheometer for this objective. This method is implemented by designing the distribution of the super-hydrophobic area on the sample. Using this method, a slip length of 40 μm for 70 wt% glycerin flow over a super-hydrophobic surface with stripe structure (the period, width and height of ridges are 150 μm, 40 μm and 65 μm, respectively) is measured. The result shows that the slip length measured using this method is in good agreement with former results measured by other methods. This method is fit for measuring the slip length of super-hydrophobic surface whose structure ranges from microto nanoscale.

关键词：疏水表面长度测量流量测量滑移液体条纹结构纳米尺度微米

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基于变形监测与数值模拟的白衣寺塔稳定性分析

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西北师范大学学报（自然科学版） 2024年第4期60卷 42-49页

作者：闫菲菲张景科李周明郑炜白东明兰州大学土木工程与力学学院甘肃兰州730000 西部灾害与环境力学教育部重点实验室甘肃兰州730000 兰州大学岩土质文物保护基础科学研究与人才培养甘肃省文物局重点科研基地甘肃兰州730000 兰州市博物馆甘肃兰州730030

古塔作为中国建筑的典型代表之一,对塔体进行稳定性分析是后续预防性保护的重要措施.以兰州市白衣寺塔为例,运用三维激光扫描技术获取点云数据,查明目前保存现状,采用位移计、摄影测量技术监测塔身整体位移变化、局部裂隙变化,并通过An... 详细信息

古塔作为中国建筑的典型代表之一,对塔体进行稳定性分析是后续预防性保护的重要措施.以兰州市白衣寺塔为例,运用三维激光扫描技术获取点云数据,查明目前保存现状,采用位移计、摄影测量技术监测塔身整体位移变化、局部裂隙变化,并通过Ansys数值软件模拟白衣寺塔的位移、应力变化,对白衣寺塔进行稳定性分析.研究表明,白衣寺塔目前存在倾斜,东西位移整体向西偏移,南北位移整体向南偏移,倾角为南偏西0.394°,塔底部顶部水平偏移量为0.170 m,整个塔体并未产生应力集中,结构表现为全截面受压,应力值在材料强度允许范围内.正常使用条件下,当塔体倾斜到6.41°时,拉应力达到限值,结构将会发生局部或整体失稳而破坏.

关键词：白衣寺塔变形监测数值模拟稳定性

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