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Synthesis, Characterization and Biological Activities of Novel Water-soluble Metalloporphyrins

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Chinese Chemical Letters 2001年第12期12卷 1085-1088页

作者： li, zy Zhang, YN Gao, ZT liu, Y Zhu, XJ Wuhan Univ Dept Chem Wuhan 430072 Peoples R China

The synthesis, characterization, and biological activities of a series of metal porphyrins were described. The complexes 3a similar to 3e were prepared from the reaction of compound 2 with M(OAc)(2) in CHCl3, and the treatment of 3a similar to 3f with pyridine gave corresponding complexes 4a similar to 4f. These new compounds were identified by absorption spectroscopies, H-1 NMR and elemental analysis. The results of biological activity,testing revealed that 4a and 4c had stronger inhibiting action for Escherichia coli (CCTCC AB91115).

关键词： water-soluble metalloporphyrin synthesis structure characterization biological activity testing

TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve

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World Journal of Gastroenterology 1998年第2期4卷 70-72页

作者： liu, CY liu, JZ Zhou, JH Wang, HR li, zy li, AJ liu, KJ Shandong Univ Dept Physiol Jinan 250012 Shandong Peoples R China

AIM To investigate the effects of TRH in DVC on motility of the gallbladder in rabbits. METHODS After fasted for 15h - 18h , rabbits were anesthetized with urethane (1 0g/kg) . Gallbladder pressure (GP) was measured by a frog bladder perfused with normal saline. RESULTS After microinjection of TRH (8 8nmol, 1μl ) into DVC, GP was raised and the frequency of phasic contraction of gallbladder (FPCGB) increased. All the doses of TRH (0 13, 0 25, 0 50, 0 80, 1 30nmol , 1μl ) injected into DVC could excite the motility of gallblader. As the dose of TRH was enlarged, the amplitude and duration of the reaction increased. Effects of TRH in DVC on motility of the gallbladder could be completely abolished by atropine ( 0 2mg/g , i.v.) or vagotomy, but could not be inhibited by phentolamine iv (1 5mg/g) or propranolol iv (1.5mg/g) or by transecting the spinal cord. CONCLUSION Thyrotropin releasing hormone in DVC can excite motility of gallbladder. This effect was mediated by vagus nerves and peripheral M receptor. Its physiological significance may be related to maintaining the phasic contraction of gallbladder in interdigestive period.

关键词： gallbladder vagus nerve dorsal vagal complex thyrotropin releasing hormone cholinergic M receptors rabbits

Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii

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Co-administration of interleukins 7 and 15 with DNA vaccine ...

Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography

第五届全国人畜共患病学术研讨会

作者： Chen J li zy Petersen E liu WG Zhu XQ State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences Ningbo University School of Medicine Department of Infectious Diseases and Clinical Microbiology Institute for Clinical MedicineFaculty of Health SciencesAarhus University Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University College of Veterinary Medicine

Toxoplasma gondii is an obligatory intracellular parasite,which can infect all warm-blooded animals including ***,including IL-15 and IL-7,play a critical role in the regulation of the homeostasis of naive and memory T ***-administration the DNA vaccine with cytokines may improve its ***-7 and IL-15 from splenic tissues of Kunming mice were cloned,and eukaryotic plasmid pVAX-IL-7-IL-15 was *** mice were

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 437-440页

作者： Digestive Department (Chen WX, lin HJ, Gu Q, Zhong XQ, Yu CH, li YM and Gu zy) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China Digestive Department First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. chenwiexing@***

Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients' cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two *** group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives.

关键词： propofol diazepam endoscopic retrograde cholangiopancreatography sedation

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小波变换和阻抗技术在胃动力研究中的应用

中国组织工程研究与临床康复 2007年第13期11卷 2434-2436页

作者：王伟李章勇任超世重庆邮电大学生物医学信息工程研究所重庆市400065 中国医学科学院生物医学工程研究所天津市300192

目的:探索基于小波变换和阻抗技术提取胃动力信息的方法。方法:实验于2006-07/10在重庆邮电大学生物医学信息工程研究所实验室完成。①选择胃动力正常的男性志愿者24名(年龄20～21岁),空腹8h后喝纯净水400mL(水温37℃),利用阻抗技术的... 详细信息

目的:探索基于小波变换和阻抗技术提取胃动力信息的方法。方法:实验于2006-07/10在重庆邮电大学生物医学信息工程研究所实验室完成。①选择胃动力正常的男性志愿者24名(年龄20～21岁),空腹8h后喝纯净水400mL(水温37℃),利用阻抗技术的四电极法进行胃排空检测。②运用小波变换方法结合Daubechies小波系对体表阻抗信号进行多分辨分析和重构,滤除呼吸阻抗和血流阻抗,进而获得胃阻抗信号。结果:24名被试均完成测试进入结果分析。被试具有喝水前基础阻抗不变,喝水后阻抗升高,然后快速下降再缓慢下降的特点,400mL纯净水的半排空时间为(8.78±1.76)min。利用小波变换对体表阻抗信号重构后获得的信号频率范围在2～4次/min,表面光滑,有效去除了呼吸阻抗和血流阻抗信号。结论:①尽管胃阻抗受到胃酸分泌、试餐成分等多种因素的影响,但选用电导率低的无营养液体仍可获得阻抗曲线和胃容积变化的对应关系,为胃排空功能研究提供一种新的体表无创检测途径。②利用小波变换重构的阻抗信号频率与健康人胃蠕动节律一致,可以对胃蠕动功能从机械特性角度进行分析和评价,从而避免了胃电信号不能准确判断胃蠕动等机械活动失常所引起的胃动力紊乱。

关键词：小波变换生物阻抗胃动力胃排空

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脊髓损伤传统治疗及细胞移植基因治疗的进展

中国组织工程研究与临床康复 2007年第28期11卷 5598-5601页

作者：刘涛邵增务李健王忠仁李振宇华中科技大学同济医学院附属协和医院骨科湖北省武汉市430022 解放军第四五七医院骨科湖北省武汉市430012

目的:脊髓损伤分为原发性损伤和继发性损伤,治疗主要目的在于阻止或减少继发性损伤。文章对采用传统疗法、细胞移植、基因治疗等方式修复脊髓损伤的研究进展作一综述。资料来源:应用计算机检索PUBMED1997-02/2007-02期间的相关文章,检... 详细信息

目的:脊髓损伤分为原发性损伤和继发性损伤,治疗主要目的在于阻止或减少继发性损伤。文章对采用传统疗法、细胞移植、基因治疗等方式修复脊髓损伤的研究进展作一综述。资料来源:应用计算机检索PUBMED1997-02/2007-02期间的相关文章,检索词为“Spinal Cord Injuries,surgery,transplants,gene cure”,并限定文章语言种类为English。同时计算机检索中国期刊全文数据库2001-01/2006-12期间的相关文章,检索词为“脊髓损伤,基因治疗,细胞移植,手术治疗”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与传统疗法、细胞移植或基因治疗等方式修复脊髓损伤相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到98篇相关文献,32篇文献符合纳入标准,排除的66篇文献为内容陈旧或重复。符合纳入标准的32篇文献中,分别涉及手术治疗、药物治疗、高压氧治疗、细胞移植、基因治疗脊髓损伤以及所面临的问题。资料综合:脊髓损伤采取手术治疗可解除脊髓压迫和(或)通过体内固定维持脊柱稳定性;药物、高压氧等非手术治疗是通过减轻脊髓继发性损伤,从而促进神经功能的恢复或再生;细胞移植、基因治疗可刺激神经细胞再生。脊髓损伤后的修复面临许多问题,主要是损伤后脊髓中的环境不利于修复的发生和发展。结论:细胞移植和基因治疗是脊髓损伤修复的重要手段,在动物实验中已取得了一定效果,具有很好的临床应用前景。

关键词：脊髓损伤手术治疗细胞移植基因治疗综述文献

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代谢综合征的临床相关指标

中国组织工程研究与临床康复 2007年第39期11卷 7988-7990页

作者：李增英李惠林张志玲赵恒侠深圳市中医院内分泌科广东省深圳市518033

目的:分析超氧化物歧化酶、丙二醛、瘦素、脂联素等指标在代谢综合征发病过程中的作用。方法:应用计算机检索中国医院知识仓库(CHKD)数据库1998-01/2005-12相关代谢综合征方面的文献,检索词"代谢综合征",限定文献语言种类为中文。对资... 详细信息

目的:分析超氧化物歧化酶、丙二醛、瘦素、脂联素等指标在代谢综合征发病过程中的作用。方法:应用计算机检索中国医院知识仓库(CHKD)数据库1998-01/2005-12相关代谢综合征方面的文献,检索词"代谢综合征",限定文献语言种类为中文。对资料进行初审,选取包括超氧化物歧化酶、丙二醛、瘦素、脂联素的文献,开始查找全文。纳入标准:临床对照研究。排除标准:综述性研究,重复性研究。共检索到24篇关于代谢综合征与超氧化物歧化酶、丙二醛、瘦素、脂联素等指标的文献,最终纳入16篇符合标准的文献。结果:研究发现超氧化物歧化酶、丙二醛、瘦素、脂联素等指标与代谢综合征的关系密切。丙二醛的高低可间接反映机体细胞受氧自由基损伤的程度,超氧化物歧化酶的检测可间接反映机体抗氧化的能力,代谢综合征患者超氧化物歧化酶活性降低、丙二醛堆积,提示其抗氧化能力减弱。代谢综合征患者多存在高瘦素、低脂联素血症,提示脂联素、瘦素在代谢综合征发生发展过程中发挥了重要作用,低脂联素血症、高瘦素血症可能是代谢综合征的重要组成成分。结论:动态观察血清瘦素、脂联素、超氧化物歧化酶水平可以了解代谢综合征发生发展的过程,亦可以作为疗效观测的指标。

关键词：代谢综合征超氧化物歧化酶丙二醛瘦素脂联素

脊髓型颈椎病应用颈椎前路钛板置入对颈椎曲度的远期影响:与单纯植骨治疗的比较

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中国组织工程研究与临床康复 2007年第47期11卷 9439-9442页

作者：申勇曹俊明杨大龙孟宪中李志远河北医科大学第三医院脊柱外科河北省石家庄市050051

目的:评价前路钢板治疗脊髓型颈椎病的相关并发症、远期疗效及其对颈椎曲度的远期影响,并与单纯植骨治疗比较。方法:回顾分析河北医科大学第三医院2000-01/2001-06行颈前路椎体次全切除减压、取自体髂骨移植治疗脊髓型颈椎病患者70例。... 详细信息

目的:评价前路钢板治疗脊髓型颈椎病的相关并发症、远期疗效及其对颈椎曲度的远期影响,并与单纯植骨治疗比较。方法:回顾分析河北医科大学第三医院2000-01/2001-06行颈前路椎体次全切除减压、取自体髂骨移植治疗脊髓型颈椎病患者70例。其中单纯植骨组30例,植骨加钛板内固定组40例(Codman钛板11例,Orion钛板17例,Caspar钛板12例)。术后患者分别在术后1周、3个月、6个月、24个月、66个月进行随访,每一次随访均拍颈椎正、侧位X射线片,部分患者行颈椎动力位X射线检查,分析患者术后植骨块骨性融合情况及融合阶段椎间高度的变化、颈椎生理曲度的改变情况。并对两组患者术后颈部轴性症状进行观察。手术疗效采用JOA评分判定。结果:术后1周随访70例、3个月随访49例、6个月随访56例、24个月随访66例、66个月随访70例。①JOA评分改善率:单纯植骨组(57.35±31.83)%,植骨加钛板内固定组(61.10±28.35)%(P>0.05)。②植骨融合率和颈椎生理曲度:植骨加钛板内固定组术后6个月内植骨融合率100%,颈椎生理曲度维持良好,较术前增加(2.51±6.75)°,无钢板和螺钉松动或断裂;单纯植骨组术后6个月内植骨融合率93.3%,颈椎生理曲度较术前减少(1.33±3.43)°,两组比较差异有显著性(P<0.01),2例术后3个月假关节形成。③椎间高度:单纯植骨组较术前下降(0.8±1.1)mm,植骨加钛板内固定组较术前增加(1.5±0.7)mm,两组比较差异有显著性(P<0.01)。④轴性症状发生率:颈部轴性症状的发生率单纯植骨组46.67%,植骨加钛板内固定组17.50%(P<0.05)。⑤材料与组织的生物相容性反应:术中所用材料均为钛合金体内植入物,与人体组织的生物相容性好,到随访结束时,无血液、免疫、组织等反应,无囊膜形成及细胞质的转变;亦无钛合金腐蚀、磨损等材料反应的发生。结论:植骨块缺乏良好的承重能力,一定应力下容易发生压缩塌陷,导致颈椎曲度丢失;前路钢板治疗脊髓型颈椎病可以有效的维持椎间高度并能很好的保持颈椎的生理曲度,减少轴性症状的发生,且相关并发症少。

关键词：颈椎病生理曲度前路钢板

Wind-sand flow simulation and radius optimization of highway embankment under different vertical curve radius

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Journal of Mountain Science 2024年第8期21卷 2533-2546页

作者： li liangying li Qi WANG Xu XIN Guowei WANG Zhenqiang School of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

It is of great practical value to explore the correlation between the vertical curve radius of desert highway and the increase of sand accumulation in local lines,and to select the appropriate vertical curve radius for reducing the risk of sand *** this study,three-dimensional models of desert highway embankments with different vertical curve radii were constructed,and Fluent software was used to simulate the wind-sand flow field and sand accumulation distribution of vertical curve *** results show that:(1)Along the direction of the road,the concave and the convex vertical curve embankments have the effect of collecting and diverging the wind-sand flow,*** the radius of the concave vertical curve is 3000 m,5000 m,8000 m,10000 m and 20000 m,the wind velocity in the middle of the vertical curve is 31.76%,22.58%,10.78%,10.53%and 10.44%,higher than that at both *** the radius of the convex vertical curve is 6500 m,8000 m,10000 m,20000 m and 30000 m,the wind velocity at both ends of the vertical curve is 14.06%,9.99%,6.14%,3.22%and 2.41%,higher than that in the *** diversion effect also decreases with the increase of the radius.(2)The conductivity of the concave and convex vertical curve embankments with different radii is greater than 1,which is the sediment transport *** conductivity increases with the increase of radius and gradually tends to be *** the radius of the concave and convex vertical curves reaches 8000 m and 20000 m respectively,the phenomenon of sand accumulation is no longer *** the same radius condition,the concave vertical curve embankment is more prone to sand accumulation than the convex one.(3)Considering the strength of the collection and diversion of the vertical curve embankment with different radii,and the sand accumulation of the vertical curve embankment in the desert section of Wuma Expressway,the radius of the concave vertical curve is not less than 8000 m,and the r

关键词： Highway engineering Vertical curve Numerical simulation Embankment wind-sand flow Radius optimization