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Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism

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Biomedical and Environmental Sciences 2019年第8期32卷 578-591页

作者： XIAO Xiang BAI Juan li ming song ZHANG Jia Yan SUN Xin Juan DONG Ying School of Food and Biological Engineering Jiangsu University

Objective We aimed to explore how fermented barley extracts with Lactobacillus plantarum dy-1(LFBE) affected the browning in adipocytes and obese *** In vitro, 3T3-L1 cells were induced by LFBE, raw barley extraction(RBE) and polyphenol compounds(PC) from LFBE to evaluate the adipocyte *** vivo, obese SD rats induced by high fat diet(HFD) were randomly divided into three groups treated with oral gavage:(a) normal control diet with distilled water,(b) HFD with distilled water,(c) HFD with 800 mg LFBE/kg body weight(bw).Results In vitro, LFBE and the PC in the extraction significantly inhibited adipogenesis and potentiated browning of 3T3-L1 preadipocytes, rather than *** vivo, we observed remarkable decreases in the body weight, serum lipid levels, white adipose tissue(WAT) weights and cell sizes of brown adipose tissues(BAT) in the LFBE group after 10 *** group could gain more mass of interscapular BAT(IBAT) and promote the dehydrogenase activity in the *** LFBE may potentiate process of the IBAT thermogenesis and epididymis adipose tissue(EAT) browning via activating the uncoupling protein 1(UCP1)-dependent mechanism to suppress the *** These results demonstrated that LFBE decreased obesity partly by increasing the BAT mass and the energy expenditure by activating BAT thermogenesis and WAT browning in a UCP1-dependent mechanism.

关键词： Fermented barley Polyphenol compounds UCP1 Thermogenesis Browning

X-ray Spectroscopy of Dips of Cir X-1

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Chinese Journal of Astronomy and Astrophysics 2007年第5期7卷 693-704页

作者： Ya-Juan Lei Fang-Jun Lu Jin-Lu Qu li-ming song Cheng-Min Zhang Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

We present X-ray spectral analyses of the low-mass X-ray binary Cir X-1 during X-ray dips, using the Rossi X-ray Timing Explorer （RXTE） data. Each dip was divided into several segments, and the spectrum of each segment was fitted with a three-component blackbody model, in which the first two components are affected by partial covering and the third one is unaffected. A Gaussian emission line is also included in the spectral model to represent the Fe Kα line at - 6.4 keV. The fitted temperatures of the two partially covered components are about 2 keV and 1 keV, while the uncovered component has a temperature of -0.5-0.6 keV. The equivalent blackbody emission radius of the hottest component is the smallest and that of the coolest component is the largest. During the dips the fluxes of the two hot components are linearly correlated, while that of the third component does not show any significant variation. The Fe line flux remains constant, within the errors, during the short dips. However, during the long dips the line flux varies significantly and is positively correlated with the fluxes of the two hot components. These results suggest; （1） that the temperature of the X-ray emitting region decreases with radius, （2） that the Fe Kα line emitting region is close to the hot continuum emitting region, and （3） that the size of the Fe line emitting region is larger than that of the obscuring matter causing the short dips but smaller than the region of that causing the long dips.

关键词： stars individual (Circinus X-1) -- stars neutron -- X-rays stars

Burst Phase Distribution of SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2023年第3期23卷 68-74页

作者： Xue-Feng Lu li-ming song ming-Yu Ge You-li Tuo Shuang-Nan Zhang Jin-Lu Qu Ce Cai Sheng-Lun Xie Cong-Zhan liu Cheng-Kui li Yu-Cong Fu Ying-Chen Xu Tian-ming li Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Institute of Astrophysics Central China Normal UniversityWuhan 430079China

On 2020 April 27,the soft gamma-ray repeater SGR J1935+2154 entered its intense outburst episode ***-HXMT carried out about one month observation of the source.A total number of 75 bursts were detected during this activity episode by Insight-HXMT,and persistent emission data were also *** report on the spin period search result and the phase distribution of burst start times and burst photon arrival times of the Insight-HXMT high energy detectors and Fermi/Gamma-ray Burst Monitor(GBM).We find that the distribution of burst start times is uniform within its spin phase for both Insight-HXMT and Fermi/GBM observations,whereas the phase distribution of burst photons is related to the type of a burst’s energy *** bursts with the same spectrum have different distribution characteristics in the initial and decay episodes for the activity of magnetar SGR J1935+2154.

关键词： spectrum Fermi distribution

Temporal and Spectral Characteristics of Persistent Emission and Special Bursts of Magnetar SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第6期24卷 225-233页

作者： Xue-Feng Lu li-ming song ming-Yu Ge Shuang-Nan Zhang Jin-Lu Qu Ce Cai Cong-Zhan liu Cheng-Kui li Yu-Cong Fu Ying-Chen Xu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Department of Astronomy Beijing Normal UniversityBeijing 100875China

In October 2022,the magnetar SGR J1935+2154 entered the active outburst *** the episode,the InsightHXMT satellite carried out a long observation that lasted for 20 *** than 300 bursts were detected,and a certain amount of persistent radiation signals were also *** paper mainly introduces the results of persistent radiation profile folding and period search based on Insight-HXMT *** the same time,the burst phase distribution characteristics,spectral lag results of burst,the spectral characteristics of zero-lag bursts and the time-resolved spectral evolution characteristics of high-flux bursts are *** found that there is no significant delay feature during different energy bands for the bursts of SGR J1935+*** observed zero-lag burst does not have a unique *** time-resolved spectrum of the individual burst has consistent spectral types and spectral parameters at different time periods of the *** also find that the burst number phase distribution and the burst photon phase distribution have the same tendency to concentrate in specific regions of the persistent emission profile.

关键词： radiation mechanisms:general dense matter magnetic fields

Pharmacological effects of Schisandra Chinensis Fructus polysaccharide on intestinal protection

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中国药理学与毒理学杂志 2021年第10期35卷 766-767页

作者： li ming-song ZHANG Dan-shen JING Yong-shuai College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China

Schisandra Chinensis Fructus(SCF)is the fruit of Schisandra chinensis(Turcz.)Baill.,a perennial *** was first recorded in Shen Nong′s herbal classic and has a long application *** have shown that SCF has anti-inflammatory,protective liver,antioxidant,antibacterial and other pharmacological *** prescriptions are commonly used in the treatment of chronic diarrhea and other intestinal diseases and *** clinical pharmacology features of SCF polysaccharide(SCFP)in diabetes,liver diseases,enteritis and other aspects have achieved excellent *** is an important digestive organ of human body,but intestinal diseases are varied,including Crohn′s disease,ulcerative colitis,intestinal flora imbalance,etc..It is a chronic and non-specific inflammatory *** disease is persisted for a long time and the incidence rate is expected to *** of the symptoms are recurrent diarrhea,bloody stool and abdominal *** is considered by the World Health Organization as a refractory *** present,there is little possibility of complete cure,which is closely related to complex environmental factors,eating habits and *** recent years,clinical studies have found that SCFP has a variety of pharmacological effects on intestinal protection.①Reduce inflammatory factors:intestinal mucositis is a common adverse reaction in patients with *** development of mucositis is related to pro-inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL^(-1)β,Interferon-γ(IFN-γ).SCFP can significantly reduce IL-6 TNF-α,IL^(-1)β,and IL-8,as well as the accumulation of T cells in the process of resisting apoptosis,reduce the inflammatory reaction and protect the damage to villi and crypts,improve the symptoms of small intestinal mucositis caused by weight loss and diarrhea.②Promote immunoglobulin A secretion:intestinal mucosal immunity is the first line of defense of the body′s immune *** main antibody

关键词： Schisandra Chinensis Fructus polysaccharide intestinal diseases inflammatory factor

The performance of out-of-time events of the follow-up X-ray telescope onboard Einstein probe

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Radiation Detection Technology and Methods 2024年第2期8卷 1148-1154页

作者： Hai-Sheng Zhao Juan Zhang Ju Guan Cheng-Kui li Shu-Mei Jia li-ming song Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing100049People’s Republic of China

Purpose:The purpose of this study is to investigate the performance of out-of-time events(OoT events)in the Follow-up X-ray Telescope(FXT)onboard the Einstein *** OoT events,registered on the PN-CCD during its readout time,can provide information on the sources,e.g.,spectral indices,and diagnose the behavior of ***:In order to analyze the characteristics of OoT events,we simulated sources,each of which had been modeled using an absorbed power law combined with Gaussians,in different FXT modes and different *** allowed us to determine the OoT spectral indices and pile-up ***:In the timing mode of FXT,the OoT events occupy a large proportion and the OoT correction must be done with the assumption that all photons originate from the source position on the *** for some bright sources,the OoT events may be sufficient to derivate the source spectra,especially when pile-up occurs,particularly in the full frame mode and the partial window mode of ***:We conclude that the OoT events can provide additional information about the celestial sources and can be used to estimate whether the pile-up occurs or not and the scope of ***,they can be also used to determine the new sources and improve the detection significance of a source.

关键词： Out-of-time Event PN-CCD Pile-up

Long-term evolution of the X-ray flux of the Crab pulsar

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Radiation Detection Technology and Methods 2023年第1期7卷 48-55页

作者： Hai-Sheng Zhao ming-Yu Ge Xiao-Bo li lin-li Yan You-li Tuo Fang-Jun Lu li-ming song Cong-Zhan liu Shu Zhang Shuang-Nan Zhang Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing 100049China School of Mathematics and Physics Anhui JianZhu UniversityHefei 230601AnhuiChina

Purpose In order to carry out in-orbit calibration,the hard X-ray modulation telescope satellite(HXMT)has made a number of observations of Crab *** study the long-term evolution of the X-ray flux of the Crab pulsar with these observational *** We use nearly four years Crab pulsar’s data obtained by HXMT and the neutron star interior composition of explorer to test whether L_(x)∝L_(sd)^(α) holds for an individual pulsar,where L_(x) is the pulsed X-ray luminosity and Lsd is its spin-down *** also combine the earlier results obtained with PCA and HEXTE data(Yan et *** ApJ 865:21,2018)to get the long-term evolution characteristics of the Crab *** We find the X-ray flux evolution can be fitted by a linear correlation:L_(x)∝L_(sd)^(1.42±0.18).In soft X-ray energy band(1–10 keV)and hard X-ray energy band(27–250 keV),αdoes not change significantly with either energy or ***,this will need to be confirmed in *** example,the interpulse component of hard X-ray may follow L_(x)∝L_(sd)^(0.96±0.34),which may be different from the correlation of soft X-rays and main pulse *** the other hand,the hard X-ray flux evolution shows that the performance of high energy X-ray telescope(HE)onboard HXMT,such as effective area,is *** We conclude that the X-ray luminosity of the Crab pulsar closely correlates with its spin-down ***,the emission mechanism responsible for these phenomena remains not fully understood.

关键词： X-rays Crab pulsar Flux evolution Spin-down luminosity

Onboard GRB trigger algorithms of SVOM-GRM

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Research in Astronomy and Astrophysics 2013年第11期13卷 1381-1396页

作者： Dong-Hua Zhao Bo-Bing Wu li-ming song Yong-Wei Dong Stphane Schanne Bertrand Cordier Jiang-Tao liu Institute of High Energy Physics Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences CEA Saclay DSM/Irfu/Service d’Astrophysique

The Gamma-Ray Monitor （GRM） is a high energy detector onboard the future Chinese-French satellite named the Space-based multi-band astronomical Variable Object Monitor which is dedicated to studies of gamma-ray bursts （GRBs）. This paper presents an investigation of the algorithms that look for GRBs by searching for a significant increase in the photon count rate for the computer onboard GRM. The trigger threshold and trigger efficiency, which are based on a given sample of GRBs, are calculated with the algorithms. The trigger characteristics of onboard instruments GRM and ECLAIRs are also analyzed. In addition, the impact of solar flares on GRM is estimated, and a method to distinguish solar flares from GRBs is investigated.

关键词： trigger algorithms -- gamma-rays: bursts -- Sun: flares

Observation data pre-processing and scientific data products generation of POLAR

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Research in Astronomy and Astrophysics 2019年第7期19卷 13-24页

作者： Zheng-Heng li Jian-Chao Sun li-ming song Bo-Bing Wu Lu li Xing Wen Hua-lin Xiao Shao-lin Xiong Lai-Yu Zhang Shuang-Nan Zhang Yong-Jie Zhang Key Laboratory of Particle Astrophysics Institute of High Energy Physics (IHEP)Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Paul Scherrer Institut 5232 Villigen PSISwitzerland

POLAR is a compact space-borne detector initially designed to measure the polarization of hard X-rays emitted from Gamma-Ray Bursts in the energy range 50–500 ke *** instrument was launched successfully onboard the Chinese space laboratory Tiangong-2(TG-2) on 2016 September *** being switched on a few days later,tens of gigabytes of raw detection data were produced in-orbit by POLAR and transferred to the ground every *** the launch date,a full pipeline and related software were designed and developed for the purpose of quickly pre-processing all the raw data from POLAR,which include both science data and engineering data,then to generate the high level scientific data products that are suitable for later science *** pipeline has been successfully applied for use by the POLAR Science Data Center in the Institute of High Energy Physics(IHEP) after POLAR was launched and switched on.A detailed introduction to the pipeline and some of the core relevant algorithms are presented in this paper.

关键词： gamma-ray burst general-methods data analysis-instrumentation polarimeters