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Subsequent bilateral acute carpal tunnel syndrome due to tophaceous infiltration:A case report

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World Journal of Clinical Cases 2024年第2期12卷 418-424页

作者： Soon-chin Yeoh Wen-Tien Wu Jui-Tien Shih Wen-chin Su Kuang-Ting yeh School of Medicine Tzu Chi UniversityHualien 970374TaiwanChina Department of Orthopedics Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Department of Orthopaedic Surgery Taoyuan Armed Forces General HospitalTaoyuan 325208TaiwanChina Department of Clinical Education Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Graduate Institute of Clinical Pharmacy Tzu Chi UniversityHualien 970374TaiwanChina

BACKGROUND Acute carpal tunnel syndrome(ACTS)is commonly caused by repetitive strain,trauma,or inflammatory ***,ACTS due to tophaceous gout is a clinical event that remains poorly understood and *** rare manifestation necessitates prompt diagnosis and intervention to prevent irreversible *** SUMMARY A 51-year-old man who had poorly controlled hyperuricemia presented with ACTS secondary to tophaceous *** of rapid symptom progression symptoms and severe median nerve compression within 3 mo,the patient underwent emergency decompression surgery for both wrists at different time ***,he exhibited complete recovery of sensory and motor functions,with no recurrence at long-term *** outcomes were achieved through immediate decompression surgery,anti-inflammatory medications,postoperative active and passive range-of-motion exercises,and intermittent wrist *** diagnosis and surgical intervention,when necessary,are crucial for preventing long-term complications and obtaining favorable outcomes in patients with *** optimal gout management strategy involving pharmacologic therapy and lifestyle modifications may help minimize ACTS recurrence and improve clinical *** Prompt surgical intervention and optimal gout management are crucial for preventing irreversible nerve damage and ACTS recurrence.

关键词： Acute carpal tunnel syndrome Gout Surgical decompression Range-of-motion exercises Case report

Non-sinusoidal transit timing variations for the exoplanet HAT-P-12b

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Research in Astronomy and Astrophysics 2021年第4期21卷 253-263页

作者： Devesh P.Sanya Ing-Guey Jiang li-Hsin Su li-chin yeh Tze-En Chang V.V.Moskvin A.A.Shlyapnikov V.Ignatov David Mkrtichian Evgeny Griv Vineet Kumar Mannaday Parijat Thakur D.K.Sahu Swadesh Chand D.Bisht Zhao Sun Jianghui Ji Department of Physics and Institute of Astronomy “National Tsing-Hua University”HsinChu 30013China Institute of Computational and Modeling Science “National Tsing-Hua University”HsinChu 30013China Crimean Astrophysical Observatory 298409NauchnyCrimea National Astronomical Research Institute of Thailand(NARIT) Siripanich Building191 Huaykaew RoadMuang DistrictChiangmaiThailand Department of Physics Ben-Gurion UniversityBeer-Sheva 84105Israel Department of Pure&Applied Physics Guru Ghasidas Vishwavidyalaya(A Central University)Bilaspur(C.G.)-495009India Indian Institute of Astrophysics Bangalore 560034India Key Laboratory for Researches in Galaxies and Cosmology University of Science and Technology of ChinaChinese Academy of Sciences Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China

Considering the importance of investigating the transit timing variations(TTVs)of transiting exoplanets,we present a follow-up study of HAT-P-12 *** include six new light curves observed between2011 and 2015 from three different observatories,in association with 25 light curves taken from the published *** sample of the data used thus covers a time span of~10.2 years with a large coverage of epochs(1160)for the transiting events of the exoplanet HAT-P-12 *** light curves are utilized to determine the orbital parameters and conduct an investigation of possible *** new linear ephemeris shows a large value of reducedχ^(2),i.e.X_(red)^(2)(23)=7.93,and the sinusoidal fitting using the prominent frequency coming from a periodogram shows a reducedχ^(2) around *** on these values and the corresponding O-C diagrams,we suspect the presence of a possible non-sinusoidal TTV in this planetary ***,we find that a scenario with an additional non-transiting exoplanet could explain this TTV with an even smaller reducedχ^(2) value of around 2.

关键词： planetary systems techniques photometric

Impact of microplastics and nanoplastics on liver health:Current understanding and future research directions

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World Journal of Gastroenterology 2024年第9期30卷 1011-1017页

作者： Chun-Cheng Chiang Hsuan yeh Ruei-Feng Shiu Wei-Chun chin Tzung-Hai Yen School of Medicine University of PittsburghPittsburghPA 15213United States Pittsburgh liver Research Center University of PittsburghPittsburghPA 15213United States Division of Experimental Pathology Department of PathologyUniversity of PittsburghPittsburghPA 15213United States Division of Endocrinology Department of PediatricsUniversity of PittsburghPittsburghPA 15213United States Center of Excellence for The Oceans National Taiwan Ocean UniversityKeelung 20224Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Materials Science and Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalTaoyuan 333TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

With continuous population and economic growth in the 21st century,plastic pollution is a major global ***,the health concern of microplastics/nanoplastics(MPs/NPs)decomposed from plastic wastes has drawn public attention only in the recent *** article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ,which is one of the primary routes that MPs/NPs enter human *** interrelated mechanisms including oxidative stress,hepatocyte energy re-distribution,cell death and autophagy,as well as immune responses and inflammation,were also *** addition,the disturbance of microbiome and gut-liver axis,and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease,steatohepatitis,liver fibrosis,and cirrhosis were briefly ***,we discussed potential directions in regard to this trending topic,highlighted current challenges in research,and proposed possible solutions.

关键词： Microplastics Nanoplastics liver Reactive oxidative species Cell death Autophagy Innate immunity Metabolic dysfunction-associated fatty liver disease Gut-liver axis

lipocoacervate,a tunable vesicle for protein delivery

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Nano Research 2024年第10期17卷 9135-9140页

作者： Chia-Wei yeh Nathaniel Wright Chelsea Loh Nabeen Chu Yadong Wang Nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityKimball Hall 290Ithaca 14853USA Human Biology Healthand Society.College of Human EcologyCornell UniversityIthaca 14853USA

Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously *** we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and *** made of heparin and a biocompatible polycation,PEAD,forms the core of the vesicle;lipids form the membrane of the *** call this vesicle lipocoacervate(lipCo),which has a high affinity for growth factors and cytokines due to *** is a tunable protein delivery *** vesicle size is controlled through polymer and salt *** functionalization enables potential for targeting capabilities with long-term storage through ***,the controlled delivery of therapeutics also avoids high toxicity to treated cells in *** we report on these key principles of lipCo assembly and design.

关键词： complex coacervate drug delivery protein delivery heparin lipid particle

Geophysical fluid dynamics in the hypergravity field

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Acta Mechanica Sinica 2024年第6期40卷 3-10页

作者： Harry yeh School of Civil&Construction Engineering Oregon State UniversityCorvallisOR97331USA

Hypergravity can be realized by creating a field imposed by centripetal acceleration in a centrifuge *** an apparatus is often used to test soil response in geotechnical engineering *** we present the potential usage of a centrifuge apparatus to study various topics in *** scaling law associated with hydrodynamics is first reviewed,and the advantage of controlling the body force is *** of the perceived disadvantages in such experiments is the unwanted presence of the Coriolis effect in the ***,we propose exploiting this effect to our advantage to study geophysical fluid-dynamic problems that occur particularly in the equatorial region.

关键词： Hypergravity Scaling Geophysical fluid dynamics Centrifuge

The Optimization Design of the Nozzle Section for theWater Jet Propulsion System Applied in Jet Skis

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2277-2304页

作者： Cheng-yeh li Jui-Hsiang Kao Department of Systems Engineering and Naval Architecture Taiwan Ocean UniversityKeelungTaiwanChina

The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and ***,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limited by stern *** entire section,from the rotor to the nozzle through the stator,must be designed based on system integration in that the individual performance of these three components will influence each ***,the section from the rotor to the nozzle significantly impacts the performance of a water jet propulsion *** study focused on nozzle design and established referable analysis results to facilitate subsequent integrated studies on the design parameters regarding nozzle *** existing studies concentrate on discussions on rotor design and the tip leakage flow of rotors or have replaced the existing complex computational domain with a simple flow ***,research has yet to implement an integrated,optimal design of the section from the rotor to the *** the above,our program conducted preliminary research on this system integration design issue,discussed the optimal nozzle for this section in-depth,and proposed design suggestions based on the *** program used an existing model as the design *** study referred to the actual trial data as the design conditions for the proposed *** prior references’simple flow field form,this study added a jet ski geometry and free surface to the computational *** the linear hull shape was considered,the inflow in the inlet duct would be closer to the actual *** on the numerical calculation result,this study recommends that the optimal nozzle outlet area should be 37%of the inlet area and that the nozzle contour should be ***,for the pump head,static pressure had a more significant impact than dynamic pressure.

关键词： Water jet propulsion system rotor nozzle outlet area nozzle contour

Designing a Secure and Scalable Data Sharing Mechanism Using Decentralized Identifiers(DID)

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 809-822页

作者： Iuon-Chang lin I-ling yeh ching-Chun Chang Jui-Chuan liu chin-Chen Chang Department of Management Information Systems National Chung Hsing UniversityTaichung402TaiwanChina Information and Communication Security Research Center Feng Chia UniversityTaichung407TaiwanChina Department of Information Engineering and Computer Science Feng Chia UniversityTaichung407TaiwanChina

Centralized storage and identity identification methods pose many risks,including hacker attacks,data misuse,and single points of ***,existing centralized identity management methods face interoperability issues and rely on a single identity provider,leaving users without control over their ***,this paper proposes a mechanism for identity identification and data sharing based on decentralized *** scheme utilizes blockchain technology to store the identifiers and data hashed on the chain to ensure permanent identity recognition and data *** is stored on InterPlanetary File System(IPFS)to avoid the risk of single points of failure and to enhance data persistence and *** the same time,compliance with World Wide Web Consortium(W3C)standards for decentralized identifiers and verifiable credentials increases the mechanism’s scalability and interoperability.

关键词： Self-sovereign identity decentralized identifier blockchain

A Multi-Objective Optimization for Locating Maintenance Stations and Operator Dispatching of Corrective Maintenance

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Computers, Materials & Continua 2024年第6期79卷 3519-3547页

作者： Chao-Lung Yang Melkamu Mengistnew Teshome Yu-Zhen yeh Tamrat Yifter Meles Department of Industrial Management National Taiwan University of Science and TechnologyTaipie106Taiwan Department of Industrial Engineering University of Gondar Institute of TechnologyGondar196Ethiopia

In this study,we introduce a novel multi-objective optimization model tailored for modern manufacturing,aiming to mitigate the cost impacts of operational disruptions through optimized corrective *** to our approach is the strategic placement of maintenance stations and the efficient allocation of personnel,addressing a crucial gap in the integration of maintenance personnel dispatching and station *** model uniquely combines the spatial distribution of machinery with the expertise of operators to achieve a harmonious balance between maintenance efficiency and *** core of our methodology is the NSGA Ⅲ+Dispatch,an advanced adaptation of the Non-Dominated Sorting Genetic Algorithm Ⅲ(NSGA-Ⅲ),meticulously designed for the selection of maintenance stations and effective operator *** method integrates a comprehensive coding process,crossover operator,and mutation operator to efficiently manage multiple *** empirical testing,including a detailed analysis from a taiwan region electronic equipment manufacturer,validated the effectiveness of our approach across various scenarios of machine failure frequencies and operator *** findings reveal that the proposed model significantly outperforms current practices by reducing response times by up to 23%in low-frequency and 28.23%in high-frequency machine failure scenarios,leading to notable improvements in efficiency and cost ***,it demonstrates significant improvements in oper-ational efficiency,particularly in selective high-frequency failure contexts,while ensuring substantial manpower cost savings without compromising on operational *** research significantly advances maintenance strategies in production environments,providing the manufacturing industry with practical,optimized solutions for diverse machine malfunction ***,the methodologies and principles developed in this study have pote

关键词： Corrective maintenance multi-objective optimization non-dominated sorting genetic algorithmⅢ operator allocation maintenance station location

TransCell:In Silico Characterization of Genomic Landscape and Cellular Responses by Deep Transfer Learning

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 157-170页

作者： Shan-Ju yeh Shreya Paithankar Ruoqiao Chen Jing Xing Mengying Sun Ke liu Jiayu Zhou Bin Chen Department of Pediatrics and Human Development Michigan State UniversityGrand RapidsMI 49503USA Department of Pharmacology and Toxicology Michigan State UniversityGrand RapidsMI 49503USA Department of Computer Science and Engineering Michigan State UniversityEast LansingMI 48824USA

Gene expression profiling of new or modified cell lines becomes routine today;however,obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines,including those derived from underrepresented groups,is not trivial when resources are *** gene expression to predict other measurements has been actively explored;however,systematic investigation of its predictive power in various measurements has not been well ***,we evaluated commonly used machine learning methods and presented TransCell,a two-step deep transfer learning framework that utilized the knowledge derived from pan-cancer tumor samples to predict molecular features and *** these models,TransCell had the best performance in predicting metabolite,gene effect score(or genetic dependency),and drug sensitivity,and had comparable performance in predicting mutation,copy number variation,and protein ***,TransCell improved the performance by over 50%in drug sensitivity prediction and achieved a correlation of 0.7 in gene effect score ***,predicted drug sensitivities revealed potential repurposing candidates for new 100 pediatric cancer cell lines,and predicted gene effect scores reflected BRAF resistance in melanoma cell ***,we investigated the predictive power of gene expression in six molecular measurement types and developed a web portal(http://***/transcell/)that enables the prediction of 352,000 genomic and cellular response features solely from gene expression profiles.

关键词： Genomics Transcriptomics Cancer dependency Drug repurposing Transfer learning