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Injectable“cocktail”hydrogel with dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic effect

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SmartMat 2024年第2期5卷 43-53页

作者： li Zhao Jiawen Xu Yao Tong Pengyu Gong Fucheng Gao Hui li Yanyan Jiang Key Laboratory for liquid-Solid Structural evolution&Processing of Materials(Ministry of education) School of Materials Science and EngineeringShandong UniversityJinanChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina Department of Clinical Laboratory The Second HospitalCheeloo College of MedicineShandong UniversityJinanChina

The combination of the first-line standard chemotherapeutic drug doxorubicin hydrochloride(DOX)and the molecular-targeted drug Herceptin(HCT)has emerged as a promising strategy for human epidermal growth receptor 2(HeR-2)overexpressing breast cancer ***,insufficient drug accumulation and severe cardiotoxicity are two major challenges that limit its clinical ***,an in situ forming gold nanorods(AuNRs)-sodium alginate(ALG)hybrid hydrogel encapsulating DOX and HCT was engineered for tumor synergistic therapy involving injectable,dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic *** photothermal agent AuNRs,anticancer drug DOX,and anticancer antibody HCT were mixed in ALG solution,and after injection,the soluble ALG was quickly transformed into a hydrogel in the presence of Ca^(2+)in the ***,the hybrid hydrogel exhibits an extremely high photothermal conversion efficiency of 70%under 808 nm laser *** thermal effect can also provide photothermal stimulation to trigger the drug release from the gel *** addition,the drug release rate and the releasing degree are also sensitive to the *** vitro studies demonstrated that the PeI-AuNR/DOX/HCT/ALG hydrogel has facilitated the therapeutic efficiency of each payload and demonstrated a strong synergistic killing effect on SK-BR-3 *** vivo imaging results showed that the local drug delivery system can effectively reduce the nonspecific distribution in normal tissues and increase drug concentration at tumor *** proposed hydrogel system shows significant clinical implications by easily introducing a sustainable photothermal therapy and a potential universal carrier for the local delivery of multiple drugs to overcome the challenges faced in HeR-2 overexpressing cancer therapy.

关键词： dual-stimuli-responsive drug release HeR-2 overexpressing breast cancer injectable hydrogel photothermal therapy synergistic effect

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Nonstoichiometric In-S group yielding efficient carrier transfer pathway in In_(2)S_(3) photoanode for solar water oxidation

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SusMat 2024年第1期4卷 154-165页

作者： Runyu Chen linxing Meng Changda Wang Weiwei Xu yulong Huang li Song liang li School of Physical Science and Technology Jiangsu Key Laboratory of Thin FilmsCenter for Energy Conversion Materials&PhysicsSoochow UniversitySuzhouJiangsuP.R.China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsuP.R.China National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefeiAnhuiP.R.China School of electronic and Information engineering Changshu Institute of TechnologyChangshuJiangsuP.R.China

The construction of high-efficiency photoanodes is essential for developing outstanding photoelectrochemical(PeC)water splitting ***,insufficient carrier transport capabilities and sluggish surface water oxidation kinetics limit its *** a solvothermal annealing strategy,we prepared a nonstoichiometric In-S(NS)group on the surface of an In_(2)S_(3) photoanode in situ and unexpectedly formed a type II transfer path of carrier,thereby reducing the interfacial recombination and promoting the bulk *** calculations and comprehensive characterizations demonstrated NS group as an excellent oxygen evolution cocatalyst(OeC)that effectively facilitated carrier transport,lowered the surface overpotential,increased the surface active site,and accelerated the surface oxygen evolution reaction kinetics by precisely altering the rate-determining steps of*to*OH and*O to**** synergistic effects remarkably enhanced the PeC performance,with a high photocurrent density of 5.02 mA cm^(−2)at 1.23 V versus reversible hydrogen electrode and a negative shift in the onset potential by 310 *** work provides a new strategy for the in situ preparation of high-efficiency OeCs and provides ideas for constructing excellent carrier transfer and transport channels.

关键词： In_(2)S_(3) photoanode water splitting

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心房粘液瘤摘除术配合体会93例

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现代医院 2005年第12期5卷 77-78页

作者：李敏仪谢庆李玉娥广东省人民医院广东广州510080

目的总结心房粘液瘤摘除术配合体会。方法全组均在全麻,浅或中度低温体外循环下进行粘液瘤摘除术,心肌保护采用冷晶体高钾停博液或血液停博液作为术中心肌保护,心脏表面置冰屑,局部降温。结果手术死亡1例,住院死亡率1．1％,死亡原因是... 详细信息

目的总结心房粘液瘤摘除术配合体会。方法全组均在全麻,浅或中度低温体外循环下进行粘液瘤摘除术,心肌保护采用冷晶体高钾停博液或血液停博液作为术中心肌保护,心脏表面置冰屑,局部降温。结果手术死亡1例,住院死亡率1．1％,死亡原因是重度低心排综合征。结论做好生命体征及体外循环的监测配合、缩短主动脉阻断时间,注重心肌保护、术中严密防止肿瘤碎片脱落而发生栓塞是促使手术成功的关键。

关键词：粘液瘤体外循环护理

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electronic engineering of Co-Ru diatomic sites and Ru nanoparticles for synergistic promotion of hydrogen evolution

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Nano Research 2024年第5期17卷 3714-3723页

作者： Wei Zhang Cong li Yongyong Cao Jun-Yang Ji Zhao-Chen li Zheng Niu Hongwei Gu Pierre Braunstein Jian-Ping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing 314001China Universitéde Strasbourg-CNRS Institut de Chimie(UMR 7177 CNRS)4 rue Blaise Pascal-CS 9003267081 StrasbourgFrance

The coexistence of multi-component active sites like single-atom sites,diatomic sites(DAS)and nanoclusters is shown to result in superior performances in the hydrogen evolution reaction(HeR).Metal diatomic sites are more complex than single-atom sites but their unique electronic structures can lead to significant enhancement of the HeR *** the synthesis and identification of DAS is usually challenging,we report a simple access to a diatomic catalyst by anchoring Co-Ru DAS on nitrogen-doped carbon supports along with Ru nanoparticles(NPs).experimental and theoretical results revealed the atomic-level characteristics of Co-Ru sites,their strong electronic coupling and their synergy with Ru NPs within the *** unique electronic structure of the catalyst resulted in an excellent HeR activity and stability in alkaline *** work provides a valuable insight into a widely applicable design of diatomic catalysts with multi-component active sites for highly efficient HeR electrocatalysis.

关键词： Co-Ru diatomic sites Ru nanoparticles multiple active sites synergistic effect hydrogen evolution reaction

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Hypolipidemic activity and mechanism of active components of Dracocephalum moldavica L. tea

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Food Science and Human Wellness 2024年

作者： Siqi li Qinyu li Na Zhang Minhui li Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute Department of Pharmacy， Baotou Medical College

Hyperlipidemia is associated with many diseases and considered the main contributing factor in the development of metabolic syndrome. The traditional Mongolian medicine Dracocephalum moldavica L. (D. moldavica) is commonly consumed as a tea (non-Camellia tea) for the prevention and treatment of coronary heart disease， hypertension， atherosclerosis， and other diseases. Here， we attempted to investigate the hypolipidemic activity and mechanisms underlying the active components of D. moldavica. First， the mechanism underlying the lipid accumulation-reducing effects of the D. moldavica ethanol extract was determined using in vitro experiments， and four polar fractions were screened for activity. Then， the effect of the ethyl acetate fraction of D. moldavica (eAD) on lowering blood lipid was confirmed in vivo. The combination of network pharmacological and serum pharmacochemistry analyses showed that apigenin， luteolin， and naringenin of eAD existed in prototype form in the drug-containing serum of rats. We also determined the content of the three active ingredients in eAD. Finally， in vitro experiments showed that apigenin， luteolin， and naringenin improved oleic acid-induced lipid accumulation in HepG2 cells by regulating the PPAR signaling pathway (PPARα， CPT1， and FABP3). Our findings provide mechanistic insights and application prospects for the prevention and treatment of hypolipidemia using D. moldavica.

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Fucoxanthin promotes the chain lengthening reaction of polyunsaturated fatty acids in vivo by enhancing FADS2 enzyme activity

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Food Science and Human Wellness 2024年

作者： Xiao-yue li Tian-Xin Yang Ying-Cai Zhao Cheng-Cheng Wang Chang-Hu Xue Teruyoshi Yanagita yu-Ming Wang Tian-Tian Zhang SKL of Marine Food Processing & Safety Control， College of Food Science and engineering， Ocean University of China Laboratory of Nutrition Biochemistry， Department of Applied Biochemistry and Food Science， Saga University

Alpha-linolenic acid (ALA) is capable of synthesizing ePA and DHA in vivo， but the conversion rate is hard to meet the body's need for rapid DHA supplementation. Studies have shown that fucoxanthin can increase DHA content in the liver of mice， but the mechanism is not clear. Moreover， the effect of fucoxanthin and its metabolite fucoxanthinol on the chain lengthening reaction of n-6 polyunsaturated fatty acids (PUFAs) is little studied. In this study， the effects of fucoxanthin and fucoxanthinol on the chain elongation of n-3 and n-6 series PUFAs were investigated in mice. Results showed that fucoxanthin and fucoxanthinol significantly increased the conversion of n-3 series ALA to DHA and n-6 series LA to AA in the serum， liver， small intestine， and heart of mice. In addition， fucoxanthin accelerated the rate of DHA supplementation by ALA in the brain. Further mechanistic studies revealed that the role of fucoxanthin in promoting PUFAs conversion was not regulated at transcriptional level， but by increasing the activity of fatty acid desaturase 2 (FADS2)， a key enzyme of chain elongation reaction of n-3 and n-6 PUFAs. This study fundamentally provided theoretical bases for a new strategy of dietary supplementation of n-3 and n-6 PUFAs.

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Squeezing-enhanced resolution of radio-frequency signals

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Chinese Optics Letters 2024年第7期22卷 100-104页

作者： Wei li Mingjian Ju Qinghui li Ruixin li Wenxiu Yao Yimiao Wu Yajun Wang Long Tian Shaoping Shi Yaohui Zheng State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of extreme Optics Shanxi UniversityTaiyuan 030006China

We demonstrate a resolution enhancement scheme of radio-frequency signals by tailoring a phase-squeezed *** echo radio-frequency signals collected by photonic radar give rise to displacements in the phase quadrature of a probe laser and are estimated by the balanced homodyne *** contrast to the conventional coherent state,the noise variances for radio-frequency estimation with a squeezed state are reduced by approximately 6.9 *** to the Rayleigh criterion that defines the resolution limit,the minimum resolvable displacement Δa with a squeezed state is reduced to 45%compared to that with a coherent state,demonstrating the quantum *** squeezing-enhanced technique has extensive applications for multitarget recognition and tracking in contemporary photonic radar systems.

关键词： phase-squeezed state radio-frequency signal resolution

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engineering design and numerical design for chemical looping combustion reactor: A review

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energy Reviews 2024年第3期3卷 129-150页

作者： Xi Chen Rongchao li Ye Tao Yongqi Tong Ao li Daofeng Mei Haibo Zhao State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan430074China Instituto de Carboquímica(ICB-CSIC) Miguel Luesma Castan450018ZaragozaSpain

Chemical looping combustion(CLC)has emerged as a cost-effective technology for carbon capture at the combustion *** reactor,being central to the implementation of CLC,primarily adheres to two technological pathways:the dual fluidized bed reactor and the packed bed ***,the intricate interaction between gas-solid reaction flow and heat/mass transfer processes in these reactors gives rise to diverse operational principles at both macroscopic and microscopic levels across various reactor forms and scales,making performance prediction ***,the rational design of CLC reactors poses a significant challenge in advancing this technology to commercial *** article offers an extensive review of the prevailing reactor designs in CLC,delving into reactor characteristics,pivotal aspects of the design process,methodologies,and representative studies in the *** predominant reactor design approaches are categorized into engineering and numerical *** former encompasses phenomenological and similarity analysis methods,whereas the latter consists of macroscopic and computational fluid dynamics simulation *** method possesses its theoretical framework,distinctive characteristics,appropriate applications,and respective advantages and *** practical applications,integrating these aspects is *** instance,the engineering design,which is less costly but also less precise,is effective for quickly screening numerous potential design *** contrast,the numerical design,despite its higher computational demand and greater model complexity,offers improved predictive accuracy and is optimal for validating and refining engineering design solutions.

关键词： Carbon capture Chemical looping combustion Reactor design engineering design Numerical design

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Predicting distant metastasis in nasopharyngeal carcinoma using gradient boosting tree model based on detailed magnetic resonance imaging reports

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World Journal of Radiology 2024年第6期16卷 203-210页

作者： yu-liang Zhu Xin-Lei Deng Xu-Cheng Zhang li Tian Chun-Yan Cui Feng Lei Gui-Qiong Xu Hao-Jiang li li-Zhi liu Hua-li Ma Department of Nasopharyngeal Head and Neck Tumor Radiotherapy Zhongshan City People's HospitalZhongshan 528400Guangdong ProvinceChina School of Public Health Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Department of Radiology Sun Yatsen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant ***,precise prediction of metastasis in patients with NPC is *** To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging(MRI)*** This retrospective study included 792 patients with non-distant metastatic NPC.A total of 469 imaging variables were obtained from detailed MRI *** were stratified and randomly split into training(50%)and testing *** boosting tree(GBT)models were built and used to select variables for predicting DM.A full model comprising all variables and a reduced model with the top-five variables were *** performance was assessed by area under the curve(AUC).ReSULTS Among the 792 patients,94 developed DM during *** number of metastatic cervical nodes(30.9%),tumor invasion in the posterior half of the nasal cavity(9.7%),two sides of the pharyngeal recess(6.2%),tubal torus(3.3%),and single side of the parapharyngeal space(2.7%)were the top-five contributors for predicting DM,based on their relative importance in GBT *** testing AUC of the full model was 0.75(95%confidence interval[CI]:0.69-0.82).The testing AUC of the reduced model was 0.75(95%CI:0.68-0.82).For the whole dataset,the full(AUC=0.76,95%CI:0.72-0.82)and reduced models(AUC=0.76,95%CI:0.71-0.81)outperformed the tumor node-staging system(AUC=0.67,95%CI:0.61-0.73).CONCLUSION The GBT model outperformed the tumor node-staging system in predicting metastasis in *** number of metastatic cervical nodes was identified as the principal contributing variable.

关键词： Nasopharyngeal carcinoma Distant metastasis Machine learning Detailed magnetic resonance imaging report Gradient boosting tree model

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A real-time performance improvement method for composite time scale

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Chinese Physics B 2024年第9期33卷 350-357页

作者： Fangmin Wang Wenlin li Hongfei Dai Chunyi li Jianhua Zhou Shenhui Xue Bo Wang State Key Laboratory of Precision Space–time Information Sensing Technology Department of Precision InstrumentTsinghua UniversityBeijing 100084China Key Laboratory of Photonic Control Technology(Tsinghua University) Ministry of EducationBeijing 100084China Beijing Satellite Navigation Center Beijing 100094China

The composite time scale(CTS)provides a stable,accurate,and reliable time scale for modern *** improvement of CTS’s real-time performance will improve its stability,which strengths related applications’*** at this goal,a method achieved by determining the optimal calculation interval and accelerating adjustment stage is proposed in this *** determinants of the CTS’s calculation interval(characteristics of the clock ensemble,the measurement noise,the time and frequency synchronization system’s noise and the auxiliary output generator noise floor)are studied and the optimal calculation interval is *** also investigate the effect of ensemble algorithm’s initial parameters on the CTS’s adjustment stage.A strategy to get the reasonable initial parameters of ensemble algorithm is *** results show that the adjustment stage can be finished rapidly or even can be shorten to zero with reasonable initial *** this basis,we experimentally generate a distributed CTS with a calculation interval of 500 s and its stability outperforms those of the member clocks when the averaging time is longer than1700 *** experimental result proves that the CTS’s real-time performance is significantly improved.

关键词： composite time scale real-time performance calculation interval adjustment stage

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