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NUMERICAL SIMULATION OF FLOW OF PULP FIBER SUSPENSIONS IN STOCK PUMP WITH SEMI-OPEN IMPELLER

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 546-549页

作者： li hong yuan Shouqi liu Weiwei Research Center of Fluid Machinery Engineering and Technology Jiangsu University Zhenjiang 212013 China

The flow of pulp fiber suspensions with a consistency below 5% through a pump falls into the turbulent region. The 2-phase 3D turbulent flow of the mixture is simulated in the hydraulic components composed by suction chamber, front board, semi-impeller and volute casing for the first time. The pseudo-fluid model and the k-ε turbulent model are modified. Phase coupled SIMPLE algorithm is applied to make pressure-velocity correction equation. Based on the results of the numerical simulation, the distribution of velocity, pressure and density of liquid and particle phase are compared and analyzed. The flow analysis in the tip between front board and impeller is emphasized, which reflects the advantage of semi-open impeller when it transports 2-phase medium. This calculation result will be helpful for the design of pump impeller and the establishment of design method of centrifugal stock pump.

关键词： Centrifugal stock pump Pulp fiber suspensions Numerical simulation

Anemia in patients on combined androgen block therapy for prostate cancer

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Asian Journal of Andrology 2004年第4期6卷 383-385页

作者： li-XinQian li-XinHua hong-FeiWu yuan-GengSui Shuang-GuanCheng WeiZhang,Jieli Xin-RuWang DepartmentofUrology FirstAffiliatedHospitalInstituteofPublicHealthNanjingMedicalUniversityNanjing210029China

Aim: To study the effect of combined androgen block therapy on hemoglobin and hematocrit values in patients with prostate cancer. Methods: One hundred and thirty-six patients with adenocarcinoma of prostate were treated with combined androgen block (orchiectomy and flutamide 250 mg, tid). Complete blood counts were determined before and after 1, 2, 3, 6, 9 and 12 months of therapy. Results: The hemoglobin and hematocrit levels declined significantly in all patients and at all the time points after treatment (P<0.05). Conclusion: Prostate cancer patients treated with combined androgen block would develop obvious anemia. Recombinant human erythropoietin can be used to treat patients with severe anemia.

关键词： prostate cancer androgen block anemia

Hydrothermal Synthesis, Characterization and Magnetic Properties of Rare Earth Iron Garnets Sm_3Fe_5O_(12) and Eu_3Fe_5O_(12)

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Chemical Research in Chinese Universities 2011年第5期27卷 715-719页

作者： GUO li yuan hong-ming HUANG Ke-ke yuan lin liU Shao-kong FENG Shou-hua State Key Laboratory of Inorganic Synthesis ＆ Preparative Chemistry College of Chemistry Jilin University Changehun 130012 P. R. China

The rare earth iron garnets R3Fe5O12（R=Sm, Eu） were synthesized under mild hydrothermal conditions, and their crystal growth was found to be sensitive to alkalinity, reaction temperature and time. The as-prepared samples were characterized by powder X-ray diffraction（XRD）, scanning electron microscopy（SEM）, infrared spectra（IR） and Raman spectrum. The M vs. H loops and magnetic parameters have been traced with a vibrating sample magnetometer（VSM） and superconducting quantum interference devices（SQUIDs） magnetometer. We proposed the formation mechanisms and formulated a reasonable explanation for their growth habits. Different morphologic characteristics were observed by changing alkalinity in the reaction systems. The magnetic studies gave saturation magnetization（Ms） and Curie temperature（TC）. The magnetic behaviors of Sm3Fe5O12 and Eu3Fe5O12 in mild hydrothermal systems are comparable with those in high temperature solid state reactions.

关键词： Rare earth iron garnet Hydrothermal synthesis Magnetism

Hydrothermal Synthesis and Characterization of Pyrochlore Titanate R_2Ti_2O_7(R=Gd^(3+),Tb^(3+),Dy^(3+))

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Chemical Research in Chinese Universities 2011年第2期27卷 161-165页

作者： PENG Wen HU Bin CHEN Yan HU Wei-wei GUO li yuan hong-ming FENG Shou-hua State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Pyrochlore titanate oxides, R2Ti2O7（R=Gd3＋, Tb3＋, Dy3＋）, were synthesized under mild hydrothermal conditions. The crystal growth of pyrochlore titanate oxides and taking place of chemical reaction in the hydrothermal processing were sensitive to the alkalinity, temperature, reaction time, the nature of the rare earth ion and the composition of initial reaction mixture. The as-prepared samples were characterized by powder X-ray diffraction, scanning electron microscopy, Raman spectrum and variable temperature dc magnetic susceptibility（Superconductivity quantum interference device, SQUIDS）. The magnetic studies gave 7.29×10-23 A·m2/Gd3＋ and -8.28 K, 8.75×10-23 A·m2/ Tb3＋ and -19.7 K, and 8.85×10-23 A·m2/Dy3＋ and 0.84 K effective moments and Weiss constants for Gd2Ti2O7, Tb2Ti2O7 and Dy2Ti2O7, respectively.

关键词： Pyrochlore Titanate Hydrothermal

GREEN QUASIFUNCTION METHOD FOR FREE VIBRATION OF SIMPLY-SUPPORTED TRAPEZOIDAL SHALLOW SPHERICAL SHELL ON WINKLER FOUNDATION

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Acta Mechanica Solida Sinica 2010年第4期23卷 370-376页

作者： Shanqing li hong yuan (MOE Key Laboratory of Disaster Forecast and Control in Engineering, Institute of Applied Mechanics, Jinan University, Guangzhou 510632, China) [a] MOE Key Laboratory of Disaster Forecast Control in Engineering Institute of Applied Mechanics Jinan University Guangzhou 510632 China

The idea of Green quasifunction method is clarified in detail by considering a free vibration problem of simply-supported trapezoidal shallow spherical shell on Winkler foundation.A Green quasifunction is established by using the fundamental solution and boundary equation of the *** function satisfies the homogeneous boundary condition of the *** mode shape differential equation of the free vibration problem of simply-supported trapezoidal shallow spherical shell on Winkler foundation is reduced to two simultaneous Fredholm integral equations of the second kind by Green *** are multiple choices for the normalized boundary *** on a chosen normalized boundary equation, the irregularity of the kernel of integral equations is ***, natural frequency is obtained by the condition that there exists a nontrivial solution in the numerically discrete algebraic equations derived from the integral *** results show high accuracy of the Green quasifunction method.

关键词： Green function integral equation shallow spherical shell free vibration Winkler foundation

Generation and Immunogenicity of a Recombinant Adenovirus Co-Expressing the E2 Protein of Classical Swine Fever Virus and the GP5 Protein of Porcine Reproduction and Respiratory Syndrome Virus

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Agricultural Sciences in China 2011年第11期10卷 1781-1791页

作者： li hong-yun SUN yuan ZHANG Xing-juan CHANG Tian-ming WANG Xiang-peng HE Fan HUANG Jun-hua QIU Hua-ji Division of Swine Infectious Diseases National Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute ChineseAcademy of Agricultural Sciences Harbin 150001 P.R. C＇hina

Classical swine fever （CSF） and porcine reproduction and respiratory syndrome （PRRS） are both economically important, highly contagious diseases of swine worldwide. To develop an effective vaccine to control these two diseases, we constructed a recombinant adenovirus rAdV-GP52AE2, using a replication-defective human adenovirus serotype 5 as a delivery vector, to co-express the GP5 protein of highly pathogenic porcine reproduction and respiratory syndrome virus （PRRSV） and the E2 protein of classical swine fever virus （CSFV）. Foot-and-mouth disease virus （FMDV） 2A peptide was used as a linker between the GP5 and E2 proteins to allow automatic self-cleavage of the polyprotein. The GP5 and E2 genes were expressed as demonstrated by immunofluorescence assay and Western blotting. Immunization of mice resulted in a CSFV-neutralizing antibody titer of 1：128 and a PRRSV-neutralizing antibody titer of 1：16. The lymphoproliferative responses were detected by Cell Counting Kit-8 assay and the stimulation index of CFSV-specific and PRRSV-specific lymphocytes in the rAdV-GP52AE2 group was significantly higher than that in the negative control group. The results show that rAdV-GP52AE2 can induce both effective humoral and cell-mediated immune responses in mice. The protective efficacy of the recombinant virus against CSF was evaluated in immunized rabbits, which were protected from fever induced by challenge with C-strain. Our study provides supporting evidence for the use of FMDV 2A to develop a bivalent genetically-engineered vaccine.

关键词： porcine reproductive and respiratory syndrome virus classical swine fever virus recombinant adenovirus,immunogenicity

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一种复非线性系统的动力学特性和同步分析

控制理论与应用 2012年第9期29卷 1181-1185页

作者：琚宏昌李红远广西工学院鹿山学院土木工程系广西柳州545616

本文介绍一种新复非线性系统并研究它的动力学特性(包括不变量、耗散度、平衡和稳定性、Lyapunov指数、混沌行为、混沌吸引子),以及该系统产生混沌的必要条件,发现在一定参数条件下,系统存在2个或4个螺线形混沌吸引子,通过研究驱动系统... 详细信息

本文介绍一种新复非线性系统并研究它的动力学特性(包括不变量、耗散度、平衡和稳定性、Lyapunov指数、混沌行为、混沌吸引子),以及该系统产生混沌的必要条件,发现在一定参数条件下,系统存在2个或4个螺线形混沌吸引子,通过研究驱动系统和响应系统的关系,导出了混沌同步的控制函数显式表达式.Lyapunov函数分析证明,系统误差是渐近稳定的,控制函数可以使主动系统和响应系统完全同步.

关键词：混沌吸引子同步主动控制平衡和稳定性

Combination therapy with topical minoxidil and nano-microneedle-assisted fibroblast growth factor for male androgenetic alopecia:a randomized controlled trial in Chinese patients

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Chinese Medical Journal 2021年第7期134卷 851-853页

作者： Cheng-Qian Yu Hui Zhang Meng-Er Guo Xiao-Kun li hong-Duo Chen yuan-hong li Xue-Gang Xu Department of Dermatology No.1 Hospital of China Medical UniversityShenyangLiaoning 110001China NHC Key Laboratory of Immunodermatology(China Medical University) Liaoning 110001China School of Pharmacy Wenzhou Medical UniversityWenzhouZhejiang 325035China.To the Editor

To the Editor:Male androgenic alopecia(MAA)is the most common hair loss disorder characterized by miniaturization of hair follicles and progressive hair loss.[1]Although oral drugs,topical agents,and laser therapy can promote hair growth,minoxidil is the only topical therapy approved by the United States Food and Drug *** growth factors(FGFs)have a wide range of biological *** basic FGF(bFGF)promotes the growth of the hair follicle in mice,indicating its potential as a therapeutic agent for MAA.[2]The nano-microneedle is a new device that can promote transdermal absorption of topical drugs,[3]and increase drug penetration by up to 10 or 20 *** this study,we compared the safety and efficacy of topical minoxidil,nano-microneedle-assisted FGF,and a combination of the two.

关键词： needle drugs alopecia

Inhibitory Effect of Arsenic Trioxide on Growth and Telomerase Activity of SMMC-7721 and BEL-7402 Hepatocarcinoma Cells and Determination of their GSH Content

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Chinese Journal of Clinical Oncology 2006年第3期3卷 207-211页

作者： Weiwei Ren hong li yuan Zhang Department of Pathophysiology and Institute of Hematology Medical College of Jinan University Guangzhou 510632China.

OBJECTIVE To explore the inhibitory effect of arsenic trioxide on growth and telomerase activity of BEL-7402 and SMMC-7721 hepatocarcinoma cells, and to measure their GSH level. METHODS Cell culture and trypan blue exclusion were used to examine the inhibitory effect of arsenic trioxide on BEL-7402 and SMMC-7721 hepatocarcinoma lines. A GSH kit and telomerase kit were used to mearsure the GSH content in cells and telomerase activity. RESULTS The growth of BEL-7402 cells was significantly inhibited at a level of 0.50μmol/L of arsenic trioxide by 24 h. The inhibitory effect increased with time and concetration of arsenic trioxide. The telomerase activity of BEL-7402 cells was also significantly inhibited at a level of 0.50μmol/L of arsenic trioxide by 24 h, after which the inhibitory effect increased with time. On the other hand, at 24 h of incubation a level of 2.00 μmol/L of arsenic trioxide was required to significantly inhibit growth of SMMC-7721 cells, and only after 48 h with 2.00μmol/L of arsenic trioxide did telomerase activity significantly decline. The GSH content of the BEL-7402 and SMMC-7721 cells was 18.7±1.4 and 50.8±5.2 nmol/mg protein respectively, a significant difference. CONCLUSION Different concentrations of arsenic trioxide are required to inhibit growth and telomerase activity of SMMC-7721 and BEL-7402 cells. Perhaps BEL-7402 cells are more sensitive to arsenic trioxide because of their low level of GSH content, which results in a low capacity for oxidation-reduction and poorer detoxification mechanisms in BEL-7402 cells.

关键词： arsenic trioxide growth telomerase hepatocarcinoma.