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Outpatient versus inpatient laparoscopic cholecystectomy:a single center clinical analysis

Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 60-64页

作者： Ji, Wu Ding, Kai li, ling-tang Wang, Dan li, Ning li, Jie-Shou Nanjing Univ Sch Med Jinling Hosp Res Inst Gen Surg Nanjing 210002 Peoples R China

BACKGROUND: Outpatient laparoscopic cholecystectomy (OPLC) developed in the United States and other developed countries as one of the fast-track surgeries performed in ambulatory centers. However, this practice has not been installed as a routine practice in the major general hospitals and medical centers in China. We designed this case-control study to evaluate the feasibility, benefits, and safety of OPLC. METHODS: Two hundred patients who had received laparoscopic cholecystectomy for various benign gallbladder pathologies from April 2007 to December 2008 at Jinling Hospital of Nanjing University School of Medicine were classified into two groups: OPLC group (100 patients), and control group (100), who were designated for inpatient laparoscopic cholecystectomy (IPLC). Data were collected for age, gender, indications for surgery, American Society of Anesthesiology (ASA) class, operative time, blood loss during surgery, length of hospitalization, and intra- and post-operative complications. The expenses of surgery and in-hospital care were calculated and analyzed. The operative procedures and instrumentation were standardized for laparoscopic cholecystectomy, and the procedures were performed by two attending surgeons specialized in laparoscopic surgery. OPLC was selected according to the standard criteria developed by surgeons in our hospital after review. Reasons for conversion from laparoscopic to open cholecystectomy were recorded and documented. RESULTS: One hundred patients underwent IPLC following the selection criteria for the procedure, and 99% completed the procedure. The median operative time for IPLC was 24.0 minutes, blood loss was 16.2 ml, and the time for resuming liquid then soft diet was 10.7 hours and 22.0 hours, respectively. Only one patient had postoperative urinary infection. The mean hospital stay for IPLC was 58.2 hours, and the cost for surgery and hospitalization was 8770.5 RMB yuan on average. Followup showed that 90% of the patients were

关键词： laparoscopic cholecystectomy outpatient surgery fast-track surgery

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Study of a Novel Brain Relatively Specific Gene LRRC4 Involved in Glioma Tumorigenesis Suppression Using the Tet-on System

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 532-540页

作者： Qiu-Hong ZHANG li-li WANG li CAO Cong PENG Xiao-ling li Ke tang Wei-Fang li Ping liAO Jie-Ru WANG Gui-Yuan li~* Cancer Research Institute,Central South University,Changsha 410078,China Cancer Research Institute Central South UniversityChangsha 410078 China

LRRC4 is a novel relatively specific gene,which displays significant down-regulation inprimary brain tumor biopsies and has the potential to suppress brain tumor *** this study,we inves-tigated the growth inhibitory effect of LRRC4 on tumorigencity in vivo and on cell proliferation in vitro by atetracycline-inducible expression *** showed that LRRC4 significantly reduced the growth andmalignant grade of xenografts arising from glioblastoma U251MG *** proliferation was markedlyinhibited after U251MG Tet-on-LRRC4 cell induction with *** cytometry and Western blotanalysis demonstrated that LRRC4 mediated a delay of the cell cycle in late G1,possibly through up-regulat-ing the expressions of p21Wafl/cip 1 and p27Kip 1 and down-regulating the expressions of cyclin-dependentkinase 2,retinoblastoma protein and epidermal growth factor ***,these findings provideclues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between theabove-mentioned cyclins,cyclin-associated molecules and tumorigenicity.

关键词： LRRC4 tumorigencity cell proliferation cell cycle delay

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Lysosomal-associated protein transmembrane-4 beta: a novel potential biomarker for cancer therapy with multiple functions

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Chinese Medical Journal 2021年第1期134卷 38-40页

作者： Xi-Chao Xu Jian-Guo Feng li-ling tang Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Department of Anesthesiology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

LAPTM4B,which is a proto-oncogene,plays important roles in cancer progression,including clinical stages and pathologic grades.[1]The LAPTM4B gene encodes the lysosomal-associated protein transmembrane-4 beta(LAPTM4B)protein and LAPTM4B is cloned from hepatocellular carcinoma(HCC).[2]There is increasing evidence that LAPTM4B is a novel oncogene,which is over-expressed in many human solid tumors.[3]Furthermore,the up-regulation of LAPTM4B is associated with chemotherapy resistance,as well as poor clinical outcomes and prognoses.[4,5]LAPTM4B also promotes cell survival,growth,proliferation,metastasis,tolerance to metabolic stress,and autophagy.[6]Thus,the LAPTM4B protein may represent an excellent candidate for individualized treatment and tumor monitoring.

关键词： cancer clinical chemotherapy

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EFFECT OF A MIDDLE LAYER ON PIEZOELECTRIC PLATE TRANSFORMER

EFFECT OF A MIDDLE LAYER ON PIEZOELECTRIC PLATE TRANSFORMER

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2013全国压电和声波理论及器件技术研讨会

作者： li-ling tang Feng JIN State Key Laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi’an Jiaotong University

An additional middle elastic layer is considered between input and output portions in a piezoelectric plate transformer due to interface bonding glue possibly used excessively.A theoretical solution of thickness-shear modes is obtained to investigate the effect of the middle layer on the piezoelectric *** examination of the numerical results demonstrates that the addition of middle layer would reduce the transforming ***,the increase of the thickness of the middle layer decreases the transforming ratio,whereas the middle layer’s elastic coefficient improves it ***,if the thickness of the middle layer vanishes small,the effect of the middle layer can be treated approximately as same as that of the imperfect interface by shear-slip *** example verifies that the difference between them is slightly small which can be ignored.

关键词： Piezoelectric transformer Thickness-shear mode Additional middle layer Shear-slip model

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Therapeutic Effect of Metformin on Patients with Polycystic Ovary Syndrome with Normal Insulin Sensitivity: A Retrospective Study

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Reproductive and Developmental Medicine 2019年第3期3卷 153-158页

作者： Wan-Wan liu Dong-Hai li Xue-Zhen Luo ling-li tang Ying-li Shi Department of Health Management Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Gynecology Obstetrics and Gynecology HospitalFudan UniversityShanghai 200090China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Fudan UniversityShanghai 200090China

Objective:This study aimed at elucidating the therapeutic effectiveness of metformin in polycystic ovary syndrome(PCOS)patients with normal clinical indices of insulin ***:This study was a retrospective cohort *** on their homeostasis model of assessment of insulin resistance(HOMA-IR)results,PCOS patients(n=113)were allocated to either the IR Group(IR,HOMA-IR>2.69)or the non-IR Group(NIR,HOMA-IR≤2.69).Metformin was administered to all patients,and their medical history,menstrual status,and endocrine and metabolic characteristics were obtained before and after *** one-way analysis of variance was used to determine the differences between the IR and NIR *** paired t-test was used to determine the differences between pre-and posttreatment ***:Analyses of baseline characteristics showed that the incidence of IR and glycolipid metabolism is higher within elder PCOS *** improved menstrual cycle and ovulation rate in NIR patients,similar to those in IR *** the NIR group,metformin decreased luteinizing hormone(LH)levels,free androgen index(FAI)levels,body mass index,and waist circumference,but had no obvious effect on glucose,insulin,and lipid *** in the IR group,metformin not only decreased LH and FAI levels,but also improved glycolipid ***:The effect of metformin on PCOS patients with normal insulin sensitivity index suggests that the mechanism of menstrual improvement may not be related to *** addition,metformin can improve glycolipid ***,metformin is suitable for long-term treatment of PCOS and should be more widely used.

关键词： Endocrine Characteristics Glycolipid Metabolism Insulin Resistance Metformin Polycystic Ovary Syndrome

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Micropillar-arrayed surfaces promote transforming growth factor beta 1 induced epithelial to mesenchymal transition by focal adhesion kinase-related signaling in A549 cells

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Chinese Medical Journal 2021年第6期134卷 754-756页

作者： Lun-Kun Ma Xing Wang Xiao-li Xu Jin Zhou Yi liao Jian-Guo Feng li-ling tang Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China Department of Thoracic Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing 400038China Department of Anesthesiology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646099China

To the Editor:Substrate rigidity and topography are two important biomechanical factors that can modulate the biological behavior of cancer cells such as epithelial to mesenchymal transition(EMT).Currently,although studies have begun to focus on how the mechanical microenvironment determines the fate of multiple cells,the mechanism of the mechanical microenvironment affecting EMT is still unclear.

关键词： transition rigidity mesenchymal

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2

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Infectious Diseases of Poverty 2020年第4期9卷 169-169页

作者： Hong-Zhi Chen ling-li tang Xin-ling Yu Jie Zhou Yun-Feng Chang Xiang Wu Department of Metabolism&Endocrinology Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of EducationNational Clinical Research Center for Metabolic DiseaseThe Second Xiangya HospitalCentral South UniversityChangsha410011HunanChina Department of Laboratory Medicine The Second Xiangya HospitalCentral South UniversityChangsha410011HunanChina Hunan Institute of Parasite Disease WHO Collaborating Center For Research and Control on Schistosomiasis in Lake RegionYueyang414000HunanChina Department of Forensic Medicine Science Xiangya School of Basic MedicineCentral South UniversityChangsha410013HunanChina Department of Parasitology Xiangya School of Basic MedicineCentral South UniversityChangsha410013HunanChina

Background An outbreak of infection caused by SARS-CoV-2 recently has brought a great challenge to public *** identification of immune epitopes would be an efficient way to screen the candidates for vaccine development at the time of *** study aimed to predict the protective epitopes with bioinformatics methods and resources for vaccine *** The genome sequence and protein sequences of SARS-CoV-2 were retrieved from the National Center for Biotechnology Information(NCBI)*** and BepiPred servers were utilized for sequential B-cell epitope *** B-cell epitopes were predicted via DiscoTope 2.0 *** server was utilized for HLA-1 and HLA-2 binding peptides *** accessibility,antigenicity,and other important features of forecasted epitopes were characterized for immunogen potential *** A total of 63 sequential B-cell epitopes on spike protein were predicted and 4 peptides(Spike315–324,Spike333–338,Spike648–663,Spike1064–1079)exhibited high antigenicity score and good surface *** residues within spike protein(Gly496,Glu498,Pro499,Thr500,Leu1141,Gln1142,Pro1143,Glu1144,Leu1145,Asp1146)are forecasted as components of discontinuous B-cell *** bioinformatics analysis of HLA binding peptides within nucleocapsid protein produced 81 and 64 peptides being able to bind MHC class I and MHC class II molecules *** peptides(Nucleocapsid66–75,Nucleocapsid104–112)were predicted to bind a wide spectrum of both HLA-1 and HLA-2 *** B-cell epitopes on spike protein and T-cell epitopes within nucleocapsid protein were identified and recommended for developing a protective vaccine against SARS-CoV-2.

关键词： SARS-CoV-2 Epitope Vaccine Bioinformatics

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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On the existence of solutions for prescribing fractional Q-curvature problem on S~n

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Acta Mathematica Sinica,English Series 2025年

作者： Yan li Zhongwei tang College of Science China University of Petroleum(Beijing) School of Mathematical Sciences Laboratory of Mathematics and Complex Systems MOEBeijing Normal University

The aim of this paper is to investigate the existence of solutions to the prescribing fractional Q-curvature problem on S~n under some reasonable assumption of the Laplacian sign at the critical point of prescribing curvature function K. Due to the lack of compactness, we choose to return to the basic elements of variational theory and study the deformation along the flow lines. The novelty of the paper is that we obtain the existence without assuming any symmetry and periodicity on K. In addition,to overcome the loss of compactness for high-order operator problem, we need more delicate estimates with the second order cases.

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