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Very Large Eddy Simulation of Cavitation from Inception to Sheet/Cloud Regimes by A Multiscale Model

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China Ocean Engineering 2021年第3期35卷 361-371页

作者： li lin-min WANG Zheng-dong li Xiao-jun WANG Yan-ping ZHU Zu-chao National-Provincial Joint Engineering Laboratory for Fluid Transmission System Technology Zhejiang Sci-Tech UniversityHangzhou 310018China

The cavitating flow in different regimes has the intricate flow structure with multiple time and space *** present work develops a multiscale model by coupling the volume of fluid(VOF)method and a discrete bubble model(DBM),to simulate the cavitating flow in a convergent-divergent test *** Schnerr-Sauer cavitation model is used to calculate the mass transfer rate to obtain the macroscale phase structure,and the simplified Rayleigh-Plesset equation is applied to simulate the growing and collapsing of discrete *** algorithm for bridging between the macroscale cavities and microscale bubbles is also developed to achieve the multiscale *** the flow field,the very large eddy simulation(VLES)approach is *** from inception to sheet/cloud cavitation regimes are taken into account and simulations are *** with the experimental observations,it is shown that the cavitation inception,bubble clouds formation and glass cavity generation are all well represented,indicating that the proposed VOF-DBM model is a promising approach to accurately and comprehensively reveal the multiscale phase field induced by cavitation.

关键词： cavitating flow multiscale model volume of fluid discrete bubble model VLES

Sphere-forming-like cells(squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma

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International Journal of Oral Science 2014年第4期6卷 212-218页

作者： Yuk-Kwan Chen Anderson Hsien-Cheng Huang li-min lin Department of Oral Pathology Faculty of Dentistry College of Dental Medicine Kaohsiung Medical University Division of Dentistry Department of Oral Pathology Kaohsiung Medical University Hospital Oral and Maxillofacial Imaging Center College of Dental Medicine Kaohsiung Medical University

Previous studies have demonstrated that spheroid type cells grown under suspension culture conditions have cancer stem cell（CSC） traits in a number of cancers, but this phenomenon has not yet been reported in the VX2 rabbit oral cancer model. Hence, this study aimed to study the spheroid cells from VX2 rabbit buccal squamous cell carcinomas（SCCs） and assess their CSC characteristics. Five adult male New Zealand white outbred rabbits were used to generate VX2 rabbit buccal SCC. Sphere-forming cell culture was performed for the VX2 rabbit buccal SCC specimens. The self-renewal capability; cluster of designation（CD） 44, CD133, acetaldehyde dehydrogenase 1（ALDH1）, B cell-specific Moloney murine leukemia virus integration site 1（Bmi-1）, Nestin, octamer-binding transcription factor 4（Oct4）and reduced expression protein-1（Rex-1） expression with reverse transcription-polymerase chain reaction（RT-PCR）; chemoresistance to cisplatin and 5-fluorouracil; and in vivo tumorigenicity of spheroid cell transplantation in nude mice were evaluated to determine the CSC characteristics of the resulting spheroid cells. We successfully obtained spheroid cells from the VX2 rabbit OSCC tissues. The spheroid cells exhibited CSC traits, including the expression of CSC and stem cell markers（CD44, Bmi-1, Nestin, Oct4 and Rex-1）, capacity to generate new spheroid colonies within 1 week of reseeding from single-dissociated spheroid cells, chemoresistance capacity and generation of tumour xenografts（with histological features resembling those of the original VX2 rabbit buccal SCC） from the transplantation of 103 undifferentiated spheroid cells into nude mice. In summary, we demonstrated that spheroid cells with CSC cell traits can be derived from VX2 rabbit buccal SCCs, indicating that this animal cancer model is applicable for studying CSCs in human oral cancers.

关键词： cancer stem-like cell squamosphere VX2 rabbit oral carcinoma

Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible

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International Journal of Oral Science 2013年第2期5卷 115-119页

作者： Ching-Yi Chen Chung-Wei Wu Wen-Chen Wang li-min lin Yuk-Kwan Chen Division of Oral Pathology & Diagnosis Department of DentistryKaohsiung Medical University Chung-Ho Memorial Hospital Division of Oral & Maxillofacial Surgery Department of DentistryKaohsiung Medical University Chung-Ho Memorial Hospital School of Dentistry College of Dental MedicineKaohsiung Medical University

We present an uncommon case （female patient aged 59 years） of the clear-cell variant of calcifying epithelial odontogenic tumor （CEOT）（also known as Pindborg tumor） in the mandible. The clinical characteristics and probable origins of the clear tumor cells of previously reported cases of clear-cell variant of intraosseous CEOT are also summarized and discussed.

关键词： calcifying epithelial odontogenic tumor clear cell Pindborg tumor

ICA方法与NIR技术用于药片中活性成分含量的测定

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化学学报 2008年第15期66卷 1791-1795页

作者：方利民林敏中国计量学院计量测试工程学院杭州310018

用独立分量分析(ICA)方法提取药片近红外光谱数据矩阵的独立成分和相应的混合矩阵,再用BP神经网络对混合矩阵和药片中活性成分的浓度矩阵进行建模,提出了新的药片活性成分含量测定的基于独立分量分析-神经网络回归(ICA-NNR)的近红外光... 详细信息

用独立分量分析(ICA)方法提取药片近红外光谱数据矩阵的独立成分和相应的混合矩阵,再用BP神经网络对混合矩阵和药片中活性成分的浓度矩阵进行建模,提出了新的药片活性成分含量测定的基于独立分量分析-神经网络回归(ICA-NNR)的近红外光谱分析方法.通过分析独立分量数和网络中间隐层的神经元数对模型性能的影响,分别建立三类药片定量分析的最优模型.该方法用于实测的三类药片中活性成分含量的测定,测试样品集的化学检测值与近红外预测值的相关系数分别达到0.962,0.980及0.979.结果表明,基于ICA-NNR的近红外光谱分析方法对制药业的药片进行定量分析是可行的.

关键词：独立分量分析神经网络回归近红外光谱药片

Identification and Characteristics of a Novel E1 like Gene nUBE1l in Human test

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 227-234页

作者： Hui ZHU,Zuomin ZHOU,Ran HUO,XiaoYan HUANG,li LU,min lin,liRong WANG, YaDong ZHOU,Jianmin Ll,and JiaHao SHA*LaboratoeProductivedicine, Naliingdical Universl,Na109angsu002China Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

A gene,Presumably involved in sPermatogenesis,was identified and characterized byusing cDNA *** intensity was 2.13 fold higher in adult testis than that in fetal *** full length of this gene was 4288 bP and it encoded a 578 amino acid *** structureand amino acid sequence analysis revealed that the Protein contained 1 Thif-domain,2 UBACT-domains,and a functional active site cysteine lay uPstream of UBACT domain,all ofthem also existed in ubiquitin-activating enzyme EI and El like Proteins.50 we named this gene as a novel ubiquitin一activatingenZyme EIlike gene(nUBEjL).ExPression Profile showed that nUBEIL was Predominantly exPressed in *** of the exPression ofnUBEIL in different develoPmental stages oftestis indicated that it washighly exPressed in adult *** conclusion,nUBEjL 15 a novel human El like gene highly exPressed inadult testis,which Plays key role in ubiquitin system,and accordingly influences sPermatogenesis and malefertility·

关键词： ubiquitinactivating enzyme EI ubiquitin sPermatogenesis

Studies on macrocyclic diterpenoids Ⅴ.Synthesis of(±)-sarcophytol-A benzyl ether

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Chinese Journal of Chemistry 1993年第2期11卷 159-163页

作者： li,Wei-Dong li,Ying MAO,Jian-min li,Yu-lin State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000

The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting *** key steps in the synthesis were double bond migration reaction of allylic alcohols 5 and 6,phase transfer catalytic coupling (PTC)reaction of Ⅱ with 7 and the cyclization reaction of dicarbonyl acyclic precursor induced by TiCl_3-AlCl_3(3:1)/Zn-Cu system.

关键词： Synthesis of Studies on macrocyclic diterpenoids sarcophytol-A benzyl ether

Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application

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Blood Science 2021年第4期3卷 122-131页

作者： li-min lin Qi Pan Yu-Meng Sun Wen-Tao Wang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory for BiocontrolSchool of Life SciencesSun YatSen UniversityGuangzhouGuangdong 510275China

Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis,prognosis,and treatment of *** has found that small nuclear RNA(snoRNA)plays an essential role in *** small non-coding RNAs are involved in ribosome biogenesis,including the 2'-O-methylation and pseudouridylation of precursor ribosomal RNA(pre-rRNA),and pre-rRNA ***,many snoRNAs were found to be orphans that have no predictable RNA modification targets,but these RNAs have always been found to be located in different subcellular organelles,and they play diverse *** high-throughput technology,snoRNA expression profiles have been revealed in leukemia,and some of the deregulated snoRNAs may regulate the cell cycle,differentiation,proliferation,and apoptosis in leukemic cells and confer drug resistance during leukemia *** this review,we discuss the expression profiles and functions of snoRNAs,particularly orphan snoRNAs,in *** is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia,which may serve as potential therapeutic targets in leukemia treatment.

关键词： 2'-O-methylation Biomarkers Drug resistance Leukemia snoRNA Targeted therapy

The solid state reactions of o-aminobenzoic acid with Zn(Ⅱ), Cu(Ⅱ), Ni(Ⅱ), Mn(Ⅱ) acetate hydrate at room temperature

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Chinese Journal of Chemistry 1994年第3期12卷 243-247页

作者： ZHENG, li-min FU, Yan lin, Jian-Jun XIN, Xin-QuanCoordination Chemistry State Key Laboratory, Department of Chemistry, Nanjing University, Nanjing, Jiangsu 210008, China

The solid-solid state reactions of o-aminobenzoic acid with Zn(OAc)2.2H2O, Cu(OAc)2 .H2O, Ni(OAc)2.4H2O and Mn(OAc)2.4H2O result in the formation of corresponding complexes M(OAB)2 (M = Zn(Ⅱ), Cu(Ⅱ), Ni(Ⅱ), Mn(IⅡ)). XRD, IR and elemental analysis methods have been used to characterize the solid products. The activation energies of these reactions, which are calculated from the kinetic data obtained by means of the isothermal electrical conductivity measurement method, have been found to increase in the order: Cu(OAc)2.H2O(37.7 ***-1)~Mn(OAc)2.4H2O (***-1) < Zn(OAc)2.2H2O (56.3 ***-1) < Ni(OAc)2.4H2O (85.2 ***-1). The trend is related to their crystal structures.

关键词： Solid state reaction transition metal acetate o-aminobenzoic acid electrical conductivity.

TIG焊流动、传热及界面跟踪动网格数值模拟

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东北大学学报（自然科学版） 2017年第10期38卷 1411-1415,1430页

作者：李林敏李宝宽刘立超曹霞东北大学冶金学院辽宁沈阳110819 河海大学能源与电气学院江苏南京211100 国家电网椒江供电公司浙江台州318000

基于磁流体力学(magnetohydrodynamics,MHD)模型,采用动网格技术(dynamic mesh method,DMM)跟踪电弧-熔池界面,建立了钨极惰性气体(tungsten insert gas,TIG)保护焊过程耦合流动、传热、凝固熔化及动网格界面跟踪的数学模型.首先计算自... 详细信息

基于磁流体力学(magnetohydrodynamics,MHD)模型,采用动网格技术(dynamic mesh method,DMM)跟踪电弧-熔池界面,建立了钨极惰性气体(tungsten insert gas,TIG)保护焊过程耦合流动、传热、凝固熔化及动网格界面跟踪的数学模型.首先计算自由燃弧,得到了准确的弧区速度、温度及压力等参数.然后分别验证了熔池内电磁力、热浮力、等离子流曳力和Marangoni力4个驱动力.考虑上述电弧-熔池相互作用,基于压力的动态平衡跟踪界面,计算了304不锈钢TIG焊过程,得到了等离子体冲击造成的熔池中央下凹及边缘上凸现象.结果表明,本模型可以得到更准确的界面及熔池形状.

关键词：数值模拟电弧等离子体磁流体力学界面跟踪动网格