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Parameters inversion of high central core rockfill dams based on a novel genetic algorithm

Science China(Technological Sciences) 2016年第5期59卷 783-794页

作者： ZHOU Wei li shao lin MA gang CHANG Xiao lin MA Xing ZHANG Chao State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Changjiang Institute of Survey Planning Design and Research

Parameters identification of rockfill materials is a crucial issue for high rockfill dams. Because of the scale effect, random sampling and sample disturbance, it is difficult to obtain the actual mechanical properties of rockfill from laboratory tests. Parameters inversion based on in situ monitoring data has been proven to be an efficient method for identifying the exact parameters of the rockfill. In this paper, we propose a modified genetic algorithm to solve the high-dimension multimodal and nonlinear optimal parameters inversion problem. A novel crossover operator based on the sum of differences in gene fragments(So DX) is proposed, inspired by the cloning of superior genes in genetic engineering. The crossover points are selected according to the difference in the gene fragments, defining the adaptive length. The crossover operator increases the speed and accuracy of algorithm convergence by reducing the inbreeding and enhancing the global search capability of the genetic algorithm. This algorithm is compared with two existing crossover operators. The modified genetic algorithm is then used in combination with radial basis function neural networks(RBFNN) to perform the parameters back analysis of a high central earth core rockfill dam. The settlements simulated using the identified parameters show good agreement with the monitoring data, illustrating that the back analysis is reasonable and accurate. The proposed genetic algorithm has considerable superiority for nonlinear multimodal parameter identification problems.

关键词： rockfill dam parameters back analysis genetic algorithm crossover operator sum of differences in gene fragments

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Improved damage tolerance and oxidation resistance of (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC by introducing chopped carbon fibers

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Journal of Advanced Ceramics 2024年第1期13卷 101-112页

作者： Feilong Huang Hailong Wang Cheng Fang Mingliang li gang shao Jinpeng Zhu Yanchun Zhou School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

High-entropy diborides(HEBs)are considered as promising high-temperature structure materials owing to their high melting point and excellent thermal ***,the intrinsic brittleness is the main obstacle that seriously limits their practical *** overcome with this obstacle,carbon fibers(Cf)with outstanding mechanical properties are used in the present work as a first attempt to improve the damage tolerance of *** as-prepared C_(f)/(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite(C_(f)/HEB–SiC)shows high relative density(97.9%)and good mechanical properties with flexural strength of 411±3 MPa and fracture toughness of 6.15±0.11 MPa·m^(1/2).More importantly,the damage tolerance parameter(Dt)has increased from 0.10 m^(1/2) for HEB–SiC to 0.29 m^(1/2) for C_(f)/HEB–*** microstructural analysis and Vickers indentation of the composite,the toughening mechanisms are *** carbon fibers coated with carbon coatings demonstrate unique capacity for prolonging the crack propagation path,which promotes the reliability of the composite ***,the C_(f)/(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite also exhibits good static oxidation resistance in the temperature range of 1100–1500℃in air due to the formation of the protective oxide layer constituting of multicomponent oxides(Zr)HfTiO4 and(Zr)Hf_(6)Ta_(2)O_(17) embedded in a continuous SiO_(2) *** results are promising,and this primary work can be used as a reference to the synthesis of C_(f)/HEBs for thermal protection materials under hightemperature serving conditions.

关键词： high-entropy ceramics carbon fibers(Cf) toughening mechanisms oxidation resistance

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骨髓血涂片镜检诊断人粒细胞无形体病1例报告

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中国临床医学 2022年第2期29卷 293-296页

作者：赵浩宏谷培云方媚王超栗绍刚齐文杰首都医科大学附属北京友谊医院感染科北京100035

人粒细胞无形体病(human granulocytic anaplasmosis,HGA)是由嗜吞噬细胞无形体(anaplasma phagocytophilum,曾称为人粒细胞埃立克体,human granulocyticehrlichiae)侵入人末梢血粒细胞引一种以发热,伴白细胞、血小板减少和多脏器功能损害为主要临床表现的疾病。1994年,第1例被定义为人粒细胞无形体感染的患者确诊于美国明尼苏达州,我国于2006年在安徽省首次发现无形体感染患者,且可能发生了院内感染[1]。立克次体是一种原核细胞微生物,常寄生在细胞内,其分类包括普氏立克次体、恙虫病立克次体、无形体、全孢菌科等多种,其中恙虫病立克次体、无形体立克次体相对多见。本文通过介绍1例以发热、血小板数量减少为主要临床表现,通过骨髓血涂片临床确诊HGA患者诊疗过程及体会。

关键词：感染粒细胞无形体骨血髓涂片

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Particle acceleration and transport in the inner heliosphere

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Science China Earth Sciences 2017年第8期60卷 1440-1465页

作者： li gang School of Geophysics and Information Technology China University of Geosciences (Beijing) Department of Space Science and CSPAR University of Alabama in Huntsville

In the solar system, our Sun is Nature's most efficient particle accelerator. In large solar flares and fast coronal mass ejections(CMEs), protons and heavy ions can be accelerated to over ~GeV/nucleon. Large flares and fast CMEs often occur together. However there are clues that different acceleration mechanisms exist in these two processes. In solar flares, particles are accelerated at magnetic reconnection sites and stochastic acceleration likely dominates. In comparison, at CME-driven shocks,diffusive shock acceleration dominates. Besides solar flares and CMEs, which are transient events, acceleration of particles has also been observed in other places in the solar system, including the solar wind termination shock, planetary bow shocks, and shocks bounding the Corotation Interaction Regions(CIRs). Understanding how particles are accelerated in these places has been a central topic of space physics. However, because observations of energetic particles are often made at spacecraft near the Earth,propagation of energetic particles in the solar wind smears out many distinct features of the acceleration process. The propagation of a charged particle in the solar wind closely relates to the turbulent electric field and magnetic field of the solar wind through particle-wave interaction. A correct interpretation of the observations therefore requires a thorough understanding of the solar wind turbulence. Conversely, one can deduce properties of the solar wind turbulence from energetic particle observations. In this article I briefly review some of the current state of knowledge of particle acceleration and transport in the inner heliosphere and discuss a few topics which may bear the key features to further understand the problem of particle acceleration and transport.

关键词： Solar energetic particles Diffusive shock acceleration Perpendicular diffusion coefficient

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Quantum Correlation Generation in a Damped Cavity

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Chinese Physics Letters 2011年第9期28卷 12-15页

作者： li Jun-gang ZOU Jian XU Bao-Ming shao Bin Department of Physics Beijing Institute of TechnologyBeijing 100081 Key Laboratory of Cluster Science of Ministry of Education Beijing Institute of TechnologyBeijing 100081

Dynamic evolutions of the quantum discord and entanglement between two charge qubits located inside a damped cavity are demonstrated *** is found that with cavity dissipation,the dynamics of the quantum discord between two qubits is sensitive to the degree of mixing of the initial qubits'*** is different from steady entanglement,which is independent of the degree of mixing of the initial state of the qubits.

关键词： state mixing quantum

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Research on the flow stability and noise reduction characteristics of quasi-periodic elastic support skin

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Defence Technology（防务技术） 2024年第3期33卷 222-236页

作者： Lu Chen shao-gang liu Dan Zhao li-qiang Dong Kai li Shuai Tang Jin Cui Hong Guo Department of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin150001China

To enhance flow stability and reduce hydrodynamic noise caused by fluctuating pressure,a quasiperiodic elastic support skin composed of flexible walls and elastic support elements is proposed for fluid noise *** arrangement of the elastic support element is determined by the equivalent periodic distance and quasi-periodic *** this paper,a dynamic model of skin in a fluid environment is *** influence of equivalent periodic distance and quasi-periodic coefficient on flow stability is *** results suggest that arranging the elastic support elements in accordance with the quasi-periodic law can effectively enhance flow ***,the hydrodynamic noise calculation results demonstrate that the skin exhibits excellent noise reduction performance,with reductions of 10 dB in the streamwise direction,11 dB in the spanwise direction,and 10 dB in the normal *** results also demonstrate that the stability analysis method can serve as a diagnostic tool for flow fields and guide the design of noise reduction structures.

关键词： Flow stability Quasi-period Flexible wall Elastic support element Hydrodynamic noise

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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妊娠糖尿病患者血清HbA1c与CRP水平的相关性分析

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现代生物医学进展 2018年第9期18卷 1701-1704页

作者：闫学平胡敬郝秀丽孙婷齐如艳李绍刚郭建巍北京市第一中西医结合医院/中国中医科学院中医基础理论研究所第一附属医院检验科北京100018 北京市第一中西医医院妇产科北京100018 北京市第一中西医结合医院/中国中医科学院中医基础理论研究所第一附属医院儿科北京100018

目的:为明确妊娠期糖尿病(gestational diabetes mellitus,GDM)患者血清糖化血红蛋白(glycosylated hemoglobin,Hb A1c)与C反应蛋白(C-reactive protein,CRP)的关系,本研究检测了GDM患者血糖、血清Hb A1c与CRP水平,并对Hb A1c与CRP的相关性进行了分析。方法:以68例2015年4月至2017年4月于我院诊治的GDM孕妇为研究对象,所有患者均符合《妇产科学》中关于GDM的诊断标准,另选取68例正常孕妇为对照组。采用葡萄糖氧化酶法检测血糖水平(空腹血糖及餐后2 h血糖水平),采用免疫凝集法检测和比较两组血清糖化血红蛋白(HbA1c)水平,采用免疫透射比浊法检测血清C反应蛋白(CRP)水平,并分析HbA1c与CRP的相关性。结果:GDM组患者空腹血糖(fasting plasma glucose,FPG)、2 h血糖(plasma glucose,PG)、血清HbA1c和CRP水平均显著高于正常组(P<0.05),GDM患者血清Hb A1c和CRP水平呈显著正相关关系(r=0.654,P<0.05)。结论:GDM患者血清HbAlC和CRP水平相较于正常孕妇有显著提高,且二者呈显著的正相关关系,二者联合检测可能作为GDM早期诊断的筛查的重要参考指标。

关键词：妊娠糖尿病血糖糖化血红蛋白 C反应蛋白相关性

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阿苯达唑致广州管圆线虫病患者肝损害的临床分析

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中国病原生物学杂志 2008年第3期3卷 209-211页

作者：王婧郑晓燕阴赪宏齐海宇李小丽刁宗礼纪爱萍栗绍刚吴赵永首都医科大学附属北京友谊医院北京热带医学研究所北京100050

目的分析口服阿苯达唑治疗广州管圆线虫病致急性肝损害作用。方法对41例广州管圆线虫病患者接受阿苯达唑治疗后出现的急性肝损害(肝功能变化)、基础疾病及转归进行分析。结果1)用阿苯达唑治疗广州管圆线虫病疗程结束后,26例患者丙氨酸... 详细信息

目的分析口服阿苯达唑治疗广州管圆线虫病致急性肝损害作用。方法对41例广州管圆线虫病患者接受阿苯达唑治疗后出现的急性肝损害(肝功能变化)、基础疾病及转归进行分析。结果1)用阿苯达唑治疗广州管圆线虫病疗程结束后,26例患者丙氨酸氨基转移酶(ALT)升高,范围为42.00～252.00U/L,平均(97.66±56.66)U/L;9例患者天门冬氨酸氨基转移酶(AST)增高,范围为41.00～131.00U/L,平均(60.66±29.34)U/L;13例患者γ-谷氨酰转移酶(GGT)升高,范围为56.90～213.00U/L,平均(99.52±46.65)U/L;碱性磷酸酶(ALP)、蛋白质及胆红素水平未见显著变化;2)阿苯达唑治疗过程中,同时加用保肝药物(甘利欣、肝泰乐)组68.42%(13/19)氨基转移酶升高,未使用保肝药物组59.09%(13/22)氨基转移酶升高,差异无统计学意义(P>0.05);3)肝功异常者停用阿苯达唑后开始出现好转,出院2个月后血清氨基转移酶大多恢复至正常水平。结论口服阿苯达唑可导致急性肝损害,其剂量须根据患者具体情况进行调整,临床应用时注意监测肝功能,并合理使用保肝药物。

关键词：阿苯达唑广州管圆线虫病急性肝损害不良反应

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基于摆锤法的成熟期油菜角果炸荚因素试验分析

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农机化研究 2025年第4期47卷 180-185页

作者：李港张敏魏德欣江东农业农村部南京农业机械化研究所南京210014

为了降低油菜联合收割机拨禾轮拨禾过程对角果打击造成的炸荚损失,采用摆锤法模拟拨禾轮拨禾对油菜角果冲击过程,对影响拨禾过程中的炸荚因素进行测试分析,并对角果损伤变化形式及过程进行分析。试验结果表明:摆锤冲击速度3.5 m/s、夹... 详细信息

为了降低油菜联合收割机拨禾轮拨禾过程对角果打击造成的炸荚损失,采用摆锤法模拟拨禾轮拨禾对油菜角果冲击过程,对影响拨禾过程中的炸荚因素进行测试分析,并对角果损伤变化形式及过程进行分析。试验结果表明:摆锤冲击速度3.5 m/s、夹持果柄位置距连接点2 mm是区分角果抗打击炸荚的最优参数;油菜角果炸荚不仅与冲击速度、果柄夹持位置有关,而且与油菜品种、冲击件材料类型、角果受力面、含水率、角果在植株上的分布位置等都有关系;冲击速度不超过1.5 m/s时,角果损伤以角果果柄发生塑性变形为主;冲击速度为2.5~4.5 m/s时,角果损伤以果皮破裂分离、果柄弹性变形为主。研究结果可为油菜拨禾轮设计和工作参数选择提供参考。

关键词：油菜角果炸荚率冲击拨禾轮摆锤法

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