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New era:prospects for managing cancer of unknown primary

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癌症生物学与医学:英文版 2023年第8期20卷 562-567页

作者： Yize li Yinmiao bai Hongchen Ji Zhihui liu Hongmei Zhang Department of Clinical Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China

Cancer of unknown primary(CUP)is a highly heterogeneous tumor type that is confirmed to be metastatic through pathological examination;however,its primary lesion cannot be determined on the basis of detailed clinical information and diagnostic *** current guidelines have not changed the basic definition of *** studies have reported a decline in the incidence of CUP,to approximately 2%1,with the development of diagnostic techniques such as radiology,histopathology,and genetic testing.

关键词： Cancer clinical cancer

The ubiquity and coexistence of two FBPases in chloroplasts of photosynthetic eukaryotes and its evolutionary and functional implications

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Plant Diversity 2020年第2期42卷 120-125页

作者： Yujin li Qingqing Ye De He Huixian bai Jianfan Wen State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Kunming College of life Science University of Chinese Academy of Sciences.KunmingYunnan650204China College of life Sciences Southwest Forestry UniversityKunmingYunnan.650224China

In photosynthetic eukaryotes,there are two well-characterized fructose-1,6-bisphosphatases(FBPases):the redox-insensitive cytosolic FBPase(cyFBPase),which participates in gluconeogenesis,and the redoxsensitive chloroplastic FBPase(cpFBPasel),which is a critical enzyme in the Calvin *** studies have identified a new chloroplastic FBPase,cpFBPase2;however,its phylogenetic distribution,evolutionary origin,and physiological function remain *** this study,we identified and characterized these three FBPase isoforms in diverse,representative photosynthetic lineages and analyzed their *** contrast to previous hypotheses,we found that cpFBPase2 is ubiquitous in photo synthetic ***,all cpFBPase2 s from diverse lineages form a monophyly,suggesting cpFBPase2 is not a recently evolved enzyme restricted to land plants but rather evolved early in the evolution of photo synthetic organisms,and most likely,in the common ancestor of photosynthetic *** was probably first duplicated to produce cpFBPase2,and then the latter duplicated to produce *** ubiquitous coexistence of these two cpFBPases in chloroplasts is most likely the consequence of adaptation to different redox conditions of photosynthesis,especially those caused by recurrent changes in light conditions.

关键词： FBPase Photosynthetic eukaryotes Coexistence Evolution Adaptation

“数字化”背景下行动导向教学法的应用研究——以学前教育专业人才培养为例

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陕西开放大学学报 2024年第2期26卷 90-96页

作者：李华万秀芬李彤尉合芳陕西开放大学学前师范学院陕西西安710119 陕西艺术幼儿园陕西西安710002

教育数字化战略行动推动学前教育的教育教学数字化转型。在此背景下,国家对学前教育行业人才素质和能力提出更高的要求。本文主要分析了行动导向教学法的主要含义及数字化背景下行动导向教学法的变革,提出“数字化”背景下行动导向教学... 详细信息

教育数字化战略行动推动学前教育的教育教学数字化转型。在此背景下,国家对学前教育行业人才素质和能力提出更高的要求。本文主要分析了行动导向教学法的主要含义及数字化背景下行动导向教学法的变革,提出“数字化”背景下行动导向教学法在学前教育专业人才培养中应用研究路径,通过在幼儿园进行实施取得较好的效果。

关键词：数字化行动导向教学法学前教育专业人才培养应用研究

Fatigue crack growth behavior of 2624-T39 aluminum alloy with different grain sizes

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Rare Metals 2021年第9期40卷 2523-2529页

作者： Guan huang Zhi-Hui li li-Ming Sun Xi-Wu li Kai Wen li-Zhen Yan bai-Qing Xiong Yong-An Zhang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China Northeast light Alloy Co. Ltd.Harbin 150060China

The microstructure of 2624-T39 aluminum alloy was analyzed by means of metallographic(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM). The effects of different microstructure characteristics on the tensile properties and fatigue crack growth rate of 2624-T39 aluminum alloy were *** showed that the grain size of the alloy was a typical fiber structure along the rolling direction, and the main second phase was the A_(l2)CuMg phase. The grain size of the alloy had an obvious influence on the fatigue crack growth rate, and the alloy showed a lower fatigue crack growth rate due to the larger grain size. The crack initiation zone on the fracture surface of alloys with lower fatigue crack growth rate was relatively rough, the crack propagation zone had obvious fatigue striations, and the transient fracture zone had a large number of smaller dimples.

关键词： 2624-T39 aluminum alloy Grain size Fatigue crack growth rate Fatigue fracture morphology

Deformation mechanism and stability control of roadway along a fault subjected to mining

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International Journal of Mining Science and Technology 2012年第4期22卷 559-565页

作者： Yan Shuai bai Jianbiao li Wenfeng Chen Jigang li Lei School of Mines China University of Mining&TechnologyXuzhou 221116China State Key Laboratory of Coal Resources and Mine Safety China University of Mining&TechnologyXuzhou 221116China Yuwu Coal Industry Co.Ltd. Changzhi 046103China

It is difficult to maintain the roadway around a fault because of the fractured surroundings, complex stress environment, and large and intense deformation in the mining process. Based on a tailgate of panel $2205 in Tunliu colliery, in Shanxi province, China, we investigated the evolution of stress and displace- ment of rocks surrounding the roadway during the drivage and mining period using theoretical analysis, numerical simulation and field trial methods. We analyzed the deformation and failure mechanisms of the tailgate near a fault. The deformation of surrounding rock caused by unloading in the drivage period is large and asymmetric, the roadway convergence increases with activation of the fault and secondary fracture develops in the mining period. Therefore, we proposed a specific control technique of the road- way along a fault as follows：（1） High-strength yielding bolt not only supports the shallow rock to load- bearing structures, but also releases primary deformation energy by use of a pressure release device in order to achieve high resistance to the pressure retained：（2） Grouting of near-fault ribside after initial stabilization of the rock deformation is used to reinforce the broken rock, and to improve the integral load-bearing capacity ol~ the roadway. The research results were successfully applied to a field trial.

关键词： Fractured zone around a faultMining pressureRoadwayHigh resistance and yielding supportGrouting

Fabrication of high-performance pervaporation composite membrane for alkaline wastewater reclamation

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Frontiers of Chemical Science and Engineering 2022年第5期16卷 709-719页

作者： Guiqin bai Jianzhong Xia Bing Cao Rui Zhang Junquan Meng Pei li College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Institute for Advance Study Shenzhen UniversityShenzhen 518060China

Pervaporation desalination has a unique advantage to recycle concentrated salt *** merit can be applied to treat alkaline wastewater if the membrane has superior *** this paper,we used polyethylene microfiltration membrane as the substrate and deposited a glutaraldehyde crosslinked sodium carboxymethylcellulose layer by *** flux of the composite membrane reached 352 kg·m^(-2)·h^(-1) with a sodium chloride rejection of 99.9%0.1%when separating a 3.5 wt-%sodium chloride solution at 70℃.The desalination performance was stable after soaking the membrane in a 20 wt-%NaOH solution at room temperature for 9 d and in a 10 wt-%NaOH solution at 60℃ for 80 ***,the membrane was stable in 4 wt-%sulfuric acid and a 500 mg·L^(-1) sodium hypochlorite *** a process of concentrating a NaOH solution from 5 to 10 wt-%at 60℃,an average water flux of 23 kg·m^(-2)·h^(-1) with a NaOH rejection over 99.98%was obtained.

关键词： pervaporation alkaline solution concentration polyethylene membrane acid resistance chlorine tolerance

首发肝外表现的药物性肝损伤致肝纤维化临床特征及误诊分析

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临床误诊误治 2024年第15期37卷 10-14页

作者：王芝利黄涵宇姚智杰梁昊白华空军军医大学第一附属医院综合诊疗中心西安710032

目的探讨药物性肝损伤(DIli)致肝纤维化的误诊原因及防范措施。方法回顾性分析2020年5月至2022年12月收治的DIli致肝纤维化误诊患者15例的临床资料。结果15例中,发热伴咳嗽1例,发热伴尿频、尿急、尿痛2例;皮肤瘙痒、荨麻疹3例;肌肉酸痛... 详细信息

目的探讨药物性肝损伤(DIli)致肝纤维化的误诊原因及防范措施。方法回顾性分析2020年5月至2022年12月收治的DIli致肝纤维化误诊患者15例的临床资料。结果15例中,发热伴咳嗽1例,发热伴尿频、尿急、尿痛2例;皮肤瘙痒、荨麻疹3例;肌肉酸痛、关节疼痛2例;食欲减退、乏力、恶心、腹泻、上腹部不适7例。4例轻度巩膜黄染;1例触及左侧颌下增大淋巴结,与周围组织无粘连,轻度压痛;1例听诊呼吸音减弱,未闻及明显湿啰音;7例上腹部轻中度压痛;1例晨起关节疼痛伴僵硬;1例腰部和髋关节活动受限。初步诊断肺部感染、类风湿关节炎、强直性脊柱炎各1例,尿路感染2例,过敏性皮疹3例,胃肠炎7例。15例完善相关检查提示肝纤维化,明确用药史后确诊为DIli致肝纤维化。误诊时间为2~7 d。确诊后立即停用可疑药物,积极给予对症及生物红外治疗仪治疗,患者症状缓解。随访6个月,肝纤维化程度改善。结论DIli起病隐匿,临床表现呈现多样性且缺乏特异性,易误诊。临床医师应提高对DIli的临床辨识能力,以减少或避免误诊。

关键词：药物性肝损伤误诊肺部感染关节炎类风湿脊柱炎强直性疹胃肠炎肝硬化

基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊对心肌缺血再灌注损伤大鼠的保护作用

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中国中药杂志 2024年第5期49卷 1361-1368页

作者：胡雅琪孙丽李雪珂卢圣花袁恒佑王伟松刘建和湖南中医药大学第一附属医院湖南长沙410007 国家中医心血管病临床医学研究中心分中心湖南长沙410007

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,... 详细信息

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,模型组,柴胡三参胶囊临床等效、高剂量组,N-乙酰半胱氨酸(N-acetylcysteine)组,蛋白激酶C抑制剂(CGP53353)组。柴胡三参胶囊各剂量组连续给药7 d后,检测各组大鼠心肌梗死面积;苏木精-伊红(HE)染色观察大鼠心肌组织病理形态;TUNEL染色观察大鼠心脏组织凋亡情况;酶联免疫吸附(enzyme-linked immunosorbent assay,EliSA)法检测大鼠心肌损伤指标和氧化应激相关指标;流式细胞仪检测心脏组织中活性氧(ROS)水平;蛋白免疫印迹法(Western blot)及实时荧光定量聚合酶链式反应(real-time quantitative PCR,RT-qPCR)检测大鼠心脏组织相关蛋白及mRNA相对表达水平。结果显示,与假手术组比较,模型组大鼠心肌梗死面积明显,心肌结构紊乱、间质水肿及出血,可见大量空泡,心肌损伤标志物及心肌凋亡水平明显升高,ROS及丙二醛(MDA)水平明显升高,超氧化物歧化酶(SOD)水平明显下降,心肌组织中蛋白激酶C(PKCβⅡ)、烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(NOX2)、半胱氨酸蛋白酶3(caspase-3)、长链脂酰辅酶A合成酶4(ACSL4)蛋白及mRNA表达水平明显升高。与模型组比较,柴胡三参胶囊可改善大鼠心肌梗死面积和心脏组织病理形态,改善心肌损伤标志物和氧化应激相关指标,减少心肌组织凋亡水平,降低心肌组织中PKCβⅡ、NOX2、caspase-3、ACSL4蛋白及mRNA的表达。结果表明,柴胡三参胶囊可通过调控PKCβⅡ/NOX2/ROS信号通路,抑制氧化应激和程序性细胞死亡(凋亡、铁死亡),从而减轻心肌缺血再灌注损伤。

关键词：心肌缺血再灌注损伤柴胡三参胶囊氧化应激程序性细胞死亡

天然气地下储气库智能化建设关键技术及其发展趋势

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石油与天然气地质 2024年第2期45卷 581-592页

作者：糜利栋曾大乾刘华郭艳东李彦峰李遵照孙旭东张广权鲁春华王佩弦中国石化石油勘探开发研究院北京100026 山西能源学院山西太原030600 中国石化大连石油化工研究院辽宁大连116045 中国石化石油工程技术研究院北京100026

中国储气库在数字化转型和智能化建设方面已经取得了重要成果,储气库智能化建设发展了油气藏-井筒-管网一体化耦合模拟和数字孪生等关键技术。搭建了智能储气库云平台框架,采用“数据+平台+应用”的建设模式,充分利用数据中心、物联网... 详细信息

中国储气库在数字化转型和智能化建设方面已经取得了重要成果,储气库智能化建设发展了油气藏-井筒-管网一体化耦合模拟和数字孪生等关键技术。搭建了智能储气库云平台框架,采用“数据+平台+应用”的建设模式,充分利用数据中心、物联网和工业互联网等新型基础设施,支撑各业务板块管理、研究、生产和服务等需求。储气库智能化建设研发了储气库信息化管理平台、储气库一体化综合管理平台、基于数字孪生一体化仿真的决策系统和储气库全生命周期数字化平台。智能储气库未来建设将重点发展地质体数字孪生、高精度建模、可视化动态展示、智能运营、实时智能风险预警、工业软件国产化以及北斗卫星导航系统、卫星互联网等新技术。

关键词：数字孪生协同优化工业物联网地理信息系统智能储气库天然气