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Identification of Known and Novel PTCH Mutations in Both Syndromic and Non-syndromic Keratocystic Odontogenic Tumors

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International Journal of Oral Science 2009年第1期1卷 34-38页

作者： Shuang Pan li-li xu li-sha Sun Tie-jun li Department of Oral Pathology Peking University School and Hospital of Storaatology Beijing China

Aim To clarify the role of PTCH in patients with NBCCS- related and non-sydromic keratocystic odontogenic tumors. Methodology Mutation analysis was undertaken in 8 sporadic and 4 NBCCS-associated KCOTs. Results Four novel and two known mutations were identifled in 2 sporadic and 3 syndromic cases, two of which being germline mutations （c.2179delT, c.2824delC） and 4 somatic mutations （c.3162dupG, c.1362-1374dup, c.1012 C〉T, c.403C〉T）. Conclusion Our findings suggest that defects of PTCH are associated with the pathogenesis of syndromic as well as a subset of non-syndromic KCOTs.

关键词： keratocystic odontogenic tumor mutation,nevoid basal cell carcinoma syndrome PTCH

Design, Syntheses and Biological Activities of Novel Anthranilic Diamide Insecticides Containing N-Pyridylpyrazole

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Chemical Research in Chinese Universities 2013年第1期29卷 51-56页

作者： ZHAO Yu li Yong-qiang XIONG li-xia xu li-ping PENG li-na li Fang li Zheng-ming National Pesticidal Engineering Centre(Tianjin) State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 P. R. China

In search of environmentally benign insecticides with high activity, low toxicity and low residue, a series of novel anthranilic diamide derivatives containing N-pyridylpyrazole was designed and synthesized. All the compounds were characterized by H NMR spectroscopy and elemental analysis. The single crystal structure of com pound 8j was determined by X-ray diffraction. The insecticidal activities of the new compounds were evaluated. The results show that some compounds exhibited moderate insecticidal activities against Lepidoptera pests. Among this series of compounds, compounds 80 and 8p showed 100% larvicidal activity against Mythimna separate Walker, Plutella xylostella linnaeus and Laphygma exigua Hubner at a test concentration of 200 mg/kg, which is equal to the commercial chlorantraniliprole.

关键词： Anthranilic diamide Ryanodine receptor Insecticidal activity

Thickness measurement approach for plasma sprayed coatings using ultrasonic testing technique

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 88-91页

作者： liN li li Xi-meng xu Zhi-hui LEI Ming-kai NDT&E Laboratory NDT&E Laboratory NDT&E Laboratory Surface Engineering Laboratory Dalian University of Technology Dalian 116024 China

The special ultrasonic testing system has been developed for thickness measurement of plasma sprayed coatings. The ultrasonic immersion method was used to obtain stable coupling condition and avoid other disadvantages of contact method. Spherical acoustic lens were designed to focus ultrasonic beam so as to improve beam directivity and concentrate ultrasonic energy. To increase testing precision and avoid mussy wave signals, moderate pulse width and frequency of the transducer has been selected. The displacement of transducer in X-Y-Z directions was precisely manipulated by step-controlled system to insure the accuracy of focus length and repetition of measurement. Optimized testing conditions (with the transducer of center frequency of 10 MHz and crystal diameter of 8 mm, focus length of 9.5 mm, diameter of focal column of 0. 1 mm and length of focal column of 0.27 mm) were selected to determine the thickness between 285 -414 μm of ZrO2 coatings plasma sprayed on the nickel based superalloy. The frequency interval of the periodic extremums in ultrasonic power spectra decreases with increasing coating thickness. The ultrasonic results accord with those of metallographical method.

关键词： plasma sprayed coatings thickness measurement ultrasonic testing interference

Study on the influence of humic acid of different molecular weight on basic ion exchange resin's adsorption capacity

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Chinese Chemical Letters 2009年第12期20卷 1478-1482页

作者： Jin Nan Wang Ai Min li Yang Zhou li xu State Key Laboratory of Pollution Control and Resource Reuse & School of the Environment Nanjing University Nanjing 210093 China

In this paper, humic acid （HA） was ultra-filtered into different molecular weight sections and was characterized by multielement analysis, UV254/TOC, FT-IR and three-dimensional fluorescence spectrometric. Since humic acids of different molecular weights have different hydrophilic and molecular size, the maximum adsorption capacity of basic ion exchange resins appears on the humic acid whose molecular weight ranges from 6000 to 10,000 Da.

关键词： Humic acid Molecular weight Basic ion exchange resin Adsorption

Improvement of xylanase production by Aspergillus niger XY-1 using response surface methodology for optimizing the medium composition

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第7期9卷 558-566页

作者： Yao-xing xu Yan-li li Shao-chun xu Yong liU Xin WANG Jiang-wu TANG Institute of Plant Protection and Microbiology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

Objective: To study the optimal medium composition for xylanase production by Aspergillus niger XY-1 in solid-state fermentation (SSF). Methods: Statistical methodology including the Plackett-Burman design (PBD) and the central composite design (CCD) was employed to investigate the individual crucial component of the medium that significantly affected the enzyme yield. Results: Firstly, NaNO3, yeast extract, urea, Na2CO3, MgSO4, peptone and (NH4)2SO4 were screened as the significant factors positively affecting the xylanase production by PBD. Secondly, by valuating the nitrogen sources effect, urea was proved to be the most effective and economic nitrogen source for xylanase production and used for further optimization. Finally, the CCD and response surface methodology (RSM) were applied to determine the optimal concentration of each sig-nificant variable, which included urea, Na2CO3 and MgSO4. Subsequently a second-order polynomial was determined by multiple regression analysis. The optimum values of the critical components for maximum xylanase production were obtained as follows: x1 (urea)=0.163 (41.63 g/L), x2 (Na2CO3)=?1.68 (2.64 g/L), x3 (MgSO4)=1.338 (10.68 g/L) and the predicted xylanase value was 14374.6 U/g dry substrate. Using the optimized condition, xylanase production by Aspergillus niger XY-1 after 48 h fermentation reached 14637 U/g dry substrate with wheat bran in the shake flask. Conclusion: By using PBD and CCD, we obtained the optimal composition for xylanase production by Aspergillus niger XY-1 in SSF, and the results of no additional expensive medium and shortened fermentation time for higher xylanase production show the potential for industrial utilization.

关键词： Xylanase Optimization of medium composition Plackett-Burman design (PBD) Central composite design (CCD) Response surface methodology (RSM). Aspergillus niger XY- 1

Syntheses,Structure and Biological Activities of 2-(1H-Benzo [1,2,3]triazole-1-yl)-1-(3-methyl-4-bromobiphenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone

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Chemical Research in Chinese Universities 2007年第1期23卷 120-122页

作者： ZHANG Shu-sheng WAN Jun li xue-mei li Chun-li xu liang-zhong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

1,2,4-Triazole derivatives represent an interesting class of heterocyclic compounds and have become the most with rapidly expanding group of antifungal compounds the advantages of toxicity, high oral bioavailability, and broad spectrum of activity against several fun- gi, including most yeasts and folanentous fungi . The triazole fungicides are agrochemicals that are used world wide in the agricultural industry because of their wide spectrum of action, A variety of benzotriazoles exhibit growth-inhibiting activities against some microorganisms and other derivatives possessing anti-inflammatory properties.

关键词： Triazole derivative Cyrstal structure Biological activity

Using Energy Conditions to Distinguish Brane Models and Study Brane Matter

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Communications in Theoretical Physics 2008年第8期50卷 383-386页

作者： PING Yong-li xu li-Xin CHANG Bao-Rong liU Hong-Ya School of Physics and Optoelectronic Technology Dalian University of Technology Dalian 116024 China

Current universe （assumed here to be normal matter on the brahe） is pressureless from observations. In this case the energy condition is po ≥ 0 and po =O. By using this condition, brahe models can be distinguished. Then, assuming arbitrary component of matter in DGP model, we use four known energy conditions to study the matter on the brahe. If there is nonnormal matter or energy （for example dark energy with w 〈-1/3） on the brane, the universe is accelerated.

关键词： brane universe cosmology energy conditions

First record of Bursaphelenchus rainulfi on pine trees from eastern China and its phylogenetic relationship with intro-genus species

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第5期8卷 345-351页

作者： JIANG li-qin li xu-qing ZHENG Jing-wu Institute of Biotechnology School of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

Bursaphelenchus rainulfi isolated from dead pine trees in Zbejiang, China, is described and illustrated. It also provided some molecular characters of the Chinese population, including the PCR-RFLP and sequences of ITS region and D2-D3 expansion region of the large subunit （LSU） rRNA gene. Both the morphological characters and ITS-RFLP patterns match with the original description. The phylogenetic trees based on the 13 sequences of D2-D3 expansion region of the LSU rRNA gene and ITS region of Bursaphelenchus species were constructed, respectively, with the results showing the similar clades. The phylogenetic relationship based on the molecular data is similar to that with morphological characters. This is the first report of the species on pine wood in eastern China.

关键词： Bursaphelenchus rainulfi Pine wood Morphology Morphometrics ITS-RFLP Phylogeny

PRINCIPLE OF STATIONARY MUTUAL POTENTIAL ENERGY AND OPTIMAL DESIGN OF VIBRATING STRUCTURES

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Chinese Science Bulletin 1989年第13期34卷 1081-1085页

作者：李旭 Tsinghua University Beijing

The principle of stationary mutual potential energy, which was introduced by Shield and Prager, can be considered as an extension of the principle of minimum potential energy from one-loading system to two-loadlng system. By this stationary principle, we can obtain the necessary and sufficient condition of optimality for structural design.

关键词： principle of stationary mutual potential energy vibrating structure minimum-weight design ealculus of variation elastic sandwich beam