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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第11期9卷 847-852页

作者： Zhong-zheng ZHU Bing liU Ai-zhong WANG Hang-ruo JIA Xia-xiang JIN Xiang-lei HE li-fang hou Guan-shan ZHU Department of Pathology No. 113 Hospital of People＇s Liberation Army Ningbo 315040 China Department of Urology Changhai Hospital the Second Military Medical University Shanghai 200433 China Department of Pathology Lihuili Hospital Ningbo 315041 China Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL 60611 USA Innovation Center China AstraZeneca Global R ＆ D Shanghai201203 China

Objective： To evaluate the association between p53 codon 72 polymorphism （R72P） and the risk ofcolorectal liver metastases. Methods： The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. Results： The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases （P=0.075）. Carriers of the 72R allele had a 2.25-fold （95% CI （confidence interval）=1.05-4.83） increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold （95% CI=1.02-11.72） and a 1.05-fold （95% CI=0.36-3.08） increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion： These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.

关键词： Colorectal cancer p53 Genetic polymorphism liver metastases Overexpression

Applications of HPLC/MS in the analysis of traditional Chinese medicines

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Journal of Pharmaceutical Analysis 2011年第2期1卷 81-91页

作者： Miao li Xiao- fang hou Jie Zhang Si-Cen Wang Qiang Fu Lang- Chong He School of Medicine Xi'an Jiaotong University Xi'an 710061 China

In China, traditional Chinese medicines （TCMs） have been used in clinical applications for thousands of years. The successful hyphenation of high-performance liquid chromatography （HPLC） and mass spectrometry （MS） has been applied widely in TCMs and biological samples analysis. Undoubtedly, HPLC/MS technique has facilitated the understanding of the treatment mechanism of TCMs. We reviewed more than 350 published papers within the last 5 years on HPLC/MS in the analysis of TCMs. The present review focused on the applications of HPLC/MS in the component analysis, metabolites analysis, and pharmacokinetics of TCMs etc. 50% of the literature is related to the component analysis of TCMs, which show that this field is the most popular type of research. In the metabolites analysis, HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry has been demonstrated to be the powerful tool for the characterization of structural features and fragmentation behavior patterns. This paper presented a brief overview of the applications of HPLC/MS in the analysis of TCMs. HPLC/MS in the fingerprint analysis is reviewed elsewhere.

关键词： traditional Chinese medicines (TCMs) HPLC/MS component analysis metabolites analysis pharmacokinetics

Genomics in personalized cancer medicine and its impact on earlydrug development in China: report from the 6th Annual Meeting of the US Chinese Anti-Cancer Association(USCACA) at the 50th ASCOAnnual Meeting

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Chinese Journal of Cancer 2014年第8期33卷 371-375页

作者： Wei Zhang Shi-Yuan Cheng li-fang hou li Yan Yun-Guang Tong Executive Committee of the US Chinese Anti-Cancer Association (USCACA) Department of Pediatrics University of Illinois at Chicago Deparment of Neurology Northwestern University Feinberg School of Medicine Deparment of Preventive Medicine Northwestern University Feinberg School of Medicine School of Oncology Peking University Department of Medicine Cedars-Sinai Medical CenterUCLA School of Medicine

The 6th Annual Meeting of the United States Chinese Anti-Cancer Association(USCACA) was held in conjunction with the 50 th Annual Meeting of American Society of Clinical Oncology(ASCO) on May 30, 2014 in Chicago, Illinois, the United States of America. With a focus on personalized medicine, the conference featured novel approaches to investigate genomic aberrations in cancer cells and innovative clinical trial designs to expedite cancer drug development in biomarker-defined patient populations. A panel discussion further provided in-depth advice on advancing development of personalized cancer medicines in China. The conference also summarized USCACA key initiatives and accomplishments, including two awards designated to recognize young investigators from China for their achievements and to support their training in the United States. As an effort to promote international collaboration, USCACA will team up with Chinese Society of Clinical Oncology(CSCO) to host a joint session on "Breakthrough Cancer Medicines" at the upcoming CSCO Annual Meeting on September 20 th, 2014 in Xiamen, China.

关键词：医学基因组学药物开发抗癌药物个性化中国美国年会临床

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang li Shan Guo Zhuang Tong Xiaotao Zhou Xu li Zhaohui hou Shuquan liang Guozhao fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

基于种族优生的进化规划用于混合非线性整数规划

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系统仿真学报 2003年第8期15卷 1076-1078页

作者：刘芳李人厚西安交通大学系统工程研究所西安710049

混合非线性整数规划是在许多工程应用中经常遇到的重要问题。本文提出一种基于种族优生的进化规划算法用于求解混合非线性整数规划。一方面,该算法基于多种群并且每一代都选择各种群的最优秀个体作为下一代的种群祖先。另一方面,该算法... 详细信息

混合非线性整数规划是在许多工程应用中经常遇到的重要问题。本文提出一种基于种族优生的进化规划算法用于求解混合非线性整数规划。一方面,该算法基于多种群并且每一代都选择各种群的最优秀个体作为下一代的种群祖先。另一方面,该算法的进化步长、种群规模和处理约束条件时所取的参数在进化过程中是动态变化的。实验表明该方法求解混合非线性整数规划问题的仿真结果优于现有的研究成果(GA,ES,SA)。

关键词：进化规划混合非线性整数规划收敛性种族优生

基于模糊进化规划和分层方法的神经网络设计方法

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信息与控制 2004年第4期33卷 385-388页

作者：刘芳李人厚西安交通大学系统工程研究所陕西西安710049

本文提出一种模糊进化规划 ,用于前向神经网络的设计 .该方法通过对神经元的部分解群体的进化 ,缩短了个体的编码长度 ,显著地减轻了计算量 ,同时这种方法不但能够在很大程度上简化适应值的计算 ,更重要的是能够降低适应值空间的复杂性 ... 详细信息

本文提出一种模糊进化规划 ,用于前向神经网络的设计 .该方法通过对神经元的部分解群体的进化 ,缩短了个体的编码长度 ,显著地减轻了计算量 ,同时这种方法不但能够在很大程度上简化适应值的计算 ,更重要的是能够降低适应值空间的复杂性 ,从而能够加速进化算法收敛到全局最优点 .仿真结果显示 ,本文提出的算法能够有效抑制进化规划算法初期收敛的发生 ,有效地提高多层前向神经网络收敛精度。

关键词：模糊进化规划前向神经网络分层方法

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent liCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle hou Jingjing Dong Dong Chen Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(liBs),properly recycling spent liBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of liB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to liCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/liCoO_(2)mass ratio of 3:1,the leaching efficiency of li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in liCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of liB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang Jinfeng li Xiaojuan hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

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基于遗传算法的进化神经网络

系统仿真学报 2003年第10期15卷 1431-1433页

作者：刘芳李人厚西安交通大学系统工程研究所西安710049

提出一种基于遗传算法的多层前向神经网络的自动化设计方法(genetic multiplayer feedforward neural network, GMFNN),用以同时完成对网络结构空间和权值空间的搜索。该算法利用双种群权值优化、结构进化自适应变异率等方法来加快算法... 详细信息

提出一种基于遗传算法的多层前向神经网络的自动化设计方法(genetic multiplayer feedforward neural network, GMFNN),用以同时完成对网络结构空间和权值空间的搜索。该算法利用双种群权值优化、结构进化自适应变异率等方法来加快算法的收敛速度,改善解的性能。仿真结果显示本文提出的算法能够有效抑制遗传算法初期收敛的发生,有效地提高多层前向神经网络的收敛精度,并可获得更为简洁的网络结构。

关键词：遗传算法前向神经网络进化规划双种群

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect