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Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： li-lin Luo Yang lin Jun-Hong linghu Wei Gong Yuan-Hong Luo Man liu Dao-Chao Jin Guy Smagghe Tong-Xian liu Shun-Hua Gui Tian-Ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12 neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics

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Nanotechnology-based delivery systems to overcome drug resistance in cancer

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Medical Review 2024年第1期4卷 5-30页

作者： Harsh Patel Jiaxin li Letao Bo Riddhi Mehta Charles R.Ashby Shanzhi Wang Wei Cai Zhe-Sheng Chen College of Pharmacy and Health Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineHuaihuaHunan ProvinceChina St.John’s College of liberal Arts and Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineNo.492 Jinxi South RoadHuaihua41800Hunan ProvinceChina College of Pharmacy and Health Sciences St.John’s UniversityNo.8000 Utopia ParkwayQueensNew YorkNY 11439USA

Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional *** resistance(MDR)in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic *** have been successes in the development of cancer nanomedicine to overcome MDR;however,relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of *** is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer ***,we discuss the advances,types of nanomedicines,and the challenges regarding the translation of in vitro to in vivo results and their relevance to effective therapies.

关键词： nanotechnology multidrug resistance drug delivery systems nanoformulations enhanced permeability and retention effect

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Mitochondrial GRIM19 Loss Induces liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-κB Signaling

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 539-550页

作者： Xiaohui Xu Jinmei Feng Xin Wang Xin Zeng Ying Luo Xinyu He Meihua Yang Tiewei Lv Zijuan Feng liming Bao li Zhao Daochao Huang Yi Huang Institute of Pediatrics Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Pediatric Metabolism and Inflammatory DiseasesChongqingChina Department of Cardiology Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Key Cardiovascular SpecialtyLaboratory of Children’s Important Organ Development and Diseases of Chongqing Municipal Health CommissionChongqingChina Department of Laboratory Medicine Chongqing Western HospitalChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases Ministry of EducationInstitute for Viral HepatitisChongqing Medical UniversityChongqingChina Department of Laboratory Medicine The Third People’s Hospital of ChengduChengduSichuanChina Departments of Neurology Epilepsy CenterBarnes-Jewish Hospital and Washington University School of MedicineSt.LouisMOUSA Department of Clinical Pathology and Laboratory Medicine Weill Cornell Medical College of Cornell UniversityNew YorkNYUSA Departments of Medicine(Oncology) Washington University School of MedicineSt.LouisMOUSA

Background and Aims:Hepatic fibrosis(HF)is a critical step in the progression of hepatocellular carcinoma(HCC).Gene associated with retinoid-IFN-induced mortality 19(GRIM19),an essential component of mitochondrial respiratory chain complex I,is frequently attenuated in various human cancers,including ***,we aimed to investigate the potential relationship and underlying mechanism between GRIM19 loss and HF ***:GRIM19 expression was evaluated in normal liver tissues,hepatitis,hepatic cirrhosis,and HCC using human liver disease spectrum tissue *** studied hepatocyte-specific GRIM19 knockout mice and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein-9(Cas9)lentivirus-mediated GRIM19 gene-editing in murine hepatocyte AML12 cells in vitro and in *** performed flow cytometry,immunofluorescence,immunohistochemistry,western blotting,and pharmacological intervention to uncover the potential mechanisms underlying GRIM19 loss-induced ***:Mitochondrial GRIM19 was progressively downregulated in chronic liver disease tissues,including hepatitis,cirrhosis,and HCC ***-specific GRIM19 heterozygous deletion induced spontaneous hepatitis and subsequent liver fibrogenesis in *** addition,GRIM19 loss caused chronic liver injury through reactive oxygen species(ROS)-mediated oxidative stress,resulting in aberrant NF-κB activation via an IKK/IKB partner in ***-more,GRIM19 loss activated NLRP3-mediated IL33 signaling administration of the NLRP3 inhibitor MCC950 dramatically via the ROS/NF-κB pathway in *** alleviated GRIM19 loss-driven HF in ***:The mitochondrial GRIM19 loss facilitates liver fibrosis through NLRP3/IL33 activation via ROS/NF-κB signaling,providing potential therapeutic approaches for earlier HF prevention.

关键词： liver fibrosis GRIM19 Reactive Oxygen Species NF-κB NLRP3 inflammasome IL33.

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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi Tang Sihui Su Sainan Wang Chenxi liao Xuecong li Jiabin liao Dongsheng Yu Tingting Ai Wei Zhao Vicky Yau Chufeng liu liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

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“Steric Armor”Strategy of Blue Fluorescent Emitters against Photooxidation-Induced Degradation

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Chinese Journal of Chemistry 2024年第11期42卷 1223-1229页

作者： Sha-Sha Wang Jing-Rui Zhang Kuan-De Wang Hao-Ran li Peng-Hui Meng Yang Zhou Xiang Yu Ying Wei Quan-You Feng Yu-He Kan ling-Hai Xie Centre for Molecular Systems and Organic Devices(CMSOD) State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjingJiangsu210023 China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials School of Chemistry and Chemical EngineeringHuaiyin Normal UniversityHuai'anJiangsu223300 China

Stability against oxygen is an important factor affecting the performance of organic semiconductor *** photooxidation stability can prolong the service life of the device and maintain the mechanical and photoelectric properties of the ***,various encapsulation methods from molecular structure to macroscopic device level are used to improve photooxidation ***,we adopted a crystallization strategy to allow 14H-spiro[dibenzo[c,h]acridine-7,9′-fluorene](SFDBA)to pack tightly to resist fluorescence decay caused by *** this case,the inert group of SFDBA acts as a“steric armor”,protecting the photosensitive group from being attacked by ***,compared with the fluorescence quenching of SFDBA powder under 2 h of sunlight,SFDBA crystal can maintain its fluorescence emission for more than 8 h under the same ***,the photoluminescence quantum yields(PLQYs)of the crystalline film is 327%higher than that of the amorphous *** shows that the crystallization strategy is an effective method to resist oxidation.

关键词： Organic semiconductor Photooxidation Spirocyclic aromatic hydrocarbons Crystal engineering Fluorescence

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Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World Journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren li-Chao Qian Xiao-Jing Lv Ying-Ying Cao Marcus J Daniels Zhong-Qiu Wang li-Na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,Plightly larger size(5.41 cm vs 3.90 cm,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

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高频燃烧-红外吸收光谱法测定土壤和水系沉积物中总有机碳和有机质的含量

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理化检验（化学分册） 2024年第5期60卷 449-454页

作者：耶曼李田义李小桂李湘西安西北有色地质研究院有限公司西安710054

传统重铬酸钾容量法已难以满足测定批量土壤样品中总有机碳和有机质的绿色环保要求,为有效提高检测效率,达到少用或不用有毒、有害试剂的目标,提出了题示方法。取0.050 0 g样品(已于105℃烘2 h)于陶瓷坩埚(已于1 000℃灼烧4 h)中,置于8... 详细信息

传统重铬酸钾容量法已难以满足测定批量土壤样品中总有机碳和有机质的绿色环保要求,为有效提高检测效率,达到少用或不用有毒、有害试剂的目标,提出了题示方法。取0.050 0 g样品(已于105℃烘2 h)于陶瓷坩埚(已于1 000℃灼烧4 h)中,置于85℃恒温电热板上,滴加体积比1∶5的盐酸-水混合溶液,直至溶液停止冒泡,蒸干后于105℃恒温干燥箱中烘烤2~3 h,取出,加入0.4 g纯铁助熔剂和1.5 g纯钨助熔剂,选择高碳池分析气路,分析时间为30 s,采用高频燃烧-红外吸收光谱法测定其中总有机碳和有机质的含量。结果表明,总有机碳的检出限(3s)为0.012%,有机质的检出限(3s)为0.021%。测定了6种标准物质中总有机碳,测定值的相对标准偏差(n=12)小于5.0%,与认定值基本一致。方法用于分析20个实际样品,测定结果与ny/T 1121.6-2006中传统重铬酸钾容量法进行对比,结果表明两种方法的测定结果具有较好的一致性。

关键词：总有机碳有机质高频燃烧-红外吸收光谱法土壤水系沉积物

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面向云存储的属性基双边访问控制方案

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通信学报 2024年第4期45卷 128-136页

作者：李琦樊昊源陈伟熊金波韩立东李瑞南京邮电大学计算机学院江苏南京210023 杭州师范大学浙江省密码技术重点实验室浙江杭州311121 南京邮电大学通达学院江苏扬州225127 福建师范大学计算机与网络空间安全学院福建福州350117 西安电子科技大学计算机科学与技术学院陕西西安710071

针对目前云存储中细粒度双边访问控制机制安全模型较弱且外包解密结果缺乏验证的问题,提出了一种面向云存储数据的属性基双边访问控制方案。首先,提出了自适应安全可验证外包双边CP-ABE的形式化定义和安全模型;其次,以此为基础并结合批... 详细信息

针对目前云存储中细粒度双边访问控制机制安全模型较弱且外包解密结果缺乏验证的问题,提出了一种面向云存储数据的属性基双边访问控制方案。首先,提出了自适应安全可验证外包双边CP-ABE的形式化定义和安全模型;其次,以此为基础并结合批量可验证技术在合数阶群上设计了双边访问控制方案,支持数据拥有者与数据使用者同时为对方定义访问策略;最后,安全性分析表明,所提方案在自适应安全模型下针对选择明文攻击与选择消息攻击是不可区分的和存在性不可伪造的。实验结果显示,所提方案减轻了用户端的匹配、解密以及验证阶段的计算开销。

关键词：云存储双边访问控制自适应安全批量可验证外包解密

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Scientific exploration and hypotheses concerning the meridian system in traditional Chinese medicine

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Acupuncture and Herbal Medicine 2024年第3期4卷 283-289页

作者： Wenchuan Qi Bin He Qingxin Gu Yongming li Fanrong liang School of Acupuncture-Moxibustion and Tuina Chengdu University of Traditional Chinese MedicineChengduChina Key Laboratory of Acupuncture for Senile Disease(Chengdu University of TCM) Ministry of EducationChengduChina American Traditional Chinese Medicine Society New YorkNYUSA Sichuan Clinical Medicine Research Center of Acupuncture-Moxibustion ChengduChina

The meridian theory is an important component of traditional Chinese medicine,playing a crucial role in disease diagnosis,treatment,and health *** as the media for the effects of acupuncture,moxibustion,herbal medicine,and acupressure massage,meridians exert undeniable impact on the human ***,the essence of meridians remains a topic of *** research has primarily focused on their anatomical structures,leading to numerous ***,other researchers have approached this subject from an energetic perspective,discovering information interactions within the meridian *** findings suggest that meridians possess both physical and information dimensions,indicating that a singular approach to their study is *** bridge this gap,a shift from purely structural research toward an exploration of the information aspects of meridians is *** integrating this information approach with traditional meridian theory,it may be possible to develop a new,modernized meridian theory that is aligned with contemporary concepts,making it more accessible and applicable in clinical settings.

关键词： Communication Information state Meridian essence Physical state

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秦岭杜鹃扦插生根及相关生理生化分析研究

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西北林学院学报 2024年第3期39卷 131-137,152页

作者：李小玲商洛学院生物医药与食品工程学院陕西商洛726000

为探讨适合秦岭杜鹃扦插生根的方法,采用不同插条切制方式和不同植物生长调节剂的质量浓度、种类及浸泡时间探究其对插条生根的影响。通过分析生根率、生根数、最长根长、可溶性糖含量、可溶性蛋白含量、全N含量、多酚氧化酶(PPO)活性... 详细信息

为探讨适合秦岭杜鹃扦插生根的方法,采用不同插条切制方式和不同植物生长调节剂的质量浓度、种类及浸泡时间探究其对插条生根的影响。通过分析生根率、生根数、最长根长、可溶性糖含量、可溶性蛋白含量、全N含量、多酚氧化酶(PPO)活性、吲哚乙酸氧化酶(IAAO)活性、过氧化物酶(POD)活性变化,选出最优方案。研究表明,在不同切制方法中,Nearing式最适于秦岭杜鹃扦插生根,生根率达66%;正交试验中,用100 mg·L^(-1)IBA浸泡3 h进行扦插效果最佳,生根率为66%。测定插条生理生化指标,在不同切制方法中,Nearing式可溶性糖、可溶性蛋白及全N含量均为最高值,分别是44.151μg·g^(-1)、2.403 mg·g^(-1)、6.267 g·(100 g)^(-1);Nearing式POD及PPO活性均为最高值,分别是42.706 U·g^(-1)·min^(-1)、1.10 U·mL^(-1);直角切IAAO活性最高,为682.33μg·g^(-1)·h^(-1)。在正交试验中,用400 mg·L^(-1)NAA和400 mg·L^(-1)IBA浸泡0 h并进行扦插时可溶性糖含量最高,为97.707μg·g^(-1);用100 mg·L^(-1)IBA浸泡3 h时可溶性蛋白、全N含量、POD和PPO活性分别达到最高,分别为2.313 mg·g^(-1)、436.67 g·(100 g)^(-1)、42.567 U·g^(-1)·min^(-1)和1.10 U·mL^(-1);用200 mg·L^(-1)NAA浸泡6 h时IAAO活性最高,达到651μg·g^(-1)·h^(-1)。因此,在不同切制方法中,以Nearing式切制更易生根且各项生理指标均达到最大值;用100 mg·L^(-1)IBA浸泡3 h时比NAA处理插条效果更佳。

关键词：杜鹃扦插生根指标营养物质酶活性

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