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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-hua Wan Hong-Wei Zhang Xiao Guo hua Guo Shou-Feng Jia Xiao-Xin li Shi-Xian Cao li-Bin Fu Meng-Meng liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Effect of Mn and Mo on microstructure and mechanical properties of Al-Si-Cu-Mg-0.6Fe alloy

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China Foundry 2023年第6期20卷 511-518页

作者： Hao He Jing Zou Hai-tao Zhang Da-chuan hu Zhi-jun Feng Yu-fei li Ze-hua li hua-cheng li National Key Laboratory of Advanced Casting Technologies Shenyang 110022China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

Effect of different Mn and Mo contents on microstructure and mechanical properties of Al-Si-Cu-Mg-0.6Fe alloy was *** indicate that the increase of Mo and decrease of Mn lead to a decrease in the size of theα-Al_(15)(FeMnMo)_(3)Si_(2) phase formed during ***α-Al_(15)(FeMnMo)_(3)Si_(2) phase reaches a minimum value of about 16.3μm at 0.2wt.%Mo and 0.1wt.%Mn *** solution treatment,theα-Al(FeMnMo)Si dispersed phase is *** only Mn is added,theα-Al(FeMnMo)Si dispersed phase mainly distributes near the grain boundaries,while when only Mo is added,it primarily distributes in the central region of the *** both Mn and Mo are added,the dispersed phase has a larger and denser dispersed region and is uniformly distributed near the Al matrix and grain ***,the best overall mechanical properties of the alloy are obtained with the combined addition of 0.1wt.%Mn and 0.2wt.%Mo,due to the smaller size ofα-Al_(15)(FeMnMo)_(3)Si_(2) phase and the larger area fraction and higher density of theα-Al(FeMnMo)Si dispersed *** yield strength,ultimate tensile strength,and elongation are respectively improved 67.7 MPa,48.5 MPa and 5.3%,respectively,compared to that of the alloy with only 0.3wt.%Mn.

关键词： Al-Si-Cu-Mg-0.6Fe alloy Mn and Mo microstructure mechanical properties solution treatment

Buried interface management via bifunctional NH_(4)BF_(4)towards efficient CsPbI_(2)Br solar cells with a V_(oc)over 1.4 V

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Journal of Energy Chemistry 2024年第2期89卷 364-370,I0009页

作者： Fazheng Qiu Ming-hua li Jinpeng Wu Jin-Song hu School of Materials Science and Engineering NingboTech UniversityNingbo 315100ZhejiangChina Beijing National Laboratory for Molecular Sciences(BNLMS) Institute of ChemistryChinese Academy of SciencesBeijing 100190China College of Chemical Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

CsPbI_(2)Br perovskite solar cells(PSCs)have drawn tremendous attention due to their suitable bandgap,excellent photothermal stability,and great potential as an ideal candidate for top cells in tandem solar ***,the abundant defects at the buried interface and perovskite layer induce severe charge recombination,resulting in the open-circuit voltage(V_(oc))output and stability much lower than ***,a novel buried interface management strategy is developed to regulate interfacial carrier dynamics and CsPbI_(2)Br defects by introducing ammonium tetrafluoroborate(NH_(4)BF_(4)),thereby resulting in both high CsPbI_(2)Br crystallization and minimized interfacial energy ***,NH_(4)^(+)ions could preferentially heal hydroxyl groups on the SnO_(2)surface and balance energy level alignment between SnO_(2)and CsPbI_(2)Br,enhancing charge transport efficiency,while BF_(4)^(-)anions as a quasi-halogen regulate crystal growth of CsPbI_(2)Br,thus reducing perovskite ***,it is proved that eliminating hydroxyl groups at the buried interface enhances the iodide migration activation energy of CsPbI_(2)Br for strengthening the phase *** a result,the optimized CsPbI_(2)Br PSCs realize a remarkable efficiency of 17.09%and an ultrahigh V_(oc)output of 1.43 V,which is one of the highest values for CsPbI_(2)Br PSCs.

关键词： Inorganic perovskite Buried interface Defect Stability Open-circuit voltage loss

Numerical investigation of sinusoidal pulsating gas intake to intensify the gas-slag momentum transfer in the top-blown smelting furnace

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 301-314页

作者： Zhanghao Wan Shiliang Yang Desong Kong Dongbo li Jianhang hu hua Wang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China Southwest Copper Branch Yunnan Copper Co.Ltd.Kunming 650102China

The variation characteristics of bubble morphology and the thermal-physical properties of bubble boundary in the top-blown smelting furnace were explored by means of the computational fluid dynamics *** essential aspects of the fluid phase(e.g.,splashing volume,dead zone of copper slag,and gas penetration depth)were explored together with the effect of sinusoidal pulsating gas intake on the momentum-transfer performance between *** results illustrated that two relatively larger vortices and two smaller vortices appear in the bubble waist and below the lance,*** expansion of larger ones as well as the shrinking of smaller ones combine to cause the contraction of the bubble *** to the results of the case with a fixed gas injection velocity(V_(g)=58 m/s),the splashing volume and dead zone volume of the slag under the V_(g)=58+10sin(2πt)condition are reduced by 24.9%and 23.5%,respectively,where t represents the instant *** penetration depth and slag motion velocity of the latter are 1.03 and 1.31 times high-er than those of the former,respectively.

关键词： top-blown smelting furnace pulsed flow volume of fluid penetration depth splashing volume

Forming limit and Thickness Transition Zone Movement for Tailor Rolled Blank during Drawing Process

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Journal of Iron and Steel Research International 2016年第3期23卷 185-189页

作者： hua-wei ZHANG Xiang-hua liU li-zhong liU Ping hu Jia-lu WU School of Control Engineering Northeastern University at Qinhuangdao Research Institute of Science and Technology Northeastern University School of Automotive Engineering Dalian University of Technology

The process of automobile lightweight can be promoted by the application of tailor rolled blank（TRB）in the automobile ***,research on the formability of TRB is of good practical significance and application value because of the enormous potential of TRB in the aspect of automobile *** at the present condition of lack of researches on the influence of characteristic parameters on TRB drawing process,the drawing formability of TRB was studied with a combination method of simulation and experiment by taking square box as the research ***,drawing simulation and experiment of TRB were carried ***,effects of thickness transition zone（TTZ）position and blank size on the drawing formability of TRB were *** limit and TTZ movement for TRB square box during the drawing process were respectively discussed,when transition zones of TRB were located at different positions and blanks were of different *** results indicate that lubrication condition exerts greater influence on TRB forming limit in comparison with TTZ movement,and the smaller blank size and TTZ being located at the blank center or slightly offset to the thinner side are preferable for acquiring greater forming limit and smaller TTZ movement.

关键词： tailor rolled blank square box forming limit thickness transition zone movement drawing formability

Modeling and analyzing point cloud generation in missile-borne liDAR

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Defence Technology（防务技术） 2020年第1期16卷 69-76页

作者： Min-le li Yi-hua hu Nan-xiang Zhao Qi-shu Qian State Key Laboratory of Pulsed Power Laser Technology College of Electronic EngineeringNational University of Defense TechnologyHefei230037China Anhui Province Key Laboratory of Electronic Restriction Technology Hefei230037China

The missile-borne liDAR has an essential prospect in precise ***,the instability of the missile has a significant impact on the precision of liDAR point cloud,thus modeling and analyzing the influencing factors of point cloud generation is *** this investigation,the authors modeled the point cloud calculation process of missile-borne linear array scanning liDAR under ideal conditions and analyzed the effect of position change on the fleld of view(FOV) in the course of platform ***,the authors summarized that the stability concerning the field of view and the target tracking are dependent on three limiting ***,the authors derived an error formula and analyzed several typical errors in missile platform flight,including scanner error,POS error,system integration error,and platform vibration *** on theo retical analysis and simulation experiments,the model proposed in this papier can provide a theoretical basis for the design of the missile-borne liDAR system and the selection of related instruments in practice.

关键词： liDAR Point cloud Precise guidance Vibration

Recommend trustworthy services using interval numbers of four parameters via cloud model for potential users

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Frontiers of Computer Science 2015年第6期9卷 887-903页

作者： hua MA Zhigang hu School of Software Central South University Changsha 410075 China School of Information Science and Engineering Hunan International Economics University Changsha 410205 China

How to discover the trustworthy services is a challenge for potential users because of the deficiency of us- age experiences and the information overload of QoE （qual- ity of experience） evaluations from consumers. Aiming to the limitations of traditional interval numbers in measuring the trustworthiness of service, this paper proposed a novel ser- vice recommendation approach using the interval numbers of four parameters （INF） for potential users. In this approach, a trustworthiness cloud model was established to identify the eigenvalue of INF via backward cloud generator, and a new formula of INF possibility degree based on geometrical anal- ysis was presented to ensure the high calculation precision. In order to select the highly valuable QoE evaluations, the similarity of client-side feature between potential user and consumers was calculated, and the multi-attributes trustwor- thiness values were aggregated into INF by the fuzzy ana- lytic hierarchy process method. On the basis of ranking INF, the sort values of trustworthiness of candidate services were obtained, and the trustworthy services were chosen to recommend to potential user. The experiments based on a real-world dataset showed that it can improve the recommendation accuracy of trustworthy services compared to other approaches, which contributes to solving cold start and information overload problem in service recommendation.

关键词： service recommendation trustworthiness interval numbers of four parameters cloud model potential users

A novel flotation scheme: selective flotation of tungsten minerals from calcium minerals using Pb–BHA complexes in Shizhuyuan

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Rare Metals 2017年第6期36卷 533-540页

作者： Hai-Sheng Han Wen-li liu Yue-hua hu Wei Sun Xiao-Dong li School of Mineral Processing and Bioengineering Central South University hu Nan Shizhuyuan Non-ferrous Metal limited liability Corporation

The similar floatabilities of calcium minerals and the huge difference between scheelite and wolframite have resulted in difficulties during their separation by flotation in Shizhuyuan Mine. In this study, novel collectors, lead complexes of benzohydroxamic acid（Pb-BHA）,were introduced to modify the surface properties of scheelite and wolframite, thereby effectively and selectively improving floatability. The Pb-BHA complexes are found to be selective for the separation of scheelite and calcium minerals with little use of depressants and enable the synchronous flotation of scheelite and ***, a novel flotation process was developed for the recovery of tungsten minerals. The process is simplified greatly, and the recovery is improved by almost 10%.Removing or decreasing the amount of water glass contributes to the improvement of tungsten and fluorite recovery and the circulation of water and reagents, which benefits the environment.

关键词： Tungsten minerals Flotation Calciumminerals Benzohydroxamic acid complexes Water glass

The comparison of ensemble or deterministic dispersion modeling on global dispersion during Fukushima Dai-ichi nuclear accident

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Science China Earth Sciences 2015年第3期58卷 356-370页

作者： SHENG li SONG ZhenXin hu JiangKai Lü Kai TONG hua li Bing QIAO QingDang National Meteorological Center China Meteorological Administration Nuclear and Radiation Safety Center Ministry of Environmental Protection of the People's Republic of China

Ensemble forcasting,originally developed for weather prediction,is lately being extended to atmospheric dispersion applications,which is a new,effective methodology for improving the atmospheric dispersion numerical *** March 2011,due to the massive 9.0 earthquakes and ensuing tsunami that struck off the northern coast of the island of Honshu,the Fukushima Nuclear Plant I had the substantial leak of radioactive materials into surrounding environment and *** aim at the global dispersion modeling of atmospheric radionuclides from Fukushima Nuclear Accident,this paper presents two approaches of atmospheric dispersion forecasting:ensemble dispersion modeling(EDM) and deterministic dispersion modeling(DDM),conducts the globally dispersion modeling cases for Fukushima nuclear accident,and analyzes and evaluates the simulation results using observation *** this paper,EDM includes three different perturbation methods:meteorological perturbation method,turbulence perturbation method,and physical parameterization ensemble forecasting *** simulation results show that the trajectories from EDM have a better performance,which is in better agreement with the atmospheric circulation and observation data; the spread from DDM is slower and not as far as ***,the results from EDM display a better performance in the modeling of transport from Japan to China East Sea on April *** reasons for these results are:the techniques of MET and TUR are performed by adding perturbations on mean wind and turbulent velocity,respectively; the various different flow fields will result in far spreading in horizontal and the simulation results closer to observation; PHY is performed by using different diffusion physical parameterizations and produces the perturbations on vertical wind,which results the spreading in smaller range and discontinuous in ***,the comparative analysis between modeling results and observation data shows that all cases r

关键词： ensemble dispersion modeling deterministic dispersion modeling atmospheric dispersion Fukushima nuclear accident