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Personalized treatment of well-differentiated gastric neuroendocrine tumors based on clinicopathological classification and grading:A multicenter retrospective study

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Chinese Medical Journal 2024年第6期137卷 720-728页

作者： Ju Huang Huimin liu Dekun Yang Tianming Xu Jing Wang jingnan li Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Key Laboratory of Gut Microbiota Translational Medicine Research Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical CollegeYantaiShandong 264000China Department of Gastroenterology Beijing Zhong-Neng-Jian HospitalBeijing 102401China

Background:The incidence of well-differentiated gastric neuroendocrine tumors(G-NET)is increasing annually,and while they have a good prognosis and low mortality rate,their high recurrence rate makes treatment options *** study aims to determine the relationship between individualized treatment plans and the recurrence of ***:We performed a multicenter,retrospective study of 94 patients with highly differentiated G-NET and treated at Peking Union Medical College Hospital,Yantai Yuhuangding Hospital,and Beijing Zhong-Neng-Jian Hospital from November 2015 to September *** factors for recurrence of G-NETs were investigated using chi-squared test and multifactorial logistic regression ***:After a median follow-up of 49 months,the overall recurrence rate among the 94 G-NET patients was 14%(13/94).The recurrence rates of endoscopic mucosal resection(EMR),endoscopic submucosal dissection(ESD),somatostatin analog(SSA)therapy,and surgery were 43%(6/14),10%(5/49),5%(1/22),and 11%(1/9),***-treatment recurrence rates were significantly different(P=0.014)among four treatments(EMR,ESD,SSA,and surgery),and further subgroup comparisons revealed lower recurrence rates in the ESD and SSA groups than in the EMR *** the second month onward,SSA therapy considerably reduced the gastrin levels from 1081.0(571.5,2472.8)pg/mL to 461.5(255.3,795.0)pg/mL(Z=-3.521,Plinicopathological parameters studied,only the pre-treatment gastrin level(P=0.018 and 0.005)and the type of treatment(P=0.014 and 0.017)were significantly associated with G-NET ***:Individualized treatment strategies may reduce the risk of relapse after G-NET ***-term SSA therapy may be a secure and efficacious treatment option for type 1 G-NET with more than six lesions,and it substantially decreases the incidence of post-treatment rec

关键词： Well-differentiated G-NET Serum gastrin Personalized treatment Endoscopic submucosal dissection Endoscopic mucosal resection Somatostatin analog therapy Surgical resection Recurrence

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基于匹配追踪算法的地震数据提高分辨率方法

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石油物探 2024年第3期63卷 571-577页

作者：李京南中石化石油物探技术研究院有限公司江苏南京211103

提高地震数据的分辨率对于薄储层的识别与表征具有重要意义。常规的反褶积、反Q滤波等提高地震分辨率处理方法,存在假设条件多、信噪比较低、算法不稳定等不足,使得方法的应用效果和适用性受限。提出了一种新的基于匹配追踪算法的地震... 详细信息

提高地震数据的分辨率对于薄储层的识别与表征具有重要意义。常规的反褶积、反Q滤波等提高地震分辨率处理方法,存在假设条件多、信噪比较低、算法不稳定等不足,使得方法的应用效果和适用性受限。提出了一种新的基于匹配追踪算法的地震数据提高分辨率方法,可以在保持较高信噪比的同时提高地震数据分辨率。首先,根据地震信号特点,利用频率加权指数函数计算基准子波,并由此构建子波字典,频率加权指数函数可以很好地拟合不同形状的频谱,更好地适应不同的工区。然后,利用匹配追踪算法将原始地震数据分解为一系列子波的线性叠加,增加较高信噪比的高频匹配子波的振幅。最后对地震数据进行重构,获得高分辨率的地震数据。应用结果表明,该方法可有效提高地震分辨率,具有较高的信噪比,并且提高分辨率处理的结果与测井合成地震记录有很好的吻合性,证明方法是可靠的,且处理结果有利于后续薄储层识别与描述。

关键词：匹配追踪高分辨率地震数据分解子波字典薄层识别

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Chinese national clinical practice guidelines on prevention, diagnosis and treatment of early colorectal cancer

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中华医学杂志(英文版) 2024年第17期137卷 2017-2039页

作者： li jingnan Yao Hongwei Lu Yun Zhang Shutian Zhang Zhongtao Society of Digestive Endoscopy of the Chinese Medical Association Colorectal Surgery Group of the Chinese Medical Association Chinese Association of Gastroenterologist & Hepatologist National Clinical Research Center for Digestive Diseases Chinese Medical Journal Clinical Practie Guideline Collaborative Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of General Surgery Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Diseases Beijing China Department of General Surgery The Affiliated Hospital of Qingdao University Qingdao Shandong China Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Disease Beijing China

Background: The incidence and mortality of colorectal cancer (CRC) in China are increasing in recent years. The clarified pathogenesis and detectable precancerous lesions of CRC make it possible to prevent, screen, and diagnose CRC at an early stage. With the development of endoscopic and surgical techniques, the choice of treatment for early CRC is also worth further discussion, and accordingly, a standard follow-up program after treatment needs to be ***: This clinical practice guideline (CPG) was developed following the recommended process of the World Health Organization, adopting Grading of Recommendations Assessment, Development and Evaluation (GRADE) in assessing evidence quality, and using the Evidence to Decision framework to formulate clinical recommendations, thereby minimizing bias and increasing transparency of the CPG development process. We used the Reporting Items for practice Guidelines in HealThcare (RIGHT) statement and Appraisal of Guidelines for Research and Evaluation II (AGREE II) as reporting and conduct guides to ensure the guideline’s completeness and ***: This CPG comprises 46 recommendations concerning prevention, screening, diagnosis, treatment, and surveillance of CRC. In these recommendations, we have indicated protective and risk factors for CRC and made recommendations for chemoprevention. We proposed a suitable screening program for CRC based on the Chinese context. We also provided normative statements for the diagnosis, treatment, and surveillance of CRC based on existing clinical evidence and ***: The 46 recommendations in this CPG are formed with consideration for stakeholders’ values and preferences, feasibility, and acceptability. Recommendations are generalizable to resource-limited settings with similar CRC epidemiology pattern as China.

关键词： Colorectal cancer Early detection of cancer Prevention Screening Diagnosis Treatment Follow-up Guideline

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胃肠胰神经内分泌肿瘤领域近十年的研究进展和热点问题

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中华内科杂志 2024年第7期63卷 641-644页

作者：徐天铭李景南中国医学科学院北京协和医学院北京协和医院消化内科北京100730

胃肠胰神经内分泌肿瘤(GEP-NENs)是一类具有神经内分泌系统标志物,并且能够合成生物活性胺和/或多肽类激素的异质性较高的肿瘤。近十年来,GEP-NENs临床诊治取得了明显进展,不论是流行病学、诊断方法、治疗手段均取得长足进步。目前,围绕... 详细信息

胃肠胰神经内分泌肿瘤(GEP-NENs)是一类具有神经内分泌系统标志物,并且能够合成生物活性胺和/或多肽类激素的异质性较高的肿瘤。近十年来,GEP-NENs临床诊治取得了明显进展,不论是流行病学、诊断方法、治疗手段均取得长足进步。目前,围绕GEP-NENs仍有不少问题需要未来进一步研究解决。

关键词：神经内分泌瘤胃肠肿瘤胰腺肿瘤消化系统疾病

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Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors

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胰腺病学杂志(英文) 2024年第2期07卷 97-105页

作者： Chen Jie Wu Wenming Bai Chunmei Chi Yihebali Huo li Jiang liming Ji Yuan Luo Jie li Jie li jingnan Lou Wenhui Shao Chenghao Shen lin Wang Feng Wang Yu Xue ling Xu Jin Yuan Chunhui Yu Xianjun Yin Xiaoyu Zhao Hong Zhu Xiongzeng Zhao Yupei Centre for Neuroendocrine Tumors Fudan University Shanghai Cancer Center Shanghai China Department of General Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Department of Medical Oncology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology Zhongshan Hospital Fudan University Shanghai China Department of Pathology China-Japan Friendship Hospital Beijing China Department of Gastroenterological Oncology Beijing Cancer Hospital Peking University Cancer Hospital &amp Institute Beijing China Department of Gastroenterology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Pancreatic Surgery Zhongshan Hospital Fudan University Shanghai China Department of Pancreatic-Biliary Surgery Second Affiliated Hospital of Naval Medical University Shanghai China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp Department of Nuclear Medicine Nanjing First Hospital Nanjing Medical University Nanjing China Depar

The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (pNECs), according to the mitotic count, Ki-67 index, and cell differentiation. As a new category, G3 pNETs remain a challenging group of tumors to manage by lacking large randomized trials and consensus to support its clinical practice. Therefore, the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association gathered experts in this field to formulate this consensus for the diagnosis and treatment of G3 pNETs.

关键词： Clinical diagnosis Grade 3 Pancreatic neuroendocrine tumors Treatment

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改变会风,追求高品质学术会议2023年中华消化年会模式改变的工作实践

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中华内科杂志 2024年第1期63卷 21-23页

作者：李景南邹多武唐承薇中国医学科学院北京协和医学院北京协和医院消化内科北京100730 上海交通大学医学院附属瑞金医院消化内科上海200025 四川大学华西医院消化内科成都610041

医学是一门需要持续学习,知识随时更新的学科。各种学术会议作为学术交流的重要平台,为各级临床医生提供了展示研究成果、交流学术观点、建立学术联系的机会。高质量的学术会议可以推动各学科新技术发展,提高临床医生的业务能力水平,更... 详细信息

医学是一门需要持续学习,知识随时更新的学科。各种学术会议作为学术交流的重要平台,为各级临床医生提供了展示研究成果、交流学术观点、建立学术联系的机会。高质量的学术会议可以推动各学科新技术发展,提高临床医生的业务能力水平,更好地服务大众,保证健康中国的顺利实施。2023年11月9—11日在武汉召开的中华医学会第二十三次全国消化系病学术会议探索性地进行了改革,提出讲出高水平、提出新问题、组织精彩会,准时高效,共享高品质学术会议的宗旨。本次会议盛况空前,学术氛围浓郁,每个会场讨论火爆,学术火花激烈碰撞。参会者交流了学术、增进了友谊,享受了一次全新的消化盛会。

关键词：消化系统疾病会议

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提高小肠疑难罕见疾病诊断水平的几点思考

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临床内科杂志 2024年第7期41卷 437-439页

作者：李骥李沐涵金欣李景南中国医学科学院北京协和医院消化内科北京100730

小肠疾病种类繁多、病因复杂,临床表现缺乏特异性,评估手段有限,且在临床实践中缺乏相应的诊治思路,易导致其漏诊、误诊。本文结合文献复习及笔者自身经验,围绕如何提高小肠疾病诊断水平提出几点思考,包括小肠疾病的分类、病史采集及体... 详细信息

小肠疾病种类繁多、病因复杂,临床表现缺乏特异性,评估手段有限,且在临床实践中缺乏相应的诊治思路,易导致其漏诊、误诊。本文结合文献复习及笔者自身经验,围绕如何提高小肠疾病诊断水平提出几点思考,包括小肠疾病的分类、病史采集及体格检查的重要性、小肠疾病辅助检查的使用、终身学习能力的提高及在临床实践中多学科团队的协作,旨在提高临床医师对此类疾病的认识和诊断水平。

关键词：小肠疑难罕见疾病诊断

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氧化亚氮小型贮气瓶的运输危险性分类方法探究

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职业卫生与应急救援 2024年第1期42卷 109-112页

作者：贺小双邹秋韵李京楠上海化工院检测有限公司上海200062 上海化工研究院有限公司上海200062

目的探究小型气体贮气瓶在运输中的危险性分类方法,为该类产品的安全包装和运输提供依据。方法以氧化亚氮小型贮气瓶为例,依据相关包装性能测试标准,设计了一套包装性能测试步骤和危险性分类程序,对样品进行适当的热水浴试验,50℃内... 详细信息

目的探究小型气体贮气瓶在运输中的危险性分类方法,为该类产品的安全包装和运输提供依据。方法以氧化亚氮小型贮气瓶为例,依据相关包装性能测试标准,设计了一套包装性能测试步骤和危险性分类程序,对样品进行适当的热水浴试验,50℃内压测试和水压试验,判定样品的运输UN编号和运输名称。结果试验结果表明样品在海洋运输和公路运输时可按特殊规定191豁免为非限制性货物;在空运时则需按照危险货物运输。结论氧化亚氮小型贮气瓶的运输危险性分类,须根据气瓶容量、运输方式和适当的包装性能测试结果进行综合判定。

关键词：危险货物氧化亚氮运输小型气体贮气瓶包装性能测试

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Single-atom skeletal editing of 2H-indazoles enabled by difluorocarbene

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Science China Chemistry 2023年第7期66卷 1975-1981页

作者： Yao Zhou Fuling Chen Ziru li Junjie Dong jingnan li Bohao Zhang Qiuling Song Hubei Key Laboratory of Pollutant Analysis&Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshi 435002China Key Laboratory of Molecule Synthesis and Function Discovery Fujian Province UniversityCollege of Chemistry at Fuzhou University Fuzhou 350108China

A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated *** bromodifluoroacetate was severed as the difluorocarbene source in the current protocol,facilitating the cleavage of the N-N bond via carbon atom *** metal-free ring expansion reaction enables the late-stage diversification of indazole skeletons,assembling a diverse array of functionalized quinazolin-4(3H)-ones in decent yields with excellent functional group compatibility.

关键词： indazoles skeletal editing difluorocarbene N-N bond cleavage quinazolin-4(3H)-ones

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Home cryopreservation of fecal samples:an effective strategy for longitudinal studies using multi-omics approaches

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Chinese Medical Journal 2022年第9期135卷 1102-1104页

作者： Pengguang Yan Mingjie Luo Fei liu jingnan li Department of Gastroenterology Peking Union Medical College HospitalBeijing 100730China School of Medicine Tsinghua UniversityBeijing 100089China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

To the Editor:Accumulating evidence has shown that gut microbiota–host interactions play vital roles in human health and ***,the dynamic equilibria between microbes and their hosts limit the utility of single strains or microbial signatures as markers for disease risk prediction and outcome assessment.[1]Analysis of changes in the gut microenvironment using multi-omics approaches has now become routine.[2]In inflammatory bowel disease,and especially during the acute phase,a significant shift in the gut microenvironment occurs within 2 ***,effective strategies to obtain fecal samples every 2 to 3 days are ***,challenges in specimen storage,transport,and handling limit long-term sampling *** microbial composition of fecal samples stored at room temperature for>24 h is significantly *** of fecal specimens at−80°C immediately after evacuation is standard procedure but is impractical in real-life *** alternative is a storage at−20°C for up to 1 month followed by sample transport and laboratory *** objective of this study was to evaluate whether the gut microenvironment in fecal specimens collected every 2 to 3 days and stored at home at−20°C for up to 1 month could be preserved.

关键词： routine limit signature

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