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Temporal lobe malacia as a rare cause of gelastic seizure:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4440-4445页

作者： Yuan-Sheng liao li-li gao Min lin Cheng-Han Wu Department of Neurology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003Fujian ProvinceChina

BACKGROUND Gelastic seizure(GS)is a rare type of epilepsy that most commonly appears in patients with hypothalamic *** is rarely associated with other types of brain *** particular type of epilepsy is relatively rare and has few links to other brain *** lobe malacia is mostly caused by cerebral infarction or cerebral hemorrhage,which can lead to *** report a case of GS in a woman with temporal lobe malacia which was reported for the first time in the *** SUMMARY A 73-year-old female,diagnosed case of GS,presented with repetitive stereotyped laughter a month prior to presentation,happening multiple times daily and with each time lasting for *** displayed a focal seizure seen in the right temporal *** resonance imaging head with contrast showed a right temporal lobe *** patient was started on levetiracetam *** patient indicated that they had fully recovered and were not experiencing any recurrent or stereotyped laughter during their daily *** results remained consistent even after a one-year follow-up *** GS can be caused by temporal lobe malacia,which is an uncommon but potentially grave *** outcome of this present case exhibited the importance of the temporal lobe in the genesis of GS.

关键词： Epilepsy Gelastic seizure Malacia Temporal lobe Cerebral ischemia Case report

Approximate subgradient projection algorithm for convex feasibility problem

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Journal of Systems Engineering and Electronics 2010年第3期21卷 527-530页

作者： li li Yan gao Business School University of Shanghai for Science and Technology Shanghai 200093 P. R. China

An ε-subgradient projection algorithm for solving a convex feasibility problem is *** on the iterative projection methods and the notion of ε-subgradient,a series of special projection hyperplanes is ***,compared with the existing projection hyperplanes methods with subgradient,the proposed hyperplanes are interactive with ε,and their ranges are more *** convergence of the proposed algorithm is given under some mild conditions,and the validity of the algorithm is proved by the numerical test.

关键词： ε-subgradient projection algorithm convex feasibility problem.

Transient ventricular arrhythmia as a rare cause of dizziness during exercise:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9205-9210页

作者： li-li gao Cheng-Han Wu Department of Neurology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003Fujian ProvinceChina

BACKGROUND Dizziness is a common symptom in adults and usually due to peripheral causes affecting semicircular canal function or central causes affecting the pons,medulla,or *** is a recognized cause of dizziness in people with structural or ischemic heart *** report a case of exercise-induced transient ventricular tachycardia and dizziness in a man with no evidence of organic heart *** SUMMARY A 42-year-old man presented with a 6 mo history of transient exercise-induced dizziness and prodromal *** patient was otherwise *** examination,otoscopy,vestibular tests,cerebellar tests,laboratory investigations,and imaging investigations were all ***-four hour Holter monitoring revealed four episodes of transient ventricular tachycardia during *** patient was started on metoprolol and subsequently underwent radiofrequency catheter *** patient reported a full recovery and no dizziness during daily *** results were maintained at the 6 mo *** Ventricular tachycardia is an uncommon but potentially serious cause of *** outcome of this case illustrates the benefits of careful clinical examination and communication with specialized *** clinical suspicion of arrhythmia in a patient with dizziness merits consultation with a cardiologist and referral to a specialized center to ensure timely diagnosis and treatment.

关键词： Dizziness Cardiac arrhythmia Ventricular tachycardia Catheter ablation Organic heart disease Case report

Effects on the local symptoms of subgenomic RNAs expressions and their translational products of Tobacco necrosis virus A Chinese isolate

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Chinese Science Bulletin 2008年第11期53卷 1682-1690页

作者： li Jiang li Min li Cui gao Yang li DaWei HAN ChengGui YU Jialin State Key Laboratory of Agro-Biotechnology China Agricultural University Beijing 100094 China

Based on a full-length infectious cDNA clone, gene modifications of Tobacco necrosis virus A Chinese isolate (TNV-AC) were made by site-directed mutagenesis or nucleotide deletions for in vitro transcrip-tion of mutant viral RNAs. Mechanical inoculations of Chenopodium amaranticolor with in vitro tran-scripts, containing a single nucleic acid substitution at the presumed transcriptional start sites for the two subgenomic (sg) RNAs, showed that the sgRNA1 and sgRNA2 of TNV-AC were initiated at G2184 or G2460, respectively. Mutagenesis of the translational initiation-codons for the open-reading frame (ORF) P8 or P6 encoded by sgRNA1 indicated that each of the two genes was essential for formation of local lesions on C. amaranticolor leaves, perhaps by blocking virus cell-to-cell movement, but were not necessary for viral RNA replication in the protoplast of tobacco cell BY-2. Results of prokaryotic expression showed that the ORF coding for coat protein on TNV-AC sgRNA2 was initiatively translated by the first AUG codon at nucleotides 2612―2614. Site-directed mutation of translational start codons, and deletion of the entire coding region, showed that the intact TNV-AC coat protein was dispensable for establishment of TNV-AC infection in C. amaranticolor, otherwise the numbers of local lesions and the viral RNA accumulation level were reduced, or the time to symptom appearance significantly delayed. These results suggested that the nucleotide sequence around the translational start codon coding for TNV-AC coat protein gene may play an important role in the local symptoms. Aspects of the involve-ment of the coat protein in the TNV-AC life cycle were discussed.

关键词：烟草坏死病毒A RNAs 染色体基因表达

Influence on Cellular Signal Transduction Pathway in Dairy Cow Mammary Gland Epithelial Cells by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第4期10卷 619-630页

作者： WAN Zhong-ying TONG Hui-li li Qing-zhang gao Xue-jun Key Laboratory of Dairy Science Ministry of Education~Northeast Agricultural University Harbin 150030 P.R.China

The galactopoietic mechanism of Vaccaria segetalis is still unknown. Understanding dibutyl phthalate （DBP） separated from Vaccaria segetalis on the expression of lactation signal transduction genes of mammary gland epithelial cells, including prlr, erα, akt1, socs2, pparγ and elf5, will be helpful to reveal the molecular mechanism. Western blot and qRT- PCR were used to study the change of prlr, erα, akt, socs2, pparγ, and elf5 expression at mRNA and protein level. Co- localization expression of prolactin receptor （PRLR） and estrogen receptor α （ERα） was observed by immunofluorescence; the expression changes of miRNAs （21, 125b, 143, and 195） and the secretion of β-casein and lactose were detected by qRT-PCR and RP-HPLC. The results showed that Vaccaria segetalis active compound had similar fuctions as estrogen and/or prolactin （PRL） in dairy cow mammary gland epithelial cells （DCMECs）, increased the expressions of prlr, erα, akt1, and elf5 genes, while repressed pparγ expressions. DBP promoted socs2 mRNA expression, but its protein expressions were repressed. Furthermore, both DBP and PRL could repress the expressions of miRNA-125b, miRNA-143 and miRNA- 195 in DCMECs. DBP could repress the expression of miRNA-21, while the influence of PRL on miRNA-21 was not certain. DBP could promote the lactation ability of DCMECs by regulating the ER and PRLR cellular signal transduction pathway.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cells signal transduction miRNAs

Segmental nature of the Red River fault revealed by seismic anisotropy and geological structures

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Science China Earth Sciences 2024年第8期67卷 2423-2443页

作者： Ying li Yuan gao School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China

As the western boundary of the Sichuan-Yunnan block(SYB),the Red River fault(RRF)is a major fault that controls deep crustal movement and deformation in the southeast margin of the Tibetan Plateau and regulates middle-lower crustal *** data suggest that the RRF is segmented and exhibits distinct variations in seismicity,velocity structure and crustal deformation from north to *** anisotropy reveals a complex pattern of lateral spatial and vertical stratified distributions.(1)From the perspective of crustal stratification,in the upper crust,the fast wave polarization in the north segment of the RRF is complex and possibly influenced by the Sanjiang lateral collision zone and adjacent faults with varying *** fast wave polarization in the middle segment is in the NW-SE direction,indicating a localized area of closed down or locked up with consistent *** in the south segment,it presents a disordered pattern,signifying complex deep tectonics and stress conditions at the wedged intersection *** the middle-lower crust in the north and south segments of the RRF,the azimuthal anisotropy is strong and consistent with the spatial strike of the weak zone characterized by low-velocity and *** suggests a connection between the anisotropy and the material migration.(2)In the whole crustal scale,the fast wave directions in two sides of the RRF are consistent with the NW-SE tectonic *** indicates that the RRF,as a large fault potentially cutting through the whole crust,strongly controls the surrounding media.(3)In the lithospheric scale,the fast wave polarizations are oriented nearly E-W and independent of the fault strike,consistent with the low P-and S-wave velocity structures and positive radial anisotropy in the upper *** fast wave directions could be related to lithospheric olivine deformation and asthenospheric *** paper suggests a decoupling of deformation between the crust and the lithospheri

关键词： Red River fault Seismic anisotropy Geological structures lithosphere Fault segmentation

Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-li Wang Wen-Jun Huang De-li gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is simplified into three categories according to common mathematical ***,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

Optimal Operation Strategy Analysis with Scenario Generation Method Based on Principal Component Analysis,Density Canopy,and K-medoids for Integrated Energy Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 89-100页

作者： Bingtuan gao Yunyu Zhu Yuanmei li School of Electrical Engineering Southeast UniversityNanjingChina

The operation of integrated energy systems(IESs)is confronted with great challenges for increasing penetration rate of renewable energy and growing complexity of energy *** generation is one of ordinary methods to alleviate the system uncertainties by extracting several typical scenarios to represent the original high-dimensional *** paper proposes a novel representative scenario generation method based on the feature extraction of panel *** original high-dimensional data are represented by an aggregated indicator matrix using principal component analysis to preserve temporal ***,the aggregated indicator matrix is clustered by an algorithm combining density canopy and *** with the proposed scenario generation method,an optimal operation model of IES is established,where the objective is to minimize the annual operation costs considering carbon trading ***,case studies based on the data of Aachen,Germany in 2019 are *** results indicate that the adjusted rand index(ARI)and silhouette coefficient(SC)of the proposed method are 0.6153 and 0.6770,respectively,both higher than the traditional methods,namely K-medoids,K-means++,and density-based spatial clustering of applications with noise(DBSCAN),which means the proposed method has better *** error between optimal operation results of the IES obtained by the proposed method and all-year time series benchmark value is 0.1%,while the calculation time is reduced from 11029 s to 188 s,which verifies that the proposed method can be used to optimize operation strategy of IES with high efficiency without loss of accuracy.

关键词： Scenario generation principal component analysis(PCA) density canopy K-medoids integrated energy system

Variable Selection for Generalized linear Model with Highly Correlated Covariates

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1458-1480页

作者： li li YUE Wei Tao WANG gao Rong li School of Statistics and Data Science Nanjing Audit UniversityNanjing 211815P.R.China School of Mathematics Statistics and MechanicsBeijing University of TechnologyBeijing 100124P.R.China School of Statistics Beijing Normal UniversityBeijing 100875P.R.China

The penalized variable selection methods are often used to select the relevant covariates and estimate the unknown regression coefficients simultaneously,but these existing methods may fail to be consistent for the setting with highly correlated *** this paper,the semi-standard partial covariance(SPAC)method with Lasso penalty is proposed to study the generalized linear model with highly correlated covariates,and the consistencies of the estimation and variable selection are shown in high-dimensional settings under some regularity *** simulation studies and an analysis of colon tumor dataset are carried out to show that the proposed method performs better in addressing highly correlated problem than the traditional penalized variable selection methods.

关键词： Generalized linear model highly correlated covariates Lasso penalty semi-standard partial covariance variable selection