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Management of solid renal tumour associated with von Hippel-lindau disease

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Chinese Medical Journal 2007年第22期120卷 2049-2052页

作者： ZHANG Jin HUANG Yi-ran liU Dong-ming ZHOU li-xin XUE Wei chen Qi DONG Bai-jun PAN Jia-hua XUAN Han-qing Department of Urology Renji Hospital Shanghai Jiaotong University Medical School Shanghai 200127 China

Von Hippel-lindau （VHL） disease is a rare autosomal dominant disorder caused by germ line mutations of the VHL tumour suppressor gene. it predisposes affected individuals to develop a variety of neoplasms, including haemangioblastomas of the central nervous system, retinal angiomas, renal cell carcinomas （RCCs）, pheochromocytomas and cysts of the kidneys and epididymis. Germ line VHL mutations have been found in all VHL disease families. RCC occurs in 25% to 45% of patients with VHL disease and is one of the leading causes of death.

关键词： Hippel-lindau disease germ line mutation renal cell carcinoma nephron -sparing surgery

Effects of Ti-based additives on Mg_2FeH_6 dehydrogenation properties

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Transactions of Nonferrous Metals Society of China 2016年第3期26卷 791-798页

作者：徐晨晨肖学章邵杰刘朗夏秦腾陈立新浙江大学材料科学与工程学院硅材料国家重点实验室浙江省电池新材料与应用技术研究重点实验室杭州310027

Mg2FeH6 doped with and without Ti and its alloys (TiMn2, TiAl) were prepared combing ball milling and heat treatment. The effects of these additives on the dehydrogenation performance of Mg2FeH6 were studied systematically. The results show that all additives have favor influence on improving the hydrogen desorption property of Mg2FeH6. Especially, TiMn2 exhibits prominent effect on enhancing the dehydrogenation kinetics of Mg2FeH6. Moreover, the activation energy of TiMn2-doped Mg2FeH6 calculated by Kissinger equation is 94.87 kJ/mol, which is 28 kJ/mol lower than that of the undoped Mg2FeH6. The cycling tests suggest that the improved dehydrogenation kinetics of Mg2FeH6 doped by TiMn2 can maintain in the second cycle.

关键词： Mg_2FeH_6 Ti-based additives dehydrogenation properties kinetics

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

供应商资金约束下双渠道供应链融资选择与定价策略——基于期望效用视角的分析

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商业研究 2017年第7期 24-33页

作者：李新军陈亭亭烟台大学经济管理学院山东烟台264005 大连理工大学经济与管理学部辽宁大连116024

随着互联网经济的发展,许多供应商利用互联网开辟了直销渠道,形成了双渠道供应链。本文假设一个供应商与一个零售商组成的双渠道供应链,外部需求随机,供应商面临资金约束而零售商资金充足,从期望效用的视角分别考察外部融资和内部融资... 详细信息

随着互联网经济的发展,许多供应商利用互联网开辟了直销渠道,形成了双渠道供应链。本文假设一个供应商与一个零售商组成的双渠道供应链,外部需求随机,供应商面临资金约束而零售商资金充足,从期望效用的视角分别考察外部融资和内部融资两种方下供应商和零售商的最优决策。研究结果表明,直销渠道的零售价会随着供应商风险厌恶程度的增大而降低,批发价根据两者之间的风险厌恶程度来确定,随供应商风险厌恶程度增大而降低,随零售商风险厌恶程度增大而提高,传统渠道的零售价随供应商和零售商的风险厌恶程度增大而降低。面临资金约束的供应商会优先选择零售商提前支付的融资方式,当供应链双方处于非风险厌恶型时最易达成无偿内部融资的"双赢"模式,但无论哪种融资方式都难以达到无资金约束下的最优期望效用。

关键词：资金约束提前支付银行借款双渠道供应链

离子抑制色谱法测定伊班膦酸钠原料药中的有关物质

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中国药房 2017年第30期28卷 4288-4291页

作者：李欣陈红张亿成都市食品药品检验研究院成都610045

目的:采用离子抑制色谱法测定伊班膦酸钠原料药中的有关物质。方法:色谱柱为Dionex IonPac AS11-HC,流动相为氢氧化钾溶液(梯度洗脱),流速为1.1 mL/min,柱温为45℃,进样量为20μL,检测器为抑制型电导检测器,检测器温度为35℃。结果:亚... 详细信息

目的:采用离子抑制色谱法测定伊班膦酸钠原料药中的有关物质。方法:色谱柱为Dionex IonPac AS11-HC,流动相为氢氧化钾溶液(梯度洗脱),流速为1.1 mL/min,柱温为45℃,进样量为20μL,检测器为抑制型电导检测器,检测器温度为35℃。结果:亚磷酸盐、杂质Ⅰ、磷酸盐检测质量浓度线性范围分别为3.08~30.83μg/mL(r=0.999 9)、2.84~28.43μg/mL(r=0.999 1)、2.95~29.52μg/mL(r=0.999 9);定量限分别为2.47、56.7、3.31 ng,检测限分别为0.75、17.2、1.0 ng;精密度、稳定性、重复性试验的RSD<4.0%;加样回收率分别为101.49%~103.57%(RSD=0.7%,n=9)、100.00%~104.85%(RSD=1.8%,n=9)、101.35%~104.08%(RSD=0.9%,n=9)。结论:该方法简便、准确、灵敏,适用于测定伊班膦酸钠原料药中的有关物质。

关键词：离子抑制色谱法伊班膦酸钠有关物质亚磷酸盐杂质Ⅰ 磷酸盐

室温硫化硅橡胶防污闪涂料有机固含量的测试方法研究

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绝缘材料 2017年第2期50卷 81-86页

作者：肖雨张翀李飞陈新全球能源互联网研究院先进输电技术国家重点实验室北京102211

为检测室温硫化硅橡胶防污闪涂料(RTV硅橡胶涂料)的基胶含量,即有机固含量,采用热失重分析、热传导分析、Fourier变换红外光谱分析、密度分析等方法,对实验室制备的RTV硅橡胶涂料样品进行检测,同时选取厂家实际产品进行验证。结果表明:... 详细信息

为检测室温硫化硅橡胶防污闪涂料(RTV硅橡胶涂料)的基胶含量,即有机固含量,采用热失重分析、热传导分析、Fourier变换红外光谱分析、密度分析等方法,对实验室制备的RTV硅橡胶涂料样品进行检测,同时选取厂家实际产品进行验证。结果表明:上述方法可以有效地检测RTV硅橡胶涂料中基胶和填料的含量比例,其中密度的测量简便易行,可以作为现场抽检的项目,为绝缘子用常温硫化硅橡胶防污闪涂料的入网前检测提供参考。

关键词：防污闪涂料室温硫化硅橡胶有机固含量测试方法

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-Jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Improved fast inra prediction algorithm of H.264/AVC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第S1期 101-105页

作者： liU Qiong, HU Rui-min, ZHU li, ZHANG xin-chen, HAN Zhen School of Computer, Wuhan University, Wuhan 430079, China TheKey Laboratory of Multimedia and Network Communications Engineering, Wuhan University, Wuhan 430079, China

With advanced prediction modes of intra prediction, intra coding of H.264/AVC offers significant coding gains compared with previous video coding standards. It uses an important tool called Lagrangian rate-distortion optimization (RDO) technique to decide the best coding mode for a block, but the computational burden is extremely high. In this paper, we proposed an improved fast intra prediction algorithm including block type selection and mode decision algorithm based on analysis of edge feature of a block. Our algorithm filters out unlikely block type and candidate modes to reduce the RDO calculations. Experimental results showed that the proposed algorithm can reduce the computation complexity of intra prediction from 52.90% to 56.31%, with 0.04 dB PSNR degradation and 2% increase of bit rate.

关键词： H.264 AVC Intra prediction Video coding

Human leukocyte antigen and donor-specific antibodies in liver transplantation

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World Journal of Gastroenterology 2025年第2期31卷 157-160页

作者： Qimudesiren Sha-Na chen li-Ren Qian School of Clinical Medicine Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Hematology International Mongolian Hospital of Inner MongoliaHohhot 010065Inner Mongolia Autonomous RegionChina Senior Department of Hematology The Fifth Medical Center of PLA General HospitalBeijing 100071China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

In this article,we comment on an article published in a recent issue of the World Journal of *** specifically focus on the roles of human leukocyte antigen(HLA)and donor-specific antibodies(DSAs)in pediatric liver transpl-antation(LT),as well as the relationship between immune rejection after LT and ***,LT remains the standard of care for pediatric patients with end-stage liver disease or severe acute liver ***,acute and chronic re-jection continues to be a significant cause of graft dysfunction and *** mismatch significantly reduces graft survival and increases the risk of acute *** them,D→R one-way mismatch at three loci was significantly related to graft-versus-host disease incidence after *** adverse impact of HLA-DSAs on LT recipients is already ***,the evaluation of HLA and DSA is crucial in pediatric LT.

关键词： liver transplantation Human leukocyte antigen Donor-specific antibodies De novo donor-specific antibody Antibody-mediated rejection