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Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones

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Synthetic and Systems Biotechnology 2021年第4期6卷 414-428页

作者： Zhitang Lyu Tingting Yu lichao Zhang Xiaona Xu Yijun Zhang Jihong li zhirong li Wei Zhang Senlin Hou School of life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaodingPR China The Second Hospital of Hebei Medical University ShijiazhuangPR China Key Laboratory of Microbial Diversity Research and Application of Hebei Province BaodingPR China Engineering Laboratory of Microbial Breeding and Preservation of Hebei Province BaodingPR China

Bacteria play an important role in the formation of primary Common Bile Duct(CBD)***,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be *** utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract *** diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed *** composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal *** and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each *** and Escherichia􀀀Shigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone *** is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(pliary *** micro-ecology of biliary and duodenal in patients with stones is complex and closely related,and there is a potential for *** decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones.

关键词： Primary common bile duct stones ERCP Dysbacteriosis Bile duct microbiota Duodenal microbiota 16S rRNA gene high-throughput sequencing Short chain fatty acids

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Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate

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Particuology 2024年第7期90卷 20-30页

作者： Jinbo Ouyang lishan liu Yin li Mingyang Chen limin Zhou zhirong liu li Xu Hamza Shehzad School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China School of Physics and Materials Science Nanchang UniversityNanchang 330013China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to *** enhance CBZ's physicochemical properties,such as water solubility and mechanical properties,we selected six cocrystal coformers(CCFs):nicotinamide(NIC),benzamide(BZM),salicylic acid(SCA),fumaric acid(FMA),trimesic acid(TMA),and hesperetin(HPE).Six CBZ cocrystals were successfully prepared using the solution *** transform infrared spectroscopy(FT-IR),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),and single crystal X-ray diffraction(SCXRD)were used to characterize the crystal structures and gain comprehensive insights into the six *** mechanical,fluorescence,and solubility properties of the six cocrystals were *** results reveal that most of the prepared cocrystals exhibit improved water solubility and mechanical properties when compared to *** them,the dissolution rate of cocrystals excluded from CBZ-HPE has increased by an average of 3 or 4 times compared to CBZ,while CBZ-HPE exhibits superior mechanical ***,all six cocrystals possess better fluorescence performance than *** thoroughly evaluated the mechanical properties of the cocrystals through both experimental and theoretical *** work provides a new direction for studying drug cocrystals to improve the physicochemical properties of drugs.

关键词： Carbamazepine Cocrystal Mechanical properties Fluorescence performance Dissolution rate

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High resolution 3D nonlinear integrated inversion

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Applied Geophysics 2009年第2期6卷 159-165页

作者： li Yong Wang Xuben li zhirong li Qiong li Zhengwen Key Lab of Earth Exploration ＆ Information Technology Chengdu University of Technology Chengdu 610059 China CNPC Chuanqing Drilling Engineering Company Limited Sichuan Geophysical Company Chengdu 610213 China

The high resolution 3D nonlinear integrated inversion method is based on nonlinear theory. Under layer control, the log data from several wells （or all wells） in the study area and seismic trace data adjacent to the wells are input to a network with multiple inputs and outputs and are integratedly trained to obtain an adaptive weight function of the entire study area. Integrated nonlinear mapping relationships are built and updated by the lateral and vertical geologic variations of the reservoirs. Therefore, the inversion process and its inversion results can be constrained and controlled and a stable seismic inversion section with high resolution with velocity inversion, impedance inversion, and density inversion sections, can be gained. Good geologic effects have been obtained in model computation tests and real data processing, which verified that this method has high precision, good practicality, and can be used for quantitative reservoir analysis.

关键词： high resolution integrated inversion network with multiple input and output hybrid intelligent learning algorithm

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One stone three birds:Ni-catalyzed asymmetric allenylic substitution of allenic ethers,hydroalkylation of 1,3-enynes and double alkylation of enynyl ethers

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Chinese Chemical Letters 2024年第8期35卷 282-287页

作者： zhirong Yang Shan Wang Ming Jiang Gengchen li Long li Fangzhi Peng Zhihui Shao Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologyYunnan Provincial Center for Research&Development of Natural Productsand State Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China

The development of low-cost,earth-abundant and environmentally benign transition metal catalysts,which can catalyze multiple different types of asymmetric reactions,is an important objective in mod-ern asymmetric *** we demonstrate that a chiral Ni/P-Phos catalyst achieves three types of asymmetric reactions:allenylic substitution of racemic allenic ethers,1,4-hydroalkylation of prochiral 1,3-enynes and double alkylation of newly designed enynyl ether *** methods complement each other and produce various axially chiral allene derivatives bearing a pyrazolidine-3,5-dione unit,which is widely present in drugs and biologically active molecules with versatile pharmacological activities.

关键词： Nickel Asymmetric catalysis Allenylic substitution Hydroalkylation Double alkylation Allene 1,3-Enyne Pyrazolidine-3,5-dione

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天津市种业发展现状、挑战与振兴策略

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中国种业 2024年第9期 29-32页

作者：王连芬李志荣齐志伟杨爱宾梁晨李争于澎湃天津市农业发展服务中心天津300061 天津市农业农村委员会天津300061

种业是农业生产的基础,品种的选择和培育直接影响作物产量和质量,种业发展对于保障国家粮食安全和促进农业可持续发展具有不可替代的重要性。天津种业在国家种业振兴行动的深入推进下,正积极构建现代种业体系,优化种业发展环境。从市场... 详细信息

种业是农业生产的基础,品种的选择和培育直接影响作物产量和质量,种业发展对于保障国家粮食安全和促进农业可持续发展具有不可替代的重要性。天津种业在国家种业振兴行动的深入推进下,正积极构建现代种业体系,优化种业发展环境。从市场竞争力、种业基地建设、生物育种创新能力等方面综述了天津市种业发展现状,并进一步分析了天津市种业发展中面临的问题,最终建议天津市可以通过培育壮大种业领军企业、激发创新活力、加强基础设施建设和强化综合服务保障等方式优化种业发展环境,实现种业振兴发展。

关键词：种业天津建设发展创新种业人才粮食安全农业生产

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The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1292-1301页

作者： Leiqiong Gao Jing Zhou Sen Yang lisha Wang Xiangyu Chen Yang Yang Ren li Zhiwei Pan Jing Zhao zhirong li Qizhao Huang Jianfang Tang li Hu Pinghuang liu Guozhong Zhang Yaokai Chen lilin Ye Institute of Immunology Third Military Medical UniversityChongqingChina Chongqing Public Health Medical Center ChongqingChina State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbinHeilongjiangChina College of Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiangChina Key Laboratory of Animal Epidemiology of the Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijingChina Cancer Center The General Hospital of Western Theater CommandChengduSichuanChina Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijingChina

The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well *** particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is ***,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 ***,these patients mounted potent virus-specific TH1 and CD8+T cell *** sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these *** results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines.

关键词： immunity patients severity

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圆柱形多自由度超声电机椭圆倾角和接触角的研究

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中国机械工程 2007年第22期18卷 2656-2658,2662页

作者：李志荣苏州市职业大学

定子驱动端面形成的椭圆运动是实现超声电机驱动的关键,因而椭圆运动的性质直接影响超声电机的性能。分析了圆柱形多自由度超声电机驱动点的椭圆运动轨迹及其特点。在此基础上给出了椭圆倾角的计算公式,分析了椭圆倾角与接触角之间的关... 详细信息

定子驱动端面形成的椭圆运动是实现超声电机驱动的关键,因而椭圆运动的性质直接影响超声电机的性能。分析了圆柱形多自由度超声电机驱动点的椭圆运动轨迹及其特点。在此基础上给出了椭圆倾角的计算公式,分析了椭圆倾角与接触角之间的关系,得到了最佳接触角。提出了保证最佳接触角的方法。通过实验,分析了接触角对电机输出性能的影响。

关键词：多自由度超声电机接触角椭圆运动椭圆倾角

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Comparative evaluation of commercial Douchi by different molds:biogenic amines,non-volatile and volatile compounds

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Food Science and Human Wellness 2024年第1期13卷 434-443页

作者： Aijun li Gang Yang zhirong Wang Shenglan liao Muying Du Jun Song Jianquan Kan College of Food Science Southwest UniversityChongqing 400715China Chinese-Hungarian Cooperative Research Centre for Food Science Chongqing 400715China Laboratory of Quality&Safety Risk Assessment for Agri-products on Storage and Preservation(Chongqing) Ministry of Agriculture and Rural Affairs of the People's Republic of ChinaChongqing 400715China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing 400715China Shu Xiang Douchi Food Research Institute limited Company Chongqing 402160China

To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fermentation of *** results showed that the biogenic amine contents of the three types of Douchi were all within the safe range and far lower than those of traditional fermented ***-type Douchi produced more free amino acids than the other two types of Douchi,and its umami taste was more prominent in sensory evaluation(Plic acid(P<0.05),the sour taste was significantly positively correlated with citric acid and most free amino acids(P<0.05),while astringency was significantly negatively correlated with glucose(P<0.001).Thirteen volatile compounds such as furfuryl alcohol,phenethyl alcohol,and benzaldehyde caused the flavor difference of three types of *** study provides theoretical basis for the selection of starting strains for commercial Douchi production.

关键词： Douchi Starting strains Non-volatile compounds Volatile compounds Sensory evaluation

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liNEAR ULTRASONIC MOTOR WITH 2-DOF USING LONG-ITUDINAL AND BENDING VIBRATION MODES

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Transactions of Nanjing University of Aeronautics and Astronautics 2007年第3期24卷 239-244页

作者：李志荣苏州市职业大学机电工程系

A two-degree-of-freedom（2-DOF） linear ultrasonic motor （USM） consists of a cylinder-shaped stator and a slider. Two bending vibration modes with orthogonality and one longitudinal vibration mode are excited in the stator by three groups of piezoelectric ceramic elements. The combinations of any one bending mode and the longitudinal mode mentioned above push the slider to move linearly in direction x or y. Some key issues for improving the motor output properties and efficiency are given. They include selection of the vibration modes, consistency of the modal frequencies, placement of the piezoelectric ceramic elements and the supporting plane, setting of pre-pressure, and influence of interfering modes.

关键词： ultrasonic motor linear motion stator mode

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Efficient continuous synthesis of 2-hydroxycarbazole and 4-hydroxycarbazole in a millimeter scale photoreactor

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Chinese Chemical Letters 2024年第4期35卷 399-403页

作者： Zhixiang li zhirong Yang Chang Yao Bin Wu Gang Qian Xuezhi Duan Xinggui Zhou Jing Zhang State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China

2-Hydroxycarbazole and 4-hydroxycarbazole are important chemicals with extensive applications in optoelectronic materials and pharmaceutical *** of the art yield of 2-hydroxycarbazole is~30%and the reaction time is typically in hours or ***,we developed a green route for the continuous and high-throughput synthesis of 2-hydroxycarbazole and 4-hydroxycarbazole via photochemical intramolecular cyclization of 3–hydroxy-2–chloro-diphenylamine using a self-designed millimeter scale photoreactor,which was designed based on sizing-up and numbering-up strategies for a decent liquid holdup(6.8 m L)and fabricated via femtosecond laser engraving *** photochemical synthesis was carried out continuously under the illumination of 365 nm UV-LED with dimethyl sulfoxide as solvent and potassium t-butoxide as *** was found that under optimized conditions a 2-hydroxycarbazole yield of 31.6%and a 4-hydroxycarbazole yield of 11.1%were obtained with a residence time of 1 *** to semibatch operations,the reaction time was shortened by 1–2 orders of *** a result,a throughput of 11.3 g/day 2-hydroxycarbazole and 4.0 g/day 4-hydroxycarbazole can be achieved from the *** was proposed that the short reaction time and high product yield are resulted from higher photon transfer rates and more uniform photon distribution provided by the millimeter scale photoreactor,which enhances the reaction rates and mitigates overreaction.

关键词： Millimeter scale reactor 2-Hydroxycarbazole Photochemistry UV-LED Process intensification

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