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Origin and evolution of a new tetraploid mangrove species in an intertidal zone

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Plant Diversity 2024年第4期46卷 476-490页

作者： Hui Feng Achyut Kumar Banerjee Wuxia Guo Yang Yuan Fuyuan Duan Wei lun Ng Xuming Zhao Yuting liu Chunmei li Ying liu linfeng li Yelin Huang State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275GuangdongChina department of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai 519041GuangdongChina China-ASEAN College of Marine Sciences Xiamen University MalaysiaSepang 43900SelangorMalaysia School of Agriculture Sun Yat-sen UniversityShenzhen 518107GuangdongChina School of Ecology Sun Yat-sen UniversityShenzhen 518107GuangdongChina

Polyploidy is a major factor in the evolution of plants,yet we know little about the origin and evolution of polyploidy in intertidal *** study aimed to identify the evolutionary transitions in three truemangrove species of the genus Acanthus distributed in the Indo-West Pacific *** this purpose,we took an integrative approach that combined data on morphology,cytology,climatic niche,phylogeny,and biogeography of 493 samples from 42 geographic *** results show that the Acanthus ilicifolius lineage distributed east of the Thai-Malay Peninsula possesses a tetraploid karyotype,which is morphologically distinct from that of the lineage on the west *** haplotype networks and phylogenetic trees for the chloroplast genome and eight nuclear genes reveal that the tetraploid species has two sub-genomes,one each from *** and ***,the paternal and maternal parents,*** structure analysis also supports the hybrid speciation history of the new tetraploid *** two sub-genomes of the tetraploid species diverged from their diploid progenitors during the *** niche models revealed that the tetraploid species not only occupied the near-entire niche space of the diploids,but also expanded into novel *** findings suggest that *** species distributed on the east side of the Thai-Malay Peninsula should be regarded as a new species,***,which originated from hybridization between *** and ***,followed by chromosome *** is the first report of a true-mangrove allopolyploid species that can reproduce sexually and clonally reproduction,which explains the long-term adaptive potential of the species.

关键词： Acanthus Allopolyploid Biogeography Evolution Hybridization Polyploidy

N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： Yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-lun Xiao Meng Gao Lu-Ming Zhang Shuan-Hu Zhou Shu-Na Yu Xiao-li Wang Yan-Song Zhao department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+NAS+FPS-ZM1 group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(EliSA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

Efficacy of Leflunomide, Telmisartan, and Clopidogrel for Immunoglobulin A Nephropathy： A Randomized Controlled Trial

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Chinese Medical Journal 2016年第16期129卷 1894-1903页

作者： Jie Wu Shu-Wei Duan Xue-Feng Sun Wen-Ge li Ya-Ping Wang Wen-Hu liu Jian-Rong Zhang li-de lun Xue-Mei li Chun-Hua Zhou Ji-Jun li Shu-Wen liu Yuan-Sheng Xie Guang-Yan Cai Lu Ma Wen Huang Hua Wu Qiang Jia Xiang-Mei Chen department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing 100853 China department of Nephrology China-Japan Friendship Hospital Beijing 100029 China department of Nephrology PLA Army General Hospital Beijing 100700 China department of Nephrology Beijing Friendship Hospital Capital Medical University Beijing 100050 China department of Nephrology General Hospital of Chinese People's Armed Police Forces Beijing 100039 China department of Nephrology Air Force General Hospital of People's Liberation Army Beijing 100142 China department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China department of Nephrology Navy General Hospital Beijing 100048 China department of Nephrology First Affiliated Hospital of General Hospital of People's Liberation Army Beijing 100048 China Treatment Center for Kidney Disease No. 281 Hospital of Beijing Military Region Qinhuangdao Hebei 066100 China department of Nephrology Beijing Tongren Hospital Capital Medical University Beijing 100730 China department of Nephrology Beijing Hospital Beijing 100730 China department of Nephrology Xuanwu Hospital Capital Medical University Beijing 100053 China

Background： The efficacy and safety of telmisartan combined with clopidogrel, leflunomide, or both drugs for immunoglobulin A nephropathy （IgAN） are unclear. This study was designed to evaluate the efficacy and safety of telmisartan combined with clopidogrel, leflunomide, or both drugs for IgAN. Methods： It is a multicenter, prospective, double-dummy randomized controlled trial. Primary IgAN patients were recruited in 13 renal units across Beijing, China, from July 2010 to June 2012. After a 4-week telmisartan （80 mg/d） wash-in, 400 patients continuing on 80 mg/d telmisartan were randomly assigned to additionally receive placebo （Group A）, 50 mg/d clopidogrel （Group B）, 20 mg/d leflunomide （Group C）, or 50 mg/d clopidogrel and 20 mg/d leflunomide （Group D）. The 24-week intervention was completed by 360 patients. The primary endpoint was change in 24-h proteinuria at 24 weeks. A linear mixed-effect model was used to analyze the changes at 4, 12, and 24 weeks. Generalized estimating equations were used to evaluate changes in hematuria grade. This trial was registered at the Chinese Clinical Trial Registry. Results： The effects oftelmisartan combined with leflunomide on changes in proteinuria （0.36 [95% confidence interval （CI） 0.18 0.55] g/d, P 〈 0.001）, in serum uric acid （76.96 [95% CI 57.44-96.49] μmol/L, P 〈 0.001）, in serum creatinine （9.49 [95% CI 6.54-12.44]μmol/L, P 〈 0.001）, and in estimated glomerular filtration rate （-6.72 [95% CI-9.46 to -3.98] *** -1. 1.73 m -2, p 〈 0.001） were statistically significant, whereas they were not statistically significant on changes in systolic and diastolic blood pressure and weight （P 〉 0.05）.Telmisartan combined with clopidogrel had no statistical effect on any outcome, and there was no interaction between the interventions. No obvious adverse reactions were observed. Conclusions： Telmisartan combined with leflunomide, not clopidogrel, is safe and effective for decreasing proteinuria in certain IgAN patients.

关键词： Clopidogrel Immunoglobulin A Nephropathy Leflunomide Randomized Controlled Trial

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Simultaneous identification of multiple animal-derived components in meat and meat products by using MNP marker based on high-throughput sequencing

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Food Science and Human Wellness 2024年

作者： Yan Yi Zhanyue Jiang lixia Ma Xiaoni Hou lun li deping Ye Juanlan Du Hai Peng Guoquan Han Huaiping li Jiangwen Tang lihua Zhou National Institute of Measurement and Testing Technology Chengdu Institute for Systems Biology Jianghan University Market Supervision and Administration Bureau of Huaxi District Sichuan Agriculture University

In order to save manpower and time costs， and to achieve simultaneous detection of multiple animal-derived components in meat and meat products， this study used MNP (Multiple Nucleotide Polymorphism) marker technology based on the principle of high-throughput sequencing， and established a multi-locus 10 animal-derived components identification method of cattle， goat， sheep， donkey， horse， chicken， duck， goose， pigeon， quail in meat and meat products. The specific loci of each species could be detected and the species could be accurately identified， including 5 loci for cattle and duck， 3 loci for sheep， 9 loci for chicken and horse， 10 loci for goose and pigeon， 6 loci for quail and 1 locus for donkey and goat， and an adulteration model was established to simulate commercially available samples. The results showed that the method established in this study had high throughput， good repeatability and accuracy， and was able to identify 10 animal-derived components simultaneously with 100% repeatability accuracy. The detection limit was 0.1% (w/w) in simulated samples of chicken， duck and horse. Using the method established in this study to test commercially available samples， four samples from 14 commercially available samples were detected to be inconsistent with the labels， of which two did not contain the target ingredient and two were adulterated with small amounts of other ingredients.

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High-rate metal-free MXene microsupercapacitors on paper substrates

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Carbon Energy 2024年第5期6卷 94-104页

作者： Han Xue Po‐Han Huang Lee‐lun Lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun Jonas Weissenrieder Kristinn BGylfason Frank Niklaus Jiantong li School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden School of Engineering Sciences KTH Royal Institute of TechnologyStockholmSweden

MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on ***,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser *** a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper ***,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive *** heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.

关键词： direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability

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基于毫米波雷达点云数据的室内人员信息检测

大连理工大学学报 2024年第4期64卷 418-425页

作者：赵亮李论大连理工大学控制科学与工程学院辽宁大连116024

在使用毫米波雷达进行室内人员信息检测时,其信号处理阶段采用的静态杂波滤除算法有效地滤除了检测区域中包括墙壁、地面、桌椅等在内的静止目标,实现了对运动人员的检测,但同时会导致静止人员被漏检.为此提出按照径向速度把点云数据划... 详细信息

在使用毫米波雷达进行室内人员信息检测时,其信号处理阶段采用的静态杂波滤除算法有效地滤除了检测区域中包括墙壁、地面、桌椅等在内的静止目标,实现了对运动人员的检测,但同时会导致静止人员被漏检.为此提出按照径向速度把点云数据划分为动态数据和静态数据,先剔除动态数据,然后累积剩余的静态数据.在达到指定的累积帧数时,进行密度聚类,以簇的数量作为人员的数量,簇的中心坐标作为人员的位置.通过实验,验证了所提出方法的有效性,在室内办公场景下,人员数量统计平均绝对误差为0.81,人员位置估计均方根误差为0.1 m.

关键词：人员数量统计室内人员信息检测毫米波雷达密度聚类

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Evaluating the clinical application and effect of acupuncture therapy in anal function rehabilitation after low-tension rectal cancer surgery

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World Journal of Clinical Cases 2024年第18期12卷 3476-3481页

作者： li-Zhong Shen Wei li Zhan-lun liu Ni Wang Yan-Feng liu ling-ling Miao department of Digestive Surgery Hebei Province Hospital of Traditional Chinese MedicineShijiazhuang 050000Hebei ProvinceChina

BACKGROUND According to the indexes of serum and anal function,acupuncture therapy was applied to patients with low rectal cancer in order to avoid the occurrence of anal incontinence and reduce *** To explore the clinical application and evaluate the effect of acupuncture therapy for anal function rehabilitation after low-tension rectal cancer *** From the anorectal surgery cases,we selected 120 patients who underwent colorectal cancer surgery between January 2020 and december 2022 and randomly divided them into a control group(n=60),observation group(n=60),and control group after surgery for lifestyle intervention(including smoking cessation and exercise),dietary factor adjustment,anal movement,and oral loperamide *** serum levels of motilin,5-hydroxytryptamine,and vasoactive intestinal peptide(VIP),Wexner score for anal incontinence,and incidence of complications were compared between *** After treatment,the VIP and 5-hydroxytryptamine levels in the observation group were lower than those in the control group(Plin level was higher than that in the control group(Pdence of complications in the observation group was 6.67%,which was significantly lower than that in the control group(21.67%;Plitation of anal function after low-tension rectal cancer surgery;it can effectively help to improve the serum indices of patients,avoid the occurrence of anal incontinence,and reduce the incidence of *** and applying it will be valuable.

关键词： Acupuncture therapy Low pull rectal cancer Anal function rehabilitation Serum indicator Wexner score

A comparative study of acupuncture combined with rehabilitation gymnastics on postoperative anal function of lower rectal cancer

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World Journal of Clinical Cases 2024年第18期12卷 3491-3496页

作者： Zhan-lun liu Yi-Wei He Yan-Feng liu Ni Wang Wei li li-Zhong Shen department of Digestive Surgery Hebei Provincial Hospital of Traditional Chinese MedicineShijiazhuang 050000Hebei ProvinceChina

BACKGROUND From the anal function,inflammatory response and other indicators,acupuncture combined with rehabilitation gymnastics was applied to patients with cancer undergoing low resection,aiming to improve the prognosis of *** To explore the effects of acupuncture combined with rehabilitation gymnastics on anal function after lower rectal cancer *** From January 2020 to december 2022,128 patients who underwent rectal cancer surgery in the department of Oncology of Hebei Provincial Hospital of Traditional Chinese Medicine Hospital were selected and divided into two groups using the random number table method,with 64 patients in each *** in the control group were not treated with acupuncture or rehabilitation gymnastics and served as blank *** in the study group were treated with acupuncture and rehabilitation gymnastics from the 7th postoperative *** anal incontinence scores,changes in serum interleukin-4,interleukin-6,and interleukin-10 Levels,and serum motilin,5-hydroxytryptamine,and vasoactive intestinal peptide levels were *** There were no significant differences in serum interleukin-4,interleukin-6,and interleukin-10 Levels between the groups before treatment(P>0.05).After treatment,these levels were better than those of the control group(P0.05).Anal incontinence scores in the study group were lower than those in the control group at 14 d,21 d,and 28 d postoperatively(Plin,5-hydroxytryptamine,or vasoactive intestinal peptide levels between the groups before treatment(P>0.05).After treatment,these levels were higher in the study group than in the control group,and vasoactive intestinal peptide level was lower in the study group than in the control group(Plitation gymnas

关键词： Low rectal cancer Anal function Acupuncture Rehabilitation gymnastics

A flexible ultra-broadband multi-layered absorber working at 2 GHz-40 GHz printed by resistive ink

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Chinese Physics B 2024年第2期33卷 329-333页

作者：汪涛闫玉伦陈巩华李迎胡俊毛剑波 School of Microelectronics Hefei University of TechnologyHefei 230601China Special Display and Imaging Technology Innovation Center of Anhui Province Academy of Photoelectric TechnologyHefei University of TechnologyHefei 230027China

A flexible extra broadband metamaterial absorber(MMA)stacked with five layers working at 2 GHz–40 GHz is *** layer is composed of polyvinyl chloride(PVC),polyimide(PI),and a frequency selective surface(FSS),which is printed on PI using conductive *** investigate this absorber,both one-dimensional analogous circuit analysis and three-dimensional full-wave simulation based on a physical model are *** crucial electromagnetic properties,such as absorption,effective impedance,complex permittivity and permeability,electric current distribution and magnetic field distribution at resonant peak points,are studied in *** shows that the working frequency of this absorber covers entire S,C,X,Ku,K and Ka bands with a minimum thickness of 0.098λ_(max)(λ_(max) is the maximum wavelength in the absorption band),and the fractional bandwidth(FBW)reaches 181.1%.Moreover,the reflection coefficient is less than-10 dB at 1.998 GHz–40.056 GHz at normal incidence,and the absorptivity of the plane wave is greater than 80%when the incident angle is smaller than 50°.Furthermore,the proposed absorber is experimentally validated,and the experimental results show good agreement with the simulation results,which demonstrates the potential applicability of this absorber at 2 GHz–40 GHz.

关键词： extra broadband physical model flexible metamaterial absorber multi-layer frequency selective surface

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