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时代农机 2017年第4期44卷 137-138页

作者：李欣忱邓华健西南大学资源环境学院重庆400715

随着城市的发展,城市生活污水污泥量也迅速增加,污泥合理处理已成为不可忽视的问题。目前,合理有效的污泥堆肥化处理已成为当下研究的热点。文章主要阐述了污泥处理现状、堆肥过程中的氮素变化过程与特征及N_2O排放的研究现状。

关键词：污泥堆肥氮素变化 N2O排放

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou Wei chen Aidong Wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo liu xin li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

Mathematical Modeling of Single Quantum Well Laser Diode

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Mathematical Modeling of Single Quantum Well Laser Diode

小柴胡汤对感染性乙肝病毒肝炎患者肝功能与HBV-DNA拷贝数的影响

亚太地区通信会议暨光电子通信会议

作者： ZHANG li, li xin, chen JianpingState Key Laboratory on Local Fiber-Optic Communication Networksand Advanced Optical Communication Systems, Shanghai Jiao Tong University1954 Hua-Shan Road, Shanghai 200030, P. R. China

Quantum wells are of high performance andwill be potentially an important light source forbroadband optical *** paper presents amathematical model for single quantum well laser diode(LD)with improved precision over th...

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中华医院感染学杂志 2018年第6期28卷 827-830页

作者：夏莉陈新瑜李小清杨浦娟刘华宝重庆市中医院肝病科重庆400021

目的探讨小柴胡汤对感染性乙肝病毒肝炎患者肝功能、HBV-DNA拷贝数的影响。方法选取2012年4月-2015年11月医院肝病科住院及门诊治疗的感染性乙肝病毒肝炎患者96例,分为对照组与试验组,各48例,对照组采用常规抗病毒、保肝降酶治疗;试验... 详细信息

目的探讨小柴胡汤对感染性乙肝病毒肝炎患者肝功能、HBV-DNA拷贝数的影响。方法选取2012年4月-2015年11月医院肝病科住院及门诊治疗的感染性乙肝病毒肝炎患者96例,分为对照组与试验组,各48例,对照组采用常规抗病毒、保肝降酶治疗;试验组在上述治疗上采用小柴胡汤加减治疗,两组持续治疗4周为一疗程,治疗前后测定患者肝功能、HBV-DNA拷贝数、肝纤维化及T淋巴细胞亚群等指标,同时对比临床疗效及不良反应状况。结果与治疗前比,两组治疗后血清AST、ALT、TBiL及HBV-DNA拷贝数降低,治疗后血清HA、ⅣC、PCⅢ及LN降低,治疗后血清CD_4^+、CD_4^+/CD_8^+升高,CD_8^+降低(P<0.05);与对照组比,试验组治疗后血清AST、ALT、TBiL及HBV-DNA拷贝数较低,治疗后血清HA、ⅣC、PCⅢ及LN较低,治疗后血清CD_4^+、CD_4^+/CD_8^+较高,CD_8^+较低(P<0.05);对照组应答率77.08%低于试验组应答率91.67%(P<0.05)。结论小柴胡汤加减有助于提高感染性乙肝病毒肝炎患者的治疗效果,显著改善肝功能,降低肝纤维化及HBV-DNA拷贝数,且安全性较为理想,可作为一种有效的治疗方案。

关键词：小柴胡汤感染性乙肝病毒肝炎肝功能肝纤维化 HBV-DNA拷贝数

覆膜支架治疗颈内动脉海绵窦段大型动脉瘤术后动眼神经麻痹1例

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介入放射学杂志 2017年第1期26卷 94-95页

作者：金戈张余李鑫陈亮杨涌涛李兴贵展群岭重庆市第五人民医院神经内科 400062 重庆市第五人民医院放射介入科 400062

临床资料患者女，49岁，因“反复发作性意识丧失3年”于2015年10月09日入院。既往3级高血压病病史6年，无动脉瘤家族史。入院体检：神志清楚，右利手，言语流利。脑神经检查未见明显异常，四肢肌力及肌张力均正常，脑膜刺激征阴性．余... 详细信息

临床资料患者女，49岁，因“反复发作性意识丧失3年”于2015年10月09日入院。既往3级高血压病病史6年，无动脉瘤家族史。入院体检：神志清楚，右利手，言语流利。脑神经检查未见明显异常，四肢肌力及肌张力均正常，脑膜刺激征阴性．余神经系统检查未见明确阳性体征。

关键词：覆膜支架大型颈内动脉瘤癫痫动眼神经麻痹

2D phosphides heterostructures on titanium microfiltration membrane for enhanced ampere-level current density overall seawater splitting

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Nano Research 2025年第1期18卷 249-259页

作者： Wenjing Dai xin Wang Yulong Ma Sisi He Ming chen Zhaohui Yin Shuheng Tian Maolin Wang Shixiang Yu Hang Zhang Yuanzhe Wang Hong Wang Jianxin li Faming Gao Bowen cheng Yun Wang Zhen Yin Ding Ma Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China Haian Institute of High-Tech Research Nanjing UniversityHaian 226600China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Separation Membranes and Membrane Processes Separation Membrane Science and Technology International Joint Research CentreTiangong UniversityTianjin 300387China Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversitySouthportQueensland 4222Australia

The advancement of direct seawater electrolysis is a significant step towards sustainable hydrogen production,addressing the critical need for renewable energy sources and efficient resource ***,direct seawater electrolysis has to face several challenges posed by the corrosiveness of highly concentrated chloride and the competitive chlorine evolution reaction(ClER).To overcome these issues,we designed a novel NiP_(2)@CoP electrocatalyst on a porous titanium microfiltration(Ti MF)*** obtained bifunctional NiP_(2)@CoP catalyst outperforms the Pt/C and IrO_(2),as evidenced by its low overpotentials of 192 and 425 mV at a current density of 500 mA·cm^(-2) for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alkaline seawater(1 M KOH+0.5 M NaCl),***,only 231 and 569 mV overpotentials are required at the current density of 1500 mA·cm^(-2) towards HER and OER in alkaline seawater,*** importantly,no ClER was observed,demonstrating its excellent selectivity to *** selection of porous Ti MF membrane as an electrode substrate further enhances the performance by providing a robust structure that promotes the fast generation and release of gas *** promising outcomes obtained with NiP_(2)@CoP catalysts on Ti MF support,therefore,pave the way for the commercial viability of direct seawater electrolysis technologies at industrial-level current densities.

关键词： direct seawater electrolysis porous titanium microfiltration membrane phosphides heterostructures NiP_(2)@CoP electrocatalyst excellent selectivity to oxygen evolution reaction(OER)

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie chen Jinyang chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin chen chengzhen liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

果糖胺联合白蛋白/球蛋白比值在IgA型多发性骨髓瘤诊断中的价值

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中国现代医学杂志 2017年第17期27卷 84-87页

作者：张靖宇范洪陈立新王丽芳张静河北省沧州中西医结合医院实验诊断科河北沧州061001

目的探讨果糖胺(FMN)联合白蛋白(ALB)/球蛋白(GLB)(A/G)比值在免疫球蛋白A(IgA)型多发性骨髓瘤(MM)诊断中的价值。方法选取IgA型MM患者(IgA型组)64例、免疫球蛋白G(Ig G)型MM患者(Ig G型组)70例、免疫球蛋白M(Ig M)型MM患者(Ig M型组)7... 详细信息

目的探讨果糖胺(FMN)联合白蛋白(ALB)/球蛋白(GLB)(A/G)比值在免疫球蛋白A(IgA)型多发性骨髓瘤(MM)诊断中的价值。方法选取IgA型MM患者(IgA型组)64例、免疫球蛋白G(Ig G)型MM患者(Ig G型组)70例、免疫球蛋白M(Ig M)型MM患者(Ig M型组)7例、自身免疫病患者(AID组)60例和健康体检者(对照组)50例。采用硝基四氮唑蓝比色法测定FMN,双缩脲法测定总蛋白(TP),溴甲酚绿法测定ALB,并计算A/G比值。所有纳入患者排除糖尿病。分析FMN与各检验指标的关系。采用受试者工作特征(ROC)曲线分析相关指标对IgA型MM的诊断价值。结果 IgA型组FMN与其他组比较,差异有统计学意义(P<0.05);直线相关分析表明,血清FMN与IgA型组的TP、GLB呈正相关(r=0.831和0.869,均P=0.000),与ALB、A/G呈负相关(r=-0.733和-0.716,均P=0.000);FMN、A/G单独及联合检测诊断IgA型MM的ROC曲线下面积分别为0.976、0.207和0.980。单独检测时FMN诊断的敏感性(98.4%)和特异性(74.9%)高于A/G(95.3%和44.4%),联合检测时可以提高诊断的特异性(90.9%),而敏感性(95.3%)未降低。结论 FMN可以作为诊断IgA型MM的参考指标之一。FMN联合A/G检测能提高诊断的特异性,同时仍具有较高敏感性,适合做IgA型MM的筛查。

关键词：果糖胺白蛋白/球蛋白比值免疫球蛋白A 多发性骨髓瘤

Multi-Stage-Based Siamese Neural Network for Seal Image Recognition

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 405-423页

作者： Jianfeng Lu Xiangye Huang Caijin li Renlin xin Shanqing Zhang Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and *** seal inspection is commonly audited manually to ensure document ***,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the *** image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image ***,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp ***,the fixed training data categories make handling new categories to be a challenging *** paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these ***,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese ***,we compare the results with the pre-stored standard seal template images in the database to obtain the seal *** evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in *** proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation ***,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets.

关键词： Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network