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Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： zhi-Chang Ba Xi-Qing Zhu zhi-Guo li yuan-Zhou li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

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An All-Optical Diode Based on Plasmonic Attenuation and Nonlinear Frequency Conversion

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Chinese Physics Letters 2013年第9期30卷 136-140页

作者： REN Ming-liang ZHONG Xiao-Lan CHEN Bao-Qin li zhi-yuan Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesP.O.Box 603Beijing 100190

We present the design of an all-optical diode in a metal-dielectric structure where plasmonic attenuation and quasi-phase-matching are harnessed to greatly improve its *** to the asymmetric design of the second-order nonlinear coefficient,different incident directions will ignite different plasmonic nonlinear processes,which compensate or accelerate plasmonic *** a result,a unidirectional output of plasmonic signal is *** designed all-optical diode shows advantages of low power consumption,short sample length,high isolation contrast,wide acceptance of structural and initial conditions,and tunable unidirectionality,and becomes of practical interest.

关键词： unidirectional Nonlinear matching

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The Measurement of Displacement and Optical Force in Multi-Optical Tweezers

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Chinese Physics Letters 2012年第1期29卷 160-163页

作者： liNG lin GUO Hong-lian HUANG Lu QU E li Zhao-lin li zhi-yuan Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190 Yunnan Academy of Scientific&Technical Information Kunming 650051

We set up a system of multiple optical tweezers based on a spatial light modulator,and measured the displacement and optical force of the trapped particles *** of the trapped particles can be clearly imaged in three dimensions by several *** displacement is obtained by calculating the gray weighted centroid in the trapped particle's *** stiffness of the trapped particles in the optical traps is measured by oscillating the sample stage in a triangular wave based on Stokes fluid *** optical force of each trapped particle can be calculated by the measured displacement and stiffness.

关键词： dynamics. displacement stiffness

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Initial Approach to the Cellular Irradiation Injury of Human Pancreatic Carcinoma Cell line MIA PaCa-2 by High Dose per Fraction

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Clinical oncology and cancer researeh 2010年第6期7卷 352-358页

作者： zhi-zhen WANG Hai-li YU zhi-yong yuan Ping WANG Department of Radiation Therapy Tianjin Medical University Cancer Institute and Hospital Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China.

OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups： 0, 2, 5, 10, 17 Gy. Cultivated cells were irradiated by 6MV-X ray in one fraction. Analysis were done as follows： comet assay, which assessed the level of DNA damage in the treated cells right after the cell was irradiated, flow cytometry, which was performed at 0, 6, 12, 24, 36 h after the cell line treated to ladder, which quantitatively asses changes of its cell cycle, DNA assessed the degree of DNA injury after 6 and 12 h, and histological examination, which analyzed cellular morphology after 24 h. RESULTS （1） After X-ray irradiated, the morphological change of human pancreatic carcinoma cell line （MIA PaCa-2） was mainly swelling. （2） When the dose of radiation was lower than 10 Gy, increasing the dose could greatly improve cell necrosis, apoptosis and blockage of cell cycle in GJM phase, which was consistent with the theory of radiation biology. （3） When radiation dose was more than the 10 Gy, the peak of apoptotic necrosis appeared strong and early. （4） The degree of DNA injury was also related to the dose of radiation therapy and most obvious in the 10 Gy group and not so obvious in the 17 Gy group. （5） When dose was less than 10 Gy, DNA ladder was a single electrophoretic band; in the 10 Gy group, the electrophoresis showed a multiple ladder band; when dose was more than 10 Gy, a vague and irregular band appeared on the electrophoresis. CONCLUSION Oncotic necrosis may be the main cell death style when dose per fraction is high, which differs from conventional dose fraction radiation therapy.

关键词： dose-response relationship drug necrosis irradiation injury.

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二维阀圆柱滑阀阀口温升研究

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液压气动与密封 2024年第5期44卷 80-90页

作者：张歌李智渊路超赵建涛曹君梦河南航天流体控制技术有限公司河南郑州451191 河南航天工业有限责任公司河南郑州451191 杭州迪微电液数控技术有限公司浙江杭州310014 河南航天液压气动技术有限公司河南郑州451191

二维阀所带来的温升主要来源于圆柱滑阀的阀口,过大的温升不仅会造成能量的耗散,也会对阀口产生变形影响,降低阀的机械性能和安全性能。分别针对不同入口油温下滑阀的4个阀口开度(0.20,0.15,0.10,0.08 mm)和5种流量边界(15,25,35,45,55 ... 详细信息

二维阀所带来的温升主要来源于圆柱滑阀的阀口,过大的温升不仅会造成能量的耗散,也会对阀口产生变形影响,降低阀的机械性能和安全性能。分别针对不同入口油温下滑阀的4个阀口开度(0.20,0.15,0.10,0.08 mm)和5种流量边界(15,25,35,45,55 L/min)对圆柱滑阀阀口温升的影响情况进行了数值模拟,得到了结果:温升随流量的增加而显著增加,流量为55 L/min时比15 L/min的最大阀口温升提高了11.127 K;阀口开度是影响温升的主要因素,随着阀口开度的减小,温升升高。同时通过实验对模拟结果进行了验证,得到实验数据与模拟数据吻合良好,两者之间的相对误差仅为0.14%,证明数值模拟的结果是可靠的。

关键词：滑阀阀口温度分布阀口开度流量

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Sigmatropic rearrangements of B(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons

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Science China Chemistry 2024年第2期67卷 568-575页

作者： Jiasheng Qian li-Cai liu zhi-Hao Chen yuan liu Yin li Qingjiang li Honggen Wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

α-Functionalized organoborons are useful building blocks and key structural elements in functional *** previous synthesis relied on the famous Matteson reaction or the late-stage borylative modification of alkynes or ***,the synthetic transformation of borylated building blocks offers another useful strategy and is currently actively *** report herein that B(MIDA)-propargylic alcohols(BPAs) are a useful type of borylated building *** two complementary functional group handles(alkyne and hydroxyl) in close proximity,the redox-neutral [3,3] and [2,3] sigmatropic rearrangements of BPAs allow the efficient synthesis of several types of α-functionalized boronates,including α,β-unsaturated acylborons,α-S/P-substituted allenylborons,boryl-substituted thiazoles and a borylated α,β-unsaturated hydrazine,some of which are otherwise challenging targets using other synthetic methods.

关键词： organoboron diverse synthesis sigmatropic rearrangement heteroarene amide

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基于分布式概率估计的并联水泵节能优化控制方法

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自动化技术与应用 2024年第10期43卷 13-17页

作者：张贵清马广运畅坤李志远中海物业管理有限公司广东深圳518057

大型制冷的并联水泵能耗较大,难以在兼顾制冷的同时降低能耗,为此提出基于分布式概率估计的并联水泵节能优化控制方法。首先基于并联水泵特性建模,得出扬程与水流量间的特性曲线,以二者间关系作为支撑构建节能优化控制的目标函数,设定... 详细信息

大型制冷的并联水泵能耗较大,难以在兼顾制冷的同时降低能耗,为此提出基于分布式概率估计的并联水泵节能优化控制方法。首先基于并联水泵特性建模,得出扬程与水流量间的特性曲线,以二者间关系作为支撑构建节能优化控制的目标函数,设定目标函数的关联约束以及边界约束,构建节能优化控制模型,运用分布式概率估计算法计算控制模型全局最优解,实现并联水泵节能优化控制。实验结果表明:所提方法的节能效果好,优化后并联水泵的扬程较高,能够在降低能耗的同时保持优异的制冷性能。

关键词：分布式概率估计并联水泵节能优化控制

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Charge regulation by ferromagnetic metal/liF spin-polarized interface for high-performance li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng Shuang Zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu Jian-Wen li yuan-Lang Wan zhi-Jia Zhang Yong Jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/liF heterogeneous films(T^(M)-liF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-liF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/liF *** and liF play individual roles in redistributing electrons and li^(+)to promote homogeneous li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while liF,with low surface diffusion barriers,ensures fast transportation of li^(+).The Co-liF-CC@li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： lithium metal anode Interfacial charge Ferromagnetic metal lithium fluoride Spin polarization

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Focal mechanics and disaster characteristics of the 2024 M 7.6 Noto Peninsula Earthquake,Japan

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1378-1387页

作者： Guang-qi CHEN Yan-qiang WU Ming-yao XIA zhi-yuan li School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300131China Graduate School of Engineering Kyushu UniversityFukuoka 819-0395Japan The First Monitoring and Application Center China Earthquake AdministrationTianjin 300180China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

On January 1,2024,a devastating M 7.6 earthquake struck the Noto Peninsula,Ishikawa Prefecture,Japan,resulting in significant casualties and property *** information from the first six days after the earthquake,this article analyzes the seismic source characteristics,disaster situation,and emergency response of this *** results show:1)The earthquake rupture was of the thrust type,with aftershock distribution showing a north-east-oriented belt-like feature of 150 km.2)Global Navigation Satellite System(GNSS)and Interferometric synthetic aperture radar(InSAR),observations detected significant westward to north-westward co-seismic displacement near the epicenter,with the maximum horizontal displacement reaching 1.2 m and the vertical uplift displacement reaching 4 m.A two-segment fault inversion model fits the observational data well.3)Near the epicenter,large Peak Ground Velocity(PGV)and Peak Ground Acceleration(PGA)were observed,with the maxima reaching 145 cm/s and 2681 gal,respectively,and the intensity reached the highest level 7 on the Japanese(Japan Meteorological Agency,JMA)intensity standard,which is higher than level 10 of the United States Geological Survey(USGS)Modified Mercalli Intensity(MMI)standard.4)The observation of the very rare multiple strong pulse-like ground motion(PLGM)waveform poses a topic worthy of research in the field of earthquake engineering.5)As of January 7,the earthquake had left 128 deaths and 560 injuries in Ishikawa Prefecture,with 1305 buildings completely or partially destroyed,and had triggered a chain of disasters including tsunamis,fires,slope failures,and road ***,this paper summarizes the emergency rescue,information dissemination,and other disaster response and management measures taken in response to this *** work provides a reference case for carrying out effective responses,and offers lessons for handling similar events in the future.

关键词： Noto Peninsula Earthquake earthquake rupture mechanism earthquake disaster emergency response pulse-like ground motion

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Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C_(6)F_(5))_(3)/chiral phosphoric acid

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Chinese Chemical Letters 2024年第5期35卷 135-140页

作者： Zhen liu zhi-yuan Ren Chen Yang Xiangyi Shao li Chen Xin li State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhenhai High School of Zhejiang Ningbo 315299China

Catalytic enantioselective alkenylation is an efficient method to construct chiral alkene molecules,but the asymmetric alkenylation of simple alkenes catalyzed by metal-free catalysts remains an elusive ***,we reported an asymmetric alkenylation of benzoxazinones with diarylethylenes by utilizing a B(C_(6)F_(5))_(3)/chiral phosphoric acid catalyst.A broad of benzoxazinones and diarylethylenes with electron-withdrawing and electron-donating groups were tolerated(up to 95%yield and 97.5:2.5 e.r.)in the methodology under mild reaction ***,the synthetic utility was confirmed by the scaled-up reaction and transformations of the *** mechanism was preliminarily explored by control reactions,nonlinear effect experiment and DFT calculations.

关键词： Asymmetric alkenylation Simple alkenes Benzoxazinones B(C_(6)F_(5))_(3)/chiral phosphoric acid Theoretical calculations

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