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MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

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Science China Chemistry 2024年第4期67卷 1216-1223页

作者： Qinyi Cao yifan Zhang Yanping Tang Changjin Wu Jizhuang Wang Dan li College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital)Jinan UniversityHeyuan 517000China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry The University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)hold significant potential as vehicles for drug delivery due to their expansive specific surface area,biocompatibility,and versatile ***,magnetically actuated micro/nano-robots(MNRs)offer distinct advantages,such as untethered and precise *** fusion of these technologies presents a promising avenue for achieving non-invasive targeted drug ***,we report a MOF-based magnetic microrobot swarm(MMRS)for targeted *** approach overcomes limitations associated with a single MNR,including limited drug loading and the risk of loss during *** select Zeolitic Imidazolate Framework-8(ZIF-8)as the drug vehicle for its superior loading potential and p H-sensitive *** design incorporates magnetic responsive components into the one-pot synthesis of Fe@ZIF-8,enabling collective behaviors under *** the yaw angle of alternating magnetic fields and nanoparticles'amount,the MMRSs with controllable size achieve instantaneous transformation among different configurations,including vortex-like swarms,chain-like swarms,and elliptical swarms,facilitating adaptation to environmental *** to the subcutaneous T24 tumor site,the MMRSs with encapsulated doxorubicin(DOX)automatically degrade and release the drug,leading to a dramatic reduction of the tumor in *** investigation signifies a significant advancement in the integration of biodegradable MOFs into microrobot swarms,ushering in new avenues for accurate and non-invasive targeted drug delivery.

关键词： magnetic microrobot swarm MOF nanoparticles magnetic propulsion pH-responsive drug release targeted drug delivery

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β-Cyclodextrin derived full-spectrum fluorescent carbon dots: The formation process investigation and biological applications

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Chinese Chemical Letters 2023年第10期34卷 215-222页

作者： Peide Zhu Wenjing li Yuqi Zhang Qiang Sun Yi lin Ailin Qiu Xinyi Chen Yujin Zhou Guangfu Wu yifan li Zhiqiang Yu Quan Xu Dixian Luo Lulu Cai State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523018China

Carbon dots(CDs), a new building unit, have been revolutionizing the fields of biomedicine, bioimaging, and optoelectronics with their excellent physical, chemical, and biological properties. However, the difficulty of preparing excitation-dependent full-spectrum fluorescent CDs has seriously hindered their further research in fluorescence emission mechanisms and biomedicine. Here, we report full-spectrum fluorescent CDs that exhibit controlled emission changes from purple(380 nm) to red(613 nm) at room temperature by changing the excitation wavelength, and the excitation dependence was closely related to the regulation of sp2 and sp3 hybrid carbon structures by β-cyclodextrin-related groups. In addition,by regulating the content of β-cyclodextrin, the optimal quantum yields of full-spectrum fluorescent CDs were 8.97%, 8.35%, 7.90%, 9.69% and 17.4% at the excitation wavelengths of 340, 350, 390, 410 and 540 nm,respectively. Due to their excellent biocompatibility and color tunability, full-spectrum fluorescent CDs emitted bright and steady purple, blue, green, yellow, and red fluorescence in MCF-7 cells. Moreover, we optimized the imaging conditions of CDs and mitochondrial-specific dyes;and realized the mitochondrialtargeted co-localization imaging of purple, blue and green fluorescence. After that, we also explored the effect of full-spectrum fluorescent CDs in vivo fluorescence imaging through the intratumorally, subcutaneously, and caudal vein, and found that full-spectrum fluorescent CDs had good fluorescence imaging ability in vivo.

关键词： Carbon dots Multi-emission Fluorescence mechanism Mitochondrial targeting Color tenability Fluorescence imaging

Effect of annealing treatment on the microstructure and mechanical properties of warm-rolled Mg-Zn-Gd-Ca-Mn alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2208-2220页

作者： yifan Song Xihai li Jinliang Xu Kai Zhang Yaozong Mao Hong Yan Huiping li Rongshi Chen School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shandong Key Laboratory of Advanced Aluminium Materials and Technology Binzhou Institute of TechnologyBinzhou 256606China

The basal texture of traditional magnesium alloy AZ31 is easy to form and exhibits poor plasticity at room *** address these problems,a multi-micro-alloyed high-plasticity Mg-1.8Zn-0.8Gd-0.1Ca-0.2Mn(wt%)alloy was developed using the unique role of rare earth and Ca solute *** addition,the influence of the annealing process on the grain size,second phase,texture,and mechanical properties of the warm-rolled sheet at room temperature was analyzed with the goal of developing high-plasticity mag-nesium alloy sheets and obtaining optimal thermal-mechanical treatment *** results show that the annealing temperature has a significant effect on the microstructure and properties due to the low alloying content:there are small amounts of larger-sized block and long string phases along the rolling direction(RD),as well as several spherical and rodlike particle phases inside the *** increas-ing annealing temperature,the grain size decreases and then increases,and the morphology,number,and size of the second phase also change *** particle phase within the grains vanishes at 450℃,and the grain size increases *** the full recrystal-lization stage at 300-350℃,the optimum strength-plasticity comprehensive mechanical properties are presented,with yield strengths of 182.1 and 176.9 MPa,tensile strengths of 271.1 and 275.8 MPa in the RD and transverse direction(TD),and elongation values of 27.4%and 32.3%,***,there are still some larger-sized phases in the alloy that influence its mechanical properties,which of-fers room for improvement.

关键词： Mg-Zn-Gd-Ca-Mn alloy annealing treatment microstructure texture dynamic recrystallization mechanical properties

Screening of Streptomyces strains helping arbuscular mycorrhizal symbiosis against pepper(Capsicum annuum L.)Phytophthora blight

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Pedosphere 2024年第2期34卷 438-446页

作者： Xin WANG yifan liU Baiping HE Minghui li Xiangui liN Fuyong WU Junli HU State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of Agriculture and Rural AffairsCollege of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China University of Chinese Academy of Sciences Beijing 100049China

Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week greenhouse pot experiment was conducted to obtain several actinomycete strains helping AM symbiosis in suppressing the Phytophthora blight of pepper(Capsicum annuum L.),using a soil inoculated with Phytophthora capsici after *** Streptomyces strains,including ***,***,***,***,and ***,as well as the AM fungus(Funneliformis caledonium)were *** Phytophthora blight severity reached 66%at full productive stage in the uninoculated control,and inoculation of ***,***,and *** alone significantly decreased(Plight *** to the feature of enhancing disease-suppression by AM symbiosis,both *** and *** were confirmed as MHB strains ***,*** had a stronger performance in directly accelerating mycorrhization,while *** was also an antagonist to the pathogenic ***,*** with the independent disease-suppression function was not an MHB strain *** redundancy analyses demonstrated that when AM fungus was present,root mycorrhizal colonization replaced soil pH becoming the main factor affecting pepper Phytophthora ***,*** and *** seemed to have the value of preparation and application in the future to help AM symbiosis against pepper Phytophthora blight.

关键词： actinomycete strain blight severity Funneliformis caledonium mycorrhiza helper bacteria Phytophthora capsici root mycorrhizal colonization soil-bornedisease

Fabrication of amorphous FeCoNiCuMnP x high-entropy phosphide/carbon composites with a heterostructured fusiform morphology for efficient oxygen evolution reaction

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Journal of Materials Science & Technology 2024年第1期168卷 62-70页

作者： yifan Zhou Longqing Gao Haoyuan Chen Hao Wang Juan Zhang Xiumin li Fangfang Duo Guoqing Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Graduate School of Sustainable Community Studies Hirosaki University1-BunkyochoHirosaki 036-8560Japan Graduate School of Science and Technology Hirosaki University3-BunkyochoHirosaki 036-8561Japan Xinxiang University School of Chemistry&Materials EngineeringXinxiang 453003China Energy Conversion Engineering Laboratory Institute of Regional InnovationHirosaki University3-BunkyochoHirosaki 036-8561Japan

Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic ***,how to fabricate such ma-terials with nanostructure as well as amorphous structure is still full of *** this work,high-entropy metal organic framework(HE-MOF)is employed as the self-sacrificial template to fabricate FeCoNiCuMnP x high-entropy phosphide/carbon(HEP/C)*** obtained composite shows a het-erostructured fusiform morphology,in which the HEP is encapsulated by a carbon layer,revealing high electron conductivity as well as rich catalytic active sites for oxygen evolution reaction(OER).Beside,it is found that there is a short-range ordered crystal structure in the amorphous phase,which is bene-ficial for revealing high OER catalytic activity as well as good *** a result,the optimum HEP/C composite shows an overpotential 239 mV@10 mA cm^(−2)with a small Tafel slope of 72.5 mV dec^(−1) for catalyzing OER in alkaline solution.

关键词： Water electrolysis Oxygen evolution reaction High-entropy MOFs High-entropy phosphides Amorphous structure

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海洋科学数据汇聚共享服务平台建设

数据与计算发展前沿 2024年第3期6卷 92-98页

作者：任焕萍李一凡张斌郑双强王彦俊冯立强李富超中国科学院海洋研究所海洋大数据中心山东青岛266071 中国科学院海洋科学数据中心山东青岛266071

【应用背景】海洋数据是认识海洋、经略海洋的基础,随着海洋观测和探测技术的快速发展,海洋数据呈爆炸式增长,数据的开放共享需求日益迫切。【目的】为了实现多源海洋科学数据的整合,打通数据存储孤岛,建立统一的元数据标准和数据共享链... 详细信息

【应用背景】海洋数据是认识海洋、经略海洋的基础,随着海洋观测和探测技术的快速发展,海洋数据呈爆炸式增长,数据的开放共享需求日益迫切。【目的】为了实现多源海洋科学数据的整合,打通数据存储孤岛,建立统一的元数据标准和数据共享链路,【方法】本文构建了一个海洋科学数据汇聚共享服务平台,提供海洋数据汇交、审核、注册、存储、检索和共享全过程管理的一体化、在线化和流程化服务,为不同用户提供公平渠道获取数据、信息、知识和技术;提供DOI/CSTR自动注册服务,加强数据知识产权保护,保护数据所有者权益。【结果】平台以数据规范为牵引,将数据存储规范、管理流程规范、元数据标准纳入系统设计中,实现数据统一编码、统一管理、统一存储、统一发布的“四统一”。【结论】通过平台的应用推广,能够更好地推进海洋科学数据高效共享和利用,充分挖掘海洋信息资源的潜在价值,高质量支撑海洋科学研究。

关键词：海洋大数据数据汇聚数据共享数据管理系统

AuNP@Co_(3)(HITP)_(2)-CNT纳米结构的制备及电化学传感性能

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微纳电子技术 2024年第6期61卷 54-61页

作者：岳王香戴灿源李京谦胡珂祺李轶凡王文达徐宏妍胡杰太原理工大学电子信息与光学工程学院纳米能源与器件实验室太原030024 中北大学材料科学与工程学院太原030051

利用一步水热法和化学还原法制备了基于金纳米颗粒负载Co_(3)(HITP)_(2)-碳纳米管(AuNP@Co_(3)(HITP)_(2)-CNT)的纳米复合材料。利用X射线光电子能谱仪(XPS)和扫描电子显微镜(SEM)对其表面微观形貌和元素组成进行表征。构建了前列腺特... 详细信息

利用一步水热法和化学还原法制备了基于金纳米颗粒负载Co_(3)(HITP)_(2)-碳纳米管(AuNP@Co_(3)(HITP)_(2)-CNT)的纳米复合材料。利用X射线光电子能谱仪(XPS)和扫描电子显微镜(SEM)对其表面微观形貌和元素组成进行表征。构建了前列腺特异性抗原(PSA)/牛血清蛋白(BSA)/PSA抗体(Ab)/AuNP@Co_(3)(HITP)_(2)-CNT/玻碳电极(GCE)电化学免疫传感器,并对PSA进行了检测,用循环伏安法(CV)、差分脉冲伏安法(DPV)和电化学阻抗谱(EIS)对其进行电化学性能分析测试。实验结果表明:基于AuNP@Co_(3)(HITP)_(2)-CNT纳米复合材料的电化学免疫传感器对PSA有较宽的检测范围,可达40 fg/mL~100 ng/mL,同时具有较好的特异性、稳定性和可重复性。

关键词：电化学免疫传感器导电金属有机框架(C-MOF) 纳米结构碳纳米管(CNT) 金纳米颗粒(AuNP) 前列腺特异性抗原(PSA)

空间基因视角下历史文化街区保护与更新探析——以济南将军庙历史街区为例

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城市建筑 2024年第5期21卷 15-19页

作者：李一凡赵静好赵鹏飞封嘉仪安清华山东建筑大学建筑城规学院

历史文化街区的发展面临肌理断裂及传统风貌趋同的问题,通过空间基因概念的植入及空间基因技术体系的应用,探讨历史街区中空间要素原真性的保留。以济南将军庙作为典型案例,提取具有代表性的三类空间基因,解析评价街区要素的价值并探讨... 详细信息

历史文化街区的发展面临肌理断裂及传统风貌趋同的问题,通过空间基因概念的植入及空间基因技术体系的应用,探讨历史街区中空间要素原真性的保留。以济南将军庙作为典型案例,提取具有代表性的三类空间基因,解析评价街区要素的价值并探讨街区内存在的活力丧失、空间秩序失衡等问题,提出了维持街道格局、延续区域肌理、恢复建筑风貌等三个层次的基因传承策略,为提升历史文化街区认同感、推动街区原真性保护提供更具针对性的发展建议。

关键词：空间基因历史文化街区原真性空间活力认同感

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中国优秀传统文化与国货品牌融合发展研究

新闻传播科学 2024年第2期12卷 424-429页

作者：李一凡丁锦吴明珠王叶月陈璐张子言合肥师范学院文学院安徽合肥

近年来,国潮热从老字号品牌重回大众视线的“1.0”进阶到国货整体营销运营的“2.0”,再到眼花缭乱的IP联名与国货走出家门的“3.0”阶段,待一波又一波的消费热情退去,消费理性重新被大众所重视,性价比高为王的当下,国货品牌们面临的考... 详细信息

近年来,国潮热从老字号品牌重回大众视线的“1.0”进阶到国货整体营销运营的“2.0”,再到眼花缭乱的IP联名与国货走出家门的“3.0”阶段,待一波又一波的消费热情退去,消费理性重新被大众所重视,性价比高为王的当下,国货品牌们面临的考验更加炙热,如何提升品牌自身文化内涵已成为各大国货品牌的当务之急。在各类国货品牌的营销宣传当中,本文章主要研究的是中华优秀传统文化的应用,进一步探索国货品牌的出路。

关键词：国货品牌国潮热中华优秀传统文化应用研究