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An electrically activable nanochip to intensify gas-ionic-immunotherapy

Science Bulletin 2025年第3期70卷 390-406页

作者： Gang Wang Jingrui li Shumin Sun Yuqi Yang Zhihui Han Zifan Pei liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China

Excess intracellular H_(2)S induces destructive mitochondrial toxicity,while overload of Zn^(2+)results in cell pyroptosis and potentiates the tumor immunogenicity for ***,the precise delivery of both therapeutics remains a great ***,an electrically activable ZnS nanochip for the controlled release of H_(2)S and Zn^(2+)was developed for enhanced gas-ionic-immunotherapy(GIIT).Under an electric field,a locality with particularly high concentrations of H_(2)S and Zn^(2+)was established by the voltage-controlled degradation of the ZnS nanoparticles(NPs).Consequently,the ZnS nanochip-mediated gas-ionic therapy(GIT)resulted in mitochondrial membrane potential depolarization,energy generation inhibition,and oxidative stress imbalance in tumor ***,the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)signaling pathway was activated due to the mitochondrial ***,the released Zn^(2+)resulted in the increase of the intracellular Zn levels and cell pyroptosis,which enhanced the immunogenicity via the release of damage-associated molecular patterns(DAMPs).In vitro and in vivo studies revealed that the ZnS nanochip-based GIT effectively eliminated the tumors under an electric field and mobilized the cytotoxic T lymphocytes for *** combination withαCTLA-4 further promoted the adaptive immune response and inhibited tumor metastasis and long-term tumor *** work presented an electrically activable ZnS nanochip for combined immunotherapy,which might inspire the development of electric stimulation therapy.

关键词： H_(2)S gas therapy lonic interference therapy Electrically controll eddelivery Cell pyroptosis CGAS-STING pathway

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Epigenetic basis for the establishment of ruminal tissue-specific functions in bovine fetuses and adults

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Journal of Genetics and Genomics 2025年第1期52卷 78-92页

作者： Jing Wang Wen Yuan fang liu Guangbo liu Xiaoxiong Geng Chen li Chenchen Zhang Nan li Xueling li State Key Laboratory of Reproductive Regulation&Breeding of Grassland livestock Research Center for Laboratory Animal ScienceInner Mongolia UniversityHohhotInner Mongolia 010070China College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control TechnologyMinistry of EducationInner Mongolia UniversityHohhotInner Mongolia 010070China

Epigenetic regulation in the rumen,a unique ruminant organ,remains largely unexplored compared with other tissues studied in model *** this study,we perform an in-depth analysis of the epigenetic and transcriptional landscapes across fetal and adult bovine tissues as well as pluripotent stem *** the extensive methylation differences across various stages and tissues,we identify tissue-specific differentially methylated regions(tsDMRs)unique to the rumen,which are crucial for regulating epithelial development and energy *** tsDMRs cluster within super-enhancer regions that overlap with transcription factor(TF)binding *** models indicate that DNA methylation,along with H3K27me3 and H3K27ac,can be used to predict enhancer *** upstream TFs,including SOX2,FOSL1/2,and SMAD2/3,primarily maintain an inhibitory state through bivalent modifications during fetal *** functional genes are maintained mainly in a stable repressive state via DNA methylation until differentiation is *** study underscores the critical role of tsDMRs in regulating distal components of rumen morphology and function,providing key insights into the epigenetic regulatory mechanisms that may influence bovine production traits.

关键词： Rumen Epigenetics DNA methylation tsDMRs Enhancers

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Design and testing research of liDAR for detecting atmospheric turbulence

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Optoelectronics Letters 2025年第3期21卷 172-176页

作者： QIU Duoyang li Xianyang YANG Hao ZHU Xiaomeng fang Zhiyuan XU Xiang School of Advanced Manufacturing Engineering Hefei University Anhui Provincial Engineering Technology Research Center of Intelligent Vehicle Control and Integrated Design Technology Hefei University Science Island Branch of Graduate School University of Science and Technology of China School of Mechanical and Energy Engineering Ningbo Tech University Key Laboratory of Atmospheric Optics Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences

Atmospheric turbulence is an important parameter affecting laser atmospheric transmission. This paper reports on a self-developed atmospheric turbulence detection li DAR system (scanning differential image motion li DAR(DIM-li DAR) system). By designing and simulating the optical system of atmospheric turbulence detection li DAR,the basic optical imaging accuracy has been determined.

关键词： A

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Improving regulatory T cell-based therapy:insights into post-translational modification regulation

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Journal of Genetics and Genomics 2025年第2期52卷 145-156页

作者： Aiting Wang Yanwen Wang Rui liang Bin li Fan Pan Center for Cancer Immunology Research Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Center for Immune-Related Diseases at Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghai 200025China

Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious *** cells exert suppressive function via distinct mechanisms,including inhibitory cytokines,granzyme or perforin-mediated cytolysis,metabolic disruption,and suppression of dendritic *** Box P3(FOXP3),the characteristic transcription factor,is essential for Treg cell function and *** evidence has demonstrated that FOXP3 activity and Treg cell function are modulated by a variety of post-translational modifications(PTMs),including ubiquitination,acetylation,phosphorylation,methylation,glycosylation,poly(ADP-ribosyl)ation,and uncharacterized *** review describes Treg cell suppressive mechanisms and summarizes the current evidence on PTM regulation of FOXP3 and Treg cell *** the regulatory role of PTMs in Treg cell plasticity and function will be helpful in designing therapeutic strategies for autoimmune diseases,GVHD,tumors,and infectious diseases.

关键词： Treg cell FOXP3 Ubiquitination Acetylation Phosphorylation Methylation Glycosylation Post-translational modification

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng li Chunyan Chen Zhenyang li Peng Yi Haihan Zou Gao Deng Ming fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam liquid metal Electromagnetic interference shielding

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Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance

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Chinese Journal of Natural Medicines 2025年第1期23卷 54-63页

作者： Pingping lin Hong Chen Zekun Cui Boyang Yu Junping Kou fang li Jiangsu Key Laboratory of TCM Evaluation and Translational Research Research Center for Traceability and Standardization of TCMs School of Traditional Chinese PharmacyChina Pharmaceutical University

Astragali Radix(AR) and Notoginseng Radix et Rhizoma(NR) are frequently employed in cardiovascular disease treatment. However, the efficacy of the AR-NR medicine pair(AN) in improving cardiac remodeling and its underlying mechanism remains unclear. This study aimed to evaluate AN's cardioprotective effect and potential mechanism on cardiac remodeling using transverse aortic constriction(TAC) in mice and angiotensin II(Ang II)-induced neonatal rat cardiomyocytes(NRCMs) and fibroblasts in vitro. High-performance liquid chromatography-quadrupole-time of flight tandem mass spectrometry(HPLC-Q-TOF-MS/MS) characterized 23 main components of AN. AN significantly improved cardiac function in the TAC-induced mice. Furthermore, AN considerably reduced the serum levels of N-terminal pro-B-type natriuretic peptide(NT-pro BNP), cardiac troponin T(CTn-T), and interleukin-6(IL-6) and mitigated inflammatory cell infiltration. Post-AN treatment, TAC-induced heart size approached normal. AN decreased cardiomyocyte cross-sectional area and attenuated the upregulation of cardiac hypertrophy marker genes(ANP, BNP, and MYH7) in vivo and in ***, AN alleviated collagen deposition in TAC-induced mice. AN also reduced the expression of fibrosis-related indicators(COL1A1 and COL3A1) and inhibited the activation of the transforming growth factor-β1(TGF-β1)/mothers against decapentaplegic homolog 3(Smad3) pathway. Thus, AN improved TAC-induced cardiac remodeling. Moreover, AN downregulated p-dynamin-related protein(Drp1)(Ser616) expression and upregulated mitogen 2(MFN-2) and optic atrophy 1(OPA1) expression in vivo and in vitro, thereby restoring mitochondrial fusion and fission balance. In conclusion, AN improves cardiac remodeling by regulating mitochondrial dynamic balance, providing experimental data for the rational application of Chinese medicine prescriptions with AN as the main component in clinical practice.

关键词： Astragali Radix−Notoginseng Radix et Rhizoma medicine pair Cardiac fibrosis Cardiac hypertrophy Mitochondrial dynamics Transforming growth factor-β1/Smad3 pathway

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DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

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Chinese Chemical Letters 2025年第2期36卷 328-331页

作者： Gaojian Yang Zhiyang li Rabia Usman Zhu Chen Yuan liu Song li Hui Chen Yan Deng Yile fang Nongyue He State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical School Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology Institute of Cytology and Genetics School of Basic Medical Sciences Hengyang Medical School University of South China Institute for Future Sciences University of South China

The extracellular vesicles show great potential as a noninvasive biomarker for the early detection of cancer. Hence, there is an urgent requirement to create biosensors that are time-saving, simple, and easily scalable in order to accomplish rapid, sensitive, and quantitative detection of extracellular vesicles. In this study, we present a self-propelled DNA walker powered by endonuclease *** CI, which enables the development of a “signal on” sensing platform for the rapid and highly sensitive detection of extracellular vesicles. The DNA motor employed tracks made of streptavidin magnetic beads, which consisted of substrate strands labeled with fluorescein and motor strands locked by aptamers. The aptamer recognition of the target protein on extracellular vesicles unlocked the motor strand, initiating the DNA motor process. After replacing the optimal buffer solution containing the endonuclease *** I, the motor strands autonomously moved along the streptavidin magnetic beads track, continuously releasing fluorescent molecules and producing detectable fluorescence signals. Under optimal conditions, the detection range was from 2×10～4particles/mL to 2×10～9particles/mL, with a detection limit of 2.9×10～3particles/mL,demonstrating excellent selectivity. This method has demonstrated good selectivity in different tumorderived extracellular vesicles and performs well in complex biological samples. The ability to effectively analyze surface proteins of extracellular vesicles in a short period of time gives our DNA walker a tremendous potential for developing simple and cost-effective clinical diagnostic devices.

关键词： Aptamer Detection Extracellular vesicles Nt.BbvCI Streptavidin magnetic beads

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Sunlight-induced Permanent Hair Dyeing

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Chinese Journal of Polymer Science 2025年第2期43卷 261-270页

作者： Ting Zhang Bo liang Jian-Hua Zhang Lei Yang Jun-Fei Hua Yi-Wen li College of Polymer Science and Engineering State Key Laboratoryof Polymer Materials EngineeringSichuan UniversityChengdu 60065China Schoolof Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China School of Emergent Soft Matter South China University of TechnologyGuangzhou 510640China

Hair coloring has emerged as an integral part of the cosmetic industry,particularly in response to the increasing global aging *** natural melanin analog,polydopamine(PDA),has garnered considerable attention as an eco-friendly hair dye,and several kinds of polymerization ways of dopamine(DA)have been proposed including alkali catalysis,metal ion catalysis,strong oxidants,and enzyme-mediated oxidation reactions and *** the controllability of polymerization and potential toxicity of involved metal ions are still in *** by the photoprotective mechanism in human skin,we have developed the melanin-inspired hair dyeing strategy that allowed for the in situ oxidative polymerization of DA under ultraviolet(UV)*** polymerization was triggered by photobase generators(PBGs),a class of compounds that produced organic bases upon UV and sunlight *** resulting hair showed an adjustable color from light brown to black by tuning the ratio of DA and PBG(DA@PBG),the concentration of DA,and light exposure *** dyed hairs showed excellent washing resistance and superior anti-static ***,Hair Color Spray DA@PBG also demonstrated a desirable hair dyeing effect and excellent biosecurity by simply spraying it on the hair under *** novel sunlight-induced method provided a new direction towards the preparation of natural hair dyes and could promote the development of green and safe hair dyes in colorful and brilliant artistic-grade hair coloring.

关键词： Polydopamine Melanin Polymerization Hair dye Photo-initiation

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting liu Quan‑liang Zhao Chen‑Sha li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Environment-friendly Ca2+/Cr3+co-doping LaAlO3 ceramics with excellent infrared radiation performance for energy-saving

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 205-214页

作者： Yuan, Xinglai Wang, Qinghu Wu, Runke Sang, Shaobai Xu, Yibiao liang, Xiong Pan, liping Fan, Bingbing li, Yawei Zhang, Rui li, Jiangtao Volkova, Olena Wuhan Univ Sci & Technol State Key Lab Refractories & Met Joint Int Res Lab Refractories & Met Wuhan 430081 Peoples R China Zhengzhou Univ Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China Henan Acad Sci Inst Adv Ceram Zhengzhou 450046 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Beijing 100190 Peoples R China TU Bergakad Freiberg Inst Iron & Steel Technol D-09599 Freiberg Germany

Ca2+/Cr3+ co-doped LaAlO3 infrared (IR) ceramics have been proven to be potential energy-saving materials for high- temperature industries because of their high emissivity and high- temperature stability. However, Cr6+ formation commonly occurs in materials and poses environmental and health risks, such as Cr6+ dissolution in water and CrO3(g) volatilization. In this study, we combined high emissivity with in situ detoxification by introducing residual Al2O3 into Ca2+/Cr3+ co-doped LaAlO3 ceramics. Compared with the undoped ceramics, the addition of 20 wt% residual Al2O3 resulted in a 78.5% reduction to 18.44 mg/kg (lower than the EU standard of 20 mg/kg) in Cr6+ dissolution and a decrease in 77.8% CrO3(g) volatilization. This significant detoxification effect can be attributed to the formation of CaAl12-xCrxO19. Additionally, as the residual Al2O3 content increased from 5 to 20 wt%, the ceramics maintained high emissivity, above 0.896 in the near-infrared band and 0.781 in the mid-infrared band. Furthermore, the IR coating effectively increased the surface temperature (from 767.1 to 790.7 degrees C/min) and the heat radiation of the heating source, increasing the heating rate from 31.7 to 34.6 degrees C/min during water heating. This work offers a promising approach for designing environmentally friendly IR ceramics with excellent IR performance for energy-saving applications in the high-temperature industry.

关键词： infrared (IR) radiation energy-saving environmentally friendly Cr6+suppression LaAlO3

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