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Intraperitoneal injection but not oral administration of ellagic acid: A novel immunomodulator via targeting casein kinase 2 signaling pathway

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Food Science and Human Wellness 2024年

作者： Wen-Hui Qi bing Han Ting-Ting Cui Pei-Xin Shen Zhuo-Hua Zhao Ya-Ping Yan li-bin wang Xin-Yu Lu Yuan Zhang Xing li Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University)， The Ministry of Education College of life Sciences， Shaanxi Normal University Department of Pharmacology， School of Pharmacy， Fourth Military Medical University The Nervous System Disease Diagnosis and Treatment Engineering Technology Research Center of Ningxia School of Medical Technology， Xi'an Medical University

Immunosuppressants currently approved for the treatment of autoimmune diseases and organ transplant rejection present diverse adverse effects that impair the life quality of patients. Therefore， the development of novel immunomodulators with high efficiency and low toxicity is essential. Ellagic acid (EA)， a natural polyphenol compound widely distributed in berries， is metabolically transformed by gut microbiome to exert systemic health benefits. Here， we identified that intraperitoneal administration of EA with no cytotoxicity， beyond its well-known oral metabolic fate， effectively decreased clinical severity and CNS inflammation/demyelination in experimental autoimmune encephalomyelitis (EAE)， a mouse model of an autoimmune disease multiple sclerosis (MS). Interestingly， intraperitoneal EA administration at incredibly low doses (0.1 mg/kg/d) is dose-sparing with fingolimod (FTY720)， the first FDA-approved oral drug for MS. In addition， intraperitoneal EA also ameliorated the brain damage in a neuromyelitis optica (NMO) model， and significantly prevented the immune rejection of allograft skin graft. Evidence from pharmacological studies combined with RNA-seq indicate that prototype EA functions by a mechanism that involves direct inhibition of casein kinase II (CKII) to suppress the expression of IL-17 and promote the expression of Cpt1a to regulate Th17 differentiation. In conclusion， our study demonstrates that the prototype EA entering the blood circulation acts as a novel therapeutic immunomodulator for the treatment of autoimmune diseases and transplant rejection through the CKⅡ-mediated JAK/STAT/Cpt1a signaling pathway.

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2001-2016年河南省平原区浅层地下水动态变化特征研究

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地下水 2024年第5期46卷 76-79+126页

作者：乐扬李王斌河南省地质局生态环境地质服务中心郑州大学综合设计研究院有限公司

河南省平原区20多年来地下水一直处于高强度开采状态，导致地下水位持续下降，地下水埋深不断加大，2011年以来，随着水资源条件、地下水取用水情况等因素的变化，以及南水北调中线工程河南省受水区和全省公共供水管网覆盖区地下水压采... 详细信息

河南省平原区20多年来地下水一直处于高强度开采状态，导致地下水位持续下降，地下水埋深不断加大，2011年以来，随着水资源条件、地下水取用水情况等因素的变化，以及南水北调中线工程河南省受水区和全省公共供水管网覆盖区地下水压采、超采区综合治理等工作的开展，平原区地下水的超采状况也发生了明显变化。选取监测数据较完整的浅层地下水监测站980处，选取时段为评价期(2001-2016年)及2017-2018年(为反映地下水的长序列变化趋势、南水北调工程和地下水压采工作的效果，进行了合理延长)。经统计分析，浅层地下水动态以下降趋势为主，平均下降速率0.057 m/a,最大下降速率1.297 m/a。

关键词：地下水动态变化对比分析

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MCS-based quantile value approach for reliability-based design of tunnel face support pressure

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Underground Space 2024年第5期18卷 187-198页

作者： bin li Changxing wang Hong li Department of Road and Bridge Engineering School of Transportation and Logistics EngineeringWuhan University of TechnologyWuhan 430063China Hubei Highway Engineering Research Center Wuhan 430063China

This paper develops a new approach for reliability-based design(RBD)of tunnel face support pressure from a quantile value perspective.A surrogate model is constructed to calculate the collapse pressures of the random samples generated by a single run of Monte Carlo simulation(MCS).The cumulative distribution function(CDF)of the collapse pressure is then obtained and the support pressure aiming at a target failure probability is chosen as the upper quantile value of the collapse *** proposed approach does not require repetitive reliability analyses compared to the existing ***,a direct relationship between the target failure probability and the required support pressure is *** illustrative example is used to demonstrate the implementation *** accuracy of the reliability-based support pressures is verified by direct MCS incorporating with three-dimensional numerical ***,the influencing factors,including the sample size of MCS,the correlation coefficient between random variables,the choice of experimental points,and the surrogate model,are *** method can play a complementary role to available approaches due to its advantages of simplicity and efficiency.

关键词： Tunnel face stability Support pressure Reliability-based design Response surface method Monte Carlo simulation

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Four-channel catalytic micro-reactor based on alumina hollow fiber membrane for efficient catalytic oxidation of CO

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Chinese Journal of Chemical Engineering 2024年第7期71卷 140-147页

作者： Baichuan Xu bin wang Tao li Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211100China

The traditional automotive catalytic converter using commercial ceramic honeycomb carriers has many problems such as high back pressure,low engine efficiency,and high usage of precious *** study proposes a four-channel catalytic micro-reactor based on alumina hollow fiber membrane,which uses phase inversion method for structural molding and *** to the advantages of its carrier,it can achieve lower ignition temperature under low noble metal *** Pd/CeO_(2) at a loading rate of 2.3%(mass),the result showed that the reaction ignition temperature is even less than 160℃,which is more than 90℃ lower than the data of commercial ceramic substrates under similar catalyst loading and airspeed *** technology in turn significantly reduces the energy consumption of the *** stability tests were conducted under constant conditions for 1000 h,which proved that this catalytic converter has high catalytic efficiency and stability,providing prospects for the design of innovative catalytic converters in the future.

关键词： Catalytic converter Precious metal catalyst Phase inversion method Hollow fiber membrane CO oxidation

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Radiofrequency ablation vs hepatic resection for solitary colorectal liver metastasis:A meta-analysis

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World Journal of Gastroenterology 2011年第36期17卷 4143-4148页

作者： Yun-Zi Wu bin li Tao wang Shuang-Jia wang Yan-Ming Zhou Department of Hepato-Biliary-Pancreato-Vascular Surgery the First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

AIM:To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for solitary colorectal liver metastases (CLM).METHODS:A literature search was performed to identify comparative studies reporting outcomes for both RFA and HR for solitary *** odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects ***:Seven nonrandomized controlled trials studies were included in this *** studies included a total of 847 patients:273 treated with RFA and 574 treated with *** 5 years overall survival rates in the HR group were significantly better than those in the RFA group (OR:0.41,95% CI:0.22-0.90,P=0.008).RFA had a higher rate of local intrahe-patic recurrence compared to HR (OR:4.89,95% CI:1.73-13.87,P=0.003).No differences were found between the two groups with respect to postoperative morbidity and ***:HR was superior to RFA in the treatment of patients with solitary ***,the findings have to be carefully interpreted due to the lower level of evidence.

关键词： Hepatic resection Colorectal liver metastases Radiofrequency ablation Efficacy Meta-analysis

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Function-reversible facets enabling SrTiO_(3)nanocrystals for improved photocatalytic hydrogen evolution

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Frontiers in Energy 2024年第1期18卷 101-109页

作者： bin wang Bei AN Xiaoqian li Shaohua SHEN School of Physics Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter(Ministry of Education)Key Laboratory of Shaanxi for Advanced Materials and Mesoscopic PhysicsXi’an Jiaotong UniversityXi’an 710049China International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

It has been widely reported that,for faceted nanocrystals,the two adjacent facets with different band levels contribute to promoted charge separation,and provide active sites for photocatalytic reduction and oxidation reaction,*** such cases,only one family of facets can be used for photocatalytic hydrogen ***,by using SrTiO_(3)nanocrystals enclosed by{023}and{001}facets as a model photocatalyst,this paper proposed a strategy to achieve the full-facets-utilization of the nanocrystals for photocatalytic hydrogen via chemically depositing Pt nanoparticles on all *** photo-deposition experiment of CdS provided direct evidence to demonstrate that the{023}facets which were responsible for photooxidation reaction can be function-reversed for photocatalytic hydrogen evolution after depositing Pt nanoparticles,together with the{001}***,the full-facets-utilization led to a much-improved activity for photocatalytic hydrogen,in contrast to those SrTiO_(3)nanocrystals with only{001}facets deposited by Pt nanoparticles via a photo-deposition method.

关键词： SrTiO_(3)nanocrystals crystal facets photocatalysis hydrogen evolution

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Effect of Al_(2)O_(3)fiber on twin intersections-induced dynamic recrystallization in fine-grained TiAl matrix composite

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Journal of Materials Science & Technology 2024年第5期172卷 1-14页

作者： Yaofeng Luo Yan wang li wang bin liu Yong liu State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Dynamic recrystallization(DRX)is of great significance for the thermomechanical processing and microstructural regulation of TiAl ***,the underlying DRX mechanism remains poorly *** this study,an Avrami kinetics model for DRX was established,which was capable of predicting the DRX fraction *** addition,the effect of Al_(2)O_(3)short fiber on the DRX mechanisms of TiAl matrix composite during the isothermal compression was investigated for the first *** re-sults showed that other than inhibiting DRX by particles in the TiAl matrix composites,the addition of Al_(2)O_(3)short fiber accelerated a novel DRX process,which was induced by twinning and twin intersec-tions(TDRX).Thus,this composite exhibited a higher DRX rate than that of the as-cast TiAl monolithic *** origin of the twin intersection and TDRX for the composite was *** stress concentration near the Al_(2)O_(3)fiber was above the critical shear stress for twinning and thus was favorable for the formation of twinning and twin *** high stored strain energy at the regions of twins and twin intersections provided the driving force for *** accelerated the grain refinement in the TiAl matrix near the Al_(2)O_(3)*** present findings would provide a new perspective on DRX mechanisms,and provide the scientific guidance for optimizing the microstructures of TiAl matrix composites.

关键词： TiAl matrix composite Al_(2)O_(3)fiber Twin intersection Dynamic recrystallization

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Vascular Damages in Rats Immunized by α_1-Adrenoceptor Peptides

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Cellular & Molecular Immunology 2008年第5期5卷 349-356页

作者： Zihua Zhou Yuhua liao liudong li Fen Wei bin wang Yumiao Wei Min wang Xiang Cheng Institute of Cardiology Union Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430022 China

Autoantibodies against the α1-adrenoceptor which had agonist activity as norepinephrine might play roles in the progression of hypertension, but whether the autoantibodies could induce vascular remodeling as norepinephrine is not clear. In this paper, the models with antibodies against the α1-adrenoceptor were made by immunizing Wistar rats with the synthesized the second extracellular loop of α1-adrenoceptor peptides. The homo-age male Wistar rats received BSA in the same immunizing manner and male spontaneous hypertensive rats （SHR） were used as control. All the rats were raised for one year. The blood pressure and morphological changes of arteries were measured. In the end, despite the systolic blood pressure of immunized rats had no difference with normal control, the media thickness of aortas and ratio of media to lumen in the third-order arteries of mesenteric vasculature were increased in immunized rats. The observation with electron microscope showed that the mitochondria of vascular smooth muscle cells （VSMCs） had notable hyperplasia, and the interstitial collagen fibril was increased too. The effects of purified antibodies against α1-adrenoceptor on the proliferation of cultured VSMCs, and the expressions of c-jun, c-fos and α1-adrenoceptor were detected. The results showed that the antibodies could promote the proliferation of cultured VSMCs, and enhance the expression of c-jun both in vitro and in vivo. So we concluded that antibodies against the α1-adrenoceptor could contribute to vascular damages in rats by stimulating the growth of VSMCs which might be caused by the increased c-jun expression, and might play particular roles in the pathological changes of hypertension.

关键词： α1-adrenoceptor autoantibody vascular remodeling

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Gene and protein expression profiles of olfactory ensheathing cells from olfactory bulb versus olfactory mucosa

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Neural Regeneration Research 2022年第2期17卷 440-449页

作者： Yuan-Xiang Lan Ping Yang Zhong Zeng Neeraj Yadav li-Jian Zhang li-bin wang He-Chun Xia School of Clinical Medicine Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Ningxia Human Stem Cell Institute General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Neurosurgery General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Clinical Laboratory Center General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina School of International Education Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Biochip Research Center General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina

Olfactory ensheathing cells(OECs) from the olfactory bulb(OB) and the olfactory mucosa(OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-derived OECs remains unclear. In this study, we extracted OECs from OB and OM and compared the gene and protein expression profiles of the cells using transcriptomics and non-quantitative proteomics techniques. The results revealed that both OB-derived OECs and OM-derived OECs highly expressed genes and proteins that regulate cell growth, proliferation, apoptosis and vascular endothelial cell regeneration. The differentially expressed genes and proteins of OB-derived OECs play a key role in regulation of nerve regeneration and axon regeneration and extension, transmission of nerve impulses and response to axon injury. The differentially expressed genes and proteins of OM-derived OECs mainly participate in the positive regulation of inflammatory response, defense response, cytokine binding, cell migration and wound healing. These findings suggest that differentially expressed genes and proteins may explain why OB-derived OECs and OM-derived OECs exhibit different therapeutic roles. This study was approved by the Animal Ethics Committee of the General Hospital of Ningxia Medical University(approval No. 2017-073) on February 13, 2017.

关键词： biological process cellular component gene Gene Ontology Kyoto Encyclopedia of Genes and Genomes molecular function olfactory bulb olfactory ensheathing cells olfactory mucosa protein

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Optics-driven drone

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Science China(Information Sciences) 2024年第2期67卷 322-324页

作者： Xuelong li Guan HUANG Zhigang wang bin ZHAO School of Artificial Intelligence OPtics and Electro Nics (iOPEN)Northwestern Polytechnical University Shanghai Artificial Intelligence Laboratory

In the field of vicinagearth security, low-altitude flying vehicles such as drones play an indispensable role in aerial remote sensing, intelligent search and rescue, etc. [1]. It can be foreseen that the autonomous and intelligent execution of complex tasks by drones is an inevitable trend for future development.

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