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Associations between Geriatric Nutrition Risk Index,bone mineral density and body composition in type 2 diabetes patients

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World Journal of Diabetes 2024年第3期15卷 403-417页

作者： Xiao-Xiao Zhu Kai-Feng Yao Hai-Yan huang li-hua wang Department of Pediatrics The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Nursing The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM),a fast-growing issue in public health,is one of the most common chronic metabolic disorders in older *** and sarcopenia are highly prevalent in T2DM patients and may result in fractures and *** people with T2DM,the association between nutrition,sarcopenia,and osteoporosis has rarely been *** To evaluate the connections among nutrition,bone mineral density(BMD)and body composition in patients with *** We enrolled 689 patients with T2DM for this cross-sectional *** patients underwent dual energy X-ray absorptiometry(DXA)examination and were categorized according to baseline Geriatric Nutritional Risk Index(GNRI)values calculated from serum albumin levels and body *** GNRI was used to evaluate nutritional status,and DXA was used to investigate BMD and body *** forward linear regression analysis was used to identify the factors associated with BMD and skeletal muscle mass *** Of the total patients,394 were men and 295 were *** with patients in tertile 1,those in tertile 3 who had a high GNRI tended to be younger and had lower HbA1c,higher BMD at all bone sites,and higher appendicular skeletal muscle index(ASMI).These important trends persisted even when the patients were divided into younger and older *** GNRI was positively related to ASMI(men:r=0.644,Plinical parameters,the GNRI was still significantly associated with BMD at the lumbar spine and femoral ***,a low lean mass index and higherβ-collagen special sequence were associated with low BMD at all bone *** was negatively correlated with

关键词： Geriatric Nutrition Risk Index Bone mineral density Skeletal muscle mass Type 2 diabetes

A fusion protein containing murine vascular endothelial growth factor and tissue factor induces thrombogenesis and suppression of tumor growth in a colon carcinoma model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 602-609页

作者： Feng-ying huaNG Yue-nan li hua wang Yong-hao huaNG Ying-ying liN Guang-hong TAN Hainan Provincial Key Laboratory of Tropical Medicine Hainan Medical College Haikou 571101 China

Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we construct and express a fusion protein containing vascular endothelial growth factor (VEGF) and tissue factor (TF) to explore whether this fusion protein has the capability of inhibiting tumor growth in a colon carcinoma model. The murine cDNA of VEGF A and TF were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned into prokaryotic expression plasmid pQE30 with a linker. The expression product recombinant VEGF-TF (rVEGF-TF) was purified and proved to have comparable enzyme activity to a commercial TF and the capability of specific binding to tumor vessels. Significant decrease of tumor growth was found in the mice administered with rVEGF-TF on Day 6 after initiated rVEGF-TF treatment (Plid thrombogenesis and tumor necrosis were observed in the tumor tissues injected with rVEGF-TF. Our results demonstrate that occlusion of tumor vasculature with rVEGF-TF is potentially an effective approach for cancer therapy.

关键词： Thrombogenesis Vascular endothelial growth factor (VEGF) Tissue factor (TF) Recombinant fusion protein

Development of a Decision Aid for Family Surrogate Decision Makers of Critically Ill Patients Requiring Renal Replacement Therapy in ICU:A User-Centered Design for Rapid Prototyping

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Chinese Medical Sciences Journal 2024年第2期39卷 91-101页

作者： Miao Zheng Yong-Hui Zhang Ying Cao Chang-lin Yin li-hua wang Department of Outpatient First Affiliated Hospital of Army Medical UniversityChongqing 400038China Department of Critical Care Medicine First Affiliated Hospital of Army Medical UniversityChongqing 400038China Administration Office First Affiliated Hospital of Army Medical UniversityChongqing 400038China

Objectives Renal replacement therapy(RRT)is increasingly adopted for critically ill patients diagnosed with acute kidney injury,but the optimal time for initiation remains unclear and prognosis is uncertain,leading to medical complexity,ethical conflicts,and decision dilemmas in intensive care unit(ICU)*** study aimed to develop a decision aid(DA)for the family surrogate of critically ill patients to support their engagement in shared decision-making process with *** Development of DA employed a systematic process with user-centered design(UCD)principle,which included:(i)competitive analysis:searched,screened,and assessed the existing DAs to gather insights for design strategies,developmental techniques,and functionalities;(ii)user needs assessment:interviewed family surrogates in our hospital to explore target user group's decision-making experience and identify their unmet needs;(iii)evidence syntheses:integrate latest clinical evidence and pertinent information to inform the content development of *** The competitive analysis included 16 relevant DAs,from which we derived valuable insights using existing *** decision needs were explored among a cohort of 15 family surrogates,revealing four thematic issues in decision-making,including stuck into dilemmas,sense of uncertainty,limited capacity,and delayed decision confirmation.A total of 27 articles were included for evidence *** decision making knowledge on disease and treatment,as delineated in the literature sourced from decision support system or clinical guidelines,were formatted as the foundational knowledge ***-one items of evidence were extracted and integrated into the content panels of benefits and risks of RRT,possible outcomes,and reasons to *** DA was drafted into a web-based phototype using the elements of *** platform could guide users in their preparation of decision-making through a sequential four-step process:identifying

关键词： decision aids renal replacement therapy intensive care units shared decision-making user-centered design surrogate

Solubility of wood-cellulose in liCl/DMAC solvent system

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Forestry Studies in China 2007年第3期9卷 217-220页

作者： He Jing liu Zhu li hua-yang wang Guo-hua Pu Jun-wen College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

A liC1/DMAC solvent system was used to dissolve wood-cellulose with aims to broaden its application in preparing functional materials of modified wood-cellulose. We studied the dissolubility complexion of wood-cellulose in a liC1/DMAC solvent system, made sure of the important function of liC1 in a cellulose solvent, and further confirmed its dissolution mechanism via the measurement of infrared spectra of soluble products. The study results are as follows： first, liC1 salts, which can form intermediate complexes with cellulose, have played an important role in the liC1/DMAC solvent system, and their solubility performance is en- hanced by reducing the hydrogen bond effect between cellulose molecules; second, the non-aqueous solvent system is a better method for dissolving wood-cellulose in homogenous phase. As found in infrared spectra, the absorption intensity of hydroxyl groups （broad peaks： 3,400 cm^-1） decreased greatly in cellulose macromolecules. This is because the degree of association between the hydroxyl groups of cellulose macromolecules is reduced, due to the destruction of the hydrogen bonds. Lastly, wood-cellulose can be dissolved in a liC1/DMAC solvent thoroughly and efficiently, and can provide a better solvent system for homogeneous synthesis in the preparation of new functional materials via modified wood-cellulose.

关键词： wood-cellulose liC1/DMAC homogeneous solution solubility

SEFormer:A lightweight CNN-Transformer Based on Separable Multiscale Depthwise Convolution and Efficient Self-Attention for Rotating Machinery Fault Diagnosis

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Computers, Materials & Continua 2025年第1期82卷 1417-1437页

作者： Hongxing wang Xilai Ju hua Zhu huafeng li State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China School of Computer Science and Engineering Nanyang Technological UniversitySingapore639798Singapore

Traditional data-driven fault diagnosis methods depend on expert experience to manually extract effective fault features of signals,which has certain ***,deep learning techniques have gained prominence as a central focus of research in the field of fault diagnosis by strong fault feature extraction ability and end-to-end fault diagnosis ***,utilizing the respective advantages of convolution neural network(CNN)and Transformer in local and global feature extraction,research on cooperating the two have demonstrated promise in the field of fault ***,the cross-channel convolution mechanism in CNN and the self-attention calculations in Transformer contribute to excessive complexity in the cooperative *** complexity results in high computational costs and limited industrial *** tackle the above challenges,this paper proposes a lightweight CNN-Transformer named as SEFormer for rotating machinery fault ***,a separable multiscale depthwise convolution block is designed to extract and integrate multiscale feature information from different channel dimensions of vibration ***,an efficient self-attention block is developed to capture critical fine-grained features of the signal from a global ***,experimental results on the planetary gearbox dataset and themotor roller bearing dataset prove that the proposed framework can balance the advantages of robustness,generalization and lightweight compared to recent state-of-the-art fault diagnosis models based on CNN and *** study presents a feasible strategy for developing a lightweight rotating machinery fault diagnosis framework aimed at economical deployment.

关键词： CNN-Transformer separable multiscale depthwise convolution efficient self-attention fault diagnosis

Optimization of Rolling Process for Bi(2223)/Ag Superconducting Tapes by a Statistical Method

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Rare Metals 2001年第1期20卷 66-68页

作者： Xuefeng li, Peiwen hua, Wenquan wang, Qijian Jin, Yiru Zhou, Guansen Yuan (General Research Institute for Nonferrous Metals, Beijing 100088, China) 北京有色冶金研究总院北京 100088

Ag-sheathed (Bi,Pb)(2)SoCa(2)Cu(3)O(x) tapes were prepared by the powder-in-tube method. The influences of rolling parameters on superconducting characteristics of Bi(2223)/Ag tapes were analyzed qualitatively with a statistical method. The results demonstrate that roll diameter and reduction per pass significantly influence the properties of Bi(2223)/Ag superconducting tapes while roll speed does less and working friction the least. An optimized rolling process was therefore achieved according to the above results.

关键词： Bi(2223)/Ag multifilamentary tapes rolling process statistical method optimization

Transcriptomic response of cowpea bruchids to N-acetylglucosamine-specific lectins

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Insect Science 2015年第1期22卷 83-94页

作者： li-hua wang Yong Hun Chi Feng-Guang Guo Hongmei li-Byarlay Susan Balfe Ji-Chao Fang Barry R. Pittendrigh Keyan Zhu-Salzman Institute of Plant Protection Jiangsu Academy of Agricultural Sciences Nanjing China Department of Entomology Texas A&M Univer-sity College Station TX USA 3Department of Entomology University of Illinois at Urbana-Champaign Urbana IL USA

Griffonia simplicifolia lectin II （GSII） and wheat germ agglutinin （WGA） are N-acetylglucosamine-binding lectins. Previous studies demonstrated that they have anti- insect activity, a property potentially useful in pest control. To gain some insight into the insect response to dietary lectins, we performed transcriptomic analysis using the cowpea bruchid （Callosobruchus maculatus） midgut microarray platform we built. Compared to the normutritional cellulose treatment, dietary lectins induced more profound changes in gene expression. Ingestion of relatively high doses oflectins for 24 h resulted in alteration of gene expression involved in sugar and lipid metabolism, transport, development, defense, and stress tolerance. Metabolic genes were largely downregulated. Moreover, we observed disorganized microvilli resulting from ingestion of WGA. This morphological change is consistent with the lectin-induced changes in genes related to midgut epithelial cell repair. In addition, suboptimal nutrient conditions may serve as a stress signal to trigger senescence processes, leading to growth arrest and developmental delay.

关键词： carbohydrate-binding lectin midgut epithelium senescence transcriptomic response

A short-term study of corneal collagen cross-linking with hypo-osmolar riboflavin solution in keratoconic corneas

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 94-97页

作者： Shao-Feng Gu Zhao-Shan Fan li-hua wang Xiang-Chen Tao Yong Zhang Chun-Qin wang Ya wang Guo-Ying Mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University

AIM: To report the 3mo outcomes of collagen crosslinking(CXL) with a hypo-osmolar riboflavin in thin corneas with the thinnest thickness less than 400 μm without ***: Eight eyes in 6 patients with age 26.2±4.8y were included in the study. All patients underwent CXL using a hypo-osmolar riboflavin solution after its de-epithelization. Best corrected visual acuity, manifest refraction, the thinnest corneal thickness, and endothelial cell density were evaluated before and 3mo after the ***: The mean thinnest thickness of the cornea was 408.5 ±29.0 μm before treatment and reduced to369.8 ±24.8 μm after the removal of epithelium. With the application of the hypo-osmolar riboflavin solution, the thickness increased to 445.0 ±26.5 μm before CXL and recover to 412.5 ±22.7 μm at 3mo after treatment, P =0.659). Before surgery, the mean K-value of the apex of the keratoconus corneas was 57.6 ±4.0 diopters, and slightly decreased(54.7±4.9 diopters) after surgery(P =0.085). Mean best-corrected visual acuity was 0.55 ±0.23 logarithm of the minimal angle of resolution, and increased to 0.53±0.26 logarithm after surgery(P =0.879).The endothelial cell density was 2706.4 ±201.6 cells/mm2 before treatment, and slightly decreased( 2641. 2 ±218.2 cells/mm2) at last fellow up(P =0.002).CONCLUSION: Corneal collagen cross-linking with a hypo-osmolar riboflavin in thin corneas seems to be a promising treatment. Further study should be done to evaluate the safety and efficiency of CXL in thin corneas for the long-term.

关键词： corneal collagen cross-linking keratoconus hypo-osmolar riboflavin thin corneas

Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice

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Acta Pharmacologica Sinica 2006年第9期27卷 1199-1205页

作者： Fei li hua-dong wang~2 Da-xiang LU Yan-ping wang Ren-bin QI Yong-mei FU Chu-jie li Department of Pathophysiology,Medical College of Jinan University,Guangzhou 510632,China Department of Pathophysiology Medical College of Jinan University Guangzhou China

Aim:Berberine is thought to be an immunomodulator,so the present study aimedto investigate the effect of berberine on mortality,lung and intestine injury inendotoxemic mice,and the mechanism of its ***:Mice were chal-lenged with lipopolysaccharide(LPS,28 mg/kg,ip),and neutral sulfate berbefinewas administrated *** was monitored every 12 h,and his-tology of the lungs and intestine as well as the plasma tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-12(IL-12),IL-10,and nitric oxide(NO)levels were ***:Pretreatment with 50 mg/kg neutral sulfate ber-berine once a day for 5 days significantly decreased the mortality rate and attenu-ated tissue injury of the lungs and small intestine in mice challenged with *** stimulated a marked increase in plasma levels of TNF-α,IFN-γ,IL-12,IL-10,and *** administration of berberine significantly reduced plasma TNF-α,IFN-γ,and NO levels,but did not suppress plasma IL-12 levels in mice exposed ***,pretreatment with neutral sulfate berbefine augmented IL-10secretion stimulated by LPS in ***:Pretreatment with neutral sul-fate berberine attenuates tissue injury and improves survival in endotoxemic mice,which may be mediated,at least in part,by the inhibition of pro-inflammatorymediator production and upregulation of IL-10 *** findings mightprovide a new strategy for the treatment of endotoxemia.

关键词： lipopolysaccharide berberine tumor necrosis factor-α interleukin-10 interleukin-12 interferon-γ nitric oxide mice