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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Ultrasound features of congenital cytomegalovirus infection in the first trimester:A case report

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World Journal of Clinical Cases 2025年第5期13卷 30-35页

作者： Xiao-li chen li-Qiang Zhang li-li Bai Department of Ultrasound Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental *** majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening *** SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal *** ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV *** karyotyping and microarray analysis of the fetus yielded no significant *** compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her *** ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female *** five months of age,the infant presented with epilepsy and significant growth and developmental *** Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal *** research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.

关键词： Prenatal diagnosis Congenital infection Cytomegalovirus Fetal ultrasound Case report

Generalized Projective Synchronization Between Rssler System and New Unified Chaotic System

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Communications in Theoretical Physics 2007年第7期 132-136页

作者： li xin chen Yong1 Nonlinear Science Center and Department of Mathematics,Ningbo University,Ningbo 315211,China2 Institute of Theoretical Computing,East China Normal University,Shanghai 200062,China3 Key Laboratory of Mathematics and Mechanization,the Chinese Academy of Sciences,Beijing 100080,China

Based on symbolic computation system Maple and Lyapunov stability theory,an active control method isused to projectively synchronize two different chaotic systems—Lorenz-chen-Lü system(LCL)and Rssler system,which belong to different dynamic *** this paper,we achieve generalized projective synchronization between thetwo different chaotic systems by directing the scaling factor onto the desired value *** illustrate our result,numerical simulations are used to perform the process of the synchronization and successfully put the orbits of drivesystem(LCL)and orbits of the response system(Rssler system)in the same plot for understanding intuitively.

关键词： Rssler system Lorenz-chen-Lü system generalized projective synchronization scaling factor active control

Enhanced dehydrogenation performances and mechanism of liBH_4/Mg_(17)Al_(12)-hydride composite

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Transactions of Nonferrous Metals Society of China 2014年第1期24卷 152-157页

作者：韩乐园肖学章范修林李芸李寿权葛红卫王启东陈立新浙江大学材料科学与工程学系浙江省电池新材料与应用技术研究重点实验室杭州310027

Mg17Al12-hydride （abbreviated as MAH） was selected as a destabilization agent to improve de/rehydrogenation properties of liBH4. 58liBH4＋Mg17Al12-hydride composite was prepared by ball-milling. It is found that the dehydrogenation of ball-milled liBH4/MAH composite presents a two-step reaction for hydrogen release. The composite starts desorbing hydrogen at about 300 ℃ and yields 9.8%of hydrogen （mass fraction） below 500 ℃. By adding MAH, the dehydrogenation kinetics of liBH4 is improved and the dehydrogenation temperature of liBH4 is also lowered by 20 ℃. High rehydriding capacity of 8.3% was obtained for the dehydrogenated composite in the first cycle at 450 ℃. The XRD analysis shows the formation of MgB2 and AlB2 in the dehydrogenation process, which reduces the thermodynamics stability of liBH4 system and is beneficial to the reversible hydrogen storage behaviors of liBH4/MAH composite.

关键词： complex hydride de/rehydrogenation behaviors reversibility

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轮转药师拓展药学服务的实践与思考

药品评价 2016年第6期13卷 58-61页

作者：李新辰刘静首都医科大学附属北京天坛医院药学部北京100050

药学服务是医院药学发展和实践的重要部分,药师是药学服务的实践者。然而对于初涉医院药学工作的处于轮转阶段的年轻药师,如何在岗位工作中自发的开展药学服务的工作,并在不同方面实现药师个人价值与药师职业价值,是这一群体关注的重要... 详细信息

药学服务是医院药学发展和实践的重要部分,药师是药学服务的实践者。然而对于初涉医院药学工作的处于轮转阶段的年轻药师,如何在岗位工作中自发的开展药学服务的工作,并在不同方面实现药师个人价值与药师职业价值,是这一群体关注的重要问题。本文根据笔者初涉药学工作岗位期间开展的工作实例,结合自身思考探讨上述问题,为处在相似发展阶段药师提供参考。

关键词：医嘱干预系统专项整改微信平台实践思考

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng li Bo-Fan chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang Lei li Yawei li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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基于像素——仿真法评估子母弹效能

系统仿真学报 2004年第3期16卷 474-476页

作者：陈立新陈万春殷兴良北京航空航天大学北京100083 中国航天科工集团北京100830

基于作者提出的像素——仿真法,利用统计试验法及计算机图形技术,简化了子母弹效能评估中计算子母弹毁伤幅员的算法,回避了计算子弹毁伤幅员重叠面积的数学难题。经使用证明,像素——仿真法计算简便,精度可靠,应用广泛,并已经发展成为... 详细信息

基于作者提出的像素——仿真法,利用统计试验法及计算机图形技术,简化了子母弹效能评估中计算子母弹毁伤幅员的算法,回避了计算子弹毁伤幅员重叠面积的数学难题。经使用证明,像素——仿真法计算简便,精度可靠,应用广泛,并已经发展成为一种计算有重叠毁伤幅员的通用方法。

关键词：像素仿真子母弹效能评估