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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 257-262页

作者： Tao li Jun Wen li-ke bie Yi Lu Biao Gong Department of Gastroenterology Digestive Endoscopy Center Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin Er Road Shanghai 200025 China Digestive Endoscopy Center The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655 China

Background： Endoscopic papillary balloon dilation （EPBD） for common bile duct （CBD） stones removal in Billroth II gastrectomy patients is feasible. However, the long-term outcomes of this technique are notclear. The aim of this study was to evaluate the procedural and long-term outcomes of EPBD for removal of CBD stones in Billroth II gastrectomy patients.

关键词： Endoscopic retrograde cholangiopancreatography Endoscopic papillary balloon dilation Common bile duct stonesBillroth II gastrectomy

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 73-78页

作者： Jun Wen Tao li Yi Lu li-ke bie Biao Gong Digestive Endoscopy Center Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine Digestive Endoscopy Center The Sixth Affiliated Hospital of Sun Yat-sen University

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography(ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy(TPS), needle-knife fistulotomy(NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Methods: Between March 2008 and December 2016, 157 consecutive patients undergoing precutting for an inaccessible bile duct during ERCP were identified. Precut techniques were chosen depending on repetitive inadvertent pancreatic cannulation and the papillary morphology. We retrospectively assessed the rates of cannulation success and procedure-related complications among three groups, namely TPS, NKF, and TPS followed by NKF. Results: The baseline characteristics of the three groups were comparable. The overall success rate of biliary cannulation reached 98.1%, including 111 of 113(98.2%) with TPS, 35 of 36(97.2%) with NKF and 8 of 8(100%) with NKF following TPS, without significant difference among groups. The incidences of total complications and post-ERCP pancreatitis were 9.6% and 7.6%, respectively. There was a trend towards less frequent post-ERCP pancreatitis after NKF(0%) compared with 11 cases(9.7%) after TPS and one case(12.5%) after NKF following TPS, but not significantly different( P = 0.07). No severe adverse event occurred during this study period. Conclusions: The choice of precut techniques by the presence of unintended pancreatic access and the papillary morphology brought about a high success rate without increasing risk in difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife fistulotomy Precut techniques Transpancreatic septotomy

Long-term outcomes of endoscopic papillary large-balloon dilation(12-15 mm)with or without limited sphincterotomy for removal of bile duct stones

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 392-398页

作者： Tao li li-Xiao Hao Chan Lv Xing-Jia li Xiao-Dan Ji Meng Chen Chang liu li-ke bie Biao Gong Department of Gastroenterology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:limited endoscopic sphincterotomy with large balloon dilation(ES-LBD)and endoscopic papillary large-balloon dilation(EPLBD)have been proven safe and effective for removal of bile duct ***,the long-term outcomes are not *** aim of this study was to assess the long-term outcomes of EPLBD(12-15 mm)with or without limited sphincterotomy for removal of common bile duct(CBD)***:Patients with EPLBD or ES-LBD referred for the removal of bile-duct stones between June 2008 and August 2020 were retrospectively *** stone clearance,endoscopic retrograde cholangiopancreatography(ERCP)-related adverse events,and late biliary complications during long-term follow-up were ***:Basic patient characteristics were not significantly different between the groups that underwent EPLBD(n=168)and ES-LBD(n=57).EPLBD compared with ES-LBD resulted in similar outcomes in terms of overall successful stone removal(99.4%vs.100%,P=1.00)and ERCP-related adverse events(7.7%vs.5.3%,P=0.77).The mean duration of the follow-up were 113.6 months and 106.7 months for patients with EPLBD and ES-LBD,respectively(P=0.13).There was no significant difference between EPLBD and ES-LBD in the incidence of stone recurrence[20(11.9%)vs.9(15.8%);P=0.49].Multivariate analysis showed that a diameter of CBD≥15 mm(OR=3.001;95%CI:1.357-6.640;P=0.007)was an independent risk factor for stone ***:The application of a large balloon(12-15 mm)via EPLBD is an effective and safe alternative to ES-LBD for extraction of large CBD *** sphincterotomy prior to EPLBD may be unnec-essary.A diameter of CBD≥15 mm is a risk factor of stone recurrence.

关键词： Endoscopic papillary large-balloon dilation Endoscopic sphincterotomy Bile duct stone

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维吾尔族男性不育症危险因素对照研究

中国男科学杂志 2010年第8期24卷 46-48页

作者：阿达力别克巴哈提古丽新疆医科大学公共卫生学院流行病学与卫生统计学教研室乌鲁木齐830054 新疆昌吉市人民医院

目的探讨维吾尔族男性不育症的危险因素。方法对133例不育症患者进行1:1配对病例对照研究。结果 Logi stic回归分析显示,与维吾尔族男性不育症有关联的危险因素是:(1)食用棉籽油(OR=5.72,95%CI:1.20～27.33);(2)吸烟(OR=8.60,95%CI:2.52... 详细信息

目的探讨维吾尔族男性不育症的危险因素。方法对133例不育症患者进行1:1配对病例对照研究。结果 Logi stic回归分析显示,与维吾尔族男性不育症有关联的危险因素是:(1)食用棉籽油(OR=5.72,95%CI:1.20～27.33);(2)吸烟(OR=8.60,95%CI:2.52～29.34);(3)生殖系统疾病史(OR=8.347,95%CI:1.027～67.846);(4)结核病史(OR=4.3 2,9 5%CI:1.1 6～1 6.07);(5)婚外性生活史(OR=3.66,95%CI:1.21～1 1.01);(6)性病史(OR=5.49,95%CI:1.38～21.85)。结论本研究显示:男性不育症是由多种危险因素导致的。应从改变不良的生活习惯及行为方式,早期积极治疗影响生殖健康的疾病以预防不育症的发生。

关键词：维吾尔族男性不育症危险因素病例对照研究

新疆吐鲁番地区维吾尔族和汉族成人支气管哮喘相关因素调查分析

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中华预防医学杂志 2009年第10期43卷 907-912页

作者：王晶齐曼古丽·吾守尔李霞何元兵克丽别娜·吐尔逊文进居来提·木塔力甫新疆医科大学第一附属医院呼吸科乌鲁木齐830054 吐鲁番地区人民医院内一科

目的探讨新疆吐鲁番地区维吾尔族、汉族成人支气管哮喘（简称哮喘）发病的相关因素，分析可能存在的民族、地区差异。方法收集吐鲁番地区医院确诊的哮喘患者166例，其中维吾尔族86例（维哮喘组），汉族80例（汉哮喘组）以同期眼科门诊... 详细信息

目的探讨新疆吐鲁番地区维吾尔族、汉族成人支气管哮喘（简称哮喘）发病的相关因素，分析可能存在的民族、地区差异。方法收集吐鲁番地区医院确诊的哮喘患者166例，其中维吾尔族86例（维哮喘组），汉族80例（汉哮喘组）以同期眼科门诊患者为对照，按1：1配对设计。采用问卷调查，血清嗜酸细胞阳离子蛋白（S-ECP）、总IgE（T—IgE）及特异性IgE（S-IgE）检测，进行单因素及多因素条件logistic回归分析。调查结果与我国其他地区的研究资料进行比较。结果呼吸道感染（OR维=5．111，95％CI值：1．203～21．710；OR汉=2．498，95％CI值：1．471-5．069）、家族史（OR维=3．078，95％CI值：1．812～5．188；OR汉=2．711，95％CI值：1．010～6．176）、过敏史（OR维=2．083，95％CI值：1．043～4．162；OR汉=3．998，95％CI值：1．739～9．198）、气候变化（OR维=2．218，95％CI值：1．199—3．778；OR汉=1．733，95％CI值：1．004～2．994）、S-IgE阳性（OR维=1．592，95％CI值：1．018～2．491；OR汉=3．858，95％CI值：2．246～8．507）与哮喘的关联有显著性。维哮喘组中呼吸道感染[59．30％（51／86）]、气候变化[36．05％（31／86）]诱发哮喘者高于汉哮喘组[分别为42．50％（34／80）和21．25％（17／80）]；汉哮喘组中有过敏史[48．75％（39／80）]、S-IgE阳性者[52．50％（42／80）]高于维哮喘组[分别为32．56％（28／86）和30．23％（26／86）]。中、重度哮喘患者血清炎症介质水平测定，S-ECP维为（7．95±3．98）μg／L，S-ECP汉为（11．21±4．74）μg/L；T—IgE维为（72．23±45．92）kU／L，T—IgE汉为（108．81±64．07）kU／L，均明显高于同民族对照[S-ECP维为（1．94±1．16）μg/L，S-ECP汉为（2．07±1．63）μg／L，T—IgE维为（46．19±32．47）kU／L，T—IgE汉为（50．97±38．51）kU／L；t值分别为8．96、10．52、2．81、4．97，P值均〈0．01]。汉族中、重度哮喘患者S-ECP和T—IgE水平均高于维吾尔族（t值3．01、2．68，P值均〈0．01）。结论呼吸道感染、家族史、过敏史、气候变化、S—IgE阳性为吐鲁番地区哮喘发病的主要相关因素。中、重度哮喘发作的患者血清中S-ECP和T—IgE水平增高，汉族患者血清S-ECP、T—IgE水平高于维吾尔族。遗传，环境因素对哮喘的发生和发展有影响。

关键词：哮喘维吾尔族汉族回归分析

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan liu Wei Wu Xuejuan li Chengyan Wang ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing Zhao Xin Min Yanghong li Ruiyu Mi Yangai liu Xiaowen Wu Minghao Fang Zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning li Long Ye lijian Zuo ke Gao key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-ke Tu Min li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation