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Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： dan li Jinning Jia Haibo Zeng Xiaoyan zhong Hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

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Robustness analysis of O-FDE algorithm for dispersion compensation in coherent fiber optical communications

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Optoelectronics Letters 2024年第5期20卷 289-293页

作者： zhong Kun ZENG Chenping DONG Jiaqiang WANG Baojiang li dan School of Information Technology Xichang UniversityXichang 615013China Key Laboratory of liangshan Agriculture Digital Transformation of Sichuan Provincial Education Department Xichang615013China

The overlapping frequency domain equalization(O-FDE) in digital signal processing(DSP) is frequently employed to provide dispersion compensation in long-distance coherent fiber optical communications. However, the change in overlapping symbol length that occurs during the processing of the O-FDE algorithm will typically be influenced by the decision and zero filling of the last subblock, which is harmful to the robustness of the O-FDE algorithm. In this study, with a thorough robustness analysis on changing overlapping symbol length, we present a novel method for decision and zero filling of the last subblock and examine the correspondingly resulting error vector magnitude(EVM) and symbol error ratio(SER) under different values of optical signal-to-noise ratio(OSNR), chromatic dispersion, and overlapped symbol lengths.

关键词： fiber dispersion symbol

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MACS-W:A modified optical clearing agent for imaging 3D cell cultures

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 24-34页

作者： Xiang zhong Chao Gao Hui li Yuening He Peng Fei Zaozao Chen zhongze Gu dan Zhu Tingting Yu Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China School of Optical and Electronic Infrmation Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University NanjingJiangsu 210096P.R.China Institute of Biomaterials and Medical Devices Southeast University Suzhou Jiangsu 215163P.R.China

Three-dimensional(3D)cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal *** modern optical sectioning microscopic methods make it possible to probe the complexity of 3D cell cultures but are limited by the inherent *** tissue optical clearing methods have emerged as powerful tools for investigating whole-mount tissues in 3D,they often have limitations,such as being too harsh for fragile 3D cell cultures,requiring complex handling protocols,or inducing tissue deformation with shrinkage or *** address this issue,we proposed a modified optical clearing method for 3D cell cultures,called MACS-W,which is simple,highly efficient,and *** our evaluation of MACS-W,we found that it exhibits excellent clearing capability in just 10 min,with minimal deformation,and helps drug evaluation on tumor *** summary,MACS-W is a fast,minimally-deformative and fluorescence compatible clearing method that has the potential to be widely used in the studies of 3D cell cultures.

关键词： Tissue optical clearing 3D cell cultures imaging

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Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： zhong-Hai li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c... 详细信息

关键词： DRIVEN CRUST

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Tuning interfacial charge transfer for efficient visible-light-driven photodegradation and simultaneous H_(2)evolution

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Journal of Materials Science & Technology 2024年第1期168卷 35-49页

作者： Zhiyang li Yaogang Chen Yinghe Zhang Wei Ai Qian Lei Tingjun Yao dan zhong Wenjie liu Wenbiao Jin Lei Yang State Key Laboratory of Urban Water Resource and Environment Shenzhen Key Laboratory of Organic Pollution Prevention and ControlSchool of Civil and Environmental EngineeringHarbin Institute of Technology ShenzhenShenzhen 518055China Key Laboratory of Northwest Water Resources Environment and EcologyMinistry of EducationSchool of Environmental and Municipal EngineeringXi’an University of Architecture and TechnologyXi’an 710055China CNAS Accredited Test Center Guangdong Engineering Technology Research Center of Air PurificationHealthlead Co.Ltd.Shenzhen 518055China School of Science Harbin Institute of Technology ShenzhenShenzhen 518055China

The edge-graphitized carbon nitride(C_(3)N_(4)-C g)was prepared by secondary pyrolysis to construct ZnO/C_(3)N_(4)-C g(ZCN)type-Ⅱheterojunction photocatalyst via a facile sonication dispersion method,which achieved∼7.04-fold and∼18.3-fold enhanced visible-light-driven photocatalytic performance for refrac-tory micropollutant removal and simultaneous hydrogen(H_(2))evolution respectively compared to con-ventional ZnO/g-C_(3)N_(4)Step-scheme *** apparent quantum efficiency of the ZCN_(0.4)het-erojunction reaches 0.92%(λ=420 nm).Such excellent performance stems from that the edge-graphene moieties stitched onto the interface of heterojunction extend light absorption to the full visible spec-trum,meanwhile,the built-in electric field generated during Fermi level alignment accompanying fa-vorable band-bending structure provides an effective pathway for the rapid migration of photoinduced electrons via the edge graphene channel to improve interfacial charge separation ***,the midgap states introduced in ZCN heterojunction could temporarily retain photoexcited electrons to effectively inhibit the in situ carrier recombination for improved photocatalytic H_(2)***,ZCN/peroxymonosulfate system exhibited excellent anti-interference performance against complex water bodies under visible illumination due to the synergistic effect between the co-existing anions and organic ***,the eco-friendly nature of the ZCN/peroxymonosulfate system showed no biotoxicity of reaction filtrate on cell proliferation after treatment,which avoided secondary ***-ering the outstanding performance in photocatalysis,the ZCN system exhibits broad potential for practical applications in water pollution control and green energy production.

关键词： ZnO C_(3)N_(4)-C g Heterojunction Photodegradation Hydrogen evolution

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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： dan Mo zhong-Hong Zeng Xin Sui Rong li Yi-Hua Yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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Revisiting aluminum current collector in lithium-ion batteries:Corrosion and countermeasures

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Journal of Energy Chemistry 2024年第2期89卷 610-634,I0014页

作者： Shanglin Yang Jinyan zhong Songmei li Bin li Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education School of Materials Science&EngineeringBeihang UniversityBeijing 100191China

With the large-scale service of lithium-ion batteries(liBs),their failures have attracted significant *** the decay of active materials is the primary cause for liB failures,the degradation of auxiliary materials,such as current collector corrosion,should not be ***,it is necessary to conduct a comprehensive review in this *** this review,from the perspectives of electrochemistry and materials,we systematically summarize the corrosion behavior of aluminum cathode current collector and propose corresponding ***,the corrosion type is clarified based on the properties of passivation layers in different organic electrolyte ***,a thoroughgoing analysis is presented to examine the impact of various factors on aluminum corrosion,including lithium salts,organic solvents,water impurities,and operating ***,strategies for electrolyte and protection layer employed to suppress corrosion are discussed in *** and most importantly,we provide insights and recommendations to prevent corrosion of current collectors,facilitate the development of advanced current collectors and the implementation of next-generation high-voltage stable liBs.

关键词： lithium-ion battery Aluminum current collector Corrosion Electrochemical performance Electrolyte Protective layer

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An Electrochemical Perspective of Aqueous Zinc Metal Anode

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Nano-Micro Letters 2024年第1期16卷 274-312页

作者： Huibo Yan Songmei li Jinyan zhong Bin li School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Based on the attributes of nonflammability,environmental benignity,and cost-effectiveness of aqueous electrolytes,as well as the favorable compatibility of zinc metal with them,aqueous zinc ions batteries(AZIBs)become the leading energy storage candidate to meet the requirements of safety and low ***,aqueous electrolytes,acting as a double-edged sword,also play a negative role by directly or indirectly causing various parasitic reactions at the zinc anode *** reactions include hydrogen evolution reaction,passivation,and dendrites,resulting in poor Coulombic efficiency and short lifespan of AZIBs.A comprehensive review of aqueous electrolytes chemistry,zinc chemistry,mechanism and chemistry of parasitic reactions,and their relationship is ***,the understanding of strategies for suppressing parasitic reactions from an electrochemical perspective is not profound *** this review,firstly,the chemistry of electrolytes,zinc anodes,and parasitic reactions and their relationship in AZIBs are deeply ***,the strategies for suppressing parasitic reactions from the perspective of enhancing the inherent thermodynamic stability of electrolytes and anodes,and lowering the dynamics of parasitic reactions at Zn/electrolyte interfaces are ***,the perspectives on the future development direction of aqueous electrolytes,zinc anodes,and Zn/electrolyte interfaces are presented.

关键词： Aqueous zinc ions batteries Parasitic reactions Aqueous electrolyte Zinc anode

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Study on the occurrence and influencing factors of gastrointestinal symptoms in hemodialysis patients with uremia

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2157-2166页

作者： dan Yuan Xiao-Qi Wang Feng Shao Jing-Jing Zhou zhong-Xin li Department of Nephrology Beijing Luhe Hospital Affiliated to Capital Medical UniversityBeijing 101100China

BACKGROUND Gastrointestinal symptoms are common in patients with uremia undergoing hemodialysis,and these symptoms seriously affect patients'*** To assess the occurrence and factors influencing gastrointestinal symptoms in patients with uremia undergoing *** We retrospectively selected 98 patients with uremia who underwent regular hemo-dialysis treatment in the blood purification center of our hospital from December 2022 to December *** gastrointestinal symptoms and scores of each dimension were evaluated using the Gastrointestinal Symptom Grading Scale(GSRS).Patients were divided into gastrointestinal symptoms and no gastrointestinal symptom groups according to whether they had gastrointestinal *** factors that may affect gastrointestinal symptoms were identified by single-factor *** logistic regression analysis was performed to identify independent risk factors for gastrointestinal *** Gastrointestinal symptoms included indigestion,constipation,reflux,diarrhea,abdominal pain,and eating disorders,and the total average GSRS score was 1.35±*** study showed that age,number of tablets,dialysis time,glucocorticoid,parathyroid hormone(PTH),combined diabetes mellitus and C-reactive protein(CRP)were independent risk factors for gastrointestinal symptoms in patients with uremia undergoing hemodialysis,whereas body mass index(BMI),hemoglobin(Hb),and urea clearance index were independent protective factors(Plinically related factors influencing the occurrence of gastrointestinal symptoms,and targeted prevention can be perform

关键词： Uremic hemodialysis Gastrointestinal symptoms Influencing factors Blood pressure dialysis Chronic renal failure

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Early diagnosis and management of neonatal sepsis:a perspective

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World Journal of Pediatrics 2024年第4期20卷 303-306页

作者： li‑zhong Du Neonatal Intensive Care Unit Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou 310052China

Neonatal sepsis is an illness caused by bloodstream bacteria or fungal infections that affect newborn infants under 28 days of *** stands as a significant contributor to morbidity and mortality in neonatal intensive care units(NICUs).With the improved survival rates of very low-birth-weight or extremely premature infants,a growing number of these vulnerable infants are receiving intensive care and undergoing invasive procedures,making nosocomial infections a persistent challenge in *** mortality rate associated with neonatal sepsis varies depending on factors such as birth weight,gestational age,and other *** can also lead to a range of long-term health consequences,including neurodevelopmental disabilities like cerebral palsy,visual or hearing impairments,and cognitive ***,neonatal sepsis is linked to various adverse outcomes,including respiratory complications,bronchopulmonary dysplasia,nutritional and growth issues,and immunological dysfunction[1].Due to its atypical clinical presentation and the low rate of specific diagnostic indicators,such as a positive blood culture,accurately diagnosing neonatal sepsis is ***,the appropriateness of antibiotic treatment is often a matter of controversy.

关键词： neonatal mortality diagnosis

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