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Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize

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Molecular Plant 2020年第11期13卷 1624-1643页

作者： Taotao Zhu Ziwen li Xueli An Yan Long Xiaofeng Xue Ke xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou lina Zhao Suowei Wu Jinping li Weiwei Jin Xiangyuan Wan Zhongzhi International Institute of Agricultural Biosciences Biology and Agriculture Research Center of USTBUniversity of Science and Technology Beijing(USTB)Beijing 100024China Beijing Engineering Laboratory of Main Crop Bio-Tech Breeding Beijing International Science and Technology Cooperation Base of Bio-Tech BreedingBeijing Solidwill Sci-Tech Co.Ltd.Beijing 100192China Risk Assessment Laboratory for Bee Products Quality and Safety of Ministry of Agriculture Institute of Apicultural ResearchChinese Academy of Agricultural SciencesBeijing 100093China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterKey Laboratory of Biology and Genetic Improvement of Maize(MOA)Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China

Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed *** GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther *** this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic *** found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther ***33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late *** in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate *** of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch *** analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP *** energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant *** together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic

关键词： ZmMs33/ZmGPAT6 chloroplast SnRK1 autophagy anther development maize

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A Study on HSV-1 Corneal Potential Infection by in Situ Nucleic Acid Hybridization

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眼科学报 1995年第3期11卷 117-119页

作者： Shaowei li, lixin xie, Xiaoguang DongInstitute of Ophthalmology & Eye Hospital,Shandong Academy of Medical Sciences, Qingdao 266071, China Institute of Ophthalmology Shandong Academy of Medical Sciences Qingdao China.

Purpose:To evaluate the possibility of HSV-1 corneal latency by in situ nucleic acid hybridization in animal ***:20 normal New Zealand White(NEW)rabbits were used,14of them were inoculated bilaterally with 3×10PFU/ml of McKrae strain HSV-1by in-trastromal injection,22/28eyes developed typical herpes simplex keratitis(HSK) *** 60day postoperation(PI),4latent corneas were transplanted to one eye of 4noninfected NZW rabbits and removed2weeks PI,Corneas at all time intervals of infection and two weeks after PKPwere detected for presence of HSV-1antigen and nucleic acid sequences by using clonal IgGHSV-1antibody and biotinylated HSV-1DNAprobe ***:The results showed that the HSV-1DNA sequences were retained with-in the corneal epithelium and anterior stromal keratocytes during acute diseases,while the corneas during latent infection and postoperation,the HSV-1DNAse-quences were retained only within the stromal layer with negative HSV-1antigne ***:These results strongly suggest that the cornea may be capable of harburing latent *** Science 1995;11:117-119.

关键词：角膜 HSV-1 核酸潜伏感染动物模型

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Single-cell transcriptome atlas reveals spatiotemporal developmental trajectories in the basal roots of moso bamboo (Phyllostachys edulis)

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Horticulture Research 2023年第8期10卷 59-71页

作者： Zhanchao Cheng Changhong Mu Xiangyu li Wenlong Cheng Miaomiao Cai Chongyang Wu Jutang Jiang Hui Fang Yucong Bai Huifang Zheng Ruiman Geng Junlei Xu Yali xie Yuping Dou Juan li Shaohua Mu Jian Gao Key Laboratory of National Forestry and Grassland Administration/Beijing for Bamboo&Rattan Science and Technology International Center for Bamboo and RattanBeijing 100102China

Roots are essential for plant growth and *** is a large Poaceae perennial with 1642 species ***,little is known about the transcriptional atlas that underpins root cell-type ***,we set up a modified protocol for protoplast preparation and report single-cell transcriptomes of 14279 filtered single cells derived from the basal root tips of moso *** identified four cell types and defined new cell-type-specific marker genes for the basal *** reconstructed the developmental trajectories of the root cap,epidermis,and ground tissues and elucidated critical factors regulating cell fate *** to in situ hybridization and pseudotime trajectory analysis,the root cap and epidermis originated from a common initial cell lineage,revealing the particularity of bamboo basal root *** further identified key regulatory factors for the differentiation of these cells and indicated divergent root developmental pathways between moso bamboo and ***,PheWOX13a and PheWOX13b ectopically expressed in Arabidopsis inhibited primary root and lateral root growth and regulated the growth and development of the root cap,which was different from WOX13 orthologs in *** together,our results offer an important resource for investigating the mechanism of root cell differentiation and root system architecture in perennial woody species of Bambusoideae.

关键词： inhibited roots bamboo

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No association exists between E-cadherin gene polymorphism and tumor recurrence in patients with hepatocellular carcinoma after transplantation

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Hepatobiliary & Pancreatic Diseases International 2007年第3期6卷 254-258页

作者： li, Xiao-Dong Wu, li-Ming xie, Hai-Yang Xu, Xiao Zhou, lin liang, Ting-Bo Wang, Wei-lin Shen, Yan Zhang, Min Zheng, Shu-Sen Zhejiang Univ Affiliated Hosp 1 Minist Publ Hlth Key Lab Combined Multiorgan TransplantatSch Med Hangzhou 310003 Peoples R China Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Hepatobiliary & Pancreat Surg Hangzhou 310003 Peoples R China Zhejiang Univ Affiliated Hosp 1 Sch Med Key Lab Organ Transplantat Zhejiang Prov Hangzhou 310003 Peoples R China

BACKGROUND: E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in liver cancer is associated with poor prognosis. A -160 C -> A polymorphism in the promoter region of E-cadherin has been reported to decrease gene transcription. This allelic variation may be a potential genetic marker for identifying those individuals at higher risk for invasive/metastatic disease. METHODS: The effect of E-cadherin gene polymorphism on risk of tumor recurrence was studied in 93 patients with hepatocellular carcinoma (HCC) after liver transplantation, and determined whether this polymorphism is a biomarker for the risk of tumor recurrence. RESULTS: The genotype frequencies in the patients with recurrence were C/C: 0.667, C/A: 0.311, and A/A: 0.022, and in-the patients without recurrence C/C: 0.604, C/A: 0.271 and A/A: 0.125. No significant difference was found between the two groups (P = 0.171). Between -160 C -> A polymorphism and the clinicopathological data, there were no statistically significant differences in the distribution of the parameters as to age, gender, portal vein tumor thrombi, preoperative alpha-fetoprotein level, tumor size, or histopathological grading (P > 0.05). CONCLUSION: The results of this study show no association exists between the E-cadherin genotype and the risk of tumor recurrence in Chinese patients with HCC.

关键词： E-cadherin single nucleotide polymorphism liver transplantation carcinoma hepatocellular

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Science China(life Sciences) 2021年第1期64卷 96-106页

作者： Zhijun Zhang Hongxing Zhang Chun-Ming xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun li Bi Wang Yongfeng Yang Xianrui li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff Department of Neurology of Affiliated Zhongda Hospital Institute of Neuropsychiatry and Medical School of Southeast UniversityNanjing210009China Department of Psychology of Xinxiang Medical University Xinxiang453003China Second Affiliated Hospital of Xinxiang Medical University Xinxiang453002China Deaprtment of Biostatistics School of Public HealthNanjing Medical UniversityNanjing211166China Shanghai Mental Health Center Shanghai Jiaotong University School of MedicineShanghai200030China Mental Health Center and 7th Hospital Zhejiang University School of MedicineHangzhou310013China Royal Ottawa Mental Health Centre University of Ottawa Institute of Mental Health ResearchOttawaONK1Z 7K4Canada

To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD *** rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five *** outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four *** was measured at days 0 *** individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good *** in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized *** reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized *** demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.

关键词： major depressive disorder visual cortex functional magnetic resonance imaging repetitive transcranial magnetic stimulation neuronavigated individualized treatment

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Novel frameshift mutation in the AHDC1 gene in a Chinese global developmental delay patient:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7517-7522页

作者： Shuang-Zhu lin Hong-Yan xie Yan-Lai Qu Wen Gao Wan-Qi Wang Jia-Yi li Xiao-Chun Feng Chun-Quan Jin Diagnosis and Treatment Center for Children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band 1p36.11,contains five noncoding 5 exons,a single 4.9-kb coding exon,and a noncoding 3 *** SUMMARY In this case report,we diagnosed and treated a 6-mo-old girl with *** primary clinical symptoms included global developmental delay,hypotonia,and mild dysmorphic *** high-throughput whole-exosome sequencing to sequence the patient and her parents,and the results showed a novel frameshift mutation of c.1155dupG(***386Alafs*3)in the AHDC1 *** paternal gene was wild *** This report extends the mutation spectrum of the AHDC1 gene to provide the diagnostic basis for genetic counseling in families with XGS.

关键词： Xia-Gibbs syndrome AT-Hook DNA-binding motif-containing protein 1 Children Global developmental delay Case report

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A Harmonic-Voltage Suppression Strategy for DFIG-based Wind Turbines in the Islanded Mode

A Harmonic-Voltage Suppression Strategy for DFIG-based Wind ...

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第37届中国控制会议

作者： li Zeyu xie Zhen School of Electrical Engineering and Automation Hefei University of Technology

When doubly-fed induction generator（DFIG）-based wind turbines operate in the islanded mode, nonlinear loads may cause voltage distortion at stator side. A control method that can improve the quality of stator voltage is proposed in this *** of all, the mathematics model of DFIG is established in the fundamental frequency synchronous reference frame. Then, the proportion integration resonance PIR controller is designed for rotor side converter RSC to suppress the 5 thand 7 thharmonic components of stator voltage. Finally, the simulation results validate the effectiveness and advantages of the proposed control strategy.

关键词： doubly-fed induction generator(DFIG) islanded mode nonlinear loads harmonic-voltage suppression proportion integration resonance(PIR)

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中国地震烈度表中物理标准取值研究与建议

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哈尔滨工业大学学报 2006年第7期38卷 1041-1044页

作者：郝敏谢礼立哈尔滨工业大学土木工程学院哈尔滨150090

通过比较基于中国烈度表绘制的集集地震烈度等震线、地震动峰值加速度和峰值速度等值线的相似度,发现中国烈度表中的这两个地震动峰值参数对应于7、8、9度区的数值范围偏低．后参照烈度等震线从视觉上找出与它最相似的PGA、PGV等值线,... 详细信息

通过比较基于中国烈度表绘制的集集地震烈度等震线、地震动峰值加速度和峰值速度等值线的相似度,发现中国烈度表中的这两个地震动峰值参数对应于7、8、9度区的数值范围偏低．后参照烈度等震线从视觉上找出与它最相似的PGA、PGV等值线,通过数字化比较和描述统计分析发现,新的地震动峰值参数等值线较基于中国烈度表物理标准取值范围而绘制的等值线与烈度等震线更为相似．由此得出了研究建议的对应于中国烈度表中7、8、9、10度区的PGA和PGV取值范围,其中7、8、9度区的参数值需要提高以保障抗震设计的安全性．

关键词：烈度等震线 PGA等值线:PGV等值线烈度物理标准

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Effects of Oxides Contents in Vanadium Slag on Corrosion Mechanism of MgO-C Bricks

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Journal of Iron and Steel Research International 2012年第10期19卷 36-42页

作者： WANG Guang-en, WANG Yu, xie Bing, li Xin-sheng, GUO Xu, li Xiao-jun (Chongqing Key Laboratory of Metallurgy Engineering, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China) Chongqing Key Laboratory of Metallurgy Engineering College of Materials Science and Engineering Chongqing University Chongqing China

The influence of V2O3, FeO, TiO2, MnO and MgO in vanadium slag on the corrosion mechanism of MgO-C bricks was studied by stationary immersion tests at vanadium-extracting temperature. Experimental results show that FeO, TiO2, and MnO could enhance the corrosion rate and V2O3 and MgO could decrease it. Microstructure and phase composition of worn samples were investigated by SEM-EDS, revealing the presence of Fe particles, produced by graphite reduction, and (Mg,Fe,Mn)O solid solution at the interface. The formation process of (Mg,Fe,Mn)O solid solution was discussed and the corrosion mechnism of MgO-C bricks was thus proposed.

关键词： MgO-C brick vanadium slag (Mg,Fe,Mn)O solid solution corrosion

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Effects of Low-dose and High-dose Rifaximin in the Treatment of Covert Hepatic Encephalopathy

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1099-1106页

作者： Wei Tan Jian Wang Pei-Mei Shi ling-Mei Feng Jian Shi Bei-Fang Ning Zong-li Yuan Xin Zeng Wei-Fen xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastro-enterology Shanghai East HospitalTongji University School of MedicineShanghaiChina

Background and Aims:Rifaximin is effective in prevent-ing and treating hepatic encephalopathy(HE).This study aimed to investigate the efficacy and safety of different dosages of rifaximin in the treatment of cirrhotic patients with covert HE(CHE).Methods:In this single-center,ran-domized,controlled,open-label study,CHE was diagnosed using a combination of the psychometric HE score and the EncephalApp Stroop *** patients with CHE were recruited and randomly assigned to low-dose rifaximin 800 mg/day,high-dose rifaximin(1,200 mg/day),and control groups,and were treated for 8 *** sickness impact profile(SIP)scale was used to evaluate the health-relat-ed quality of life(HRQOL)of *** patients were included in the study,12 were assigned to the low-dose group,14 to the high-dose group,and 14 patients to the control ***:The percentage of patients with CHE reversal was significantly higher in both the low-dose(41.67%,5/12)and high-dose(57.14%,8/14)groups than in the control group(7.14%,1/14)at 8 weeks(p=0.037 and p=0.005,respectively).In addition,both doses of ri-faximin resulted in significant improvement of the total SIP score compared with the control *** were no sig-nificant differences in the CHE reversal rate,total SIP score improvement,and incidence of adverse event between the low-dose and high-dose groups(p>0.05).Conclusions:Low-dose rifaximin reverses CHE and improves HRQOL in cirrhotic patients with comparable effects and safety to high-dose rifaximin.

关键词： Single-center open-label study Randomized prospective study liver cirrhosis Covert hepatic encephalopathy Rifaximin

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