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Five-year analysis of isolated pathogens and antibiotic resistance of ocular infections from two large tertiary comprehensive hospitals in east China

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1707-1716页

作者： Pan-Pan li li li Jun-Fang Zhang Bai Qin li-hua kang Min Ji huai-Jin Guan Suzhou Medical College of Soochow University Suzhou 215123Jiangsu ProvinceChina Department of Ophthalmology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Clinical Laboratory Nantong City No.1 People’s Hospital and Second Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

AIM:To analyze the spectrum of isolated pathogens and antibiotic resistance for ocular infections within 5y at two tertiary hospitals in east ***:Ocular specimen data were collected from January 2019 to October *** pathogen spectrum and positive culture rate for different infection location,such as keratitis,endophthalmitis,and periocular infections,along with antibiotic resistance were ***:We included 2727 specimens,including 827(30.33%)positive cultures.A total of 871 strains were isolated,530(60.85%)bacterial and 341(39.15%)fungal strains were ***-positive cocci(GPC)were the most common ocular *** most common bacterial isolates were Staphylococcus epidermidis(25.03%),Staphylococcus aureus(7.46%),Streptococcus pneumoniae(4.59%),Corynebacterium macginleyi(3.44%),and Pseudomonas aeruginosa(3.33%).The most common fungal genera were Fusarium spp.(12.74%),Aspergillus spp.(6.54%),and Scedosporium spp.(5.74%).Staphylococcus epidermidis strains showed more than 50%resistance to *** pneumoniae and Corynebacterium macginleyi showed more than 90%resistance to *** percentage of bacteria showing multidrug resistance(MDR)significantly decreased(χ^(2)=17.44,P=0.002).CONCLUSION:GPC are the most common ocular *** macginleyi,as the fourth common bacterium,may currently be the local microbiological feature of east *** *** the most common *** than 50%of the GPC are resistant to fluoroquinolones,penicillins,and ***,the proportion of MDR strains has been reduced over time.

关键词： ocular infections bacteria fungus antibiotic resistance multidrug resistance

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国际教育的挑战——跨文化的国际情怀的培养为何如此困难?

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基础教育 2024年第1期21卷 19-30,40页

作者：李康华吴月竹华东师范大学国际汉语文化学院上海200062 华东师范大学教育学部上海200062

联合国以及世界很多国家都致力于国际理解教育,以此培养跨文化的国际情怀。但这一努力的成果并不尽如人意。本文主要以国际学校为对象,从国际教育的外部威胁、内部挑战以及脑科学研究的角度分析了国际理解教育在民族主义、功利主义的教... 详细信息

联合国以及世界很多国家都致力于国际理解教育,以此培养跨文化的国际情怀。但这一努力的成果并不尽如人意。本文主要以国际学校为对象,从国际教育的外部威胁、内部挑战以及脑科学研究的角度分析了国际理解教育在民族主义、功利主义的教育生态,国际教育的孤立性和排他性,大脑认知能力的阶段性发展,人类本能的族群认同等诸多方面面临的挑战。在后疫情时代的当下,我们可以重新审视国际教育领域在这方面的经验和教训,在我国的基础教育体系中推进国际理解与人类命运共同体的建构。

关键词：国际教育国际理解国际情怀人类命运共同体

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Activation of autophagy in the retina after optic nerve crush injury in rats

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1395-1401页

作者： li-hua kang Su Zhang Sheng Jiang Nan Hu Eye Institute Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Nanjing Medical University Affiliated Eye Hospital Nanjing 210000Jiangsu ProvinceChina

AIM: To investigate the activation of autophagy in rat retina after optic nerve crush(ONC) and evaluate its relationship with apoptosis of retinal ganglion cells(RGCs).METHODS: The ONC model was established. Western blots were performed to investigate expression of p62, LC3 and Beclin-1. Transmission electron microscopy was performed to discover the autophagosomes in the retina after ONC. Immunohistochemistry was used to confirm the distribution of LC3. TUNEL was performed to confirm the relationship between autophagy and RGC apoptosis. RESULTS: p62/Beclin-1 ratio was declined shortly after ONC until to day 7 after ONC and then restored to a normal level at day 21. There was an opposite change in the LC3-II/LC3 I ratio in the retina compared to the p62/Beclin-1 ratio. Increased autophagosomes were found after ONC using transmission electron microscopy, and most of the LC3-stained cells were colocalized with RGCs and Müller cells. More LC3-immunoreactive cells and apoptotic RGCs were found on day 7 following ONC. CONCLUSION: Possible activation of autophagy in RGCs after ONC;autophagy mainly occurred in RGCs and Müller cells, and the apoptosis of RGCs after ONC may be partly associated with autophagic activation.

关键词： autophagy optic nerve crush apoptosis retinal ganglion cells rat

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从“壮火食气”理论论治肺癌放疗后血小板减少

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中医肿瘤学杂志 2024年第4期6卷 23-28页

作者：贾芸菁李桦康吴籽良肖淇林冰成都中医药大学附属医院四川成都610072

血小板减少是放疗后不良反应之一,其发生会影响肿瘤患者的治疗进程及生活质量。现代医学治疗该病有一定局限性。本文基于《黄帝内经》“壮火食气”的理论内涵,探讨其对中医治疗放疗后血小板减少的指导作用,并举临床验案2例,以期为临床... 详细信息

血小板减少是放疗后不良反应之一,其发生会影响肿瘤患者的治疗进程及生活质量。现代医学治疗该病有一定局限性。本文基于《黄帝内经》“壮火食气”的理论内涵,探讨其对中医治疗放疗后血小板减少的指导作用,并举临床验案2例,以期为临床多维度认识和治疗放疗后血小板减少提供有价值的思路。

关键词：壮火放疗血小板减少肺癌

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Mechanism of apoptosis of human osteosarcoma M-G63 induced by arsenic trioxide

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Journal of Central South University of Technology 2005年第Z1期12卷 317-321页

作者： XIAO Tao li kang-hua FANG Jian-zhen WANG Wan-chun li Gui-yuan Cancer Research Institute Xiangya School of MedicineCentral South University Changsha 410078 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics Xiangya Hospital Central South University Changsha 410008 China Department of Central Laboratory the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Cancer Research InstituteXiangya School of MedicineCentral South University Changsha 410078 China

Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and *** The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.

关键词： arsenic trioxide osteosarcorna MG-63 apoptosis IEX-1

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心电图在预测急性下壁心肌梗死罪犯血管中的应用

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局解手术学杂志 2024年第5期33卷 440-444页

作者：马源秋子刘锋李华康陈彦秀蔡晓莲陆军军医大学第一附属医院健康管理中心重庆400038 陆军军医大学第一附属医院心血管内科重庆400038

目的探讨心电图预测急性下壁心肌梗死罪犯血管的价值。方法回顾性分析2015年1月至2021年12月陆军军医大学第一附属医院收治的129例急性下壁心肌梗死患者的临床资料,患者采用冠状动脉介入治疗,术中行冠状动脉造影确定罪犯血管。记录术中... 详细信息

目的探讨心电图预测急性下壁心肌梗死罪犯血管的价值。方法回顾性分析2015年1月至2021年12月陆军军医大学第一附属医院收治的129例急性下壁心肌梗死患者的临床资料,患者采用冠状动脉介入治疗,术中行冠状动脉造影确定罪犯血管。记录术中罪犯血管情况。分析患者术前心电图,基于以往研究建立心电图预测急性下壁心肌梗死罪犯血管的新方法,并统计Fiol法、Tierala法、黄氏算法和新方法预测急性下壁心肌梗死罪犯血管的准确性。采用受试者工作特征(ROC)曲线评估各种方法对罪犯血管的预测能力,计算曲线下面积(AUC)。结果109例患者罪犯血管为右冠状动脉,16例为回旋支,4例为前降支。52例患者出现临床合并症,罪犯血管为右冠状动脉47例,为回旋支5例。Fiol法、Tierala法、黄氏算法和新方法预测罪犯血管的准确性分别为83.7%、81.4%、82.9%和85.3%。ROC曲线分析显示:Fiol法(AUC=0.941)、Tierala法(AUC=0.945)、黄氏算法(AUC=0.945)和新方法(AUC=0.964)均对罪犯血管具有较强的预测能力。结论对于急性下壁心肌梗死患者,运用Fiol法、Tierala法、黄氏算法和新方法对术前心电图进行分析,均对罪犯血管有较高的预测价值,其中新方法的预测价值更高。

关键词：心电图心肌梗死罪犯血管右冠状动脉左回旋支

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Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo Yao Nan kang Xiangyu li Dou li Mohamed EL Mansori Jing Chen Haiou Yang hua Tan Xin lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic *** essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and *** this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selection of Nd-Fe-B magnets were then clarified in *** results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase *** terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is *** the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B ***,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic ***,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic perfor

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

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Differentially expressed long noncoding RNAs and regulatory mechanism of liNC02407 in human gastric adenocarcinoma

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World Journal of Gastroenterology 2019年第39期25卷 5973-5990页

作者： li-li Zhou Yan Jiao Hong-Mei Chen li-hua kang Qi Yang Jing li Meng Guan Ge Zhu Fei-Qi liu Shuang Wang Xue Bai Yan-Qiu Song Cancer Center The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Radiology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Long noncoding RNAs(lncRNAs)have been identified to play important roles in the development and progression of various tumors,including gastric cancer(GC).However,the molecular role of lncRNAs in GC progression remains *** To investigate the differential expression of lncRNAs in human GC and elucidate the function and regulatory mechanism of *** The Cancer Genome Atlas database was used to investigate the involvement of lncRNAs in *** real-time polymerase chain reaction was used to estimate the relative expression level of liNC02407 in GC tissues and *** experiments including CCK8 assay,apoptosis assay,wound healing assay,and transwell assay were used to investigate the effect of liNC02407 on GC *** microRNAs were predicted and verified via bioinformatics analysis and the luciferase reporter *** analysis and Western blot assay were used to analyze the expression of related *** Many differentially expressed lncRNAs were identified in GC,and some of them including liNC02407 can affect the ***02407 was upregulated in tumor tissues compared with adjacent ***-27 cells showed the highest liNC02407 expression and HaCaT cells exhibited the lowest *** experiment groups were constructed using liNC02407 overexpressing plasmids and related *** results of functional experiments showed that liNC02407 can promote the proliferation,migration,and invasion of GC cells but inhibit *** reporter assay showed that hsa-miR-6845-5p and hsa-miR-4455 was downstream regulated by *** blot analysis showed that adhesion G protein-coupled receptor D1(ADGRD1)was regulated by the liNC02407-miR-6845-5p/miR-4455-ADGRD1 *** liNC02407 plays a role in GC through the liNC02407-miR-6845-5p/miR-4455-ADGRD1 pathways,and thus,it may be an important oncogene and has potential value in GC diagnosis and treatment.

关键词： Gastric cancer Long noncoding RNAs liNC02407 Adhesion G proteincoupled receptor D1 MicroRNA-6845-5p MicroRNA-4455

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Local tetragonal distortion of Pt alloy catalysts for enhanced oxygen reduction reaction efficiency

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Carbon Energy 2024年第7期6卷 41-52页

作者： Xiaoke li Xiao Duan kang hua Yongkang Wu Zhiyan Rui Rui Ding Aidong li Chen Ouyang Jia li Ting li Jianguo liu National Laboratory of Solid-State Microstructures College of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina Long-life Fuel Cell Key Laboratory in Sichuan Province Dongfang Electric(Chengdu)Hydrogen Fuel Cell Technology Co.Ltd.ChengduChina Institute of Energy Power Innovation North China Electric Power UniversityBeijingChina

Platinum-based alloy nanoparticles are the most attractive catalysts for the oxygen reduction reaction at present,but an in-depth understanding of the relationship between their short-range structural information and catalytic performance is still ***,we present a synthetic strategy that uses transition-metal oxide-assisted thermal ***/C catalysts with localized tetragonal distortion were obtained by controlling the thermal diffusion process of transition-metal *** localized structural distortion induced a significant strain effect on the nanoparticle surface,which further shortened the length of the Pt-Pt bond,improved the electronic state of the Pt surface,and enhanced the performance of the ***/C catalysts with special short-range structures achieved excellent mass activity(2.27 Amg_(Pt)^(-1))and specific activity(3.34 A cm^(-2)).In addition,the localized tetragonal distortion-induced surface compression of the Pt skin improved the stability of the *** mass activity decreased by only 13%after 30,000 *** catalyst activity and excellent durability have also been demonstrated in the proton exchange membrane fuel cell *** study provides valuable insights into the development of advanced Pt-based nanocatalysts and paves the way for reducing noble-metal loading and increasing the catalytic activity and catalyst stability.

关键词： electrocatalysts fuel cells local tetragonal distortion oxygen reduction

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Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 248-256页

作者： Gang huang kang-kang Wu Xiao-Na li Jing-hua Kuai Ai-Jun Zhang Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and *** bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more *** SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal *** patients underwent blood tests and imaging *** bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal *** patient ultimately underwent surgical *** a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their *** Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal *** diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications.

关键词： Intestinal tuberculosis Gastrointestinal hemorrhage Small bowel endoscopy Case report

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