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Frontiers of Medicine 2021年第5期15卷 750-766页

作者： Manling liu Zhaoling Shi Yue Yin yishi Wang Nan Mu Chen li Heng Ma Qiong Wang Department of Physiology and Pathophysiology Fourth Military Medical UniversityXi’an 710032China Department of Pediatrics Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712046China Department of Cardiovascular Medicine Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Exposure to particulate matter 2.5(PM2.5)potentially triggers airway inflammation by activating nuclear factor-κB(NF-κB).Sirtuin 2(SIRT2)is a key modulator in ***,the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largely ***,this work investigated the mechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65 influenced by PM2.5-induced airway inflammation and bronchial *** revealed that PM2.5 exposure lowered the expression and activity of SIRT2 in bronchial ***,SIRT2 impairment promoted the phosphorylation and acetylation of p65 and activated the NF-κB signaling *** activation of p65 triggered airway inflammation,increment of mucus secretion by goblet cells,and acceleration of tracheal ***,p65 phosphorylation and acetylation,airway inflammation,and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice exposed to ***(a specific p65 inhibitor)reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial *** findings provide novel insights into the molecular mechanisms underlying the toxicity of PM2.5 *** inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness.

关键词： particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide

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原发性高血压昼夜血压特点及其影响因素

武警医学 2017年第6期28卷 578-581页

作者：郭婷婷王莉娄莹庞会敏黄一玲康健华潞李一石中国医学科学院阜外医院心内科北京100037 中国医学科学院阜外医院临床药理中心北京100037

目的探讨原发性高血压24 h动态血压患者的特点及其影响因素。方法选取312例原发性高血压患者进行24 h动态血压监测(ABPM),根据年龄分为<40岁组、40~49岁组、50~59岁组和≥60岁组,分析不同年龄及性别对高血压患者血压型及清晨血压的影响... 详细信息

目的探讨原发性高血压24 h动态血压患者的特点及其影响因素。方法选取312例原发性高血压患者进行24 h动态血压监测(ABPM),根据年龄分为<40岁组、40~49岁组、50~59岁组和≥60岁组,分析不同年龄及性别对高血压患者血压型及清晨血压的影响。结果 312例中杓形、非杓形、反杓形和超杓形血压者分别为45.19%、41.35%、7.37%和6.09%。杓形血压在<40岁的青年组比例最高(65.00%),反杓形血压在≥60岁的老年组比例最高(18.92%)。性别对血压类型无明显影响,仅反杓形血压比例男性低于女性(P<0.01),其他血压类型男女两组差异无统计学意义。312例患者清晨高血压比例高达96.5%。年龄对清晨高血压比例无明显影响,而性别对清晨高血压比例有影响:男性组检出率明显高于女性(P<0.05)。结论老年患者血压节律异常比例较高,男性患者更易发生清晨高血压,应根据患者血压昼夜节律制定个体化降压治疗方案。

关键词：高血压昼夜血压清晨高血压年龄性别

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中华老年多器官疾病杂志 2011年第1期10卷 44-48页

作者：陈国良刘立伟谢爽刘红刘玉清李一石阜外心血管病医院临床药理中心卫生部心血管药物临床研究重点实验室北京100037

目的观察高密度脂蛋白胆固醇(HDL-C)相关因子载脂蛋白A-Ⅰ(apoA-Ⅰ)和血清淀粉样蛋白A(SAA)对非糖尿病性冠心病的影响。方法应用酶联免疫吸附法分别检测冠心病组(94例)及对照组(86例)患者血浆中apoA-Ⅰ和SAA,观察HDL-C,apoA-Ⅰ及SAA和... 详细信息

目的观察高密度脂蛋白胆固醇(HDL-C)相关因子载脂蛋白A-Ⅰ(apoA-Ⅰ)和血清淀粉样蛋白A(SAA)对非糖尿病性冠心病的影响。方法应用酶联免疫吸附法分别检测冠心病组(94例)及对照组(86例)患者血浆中apoA-Ⅰ和SAA,观察HDL-C,apoA-Ⅰ及SAA和冠心病发病之间的关系,并与人口学因素、血脂和炎症相关因素对冠心病的影响进行比较。结果冠心病组患者的高血压病史、吸烟史、早发冠心病家族史的发病率明显高于对照组(P<0.05),同样,甘油三酯、脂蛋白(a)、高敏C反应蛋白、SAA含量高于对照组(P<0.05),而HDL-C和apoA-Ⅰ明显降低(P<0.05)。Logistic回归分析显示HDL-C,apoA-Ⅰ和SAA对冠心病发病的OR分别为0.125(0.039～0.397),0.012(0.001～0.99)和1.166(1.054～1.291)。apoA-Ⅰ对冠心病发病的预测作用不受其他冠心病危险因素的影响,而HDL-C和SAA与冠心病的关系受到血脂相关因素和炎症因子的影响。结论 apoA-Ⅰ含量降低是非糖尿病性冠心病的独立危险因素。观察HDL内apoA-Ⅰ含量的变化是更为准确、有效的评价HDL-C对冠心病影响的方法。

关键词：冠状动脉疾病胆固醇高密度脂蛋白载脂蛋白A-I 血清淀粉样蛋白A

一步法实现Rb^(+)/Cl^(-)双位点共掺杂高性能锂离子电池正极材料liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)

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矿冶工程 2024年第2期44卷 141-144页

作者：杨桂芬杨广场方明杨怡诗赖飞燕深圳市计量质量检测研究院广东深圳518055 贺州学院广西碳酸钙资源综合利用重点实验室广西贺州542899

针对liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM)正极材料在循环过程中结构不稳定的问题,提出了Rb^(+)/Cl^(-)双位点共掺杂NCM材料的策略。NCM晶格中Rb^(+)/Cl^(-)双位点共掺杂的协同效应提高了li^(+)扩散速率,缓解了内部应变,抑制了高截止... 详细信息

针对liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM)正极材料在循环过程中结构不稳定的问题,提出了Rb^(+)/Cl^(-)双位点共掺杂NCM材料的策略。NCM晶格中Rb^(+)/Cl^(-)双位点共掺杂的协同效应提高了li^(+)扩散速率,缓解了内部应变,抑制了高截止电压循环时li^(+)/Ni^(2+)的混排。电化学测试结果表明,li_(0.99)Rb_(0.01)(Ni_(0.8)Co_(0.1)Mn_(0.1))O_(1.99)Cl_(0.01)(RbCl-NCM)材料在电流密度10C下放电容量高达176.9 mAh/g;RbCl-NCM材料在电流密度1C下首次放电容量203.5 mAh/g,且具有优异的循环性能,经200个循环后,容量保持率高达87.8%,而NCM材料在相同测试条件下的容量保持率仅57.3%。

关键词：锂离子电池三元正极材料富镍层状氧化物双位点掺杂放电容量电流密度循环性能容量保持率

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古基因组揭示河西走廊两千年以来的人群历史

Science Bulletin 2024年第5期69卷 606-611页

作者：熊建雪王睿陈国科杨谊时杜盼新蒙海亮马敏敏安达陶乐王辉金力王传超文少卿 Institute of Archaeological Science Fudan UniversityShanghai 200433China State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361102China Institute of Cultural Relics and Archaeology in Gansu Province Lanzhou 730000China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciencesand Human Phenome InstituteFudan UniversityShanghai 201203China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental ScienceLanzhou UniversityLanzhou 730000China Center for the Belt and Road Archaeology and Ancient Civilizations Fudan UniversityShanghai 200433China Department of Anthropology and Ethnology Institute of AnthropologySchool of Sociology and AnthropologyFujian Provincial Key Laboratory of Philosophy and Social Sciences in BioanthropologyXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China MOE Laboratory for National Development and Intelligent Governance Fudan UniversityShanghai 200433China

The Hexi Corridor in northwest China has for millennia served as a crossroads for interactions between East Asia,Central Asia and lands further west,while also connecting the Chinese heartland and the northern Mongolian Steppe and Tibetan Plateau(TP)to the south(Fig.1a).Previous studies have revealed the details of this cross-continental material and cultural transmission as early as the Bronze Age *** and technologies exchanged along the ancient Silk Road included East Asian millets and painted pottery,West Asian wheat and barley,bronze metal-lurgy,domesticated sheep,horses,and cattle[1].To date.

关键词： connecting details northwest

lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities

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Science China(life Sciences) 2021年第6期64卷 1000-1012页

作者： Zhaoling Shi Yue Yin Chen li Hui Ding Nan Mu yishi Wang Shanshan Jin Heng Ma Manling liu Jie Zhou Department of Pediatrics Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000China Department of Physiology and Pathophysiology School of Basic Medical SciencesFourth Military Medical UniversityXi’an 710032China Department of Endocrinology Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Clinical cases have reported pulmonary arterial structural and functional abnormalities in patients with Kawasaki disease(KD);however,the underlying mechanisms are *** this study,a KD rat model was established via the intraperitoneal injection of Lactobacillus casei cell wall extract(LCWE).The results showed that pulmonary arterial functional and structural abnormalities were observed in KD ***,proliferative endoplasmic reticulum stress(ER stress)was observed in the pulmonary arteries of KD ***,the level of lipocalin-2(Lcn 2),a trigger factor of inflammation,was remarkably elevated in the plasma and lung tissues of KD rats;increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils(PMNs).Correspondingly,in cultured pulmonary artery smooth muscle cells(PASMCs),Lcn 2 markedly augmented the cleavage and nuclear localization of activating transcription factor-6(ATF6),upregulated the transcription of glucose regulated protein 78(GRP78)and neurite outgrowth inhibitor(NOGO),and promoted PASMCs ***,proapoptotic C/EBP homologous protein(CHOP)and caspase 12 levels were not *** with 4-phenyl butyric acid(4-PBA,a specific inhibitor of ER stress)inhibited PASMCs proliferation induced by Lcn 2 and attenuated pulmonary arterial abnormalities and right ventricular hypertrophy and reduced right ventricular systolic pressure in KD *** conclusion,Lcn 2 remarkably facilitates proliferative ER stress in PASMCs,which probably accounts for KD-related pulmonary arterial abnormalities.

关键词： Kawasaki disease lipocalin-2 endoplasmic reticulum stress pulmonary arterial structural and functional abnormalities

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经支气管冷冻肺活检术的围术期护理经验分享

重庆医学 2020年第19期49卷 3312-3314页

作者：金星星肖洋张霞肖梅玲谭太荣郭述良李一诗丁敏重庆医科大学附属第一医院呼吸与危重症医学科 400016

总结经支气管冷冻肺活检术(TBCB)的护理方法。要点包括:参加术前讨论,熟悉手术计划;做好患者术前心理护理,协助患者完善相关检查;准备术中所需仪器设备、物品及药品;术中与医生密切配合,观察并发症并及时处理;正确处理组织标本;加强术... 详细信息

总结经支气管冷冻肺活检术(TBCB)的护理方法。要点包括:参加术前讨论,熟悉手术计划;做好患者术前心理护理,协助患者完善相关检查;准备术中所需仪器设备、物品及药品;术中与医生密切配合,观察并发症并及时处理;正确处理组织标本;加强术后护理及并发症的观察处理。

关键词：经支气管冷冻肺活检术围术期护理

Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China

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Science China Earth Sciences 2019年第10期62卷 1578-1590页

作者： yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming li Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG Gansu Provincial Institute of Cultural Relics and Archaeology Lanzhou730000China MOE Key Laboratory of Western China抯Environmental Systems College of Earth&Environmental SciencesLanzhou UniversityLanzhou730000China History and Culture School Lanzhou UniversityLanzhou730000China CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences(CAS)Beijing100101China

The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change.

关键词： Bayesian modelling Radiocarbon dating Neolithic and Bronze Age Chronology Geopolitical situation Climate change Hexi Corridor

Effects of different aggregation forms of LHC Ⅱ from Bryopsis corticulans on the excited state properties of Chl a

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Chinese Science Bulletin 2006年第12期51卷 1444-1451页

作者： ZUO Ping CHEN Hui WU yishi SHEN Shihua WANG Peng AI Xicheng ZHANG Jianping li liangbi KUANG Tingyun State Key Laboratory for Structural Chemistry of Stable and Unstable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China

Steady-state and time-resolved fluo- rescence spectroscopies have been used to study the excited state properties of Chl a in different ag- gregation forms of light-harvesting complex II (LHC II) from an intertidal green alga, Bryopsis corticulans, i.e. LHC II monomer, trimer and oligomer. When either Chl a or Chl b was selectively excited, the observed decrease in Chl a fluorescence in the oligomer is proved to be caused mainly by the fast fluorescence quenching among Chl a molecules, rather than by the decrease in Chl b-to-Chl a singlet excitation transfer efficiency. Analyses of the picosecond time-resolved fluorescence kinetics identified two exponential de- cay components in all of the three forms of LHC II: a longer-lived component (4.1―4.7 ns) originating from fluorescence emission of Chl a, and a shorter-lived one (135―540 ps) from the rapid equilibration of singlet excitation among Chl a molecules. The time constant of excitation equilibration is 135 ps in oli- gomer, 520 ps in trimer and 540 ps in monomer. These results imply that LHC II in oligomer form is inherently able to quench Chl a excitation, a mecha- nism which may be related to the photoprotection of PS II via changing the degree of LHC II aggregation in Bryopsis corticulans.

关键词： LHC Ⅱ 聚集形式 Chl a 荧光光捕获化合物能量转变

触珠蛋白-CD163-血红素加氧酶1通路基因多态性及交互作用与2型糖尿病并发冠心病的相关性

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中国循证心血管医学杂志 2020年第9期12卷 1101-1105页

作者：江岳鑫华潞韩璐璐柴琳严岩蒋娟娟刘红田蕾李一石首都医科大学附属北京安贞医院心内科北京100029 中国医学科学院阜外医院国家卫生健康委员会心血管药物临床研究重点实验室北京100037

目的本研究拟通过分析触珠蛋白-CD163-氧应激诱导型血红素加氧酶1(Hp-CD163-HO-1)通路主要基因的交互作用,探索其与2型糖尿病(T2DM)患者冠状动脉粥样硬化性心脏病(冠心病,CAD)发生及病变复杂程度的关联。方法入选2010年至2015年于阜外... 详细信息

目的本研究拟通过分析触珠蛋白-CD163-氧应激诱导型血红素加氧酶1(Hp-CD163-HO-1)通路主要基因的交互作用,探索其与2型糖尿病(T2DM)患者冠状动脉粥样硬化性心脏病(冠心病,CAD)发生及病变复杂程度的关联。方法入选2010年至2015年于阜外心血管病医院行冠状动脉(冠脉)造影检查的T2DM患者共573例,依据造影检查结果分为T2DM+CAD组(n=301)及T2DM-CAD组(n=272);选取T2DM+CAD组中未合并既往事件、经皮冠脉介入治疗、或行冠脉搭桥术的病例作为SYNTAX组(n=131),应用生物信息学筛选通路tagSNPs,以二次PCR及qRT-PCR法进行基因型检测,使用Plink软件及广义多因子降维法统计方法分析tagSNPs及其交互作用在T2DM患者中与CAD发生风险及病变复杂程度的关联。结果CD163 rs11054072 GA型、白介素4(IL-4)rs3756074 TT型及氧应激诱导型血红素加氧酶1(HMOX1)rs743811 TT型与T2DM患者CAD风险相关;HMOX1 rs743811 TC型及干扰素-γ(IFN-γ)rs2069705 AG型与T2DM合并CAD患者的SYNTAX评分相关。IFNγrs2069705与白介素10(IL-10)rs3790622,白介素6(IL-6)rs1800796、HMOX1 rs743811与IL10 rs1800871分别存在交互作用,并且与T2DM患者冠脉SYNTAX评分相关(P<0.05)。结论Hp-CD163-HO-1通路基因的多态性及交互作用与T2DM患者CAD的发生风险和病变复杂程度有关。

关键词：触珠蛋白糖尿病冠心病基因多态性基因-基因交互作用