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Chronic blocking of β_3-adrenoceptor ameliorates cardiac function in rat model of heart failure

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Chinese Medical Journal 2007年第24期120卷 2250-2255页

作者： GAN Run-tao li wei-min XIU Chun-hong SHEN Jing-xia WANG Xu WU Shuang KONG Yi-hui Department of Cardiology First Clinical Hospital Harbin Medical University Harbin 150001 China

Background Stimulation of the heart β3-adrenoceptor （AR） may result in a negative inotropic effect. Being up-regulated, β3-AR plays a more important role in the regulation of cardiac function during heart failure. However, the effect of chronic blocking of β3-AR on heart failure has not been fully elucidated. In this study, we used a selective β3-AR antagonist SR59230A to treat a well defined heart failure rat model chronically, then evaluated its effect on cardiac function and investigated the mechanism. Methods Male Wistar rats were chosen randomly as controls （n=-8）. Isoproterenol induced heart failure rats were randomly divided into ISO group （n=-10） and SR group （n=10）. The ISO group received intraperitoneal injection of 1 ml saline twice a day; the SR group received intraperitoneal injection of SR59230A 85 nmol in 1 ml saline twice a day; and the control group received no treatment. The treatment was started 24 hours after the last isoproterenol injection and continued for 7 weeks. Then we measured the following indexes： the ratio of heart weight to body weight （HW/BW） and the ratio of left ventricular weight to body weight （LVW/BW）, collagen volume fraction （CVF）, left ventricular end diastolic dimension （LVEDd）, left ventricular end systolic dimension （LVESd）, ejection fraction （EF）, fractional shortening （FS） and the ratio of E wave to A wave （E/A）, the mRNA and protein expression of β3-AR and eNOS, and cGMP level in the heart. Results The ratios HW/BW and LVW/BW were significantly increased in the ISO group compared with the control group （P〈0.01）, but they were limited in the SR group （P〈0.05 compared with the ISO group）. CVF increased in the ISO group and the SR group （P〈0.01）, but it was significantly attenuated in the SR group （P〈0.01）. LVEDd, LVESd and E/A ratio were significantly increased in the ISO group compared with the control group （P〈0.01）, while EF and FS were significantly decreased （P〈0.01）. Compared with the ISO group, the SR group showe

关键词： adrenoceptor cardiac function antagonist heart failure rats

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： wei-min Qin Zhongliang li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

Critical care for severe coronavirus disease 2019:a population-based study from a province with low case-fatality rate in China

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Chinese Medical Journal 2021年第1期134卷 98-100页

作者： Xue-lian liao Hong Chen Zhen li Bo Wang Zhong-wei Zhang wei-min li Zong-An liang Jin Tang Jian Wang Rui Shi Xiao-Dong Jin Yan Kang SUNRISE Group Department of Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Critical Care Medicine Public Health Clinical Centre of ChengduChengduSichuan 610066China Clinical Research Centre Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Critical Care Medicine Guang'an People's HospitalGuang'anSichuan 638001China Department of Orthopaedics West China HospitalSichuan UniversityChengduSichuan 610041China ‘Department of Infectious Disease Ganzi Hospital of West China HospitalGanzi Tibetan Autonomous Prefecture People's HospitalGanziSichuan 626000China.

The coronavirus disease 2019(COVID-19)pandemic has affected over twenty million people worldwide since its outbreak,[1]in which approximately 19%are expected to progress to severe or critical disease,constituting the high-risk group for death.[2]The reported case-fatality rates among the severe COVID-19 varied a lot across different regions from zero to 61.5%[1,3]and the reason behind remained *** limited data concerning management of severe cases were reported from low case-fatality *** this study,we described the clinical features,multi-strategy management,and respiratory support resources usage for the severe COVID-19 in Sichuan province,where the 28-day case-fatality rate was 0.6%in all patients and 3.7%in severe cases,which was much lower compared with that reported in most of the studies worldwide.

关键词： concerning province const

6 000 000 t/a艾萨熔炼及其崛起

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中国有色冶金 2009年第6期38卷 1-6,17页

作者：李卫民云南铜业股份有限公司云南昆明650102

艾萨熔炼是一种浸没喷枪熔炼技术,澳大利亚、美国、比利时、印度、德国、马来西亚和中国的多家冶炼厂都在使用该技术。目前,秘鲁和赞比亚正在兴建艾萨熔炼厂。赛洛喷枪技术发明之后,芒特·艾萨矿业公司意识到这一新颖的顶吹熔池熔炼工... 详细信息

艾萨熔炼是一种浸没喷枪熔炼技术,澳大利亚、美国、比利时、印度、德国、马来西亚和中国的多家冶炼厂都在使用该技术。目前,秘鲁和赞比亚正在兴建艾萨熔炼厂。赛洛喷枪技术发明之后,芒特·艾萨矿业公司意识到这一新颖的顶吹熔池熔炼工艺的商业潜力,进行了长达25年的研发。铜和铅试验工厂和示范工厂成功生产后,芒特·艾萨矿业公司决定向其它公司出售该技术。2003年超达公司收购芒特·艾萨矿业公司后,超达技术公司承担起了转让艾萨熔炼技术的责任。第一台艾萨炉投产后的15年,已建的工厂(或在建的工厂)每年精矿或再生物料总熔炼能力已超过六百万吨。芒特·艾萨及其它地区的工厂一直在进行工艺的持续开发。工厂操作人员进行的多项改进已传授给其它用户。通过对用户工厂的上门访问和由超达技术公司安排的定期许可证用户研讨会,各家工厂相互间进行交流和技术改进。本文向读者介绍了正在使用艾萨熔炼技术的冶炼厂或正在兴建中的艾萨冶炼厂的状况,强调了技术提供者的操作经验在保证新建冶炼厂迅速达到额定生产能力时所起的作用。

关键词：浸没喷枪熔炼商业化达产

做有现代感的古代史研究——定宜庄研究员访谈录

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晋阳学刊 2010年第6期 3-12页

作者：李卫民

新世纪的中国古代史研究应该有新的学术突破。严格意义上的突破,既不能离开对中国传统史学方法的继承,也不应忽视对西方社科理论的借鉴。但是,中西融合并不是一件轻而易举的事情,这方面的经验,尤其值得我们珍视。定宜庄研究员在近30年... 详细信息

新世纪的中国古代史研究应该有新的学术突破。严格意义上的突破,既不能离开对中国传统史学方法的继承,也不应忽视对西方社科理论的借鉴。但是,中西融合并不是一件轻而易举的事情,这方面的经验,尤其值得我们珍视。定宜庄研究员在近30年的清代历史研究中,一直追踪国际学术前沿,不断尝试运用西方理论和方法,取得不少引人注目的成果,她既是有成就的古代史学者,也是引人注目的口述史专家。尤其应该指出,定先生对西方理论的借鉴,是有分析、有选择的,体现了较强的批判精神,并不是对西方的盲从和膜拜。定先生此次接受本刊采访,详述其学术观点,一定会引起学界的高度重视。

关键词：古代史研究访谈录研究员现代感中国传统史学方法社科理论

全力以赴,让研究成果逼近历史真相——杨天石研究员访谈录

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晋阳学刊 2008年第6期 3-10页

作者：李卫民浙江大学中国社科院近代史研究所清华大学研究生院教授中央文史研究馆中国社科院文史哲学部荣誉学部

杨天石先生从事中国近代史研究已逾30年,他的研究独具特色:选题重大,材料新颖,证据确凿,推勘严密,结论很具说服力,文字表达流畅生动。杨先生的研究成果,自1980年代初以来,屡屡引发学术界内外的强烈反响,反响之大,还常常波及海外。杨先... 详细信息

杨天石先生从事中国近代史研究已逾30年,他的研究独具特色:选题重大,材料新颖,证据确凿,推勘严密,结论很具说服力,文字表达流畅生动。杨先生的研究成果,自1980年代初以来,屡屡引发学术界内外的强烈反响,反响之大,还常常波及海外。杨先生作为中华民国史研究权威,他目前的研究动态,是广受关注的。此次杨先生接受本刊采访,详述个人治学历程,就他研究当中的着力点,有明确、详实的阐释,并就推动中华民国史研究,提出了很多的看法、主张,很值得史学工作者留意。

关键词：杨天石国民党共产党东西胡汉民蒋介石研究近代史研究历史真相

Study of Neuropathways of Acupuncture Effect on Functional Regulation and Disease Treatment

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 261-263页

作者：李为民 Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Department of Mechanics and Engineering ScienceFudan UniversityShanghai 200433P.R.China

Objective： To reveal the neuropathways of acupuncture effect on regulation of autonomic functions, treatment of diseases and the relationship between treating acupoint and certain target tissue or organ. Methods： it is reviewed for the authors＇ studies of characteristics of afferent nerve response, somato-sympathetic reflex （one of the somato-autonomic reflexes） and glutamate derived central modulation, target tissue and organ responses to somatic stimulation of acupuncture or electrical shock in rats and mice. Results and Conclusion： An electrical discharge from the nerve afferent serving Zusanli （ST 36） was recorded by applying manual acupuncture or electroacupuncture to Zusanli （ST 36）. Such process could be replaced by applying electric shock directly to the afferent nerve assumingly. Somatic electrical stimulation of the afferent nerve e.g. tibia nerve can reflexively elicit an electrical discharge from autonomic efferent nerve e.g. sympathetic nerve that is defined as somato-sympathetic reflex. The reflex can be modulated by an excitatory neurotransmitter of glutamate in the central pathways. On the other hand, somatic stimulation of Zusanli （ST 36）, etc. by electroacupuncture showed that there were inhibitory modulation of somatic sensory input from target tissue of the inflammatory pain in the hind paw of the mouse and visceral sensory input from target organ of the colorectum hyperagesia in the irritable bowel syndrome （IBS） rat. Spinal GABA and NMDA receptors were proved to be involved in the former and latter processes, respectively.

关键词： Points, Zusanli (ST 36) Acupuncture Neural Conduction Neurotransmitter Acupuncture Analgesia Rats Mice

永远的莎士比亚,永远的朱生豪——朱生豪译莎剧的独特价值

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山东外语教学 2013年第4期34卷 13-18页

作者：李伟民四川外国语大学莎士比亚研究所重庆400031

朱生豪翻译的莎士比亚戏剧在中国莎学史上占有重要位置,他的莎剧译文经受了时间的考验,受到几代汉语读者的喜爱。朱生豪翻译莎士比亚戏剧能达到"文而不越,质而意显"这样的高度,将莎士比亚戏剧以具有强烈诗歌韵味的口语化汉语散文形式表... 详细信息

朱生豪翻译的莎士比亚戏剧在中国莎学史上占有重要位置,他的莎剧译文经受了时间的考验,受到几代汉语读者的喜爱。朱生豪翻译莎士比亚戏剧能达到"文而不越,质而意显"这样的高度,将莎士比亚戏剧以具有强烈诗歌韵味的口语化汉语散文形式表达出来,个中的成败得失之处值得我们深入探讨。

关键词：朱生豪莎士比亚戏剧译文

莎士比亚喜剧的跨文化演绎——京剧《温莎的风流娘儿们》与“福氏喜剧”精神

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解放军外国语学院学报 2020年第5期43卷 55-61,159页

作者：李伟民浙江越秀外国语学院浙江绍兴312000 四川外国语大学研究生院重庆400031

京剧《温莎的风流娘儿们》的"跨界"对莎士比亚原作进行了适合中国戏曲表达方式的改写。该剧在"移步与换形"中既以彰显原作的喜剧精神为旨归,又以鲜明的京剧表现手段成功地在莎士比亚和中国京剧之间寻找融通之道;既在表演中利用京剧的唱... 详细信息

京剧《温莎的风流娘儿们》的"跨界"对莎士比亚原作进行了适合中国戏曲表达方式的改写。该剧在"移步与换形"中既以彰显原作的喜剧精神为旨归,又以鲜明的京剧表现手段成功地在莎士比亚和中国京剧之间寻找融通之道;既在表演中利用京剧的唱腔、程式成功塑造出原作中人物的性格,又充分利用假定性原则和戏曲写意性的呈现方式,在轻松、幽默、调侃、戏谑的喜剧空间中,让莎剧与京剧通过跨文化的互渐、互识、互释、互文与互彰释放出各自的审美艺术张力,彰显了原作蕴涵的"福氏喜剧"的深刻内涵。

关键词：莎士比亚京剧温莎的风流娘儿们福氏喜剧