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Overlapping syndrome of recurrent anti-N-methyl-D-aspartate receptor encephalitis and anti-myelin oligodendrocyte glycoprotein demyelinating diseases:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6148-6155页

作者： Xue-Jing Yin li-Fang Zhang li-hua bao Zhi-Chao Feng Jin-hua Chen Bing-Xia li Juan Zhang Department of Neurology Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Neurology Changzhi People's HospitalChangzhi 046000Shanxi ProvinceChina

BACKGROUND Anti-N-methyl-D-aspartate receptor encephalitis(NMDARe)is capable of presenting a relapsing course and coexisting with myelin oligodendrocyte glycoprotein antibody disease,whereas it has been relatively *** describe a man with no history of tumor who successively developed anti-NMDARe and anti-myelin oligodendrocyte glycoprotein antibody *** SUMMARY A 29-year-old man was initially admitted with headache,fever,intermittent abnormal behavior,decreased intelligence,limb twitching and loss of consciousness on July 16,*** admission,examination reported no *** his presentation,he experienced aggravated symptoms,and the reexamination of cranial magnetic resonance imaging(MRI)indicated punctate abnormal signals in the left parietal *** examination of cerebrospinal fluid and serum results revealed serum NMDAR antibody(Ab)(-),cerebrospinal fluid NMDAR-Ab(+)1:10 and Epstein-Barr virus capsid antigen antibody Ig G(+).Due to the imaging findings,anti-NMDARe was our primary *** patient was treated with methylprednisolone and gamma globulin pulse therapy,mannitol injection dehydration to reduce intracranial pressure,sodium valproate sustained-release tablets for anti-epilepsy and olanzapine and risperidone to mitigate psychiatric *** patient was admitted to the hospital for the second time for“abnormal mental behavior and increased limb movements”on December 14,***-examination of electroencephalography and cranial MRI showed no *** results of autoimmune encephalitis antibody revealed that serum NMDAR-Ab was weakly positive and cerebrospinal fluid NMDAR-Ab was *** comprehensive recurrent anti-NMDARe,the patient was treated with propylene-hormone pulse combined with immunosuppressive agents(mycophenolate mofetil),and the symptoms were *** patient was admitted for“hoarseness and double vision”for the third time on August 23,***-examination of cranial MRI showed ab

关键词： Autoimmune encephalitis Recurrent anti-N-methyl-D-aspartate receptor encephalitis Myelin oligodendrocyte glycoprotein Psoriasis Case report

Involvement of the autophagy-related gene BdATG8 in development and pathogenicity in Botryosphaeria dothidea

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Journal of Integrative Agriculture 2022年第8期21卷 2319-2328页

作者： liU Na liAN Sen ZHOU Shan-yue WANG Cai-xia REN Wei-chao li bao-hua College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109P.R.China

Botryosphaeria dothidea is a destructive fungal pathogen that causes Botryosphaeria canker and fruit ring rot on apple *** is a process of self-degradation that maintains intracellular homeostasis via lysosomal *** date,the biological role of autophagy in *** remains *** this study,we identified and characterized the autophagy-related gene BdATG8 in ***8 was able to restore the defect in nitrogen starvation tolerance of Saccharomyces cerevisiae ATG8 deletion ***-BdAtg8 was shown to be a useful marker for monitoring autophagy in *** deletion of Bd ATG8(ΔBd Atg8)blocked autophagy and significantly impaired mycelial growth,conidiation and perithecium *** addition,ΔBdAtg8 showed significantly increased sensitivity to phytoalexin and oxidative stress,suggesting that BdATG8 plays critical roles in overcoming phytoalexin and reactive oxygen species(ROS)-mediated plant *** assays revealed thatΔBdAtg8 almost lost ability to infect ***,our results indicate that BdATG8 plays an important role in fungal development,stress responses and pathogenesis in ***.

关键词： Botryosphaeria dothidea autophagy BdATG8 development pathogenicity

Neopestalotiopsis eucalypti,a causal agent of grapevine shoot rot in cutting nurseries in China

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Journal of Integrative Agriculture 2022年第12期21卷 3684-3691页

作者： MA Xuan-yan JIAO Wei-qi li Heng ZHANG Wei REN Wei-chao WU Yan ZHANG Zhi-chang li bao-hua ZHOU Shan-yue College of Plant Health and Medicine Qingdao Agricultural University/Engineering Research Center for Precision Pest Management for Fruits and Vegetables of QingdaoQingdao 266109P.R.China Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097P.R.China Shandong Zhichang Agricultural Science and Technology Development Co. Ltd.Rizhao 276500P.R.China

Grapevine(Vitis vinifera L.)is an economically important fruit crop in the world,and China ranks first in the production of grapes with approximately 15%of the world’s total ***,diseases that cause the death of grapevine shoots pose a severe threat to the production of *** this study,the fungus Neopestalotiopsis eucalypti was identified as a causal pathogen of grapevine shoot rot based on the morphology of conidia and a phylogenetic *** phylogenetic analysis was performed with three isolates based on the combined sequence of internal transcribed spacer(ITS)region of ribosomal DNA,part of the translation elongation factor 1-alpha(Tef)and theβ-tubulin(Tub2)*** three isolates were all identified as *** tests of the three fungal isolates were conducted on grapevines shoots in vitro and in *** results showed that all three fungal isolates caused severe rot lesions on the inoculated grapevine shoots,and *** was re-isolated from the inoculated grapevine ***,*** was confirmed as a causal agent of the grapevine shoot *** is the first report of *** causing grapevine shoot disease in China.

关键词： Neopestalotiopsis eucalypti grapevine shoot rot multigene phylogenetic analysis pathogenicity

Priming　effect　of　substance　Ponsuper　oxideanionradical　production　inhumanneu　trophils

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中国药理学与毒理学杂志 1996年第2期 14-18页

作者： bao li-hua, YANG bao-Feng, FENG Bin 1 , li bao-Xin, HE Shu-Zhuang, li Wen-Han (Department of Pharmacology, Harbin Medical University, Harbin 150086 1 Department of Medicine, First Hospital of Harbin, Harbin 150010)

神经肽Ｐ物质能激活多种参与炎症和免疫反应的细胞．然而Ｐ物质直接刺激人粒细胞产生超氧阴离子（Ｏ÷２）需要较高的浓度（＞１０μｍｏｌ·Ｌ－１）．本实验观察了低浓度Ｐ物质对人粒细胞超氧阴离子生成的活化作用．结果表明，Ｐ物质... 详细信息

神经肽Ｐ物质能激活多种参与炎症和免疫反应的细胞．然而Ｐ物质直接刺激人粒细胞产生超氧阴离子（Ｏ÷２）需要较高的浓度（＞１０μｍｏｌ·Ｌ－１）．本实验观察了低浓度Ｐ物质对人粒细胞超氧阴离子生成的活化作用．结果表明，Ｐ物质在低浓度时（３μｍｏｌ·Ｌ－１）能活化人粒细胞，使甲酰基－甲硫氨酰基－亮氨酰基苯丙氨酸（ｆＭＬＰ）刺激产生的超氧阴离子明显增多．Ｐ物质的这一活化作用呈剂量和时间依赖性．在无细胞外钙的情况下，Ｐ物质没有这种活化作用．Ｐ物质活化ｆＭＬＰ引起的Ｏ÷２生成增多作用可被神经激肽（ＮＫ）－１受体阻断剂ｓｐｅｎｔｉｄｅ（１μｍｏｌ·Ｌ－１），磷脂酶Ｃ抑制剂Ｕ－７３１２２（１０ｎｍｏｌ·Ｌ－１）以及Ｃａ２＋通道阻断剂尼卡地平（１μｍｏｌ·Ｌ－１）所抑制．这些发现提示，Ｐ物质活化人粒细胞可能是经ＮＫ－１受体偶联的磷脂酰肌醇代谢途径，并且是细胞外钙依赖性的

关键词： P物质中性粒细胞,人超氧化物钙,细胞外

Blue light induces leaf color change by modulating carotenoid metabolites in orange-head Chinese cabbage(Brassica rapa ***. pekinensis)

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Journal of Integrative Agriculture 2023年第11期22卷 3296-3311页

作者： ZHANG Rui-xing ZHANG Ni-nan WANG Ya-xiu Khan ABID MA Shuai BAI Xue ZENG Qi PAN Qi-ming li bao-hua ZHANG Lu-gang State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China Department of Horticulture The University of HaripurHaripur 22620Pakistan

Carotenoids are involved in the formation of plant leaf color as well as photosystem photoprotection. This study showed that blue light significantly induced up-regulation of the total carotenoid content in the inner leaves of orange-head Chinese cabbage(OHCC). Furthermore, the transcriptomic analysis revealed that blue light treatment induced upregulation of genes in photosynthesis(BrHY5-2, BrCOP1 and BrDET1) and the methylerythritol 4-phosphate pathways(BrGGPS, BrDXS and BrHDR) upstream of the carotenoid metabolic pathway. Carotenoid metabolomic analysis revealed that the accumulation of several orange and red carotenoids(lycopene, zeaxanthin, β-carotene, lutein, and β-cryptoxanthin) after blue light treatment contributed to the deepening of the leaf coloration, suggesting that short-term blue light treatment could be used to boost nutritional quality. The light signal gene BrHY5-2 participated in the blue light-induced transcriptional regulation of carotenoid biosynthesis in OHCC. Overexpression of BrHY5-2 in Arabidopsis significantly increased the total carotenoid content and the sensitivity to blue light. The above findings revealed new insights about blue-light-induced carotenoid synthesis and accumulation in OHCC lines. They suggested a new engineering approach to increase the nutritional value of vegetables.

关键词： orange-head Chinese cabbage(OHCC) carotenoid nutrition blue LED light secondary metabolite transcriptome

Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction

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Chinese Medical Journal 2009年第15期122卷 1738-1742页

作者： li Dong-bao hua Qi liU Zhi li Jing XU li-qing WANG Shan JIN Wei-ying Department of Cardiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Background Inflammatory mechanisms had played an important role in the occurrence and prognosis of acute myocardial infarction, inflammatory mediators was associated with adverse outcomes of acute myocardial infarction. This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, neutrophil count and high-sensitivity C-reactive protein are predictive of angiographic morphologic features that indicate thrombus formation in the infarct-related artery. Methods This retrospective study included 182 consecutive patients with acute myocardial infarction and ST-segment elevation. Patients were assigned to a thrombus-formation group （n=77） and a non-thrombus-formation group （n=-106）. All patients had a Killip＇s classification 〈3 and onset 〈12 hours prior to presentation. All the cases were going to undergo coronary angiography, including primary percutaneous coronary intervention, simple coronary angiography, or thrombolysis in a coronary artery （or arteries） or coronary artery bypass graft（s）. Blood samples for measurement of high-sensitivity C-reactive protein and for routine blood laboratory studies were collected prior to coronary angiography. Results The levels of high-sensitivity C-reactive protein, total leukocyte counts, neutrophil counts, and neutrophil/ lymphocyte ratios were substantially higher in the thrombus-formation group than in the non-thrombus-formation group patients （for each, P 〈0.05）. Stepwise Logistic regression analyses identified high-sensitivity C-reactive protein, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery （for each, P 〈0.05）. Conclusions In patients with acute myocardial infarction levels of high-sensitivity C-reactive protein are predictors to higher neutrophil counts, neutrophil/lymphocyte ratio, and ndicate thrombus formation

关键词： acute myocardial infarction thrombosis neutrophil percutaneous coronary intervention C-reactive protein

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林慎思《续孟子》对孟子的解读

北方论丛 2005年第3期 28-30页

作者：李葆华哈尔滨学院人文学院中文系

《续孟子》为唐代见于著录的除注本外仅存的一部孟子研究专著。虽然所表达的思想与孟子文本出入较大,但反映了唐代孟子研究的基本面貌,其中一些很有价值的章节,是唐代孟子研究的重要史料。

关键词：林慎思续孟子述评

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择校费、分离均衡与教育公平化的反思

财经问题研究 2008年第10期 24-29页

作者：李保华东北财经大学富虹经济学院辽宁大连116025

近一段时期以来由"择校费"所引发的有关教育公平化问题成为社会和学界所探讨的热点问题。本文尝试从信息经济学的角度对这一问题进行经济解释,即"择校费"是一种实现从混同均衡到分离均衡过程中的合理性制度安排。从动态效率来看,这一看... 详细信息

近一段时期以来由"择校费"所引发的有关教育公平化问题成为社会和学界所探讨的热点问题。本文尝试从信息经济学的角度对这一问题进行经济解释,即"择校费"是一种实现从混同均衡到分离均衡过程中的合理性制度安排。从动态效率来看,这一看似不合理的制度安排能够实现社会总体效率的提升和社会总体福利的最大化,即实现动态效率上的公平化。最后,本文对人们普通接受的教育公平化概念进行反思,并在此基础上提出相关的政策建议。

关键词：择校费混同均衡分离均衡教育公平化

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基于AE-UKF的航天器自主导航方法

宇航学报 2011年第3期32卷 482-488页

作者：李璟璟张迎春李葆华哈尔滨工业大学卫星技术研究所哈尔滨150001 深圳航天东方红海特卫星有限公司深圳518057

针对自主导航过程中不确定的测量噪声和干扰的影响,提出了一种具有自适应能力的状态估计方法AE-UKF方法。该方法通过对非线性的状态方程进行Unscented变换,对非线性的测量方程求取雅可比矩阵,同时在滤波迭代过程中引入自适应因子,使滤... 详细信息

针对自主导航过程中不确定的测量噪声和干扰的影响,提出了一种具有自适应能力的状态估计方法AE-UKF方法。该方法通过对非线性的状态方程进行Unscented变换,对非线性的测量方程求取雅可比矩阵,同时在滤波迭代过程中引入自适应因子,使滤波器具有自适应能力。将AE-UKF方法应用于自主导航系统导航信息的估计过程中,仿真结果表明:AE-UKF方法在达到UKF方法精度的同时,能够克服自主导航过程中不确定的噪声和随机干扰的影响。

关键词： AE-UKF Unscented变换自适应因子自主导航