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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen li liu Fang-Zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-lin Wang Bin Chen De-Le liu Yun liu zheng-zheng li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

Particle Deposition in Oral-tracheal Airway Models with Very Low Inhalation Profiles

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Journal of Bionic Engineering 2012年第2期9卷 252-261页

作者： zheng li International Biomedical 8206 Cross Park Dr Austin TX 78754 USA

Considerable progress has been made on modeling particle deposition in the oral-tracheal airway under some normal breathing conditions, i.e., resting, light activity and moderate exercise. None of these standard breathing patterns correspond to very low inhalation profiles. It is known that particle deposition in the oral-tracheal airway is greatly influenced by flow and particle inlet conditions. In this work, very low inhalation flow rates are considered. Particle deposition is numerically investigated in different oral-tracheal airway models, i.e., circular, elliptic and realistic oral-tracheal airway models. Both micro- and nano-particles that are normally present in cigarette smoke are considered. Results show that inhalation profiles greatly influence the particle deposition. Due to relatively low flow rate, for ultra-fine particles, the oral deposition is enhanced due to longer residence time in oral cavity and stronger Brownian motion. However, for larger particles, less particles deposit in the oral-tracheal airway due to the weaker impaction. The transition happens when particle size changes from 0.01 μm to 0.1 μm. The influence of the limited entrance area is shown and discussed. Under the low inhalation profiles, the highest deposition fraction could be in either circular or realistic models depending on the particle property and the geometric characteristic of oral cavity. The knowledge obtained in this study may be beneficial for the design of bionic inhaler and understanding of health effect from smoke particle on human being.

关键词： particle deposition airway airflow CFD low inhalation profile

Sand particle dislodgement in windblown sand

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Acta Mechanica Sinica 2014年第6期30卷 910-916页

作者： Tian-li Bo zheng li Xiao-Jing zheng Key Laboratory of Mechanics on Western Disaster and Environment Lanzhou University Department of Mechanics Lanzhou University School of Electronical and Machanical Engineering Xidian University

The incipient motion of sand particle from sand bed plays a very important role in the prediction of windblown *** this paper,we proposed a new method for predicting the incipient motion of sand particle based on wind speed fluctuation as follows,when the wind speed is larger than the critical wind speed,if the total impulse on sand particle is larger than the critical impulse,incipient motion of sand particle would take place,otherwise if ***,from the analysis of entrainment in the rolling and lifting modes,we come to the following *** the average wind speed is smaller than the critical wind speed,if the average wind speed is used to judge the incipient motion of sand particle,one will underestimate the number of sand particles jumping from the bed,if the instantaneous wind speed is used to judge incipient motion of sand particle,one will overestimate the number of sand particles jumping from the bed;When the average wind speed is larger than the critical wind speed,either the average or the instantaneous wind speeds is used to judge the incipientmotion of sand particles,one will overestimate the number of sand particles jumping from the bed.

关键词： Incipient motion Rolling mode Average wind speed Total impulse Windblown sand

Okazaki fragment maturation:nucleases take centre stage

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Journal of Molecular Cell Biology 2011年第1期3卷 23-30页

作者： li zheng Binghui Shen Department of Cancer Biology City of Hope National Medical Center and Beckman Research InstituteDuarteCA 91010USA

Completion of lagging strand DNA synthesis requires processing of up to 50 million Okazaki fragments per cell cycle in mammalian *** in yeast,the Okazaki fragment maturation happens approximately a million times during a single round of DNA ***,efficient processing of Okazaki fragments is vital for DNA replication and cell *** this process,primase-synthesized RNA/DNA primers are removed,and Okazaki fragments are joined into an intact lagging strand *** processing of RNA/DNA primers requires a group of structure-specific nucleases typified by flap endonuclease 1(FEN1).Here,we sum-marize the distinct roles of these nucleases in different pathways for removal of RNA/DNA *** findings reveal that Okazaki fragment maturation is highly *** dynamic interactions of polymerase d,FEN1 and DNA ligase I with prolif-erating cell nuclear antigen allow these enzymes to act sequentially during Okazaki fragment *** protein–protein interactions may be regulated by post-translational *** also discuss studies using mutant mouse models that suggest two distinct cancer etiological mechanisms arising from defects in different steps of Okazaki fragment *** that affect the efficiency of RNA primer removal may result in accumulation of unligated nicks and DNA double-strand *** DNA strand breaks can cause varying forms of chromosome aberrations,contributing to development of cancer that associates with aneuploidy and gross chromosomal *** the other hand,mutations that impair editing out of polymerase a incorporation errors result in cancer displaying a strong mutator phenotype.

关键词： Okazaki fragment maturation FEN1 DNA2 PCNA RPA cancer

Quantum Decoherence of Macroscopic Object Induced by Inner Environments： an Exactly Solvable Model

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Communications in Theoretical Physics 2007年第2期47卷 229-234页

作者： zheng li zheng Tai-Yu College of Info Science and Engineering Dalian Institute of Light Industry Dalian 116034 China Institute of Theoretical Physics the Chinese Academy of Sciences Beijing 100080 China The Institute of Theoretical Physics Northeast Normal University Changchun 130022 China

We revisit the quantum decoherence problem of the center of mass motion of a macroscopic object, which is modelled as a one-dimensional atom chain. Induced by the coupling of the center of mass （C.M） motion with the inner degrees of freedom, this inner-environment-induced decoherence is reflected by the localization of the C.M wave packet. We show that, the C.M motion is coupled to the inner states only when the chain has interaction with the external potential. This result provides a realistic mechanism for the analysis of the inner-environment-induced localization of a macroscopic object.

关键词： quantum decoherence macroscopic object inner environments

Strain Multipoint Measurements Based on Chirped Bragg Grating Sensors

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稀有金属材料与工程 2006年第A3期35卷 607-610页

作者： li zheng Department of Physics and Electronics Huaiyin Teacher College Huaian 223001 China

In this paper,we propose the novel system of multipoint *** sensors of measurements are chirped Bragg grating and the interrogation of sensors is sub-carrier *** wavelength division multiplexing technique is used for addressing a network of FBG sensors and the time-division multiplexing technique is used for multipoint *** the system,the modulation frequency of 200 MHz is *** range of dectetion is from 0 to 900μεand the resolution is 12με. The time of the sensor response is about 1ns.

关键词： optical fiber sensor chirped grating WDM sub-carrier phase

Reconfigurable metamaterial for asymmetric and symmetric elastic wave absorption based on exceptional point in resonant bandgap

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Applied Mathematics and Mechanics(English Edition) 2023年第1期44卷 1-20页

作者： Jianlin YI zheng WU Rongyu XIA zheng li State Key Laboratory for Turbulence and Complex Systems College of EngineeringPeking UniversityBeijing 100871China

Elastic wave absorption at subwavelength scale is of significance in many engineering ***-Hermitian metamaterials show the ability in high-efficiency wave ***,the single functionality of metamaterials is an important limitation on their practical applications for lack of tunability and ***,we propose a tunable and reconfigurable non-Hermitian piezoelectric metamaterial bar,in which piezoelectric bars connect with resonant circuits,to achieve asymmetric unidirectional perfect absorption(UPA)and symmetric bidirectional perfect absorption(PA)at low *** two functions can be arbitrarily switched by rearranging shunted *** on the reverberation-ray matrix(RRM)method,an approach is provided to achieve UPA by setting an exceptional point(EP)in the coupled resonant *** using the transfer matrix method(TMM)and the finite element method(FEM),it is observed that a non-Hermitian pseudo-band forms between two resonant bandgaps,and the EP appears at the bottom of the *** addition,the genetic algorithm is used to accurately and efficiently design the shunted circuits for desired low-frequency UPA and *** present work may provide new strategies for vibration suppression and guided waves manipulation in wide potential applications.

关键词： non-Hermitian metamaterial exceptional point(EP) unidirectional perfect absorption(UPA) piezoelectric metamaterial reverberation-ray matrix(RRM)method genetic algorithm

Dynamic defenses in cyber security:Techniques,methods and challenges Author links open overlay panel

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Digital Communications and Networks 2022年第4期8卷 422-435页

作者： Yu zheng zheng li Xiaolong Xu Qingzhan Zhao School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044JiangsuChina Key Laboratory for Novel Software Technology Nanjing UniversityNanjing210023JiangsuChina College of Information Science and Technology Shihezi University Geospatial Information Engineering Research CenterChina

Driven by the rapid development of the Internet of Things,cloud computing and other emerging technologies,the connotation of cyberspace is constantly expanding and becoming the fifth dimension of human ***,security problems in cyberspace are becoming serious,and traditional defense measures(e.g.,firewall,intrusion detection systems,and security audits)often fall into a passive situation of being prone to attacks and difficult to take effect when responding to new types of network attacks with a higher and higher degree of coordination and *** constructing and implementing the diverse strategy of dynamic transformation,the configuration characteristics of systems are constantly changing,and the probability of vulnerability exposure is ***,the difficulty and cost of attack are increasing,which provides new ideas for reversing the asymmetric situation of defense and attack in ***,few related works systematically introduce dynamic defense mechanisms for cyber *** related concepts and development strategies of dynamic defense are rarely analyzed and *** bridge this gap,we conduct a comprehensive and concrete survey of recent research efforts on dynamic defense in cyber ***,we firstly introduce basic concepts and define dynamic defense in cyber ***,we review the architectures,enabling techniques and methods for moving target defense and mimic *** is followed by taxonomically summarizing the implementation and evaluation of dynamic ***,we discuss some open challenges and opportunities for dynamic defense in cyber security.

关键词： Cyber security Dynamic defense Moving target defense Mimic defense

Combining Neutron Scattering,Deuteration Technique,and Molecular Dynamics Simulations to Study Dynamics of Protein and Its Surface Water Molecules

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Chinese Journal of Polymer Science 2019年第11期37卷 1083-1091页

作者： li-Rong zheng liang Hong School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute of Natural Sciences Shanghai Jiao Tong University Shanghai 200240 China

Protein internal dynamics is essential for its function. Exploring the internal dynamics of protein molecules as well as its connection to protein structure and function is a central topic in biophysics. However, the atomic motions in protein molecules exhibit a great degree of complexities. These complexities arise from the complex chemical composition and superposition of different types of atomic motions on the similar time scales, and render it challenging to explicitly understand the microscopic mechanism governing protein motions, functions, and their connections. Here, we demonstrate that, by using neutron scattering, molecular dynamics simulation, and deuteration technique, one can address this challenge to a large extent.

关键词： Neutron scattering Deuteration techniques Molecular dynamics simulations Protein Hydration water Dynamics