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Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination

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National Science Review 2023年第5期10卷 112-123页

作者： Yue-Miao Zhang Xing-Zi liu Zhao Zhang Tai-Cheng Zhou Xin Zhang Hong-Yu Yang Meng Tan Nan Hu Su-Fang Shi Fang Wang Rong Xu li-jun liu Su-Xia Wang Gang liu Fu-De Zhou Ming-Hui Zhao Hong Zhang Ji-Cheng Lv Ya-Ping Zhang Zi-Jie Zhang li Yang Renal Division Department of MedicinePeking University First Hospital Renal Pathology Center Institute of NephrologyPeking University Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Central Laboratory and liver Disease Research Center The Affiliated Hospital of Yunnan University Laboratory of Electron Microscopy Pathological CentrePeking University First Hospital State Key Laboratory for Conservation and Utilization of Bio-Resource and School of life Sciences Yunnan University

The onset of various kidney diseases has been reported after severe acute respiratory syndrome coronavirus2(SARS-CoV-2) ***,detailed clinical and pathological features are *** screened and analyzed patients with newly diagnosed kidney diseases after inactivated SARS-CoV-2 vaccination in Peking University First Hospital from January 2021 to August 2021,and compared them with the reported cases in the *** obtained samples of blood,urine and renal biopsy *** and laboratory information,as well as light microscopy,immunostaining and ultrastructural observations,were *** SARS-CoV-2 spike protein and nucle oprotein were stained using the immunofluorescence technique in the kidney biopsy ***-CoV-2 specific antibodies were tested using magnetic particle chemiluminescence *** study group included 17 patients with a range of conditions including immune-complex-mediated kidney diseases(IgA nephropathy,membranous nephropathy and lupus nephritis),podocytopathy(minimal change disease and focal segmental glomerulosclerosis) and others(antineutrophil-cytoplasmic-antibody-associated vasculitis,anti-glomerular basement membrane nephritis,acute tubulointerstitial nephritis and thrombotic micro angiopathy).Seven patients(41.18%)developed renal disease after the first dose and ten(58.82%) after the second *** kidney disease spectrum as well as clinicopathological features are similar across different types of SARS-CoV-2 *** found no definitive evidence of SARS-CoV-2 spike protein or nucleoprotein deposition in the kidney biopsy *** markers implicated abnormal immune responses in predisposed *** and follow-up(median=86 days) showed that biopsy diagnosis informed treatment and prognosis in all *** conclusion,we observed various kidney diseases following SARS-CoV-2 vaccine administration,which show a high consistency across different types of SARS-CoV-2 vaccin

关键词： kidney disease SARS-CoV-2 vaccination abnormal immune response

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Theoretical study on tetranuclear boron clusters: B4X4 (X = H, F, Cl, Br, I)

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Chinese Journal of Chemistry 1994年第4期12卷 305-313页

作者： liN, Chen-Sheng li, jun liu, Chun-WanFujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, China Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences State Key Laboratory of Structural Chemistry Fuxhou Fujian 350002 China

The molecular orbitals for B4H4, B4F4, B4Cl4, B4Br4 and B4I4 have been calculated by using all-electron or effective core potential ab initio method at the self-consistent field level using basis sets with diffuse and polarization functions. The boron-boron and boron-halide (-hydrogen) distances of these cage compounds are optimized with three kinds of basis sets constrained to a tetrahedral symmetry. According to the localization scheme of Boys, four three-centered two-electron (3c2e) B-B-B bonds localized on each of the faces of the B4 tetrahedron are derived for B4X4 clusters. The HOMO-LUMO energy gaps, atomization energies and Mulliken overlap populations of these compounds indicate that the stabilities of the clusters decrease in the sequence of B4F4 > B4Cl4, B4H4 > B4Br4 > B4I4.

关键词： Ab initio tetraboron balogenide multi-center bonds localized molecular orbitals.

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Theoretical studies on the band structures of superconducting solid compounds: Nb3X (X=Si, Ge, Sn, Pb)

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Chinese Journal of Chemistry 1994年第5期12卷 385-391页

作者： CAI, Shu-Hui li, jun liu, Chun-WanFujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian 350002, China Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences State Key Laboratory of Structural Chemistry Fushou Fujian 350002 China

The band structures of several analogous superconducting A-15 type solid compounds, Nb3X (X=Si, Ge, Sn, Pb), have been calculated by use of the tight-binding method within the Extended Huckel approximation (EHT). By analysis of their energy bands, densities of states and crystal orbital overlap populations, the dependence of the superconducting transition temperatures (Tc) on the electronic structures and bondings is qualitatively elucidated.

关键词： Nb3X EHT band structures,Tc.

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China life Sciences 2025年第1期68卷 303-305页

作者： Ziqian Xu lianpan Dai jun liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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A FACILE TOTAL SYNTHESIS OF (±)-SEliNA-3,11-DIEN-9-OL

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Chinese Chemical Letters 1994年第9期5卷 721-724页

作者： li jun liu Zhao Ming XIONG Fa jun NAN Tong Shuang li Yu lin li(State Key Laboratory of Applied Organic Chemistry and Institute or Organic Chemistry, Lanzhou University. Lanzhou 730000)

A ffcile tatal synthesis of (±)-selina-3. 11-dien-9-ol (1) has been described. The key step is the onepot reductive fragmentation of α,β-unsaturated p-tosylhydrazone and deduction of 9-carbonyl of 5 With sodium bor... 详细信息

关键词： SEliNA-3,11-DIEN-9-OL TOTAL A FACILE TOTAL SYNTHESIS OF

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Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第10期18卷 833-844页

作者： ling HONG jun-li liu Samira Z.MIDOUN Philip C.MILLER Department of Genetics and Developmental Biology College of Life Science and TechnologyHuazhong University of Science and Technology Systems Biology Research Group Bioengineering Department University of California

The unicellular green alga Dunaliella salina is well adapted to salt stress and contains compounds（including β-carotene and vitamins） with potential commercial value.A large transcriptome database of *** during the adjustment, exponential and stationary growth phases was generated using a high throughput sequencing *** characterized the metabolic processes in *** with a focus on valuable metabolites, with the aim of manipulating *** to achieve greater economic value in large-scale production through a bioengineering *** expression profiles under salt stress verified using quantitative polymerase chain reaction（qPCR） implied that salt can regulate the expression of key *** study generated a substantial fraction of *** transcriptional sequences for the entire growth cycle, providing a basis for the discovery of novel *** first full-scale transcriptome study of *** establishes a foundation for further comparative genomic studies.

关键词： Dunaliella salina Transcriptome profile Metabolic processes and adjustment Regulatory metabolism Salt stress

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Research and exploration progress on lithium deposits in China

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China Geology 2020年第1期3卷 137-152页

作者： Deng-hong Wang Hong-zhang Dai Shan-bao liu Cheng-hui Wang Yang Yu Jing-jing Dai li-jun liu Yue-qing Yang Sheng-chao Ma Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Sichuan Institute of Geology&Mineral Resources Bureau of Geology and Mineral Exploration&Development of Sichuan ProvinceChengdu 610000China

Since 2012,some advances have been made through the resource investigation,metallogenesis research,and comprehensive utilizing of lithium deposits in ***,the progress of lithium exploration has been made in Sichuan,Xinjiang,Qinghai and Jiangxi provinces(autonomous region).li deposits are not only found within the pegmatite rocks but also within the granitic rocks and sedimentary ***,the methods of geological survey,geochemical and geophysical exploration,remote sensing technology and even drilling technology have been improved,which can be delineating orebodies ***,the mechanisms of li mineralization were summarized by analyzing the relationship between the li contents and kinds of geological *** on practice,a new understanding of"multi-cycle,deep circulation,integration of internal and external"metallogenic mechanism or"MDIE"metallogenic mechanism for short has been put forwarded further in this paper,and the"five levels+basement"exploration model has been successfully expanded to guide the prospecting work both in the Jiajika and Keeryin pegmatite ore fields in western Sichuan ***,new progress has been made in the aspect of amblygonite deposits of granite-type and hydrothermal type in the Mufushan-Jiuling ore district,which points out a new direction for prospecting new types of lithium deposits in China.

关键词： lithium deposits Amblygonite "MDIE"metallogenic mechanism "Five levels+basement"exploration model Mineral exploration engineering China

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曲轴箱通风对GDI汽油机微粒排放的影响

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内燃机学报 2016年第5期34卷 438-442页

作者：乔世杰李君刘宇吉林大学汽车仿真与控制国家重点实验室吉林长春130022

缸内直喷(GDI)汽油机微粒生成是由于雾化时间短及局部混合气过浓;同时,因为机油不可避免地参与燃烧也导致微粒排放增加.曲轴箱通风中未被油气分离器分离的机油蒸气占据机油消耗量比重较大,理论上这部分机油参与燃烧所产生的颗粒物对发... 详细信息

缸内直喷(GDI)汽油机微粒生成是由于雾化时间短及局部混合气过浓;同时,因为机油不可避免地参与燃烧也导致微粒排放增加.曲轴箱通风中未被油气分离器分离的机油蒸气占据机油消耗量比重较大,理论上这部分机油参与燃烧所产生的颗粒物对发动机最终的微粒排放影响也相应较大.因此,笔者在国产4G75缸内直喷汽油机上使用EEPS测定不同机油消耗条件下微粒排放特性,研究不同曲轴箱通风状态下未分离机油对GDI发动机微粒排放影响规律.结果表明:未被分离的机油消耗量增加导致微粒迅速升高,尤其在怠速工况下显著影响微粒生成质量;随发动机转速逐渐升高,机油消耗量对微粒生成的影响明显降低.

关键词：缸内直喷汽油机机油消耗量微粒质量浓度粒径分布

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Tetra-n-butylammonium Hydroxide:an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

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Chemical Research in Chinese Universities 2006年第4期22卷 451-454页

作者： ZHANG Zhi-li~ , ZHOU Shou-xin, WANG Xiao-wei, WANG Hong-tao, CHEN Yan-li and liu jun-yi Department of Chemical Biology, School of Pharmaceutical Sciences State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China Department of Chemical Biology School of Pharmaceutical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100083 P. R. China

An efficient procedure for N-alkylation of pyrimidines and purines in the presence of tetra-n-butylammonium hydroxide（TBAH） is described. The method is very practical and the alkylation can occur at room temperature... 详细信息

关键词： Tetra-n-butylammonium hydroxide N-Alkylation Purine Pyrimidine

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