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Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome

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World Journal of Pediatrics 2020年第2期16卷 159-167页

作者： Hai-Xia Chen qia.Cheng Fang li Qing-Nan He Yan Cao Zhu-Wen Yi Xiao-Chuan Wu Department of Pediatrics The Second Xiangya HospitalCentral South UniversityChangsha 410011China

Background Tacrolimus,a calcineurin inhibitor,is recommended by the recent guidelines from the Kidney Disease Improving Global Outcomes Group as the first-line treatment for steroid-resistant nephrotic syndrome(SRNS),but its clinical application in China is still *** investigated the efficacy and safety of tacrolimus combined with low-dose corticosteroids in a population of Chinese children with *** In this prospective non-randomized,non-controlled study,Chinese children with SRNS who failed the previous full-dose prednisone treatment were given tacrolimus(0.1 mg/kg/day)and low-dose prednisone(0.25-0.50 mg/kg/day).We compared the overall remission rate(ORR)and adverse events in the follow-up period with this therapeutic *** A total of 76 children were enrolled into the study with an average follow-up period of 18±6 months(maximum 36 months).ORR achieved by the first,third,and sixth months was 94.7%,94.7%,and 96.0%,*** patients who attained an initial tacrolimus trough concentration(FK506C0)>6 ng/mL(60.3%)achieved *** relative risk of relapse at FK506C0limus and low-dose prednisone was safe and effective for the treatment of children with SRNS,with high remission rates observed as early as the first *** were infrequent,but tended to increase significantly with decreases in FK506C0.

关键词： Children Low-dose prednisone Steroid-resistant nephrotic syndrome Tacrolimus

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深厚覆盖层地区无塔平拉索道桥锚碇结构设计

水利科学与寒区工程 2024年第5期7卷 103-107页

作者：于标张立影林恰中国电建集团北京勘测设计研究院有限公司北京100024

本文以苏洼龙水电站下游索道桥锚碇结构为研究对象,研究深厚覆盖层地区无塔平拉索桥锚碇设计,以期为类似桥梁锚碇型式选择提供可借鉴的经验。结果表明:采用了梯形地笼式锚碇,构造简单,对地基承载能力要求低,适应整体变形能力强,经济性好。

关键词：深厚覆盖层锚碇结构设计受力分析变形能力强

A new diagnostic model of primary open angle glaucoma based on FD-OCT parameters

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 951-957页

作者： Ya-Jie Zheng Ying-Zi Pan Xue-Ying li Yuan Fang Mei li Rong-Hua qia.Yu Cai Department of Ophthalmology MEM Eye Care System Beijing 100039 China Department of Ophthalmology Peking University First Hospital Beijing 100034 China

AIM： To build a clinical diagnostic model of primary open angle glaucoma （POAG） using the normal probability cha.t of frequency-domain optical coherence tomography （FD-OCT）. METHODS： This is a cross-sectional study. Total 133 eyes from 133 healthy subjects and 99 eyes from 99 early POAG patients were included in the study. The retinal nerve fibre layer （RNFL） thickness parameters of optic nerve head （ONH） and RNFL3.45 scan were measured in one randomly selected eye of each subject using RTVue-100 FD-OCT. Then, we used these parameters to establish the diagnostic models. Four different diagnostic models based on two different area partition strategies on ONH and RNFL3.45 parameters, including ONH traditional area partition model （ONH-T）, ONH new area partition model （ONH-N）, RNFL3.45 traditional area partition model （RNFL3.45-T） and RNFL3.45 new area partition model （RNFL3.45-N）, were built and tested by cross-validation. RESULTS： The new area partition models had higher area under the receiver operating cha.acteristic （AROC; ONH-N： 0.990; RNFL3.45-N： 0.939） than corresponding traditional area partition models （ONH-T： 0.979; RNFL3.45-T： 0.881）. There was no statistical difference among AROC of ONH-T, ONH-N, and RNFL3.45-N. Nevertheless, ONH-N was the simplest model. CONCLUSION： The new area partition models had higher diagnostic accuracy than corresponding traditional area partition models, which can improve the diagnostic ability of early POAG. In particular, the simplest ONH-N diagnostic model may be convenient for clinical application.

关键词： primary open angle glaucoma opticalcoherence tomography ethnic-specific database diagnostic model

A KIND OF SINGULAR PERTURBATION METHOD FOR SOLVING THE BOLTZMANN EQUATION WITH SMALL KNUDSEN NUMBER

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Chinese Physics Letters 1984年第1期1卷 31-34页

作者： DING E-jiang HUANG Zu-qia Low Energy Nuclear Physics Institute Beijing Normal University

A singular perturbation method is used to remove secular terms in Hilbert expansion and Enskog expansion of the normal solution and those in Grad expansion of the"initial layer"solution of Boltzmann equation(B.e.).Sol... 详细信息

关键词： equations. expansion algebraic

Association between FOXO3A gene polymorphisms and human longevity： a meta-analysis

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Asian Journal of Andrology 2014年第3期16卷 446-452页

作者： Ji-Ming Bao Xian-Lu Song Ying-qia.Hong Hai-li Zhu Cui li Tao Zhang Wei Chen Shan-cha. Zhao Qing Chen Department of Urology and Medical Center for Overseas Patients Nanfang HospitaIGuangzhou Department of Radiotherapy Cancer Center of Guangzhou Medical University Guangzhou Department of Pediatric Surgery The First Affiliated Hospital of Shantou University Medical College Shantou School of Basic Medical Sciences Southern Medical University Guangzhou Department of Epidemiology School of Public Health and Tropical Medicine Southern Medical University Guangzhou China.

Numerous studies have shown associations between the FOXO3A gene, encoding the forkhead box 03 transcription factor, and human or specifically male longevity. However, the associations of specific FOXO3A polymorphisms with longevity remain inconclusive. We performed a meta-analysis of existing studies to clarify these potential associations. A comprehensive search was conducted to identify studies of FOXO3A gene polymorphisms and longevity. Pooled odds ratios （ORs） and 95% confidence intervals （Cls） were calculated by comparing the minor and major alleles. A total of seven articles reporting associations of FOXO3A polymorphisms with longevity were identified and included in this meta-analysis. These comprised 11 independent studies with 5241 cases and 5724 controls from different ethnic groups, rs2802292, rs2764264, rs13217795, rs1935949 and rs2802288 polymorphisms were associated with human longevity （OR = 1.36, 95% Cl = 1.10-1.69, P= 0.005; OR = 1.20, 95% CI = 1.04-1.37, P= 0.01; OR = 1.27, 95% CI = 1.10-1.46, P= 0.001; OR = 1.14, 95% CI = 1.01-1.27 and OR = 1.24, 95% CI = 1.07-1.43, P= 0.003, respectively）. Analysis stratified by gender indicated significant associations between rs2802292, rs2764264 and rs13217795 and male longevity （OR = 1.54, 95% Cl = 1.33-1.79, P〈 0.001; OR = 1.38, 95% Cl = 1,15-1.66, P= 0.001; and OR = 1.39, 95% Cl = 1.15-1.67, P= 0.001）, but rs2802292, rs2764264 and rs1935949 were not linked to female longevity. Moreover, our study showed no association between rs2153960, rs7762395 or rs13220810 polymorphisms and longevity. In conclusion, this meta-analysis indicates a significant association of five FOXO3A gene polymorphisms with longevity, with the effects of rs2802292 and rs2764264 being male-specific, Further investigations are required to confirm these findings.

关键词： FOXO3A longevity meta-analysis polymorphism

Modified Dust-Acoustic Solitons by Adiabatic Variation of Dust cha.ges

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Chinese Physics Letters 1998年第12期15卷 892-894页

作者： XIE Bai-song HE Kai-fen HUANG Zu-qia Institute of Low Energy Nuclear Physics Beijing Normal UniversityBeijing 100875

By the multi-scale expansion method an effect of adiabatic variation of dust cha.ges on dust-acoustic soliton is *** is found that the amplitude of the soliton decreases while its width narrows in comparison with the ... 详细信息

关键词： soliton cha.ges narrow

Dust-Acoustic Solitons in Dusty Plasma with Two-Temperature Ions

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Chinese Physics Letters 2000年第11期17卷 815-817页

作者： XIE Bai-Song HE Kai-Fen HUANG Zu-qia Key Laboratory in University for Beam Technology and Materials Modification Beijing Normal UniversityBeijing 100875 Institute of Low Energy Nuclear Physics Beijing Normal UniversityBeijing 100875 Beijing Radiation Center Beijing 100875

Dust-acoustic solitons in dusty plasmas with two-temperature isothermal ions are investigated by considering an effect of self-consistent dust-cha.ge *** the reductive perturbation technique we derived dust-acoustic *** is found that both rarefactive and compressive solitons exist and the approximate similarity law which holds in dust-cha.ge-fluctuation plasma system with one-temperature ion does not survive in the present studied dusty plasma with two-temperature isothermal ions.

关键词： solitons holds perturbation

Stocha.tic coordinated operation of wind and battery energy storage system considering battery degradation

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Journal of Modern Power Systems and Clean Energy 2016年第4期4卷 581-592页

作者： Ying WANG Zhi ZHOU Audun BOTTERUD Kaifeng ZHANG qia.DING Key Laboratory of Measurement and Control of CSE School of AutomationSoutheast UniversityNanjing 210096China Argonne National Laboratory LemontIL 60439USA NARI Technology Co.Ltd. Nanjing 211106

Grid-scale battery energy storage systems(BESSs)are promising to solve multiple problems for future power *** to the limited lifespan and high cost of BESS,there is a cost-benefit trade-off between battery effort and operational ***,we develop a battery degradation model to accurately represent the battery degradation and related cost during battery operation and cycling.A linearization method is proposed to transform the developed battery degradation model into the mixed integer linear programming(MILP)optimization *** battery degradation model is incorporated with a hybrid deterministic/stocha.tic look-ahead rolling optimization model of windBESS bidding and operation in the real-time electricity *** results show that the developed battery degradation model is able to effectively help to extend the battery cycle life and make more profits for ***,the proposed rolling look-ahead operational optimization strategy can utilize the updated wind power forecast,thereby also increase the wind-BESS profit.

关键词： Wind power Battery energy storage system(BESS) Battery degradation Stocha.tic programming Rolling optimization

基于结构方程模型分析海洋环境因子对南海鸢乌贼的影响

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南方水产科学 2024年第2期20卷 11-18页

作者：廖祖军王学锋周艳波张磊吕少梁吴洽儿董建宇马胜伟广东海洋大学水产学院广东湛江524088 青岛海洋科学与技术试点国家实验室山东青岛266237 中国水产科学研究院南海水产研究所广东广州510300 农业农村部外海渔业开发重点实验室广东广州510300 上海海洋大学海洋文化与法律学院上海201306

为探究鸢乌贼(Sthenoteuthis oualaniensis)资源变化与海洋环境因子的关系,基于2019—2020年南海围网捕捞鸢乌贼的电子渔捞日志数据,首先分析了鸢乌贼资源的月间变动特征,之后利用结构方程模型解析海洋环境因子对其资源时空分布的影响... 详细信息

为探究鸢乌贼(Sthenoteuthis oualaniensis)资源变化与海洋环境因子的关系,基于2019—2020年南海围网捕捞鸢乌贼的电子渔捞日志数据,首先分析了鸢乌贼资源的月间变动特征,之后利用结构方程模型解析海洋环境因子对其资源时空分布的影响。结果表明:围网月间的平均单位捕捞努力量渔获量(Catch per unit effort,CPUE)变化趋势基本一致,年平均CPUE则为2020年大于2019年。南海鸢乌贼渔汛期为3—4月,高产区域集中在112°E—117°E、8°N—12°N,渔汛期CPUE呈现向东和向北偏移的趋势。海洋环境对鸢乌贼资源分布的综合影响系数为0.38,而海表盐度和光合有效辐射在海洋环境上的载荷量分别为0.87和0.82,两者是影响鸢乌贼资源分布的重要环境因子。所用结构方程模型为量化海洋环境因子与鸢乌贼资源分布之间的复杂关系提供了新的研究思路,可为鸢乌贼资源可持续利用和管理提供参考依据。

关键词：鸢乌贼电子渔捞日志结构方程模型海洋环境因子南海