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Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma

World Journal of Gastroenterology 2018年第34期24卷 3884-3897页

作者： Yuan-Feng Zeng Yi-Sheng Xiao Yong liu Xiao-Jiang Luo li-dan wen Qian liu Min Chen Department of Pathology Jiangxi Provincial People’s Hospital Teaching and Researching Section of Morphology College of Basic Medicine Jiangxi University of Traditional Chinese Medicine Department of General Surgery Jiangxi Provincial People’s Hospital Clinical Medical Sciences Institute Jiangxi Provincial People’s Hospital

AIM To clarify the underlying mechanism of formin-like 3(FMNL3)in the promotion of colorectal carcinoma(CRC)cell *** The in vitro biological function analyses of FMNL3 were performed by gain-and loss-of function *** in the F-actin cytoskeleton were detected by the technologies of phalloidin-TRITC labeling and confocal *** signaling pathway mediated by FMNL3 was explored by western blot,gelatin zymograph assay,co-immunoprecipitation(co-IP),immunofluorescence colocalization,and glutathione S-transferase(GST)pulldown *** The in vitro experimental results showed that FMNL3 significantly promoted the proliferation,invasion,and migration of CRC cells(Pling of actin-based protrusions such as filopodia and lamellipodia in a RhoC-dependent *** western blot and gelatin zymograph assay results indicated that FMNL3 was involved in the RhoC/focal adhesion kinase(FAK)pathway and acted as an effector of RhoC to activate the downstream signaling of p-FAK as well as p-MAPK and *** resulted in the increased expression of matrix metalloproteinase 2(MMP2),matrix metalloproteinase 9(MMP9)and vascular endothelial growth factor(VEGF),and the subsequent promotion of CRC cell *** results of TAE226,U0126 or Ly294002 treatment confirmed an essential role of FMNL3 in activation of the RhoC/FAK pathway and the subsequent promotion of CRC ***-IP,colocalization and GST pull-down assays showed the direct interaction of FMNL3 with RhoC in vivo and in *** FMNL3 regulates the RhoC/FAK signaling pathway and RhoC-dependent remodeling of actin-based protrusions to promote CRC invasion.

关键词： Formin-like 3 Colorectal carcinoma Invasion RhoC/FAK pathway Actin assembly

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong li li dan Jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

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An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan Qin Qiaoyan wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

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复杂河口汊道封堵后有关的潮流和泥沙问题

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水利学报 2010年第12期40卷 1438-1445页

作者：李孟国闫勇麦苗李文丹交通运输部天津水运工程科学研究所工程泥沙交通行业重点实验室天津300456

研究了瓯江南口封堵后有关的潮流和泥沙问题。首先对复杂的瓯江口的自然条件和冲淤演变进行了分析;其次,使用二维波浪潮流泥沙数学模型、波浪潮流泥沙物理模型及三维潮流数学模型等研究手段,对瓯江南口现有潜堤加高进行封堵后的二维潮... 详细信息

研究了瓯江南口封堵后有关的潮流和泥沙问题。首先对复杂的瓯江口的自然条件和冲淤演变进行了分析;其次,使用二维波浪潮流泥沙数学模型、波浪潮流泥沙物理模型及三维潮流数学模型等研究手段,对瓯江南口现有潜堤加高进行封堵后的二维潮流场、泥沙场、地形冲淤变化和三维潮流场进行了模拟研究,对瓯江泄洪排涝的影响进行了计算和分析。研究结果表明,从对周围水沙环境和瓯江泄洪排涝的影响角度考虑,将现潜堤加高进行南口封堵的方案是可行的。

关键词：复杂河口汊道封堵数学模型瓯江口潮流泥沙

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丹江口水库及其入库支流水体中微塑料组成与分布特征

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环境科学 2021年第3期42卷 1372-1379页

作者：潘雄林莉张胜翟文亮陶晶祥李丹文长江科学院流域水环境研究所武汉430010 长江科学院流域水资源与生态环境科学湖北省重点实验室武汉430010 华中科技大学环境科学与工程学院武汉430074

微塑料污染是当前环境科学关注的研究热点.为探究国家一级水源保护区丹江口水库中微塑料的赋存状况,以水库及其入库支流表层水体为对象,于2019年丰水期进行采样调查分析,研究该区域的微塑料丰度、形状和类型,并结合丹江口水库的水文水... 详细信息

微塑料污染是当前环境科学关注的研究热点.为探究国家一级水源保护区丹江口水库中微塑料的赋存状况,以水库及其入库支流表层水体为对象,于2019年丰水期进行采样调查分析,研究该区域的微塑料丰度、形状和类型,并结合丹江口水库的水文水动力条件揭示其微塑料空间分布特征.结果表明,丹江口水库水体中微塑料颜色各异,主要形状有颗粒、碎片、薄膜以及纤维类这4类,其中碎片类占比为84.2%,棕色和透明微塑料最为常见,而不同形状微塑料丰度空间分布差异明显;丰水期,水库库区微塑料平均丰度7 248 n·m^(-3),丹库的微塑料含量显著高于汉库;库区与支流中微塑料粒径大小主要在75~4 703μm之间,微塑料丰度随粒径的增加而下降,其中73.4%的微塑料粒径在500μm以下;就微塑料材质而言,尼龙在丹江口水库中最普遍,数量比例为36.4%;其次是聚乙烯(PE)和聚丙烯(PP)等.

关键词：丹江口水库微塑料表层水体入库支流分布特征

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气候变暖对四川盆地水稻土有机碳含量变化的影响

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环境科学 2023年第8期44卷 4679-4688页

作者：李艾雯宋靓颖冉敏李文丹张元媛李呈吉史文娇李启权四川农业大学资源学院成都611130 中国科学院地理科学与资源研究所北京100101

气候变暖会提高土壤温度从而导致土壤碳释放,但也可以通过提高初级生产力增加土壤有机碳.农田土壤被认为具有巨大的固碳潜力,然而大区域尺度上气候变暖如何影响农田土壤有机碳变化尚缺少直接观测.水稻土是我国重要的耕作土壤之一,基于19... 详细信息

气候变暖会提高土壤温度从而导致土壤碳释放,但也可以通过提高初级生产力增加土壤有机碳.农田土壤被认为具有巨大的固碳潜力,然而大区域尺度上气候变暖如何影响农田土壤有机碳变化尚缺少直接观测.水稻土是我国重要的耕作土壤之一,基于1980~1985年全国第二次土壤普查获得的2217个样点数据和2017~2019年2382个实地采样数据,分析了四川盆地水稻土表层土壤有机碳含量的变化特征,并探究了水稻土有机碳含量变化与气温、降雨量、农田利用方式、施肥强度和粮食产量的关系.结果表明,近40年间四川盆地水稻土表层有机碳含量从13.33 g·kg^(-1)上升到15.96 g·kg^(-1),增长了2.63 g·kg^(-1),呈“碳汇”效应;不同地貌区和不同二级流域水稻土有机碳含量变化幅度不同.水稻土有机碳含量增加量与年均气温呈正相关关系,与年均降雨量呈负相关关系,与年均施肥量及其增长速率、年均粮食产量及增长率则均呈先增加后降低的抛物线关系.不同农田利用方式下水稻土有机碳含量增加量与年均气温增长率关系不同,年均气温增长率的增加仅在水旱轮作下对有机碳增长具有显著影响.以上结果表明,四川盆地水稻土有机碳变化受多种因素共同影响,但气候变暖是导致区域水稻土有机碳变化的重要因素,且其影响受农田利用方式决定的水分条件控制.

关键词：土壤有机碳(SOC) 时空变化水稻土气候变化四川盆地

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang li Xuechun Chen wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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温州港深水航道三维潮流数值模拟

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水运工程 2010年第1期 86-93页

作者：李孟国李文丹交通部天津水运工程科学研究所工程泥沙交通行业重点实验室天津300456

根据实测资料对温州港大小门岛港区深水航道海区的三维潮流特征进行了分析。针对工程海区岸线不规则、地形复杂、岛屿众多、存在动边界等特点,使用垂向σ坐标变换技术,建立了基于不规则三角形网格的三维潮流数学模型,提出了三角形网格... 详细信息

根据实测资料对温州港大小门岛港区深水航道海区的三维潮流特征进行了分析。针对工程海区岸线不规则、地形复杂、岛屿众多、存在动边界等特点,使用垂向σ坐标变换技术,建立了基于不规则三角形网格的三维潮流数学模型,提出了三角形网格三维潮流数学模型处理动边界的方法。使用现场资料对模型进行了验证,潮位、不同水层的流速和流向均与实测资料吻合良好。在模型验证的基础上,对温州港深水航道工程实施后的三维流场进行了模拟,对表、中、底层流速流向的变化进行了分析,对航道表层最大横流进行了计算。建立的三维模型非常适合于复杂河口海岸地区的三维潮流场模拟。

关键词：深水航道三维潮流数学模型数值模拟三角形网格 σ坐标变换

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Mechanical Properties of Railway High-strength Manufactured Sand Concrete: Typical lithology, Stone Powder Content and Strength Grade

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 194-203页

作者： WANG Zhen li Huajian HUANG Fali YANG Zhiqiang wen Jiaxin SHI Henan Railway Engineering Research Institute China Academy of Railway Science Corporation LimitedBeijing 100081China State Key Laboratory for Track Technology of High-Speed Railway Beijing 100081China

In order to achieve the large-scale application of manufactured sand in railway high-strength concrete structure,a series of high-strength manufactured sand concrete(HMC)are prepared by taking the manufactured sand lithology(tuff,limestone,basalt,granite),stone powder content(0,5%,10%,15%)and concrete strength grade(C60,C80,C100)as *** evolution of mechanical properties of HMC and the correlation between cubic compressive strength and other mechanical properties are *** to river sand,manufactured sand enhances the cubic compressive strength,axial compressive strength and elastic modulus of concrete,while its potential microcracks weaken the flexural strength and splitting tensile strength of *** powder content displays both positive and negative effects on mechanical properties of HMC,and the stone powder content is suggested to be less than 10%.The empirical formulas between cubic compressive strength and other mechanical properties are proposed.

关键词： manufactured sand concrete railway mechanical property lithology stone powder content

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瓯江南口封堵方案研究

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中国港湾建设 2009年第3期29卷 19-22页

作者：李孟国李文丹交通部天津水运工程科学研究所工程泥沙交通行业重点实验室天津300456

使用二维波浪潮流泥沙数学模型研究手段,通过工程实施前后的波浪场、二维潮流场、泥沙场、地形冲淤变化场的数值模拟和分析,对复杂的瓯江河口南口封堵工程的各种方案进行了研究,从对周围水沙环境影响角度论证了南口封堵工程方案的可行... 详细信息

使用二维波浪潮流泥沙数学模型研究手段,通过工程实施前后的波浪场、二维潮流场、泥沙场、地形冲淤变化场的数值模拟和分析,对复杂的瓯江河口南口封堵工程的各种方案进行了研究,从对周围水沙环境影响角度论证了南口封堵工程方案的可行性。研究结果表明,将现潜堤加高的南口完全封堵方案是基本可行的,南口半堵方案是完全可行的。建议瓯江南口从半堵起步,逐步完成南口的完全封堵。

关键词：瓯江南口汊道封堵数学模型可行性复杂河口

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