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2022年某院侵袭性念珠菌医院感染临床及流行病学特征

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中华医院感染学杂志 2024年第5期34卷 668-672页

作者：臧凤刘娟李松琴张卫红李占结杨乐宋舸江苏省人民医院(南京医科大学第一附属医院江苏省妇幼保健院)感染管理处江苏南京210029 南京医科大学附属常州第二人民医院感染管理科江苏常州213000

目的研究念珠菌分离及医院感染的流行病学特征,为控制侵袭性念珠菌医院感染提供依据。方法回顾性收集江苏省人民医院2022年1月1日-2022年12月31日检出的7667株假丝酵母及临床资料,分析假丝酵母分离来源及医院感染分布情况。结果白假... 详细信息

目的研究念珠菌分离及医院感染的流行病学特征,为控制侵袭性念珠菌医院感染提供依据。方法回顾性收集江苏省人民医院2022年1月1日-2022年12月31日检出的7667株假丝酵母及临床资料,分析假丝酵母分离来源及医院感染分布情况。结果白假丝酵母整体分离率最高(58.49%),其次为近平滑假丝酵母(22.58%)、热带假丝酵母(15.52%)、光滑假丝酵母(2.13%)、克柔假丝酵母(1.02%),标本类型中来自于痰标本的菌株数量4550株,占59.35%,其次为泌尿道(1183株,15.43%)及粪便(682株,8.90%)。分离科室最多是内科(2879株,37.55%),其次为外科(2366株,30.86%)、重症监护病房(ICU)(2232株,29.11%)及急诊(190株,2.48%)。共有688例患者发生侵袭性念珠菌医院感染,占全年医院感染的23.93%,年龄>60岁的侵袭性念珠菌医院感染患者占66.72%(459/688),基础疾病以高血压和心血管疾病为主,感染科室主要在ICU(41.13%,283/688),住院时间主要集中在15~30d(49.42%,340/688),抗菌药物使用时间≥3周的比例占65.12%(448/688)。结论侵袭性念珠菌医院感染的患者逐渐增多,侵袭性念珠菌医院感染与年龄、基础疾病、科室、住院时间、抗菌药物使用时间等因素有关,亟需加强医院防控。

关键词：医院感染侵袭性真菌假丝酵母流行病学分布感染防控侵袭性念珠菌病

THE WALL EFFECT ON VENTILATED CAVITATING FLOWS IN CLOSED CAVITATION TUNNELS

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Journal of Hydrodynamics 2008年第5期20卷 561-566页

作者： CHEN Xin LU Chuan-jing li jie PAN zhan-cheng Department of Engineering Mechanics Shanghai Jiao Tong University Shanghai 200240 China

For ventilated cavitating flows in a closed water tunnel, the wall effect may exert an important influence on cavity shape and hydrodynamics, An isotropic mixture multiphase model was established to study the wall effect based on the RANS equations, coupled with a natural cavitation model and the RNG k-ε turbulent model. The governing equations were discretized using the finite volume method and solved by the Gauss-Seidel linear equation solver on the basis of a segregation algorithm. The algebraic multigrid approach was carried through to accelerate the convergence of solution. The steady ventilated cavitating flows in water tunnels of different diameter were simulated for a conceptual underwater vehicle model which had a disk cavitator. It is found that the choked cavitation number derived is close to the approximate solution of natural cavitating flow for a 3-D disk. The critical ventilation rate falls with decreasing diameter of the water tunnel. However, the cavity size and drag coeflicient are rising with the decrease in tunnel diameter for the same ventilation rate, and the cavity size will be much different in water tunnels of different diameter even for the same ventilated cavitation number.

关键词： ventilated cavitation water tunnel choked cavitation number critical ventilation rate

A study of the effect of local scour on the flow field near the spur dike

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 98-105页

作者： Yu-Tian li jie-Min zhan Wing-Hong Onyx Wai Department of Industrial Design School of Industrial Design and Ceramic ArtFoshan UniversityFoshan 528000China Department of Applied Mechanics and Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China

The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with *** this study,large eddy simulations with fixed-bed at different scouring stages were conducted to investigate the changes in flow *** results imply that the bed deformation leads to an increase in flow rate per unit area,which represent the capability of sediment transportation by water,in the scour ***,the intensity of turbulent kinetic energy and bimodal motion near the sand bed induced by the HVS were also ***,the peak moments between the two sediment transport mechanisms were ***,understanding the complex feedback mechanism between topography and flow field is essential for the local scour problem.

关键词： Spur dike Local scour Large eddy simulation Down flow Horseshoe vortex system

医院感染诊断病原学送检标本与目标感染部位的匹配情况

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中华医院感染学杂志 2024年第3期34卷 455-459页

作者：陈晓旭李松琴谢秀璋吴赛萍张永祥张卫红李占结南京医科大学第一附属医院感染管理处江苏南京210029 江苏大学附属武进医院感染管理科江苏常州213003 徐州医科大学武进临床学院感染管理科江苏常州213000

目的研究医院感染诊断病原学送检标本与目标感染部位的匹配情况.方法纳入2021年1月1日-2021年12月31日南京医科大学第一附属医院发生医院感染的住院患者,纳入2591例医院感染患者,包含2827个感染诊断,分析医院感染诊断相关病原学送检率... 详细信息

目的研究医院感染诊断病原学送检标本与目标感染部位的匹配情况.方法纳入2021年1月1日-2021年12月31日南京医科大学第一附属医院发生医院感染的住院患者,纳入2591例医院感染患者,包含2827个感染诊断,分析医院感染诊断相关病原学送检率、医院感染诊断相关病原学送检标本匹配率、不同感染部位医院感染诊断相关病原学送检标本匹配率.结果全院医院感染率为1.53%(2951/192584),医院感染诊断相关病原学送检率为95.72%(2480/2591);不同片区间送检率差异有统计学意义(P<0.001),其中ICU的医院感染诊断相关病原学送检率最高(99.83%),外科组(93.09%)和急诊组(91.30%)相对较低;全院医院感染诊断相关病原学送检标本匹配率为87.44%,不同片区间匹配率差异有统计学意义(P<0.001),其中ICU最高(94.61%),内科最低(76.27%),其中血液科为76.69%(181/236);医院感染诊断相关病原学送检标本匹配率最高的三个感染部位分别为血液系统(98.13%)、泌尿系统(92.97%)和手术部位(87.56%);送检标本匹配率<80%的感染部位主要有皮肤与软组织和眼耳鼻喉部位感染.结论不同科室与不同部位医院感染送检标本的匹配性差异较大,医疗机构应根据不同科室以及不同感染部位的特点采取针对性改进措施,提高医院感染送检标本匹配率,进一步提升抗菌药物合理使用.

关键词：医院感染诊断病原学送检标本感染部位匹配

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN Jia-qi zhanG Jia-qi zhan li HU li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengyu zhang Zhiyang zhang Heng Sun jie li Yi Chen Jiang Wang Chuanlang zhan Key Laboratory of Advanced Materials Chemistry and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent years, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have exceeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of *** ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency *** this review, a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.

关键词： Organic solar cell Ternary/quaternary strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

A Virtual Reality Platform for Context-Dependent Cognitive Research in

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Neuroscience Bulletin 2023年第5期39卷 717-730页

作者： Xue-Tong Qu Jin-Ni Wu Yunqing Wen Long Che Shi-Lei Lv li liu li-jie zhan Tian-Yi liu Hua He Yu liu Chun Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Automation Chinese Academy of SciencesBeijing 100190China Department of Neurosurgery Third Affiliated Hospital of Navy Military Medical UniversityShanghai 200438China

Animal survival necessitates adaptive behav-iors in volatile environmental *** reality(VR)technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental con-text by simulating the real world with maximized control of contextual *** current VR tools for rodents have limited flexibility and performance(e.g.,frame rate)for context-dependent cognitive ***,we describe a high-performance VR platform with which to study con-textual behaviors immersed in editable virtual *** platform was assembled from modular hardware and custom-written software with flexibility and *** this platform,we trained mice to perform context-dependent cognitive tasks with rules ranging from discrim-ination to delayed-sample-to-match while recording from thousands of hippocampal place *** precise manipula-tions of context elements,we found that the context recogni-tion was intact with partial context elements,but impaired by exchanges of context ***,our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording.

关键词： Virtual reality Spatial context Contextual behavior Hippocampus Place cell-Learning and memory Ca^(2+)imaging

Enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials Science & Technology 2024年第4期171卷 139-146页

作者： Zhi Yun Yue Zhi Dong zhang zhan jie Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching

Multiscale engineering of molecular electrocatalysts for the rapid hydrogen evolution reaction

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Nano Research 2024年第7期17卷 6026-6031页

作者： Huan li zhan Jiang Yubo Yuan Yirong Tang jie Zao Wentao zhang Peiyi Han Xun zhang Bulin Chen Yongye liang Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China South China Institute of Environmental Sciences Guangzhou 510655China

Molecular electrocatalysts have demonstrated potential for the hydrogen evolution reaction(HER)due to their well-defined structures and high intrinsic *** rapid production of hydrogen requires molecular electrocatalysts to operate at high current densities,which still presents a *** this work,we demonstrate that molecularly dispersed electrocatalysts of cobalt phthalocyanine anchored on carbon nanotubes(CoPc MDEs)are superior candidates due to the efficient charge transport between the substrate and the active *** intrinsic activity can be enhanced by introducing functional groups on *** facilitate mass transport,di(ethylene glycol)substituted CoPc molecules are further anchored on a threedimensional self-supported electrode(CoPc-DEG MDE@CC),enabling continuous operation for 25 h at−1000 mA/cm^(2)in 1.0 M *** study demonstrates the potential of molecular electrocatalysts for HER and emphasizes the importance of adjusting intrinsic activity,and charge and mass transport capacity for practical molecular electrocatalysts.

关键词： hydrogen evolution reaction cobalt phthalocyanine intrinsic activity mass transport