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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai Bao Qiong Yuan Qian Feng ling li Meiqi li yanli Tang Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very ***,we initiated a multifunctional nanoparticle to regulate the Keap1-Nrf2 antioxidative stress pathway to promote cancer cell *** OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and ***-SnMP@GE11 accumulated at tumor sites through specific targeting with ***-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the Keap1-Nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ***,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative *** strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： Keap1-Nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

2000—2022年医学统计学教学模式的可视化分析

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中国医院统计 2024年第1期31卷 56-60页

作者：王凤琳孔雨佳王清华李艳丽石福艳王素珍潍坊医学院公共卫生学院山东潍坊261053 潍坊医学院图书馆信息咨询部山东潍坊261053

目的分析医学统计学教学模式的研究热点及发展趋势。方法采用NoteExpress软件对获取的569篇与医学统计学教学模式相关的有效文献进行格式修改和整合,转化成能够被CiteSpace软件识别的形式,然后利用CiteSpace 6.1.R2软件进行可视化分析,... 详细信息

目的分析医学统计学教学模式的研究热点及发展趋势。方法采用NoteExpress软件对获取的569篇与医学统计学教学模式相关的有效文献进行格式修改和整合,转化成能够被CiteSpace软件识别的形式,然后利用CiteSpace 6.1.R2软件进行可视化分析,分析内容包括相关文献增长趋势、高产机构、核心作者、高频关键词、关键词聚类、突现词等。结果医学统计学教学模式相关文献发文量总体上升趋势。该研究领域各机构间几乎没有学术合作,发文量排名前3的作者分别发表文献26篇、23篇和12篇。关键词共现网络图谱共识别出378个节点、912条连线,网络密度为0.013,排名位居前3位的关键词分别是“教学改革”129次、“教学方法”53次、“教学”50次。关键词聚为11个类,其中模块值为0.623,平均轮廓值为0.858。共识别出19个突现词,其中突现强度排名前3位的关键词分别是“教学方法”“翻转课堂”“医学统计”。结论目前学者对于《医学统计学》教学模式的研究处于稳定发展期。该领域各机构间几乎没有学术合作,但高产学者间存在密切合作交流;研究热点主题有教学改革、教学方法、教学、教学效果、教学模式;医学院校是《医学统计学》教学改革模式的主要研究趋势。

关键词：医学统计学教学模式可视化分析

Analysis of the supply-demand status of China's natural gas to 2020

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Petroleum Science 2010年第1期7卷 132-135页

作者： MA Yifei li yanli School of Business Administration China University of Petroleum Beijing 102249 China

The reserves, distribution, production and utilization of natural gas resources in China are introduced in this paper which leads a point of view that China＇s natural gas resources are relatively rich while distributed unevenly. The future production and consumption of China＇s natural gas are predicted using the Generalized Weng model and the Gray prediction model. The prediction suggests that with the increasing gas consumption China＇s natural gas production will not meet demand after 2010. In order to ease the supply-demand gap and realize rational development and utilization of China＇s natural gas resources, this paper puts forward some measures, such as using advanced technologies for natural gas development, establishing a long-distance pipeline network to rationalize the availability of natural gas across China and importing foreign natural gas and liquid natural gas （LNG）.

关键词： Natural gas resources natural gas production natural gas consumption generalized Weng's Model

Fabrication of a superamphiphobic coating by a simple and flexible method

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Particuology 2018年第4期16卷 33-39页

作者： Pengfei Jiang yanli li Chuan Zhang Xuan Zhou YongJiang School of Chemistry and Chemical Engineering. Southeast University Nanjing 211189 China Chengxian College Southeast University Nanjing 210088 China

A facile and flexible method to prepare raspberry-like nanoparticles that can be used as a superamphipho- bic coating is reported. Anatase TiO2 nanoparticles were chosen as the core because of their irregular morphology and photocatalytic performance. Anatase TiO2 nanoparticles were surrounded tightly by tiny functional fluoride-silica nanoparticles via the hydrolysis-condensation reaction of tetraethoxysi- lane and IH, 1H, 2H, 2H-perfluorodecyl triethoxysilane. The obtained Si-F@TiO2 nanoparticles can be sprayed or dipped directly onto various substrates. The coated film exhibited quite good liquid resistance, even when subjected to water jetting and sand abrasion. The photocatalytic effect of the coated anatase TiO2 with respect to formaldehyde was also studied and discussed. This method will provide more opportunities and fast access to practical applications in surface, environmental, and energy engineering.

关键词： Superamphiphobic coating TiO2 nanoparticle Fluoride-silica nanoparticle Photocatalytic effect Formaldehyde

Catalytic oxidation of toluene by manganese oxides:Effect of K^(+)doping on oxygen vacancy

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Journal of Environmental Sciences 2024年第8期142卷 43-56页

作者： Zhenzhen Huang Haiyang li Xuejun Zhang yanli Mao Yinghan Wu Wei liu Hongrun Gao Mengru Zhang Zhongxian Song Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyHenan University of Urban ConstructionPingdingshan 467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang 110142China

Alkali metal potassium was beneficial to the electronic regulation and structural stability of transition metal ***,K ions were introduced into manganese oxides by different methods to improve the degradation efficiency of *** results of activity experiments indicated that KMnO_(4)-HT(HT:Hydrothermal method)exhibited outstanding low-temperature catalytic activity,and 90%conversion of toluene can be achieved at 243℃,which was 41℃and 43℃lower than that of KNO_(3)-HT and Mn-HT,*** largest specific surface area was observed on KMnO_(4)-HT,facilitating the adsorption of *** formation of cryptomelane structure over KMnO_(4)-HT could contribute to higher content of Mn^(3+)and lattice oxygen(Olatt),excellent low-temperature reducibility,and high oxygen mobility,which could increase the catalytic ***,two distinct degradation pathways were ***Ⅰ(KMnO_(4)-HT):toluene→benzyl→benzoic acid→carbonate→CO_(2)and H2O;PathwayⅡ(Mn-HT):toluene→benzyl alcohol→benzoic acid→phenol→maleic anhydride→CO_(2)and *** intermediates were detected on KMnO_(4)-HT,indicating its stronger oxidation capacity of toluene,which was originated from the doping of K^(+)and the interaction between *** intermediates were observed on Mn-HT,which can be attributed to the weaker oxidation ability of pure *** results indicated that the doping of K^(+)can improve the catalytic oxidation capacity of toluene,resulting in promoted degradation of intermediates during the oxidation of toluene.

关键词： Catalytic oxidation Preparation method Cryptomelane Mn^(3+)and lattice oxygen

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植物miRNA参与胁迫响应研究进展

分子植物育种 2024年第11期22卷 3603-3614页

作者：江建霞张俊英李延莉蒋美艳朱吉风周熙荣王伟荣孙超才杨立勇上海市农业科学院作物育种栽培研究所上海201403

microRNAs(miRNAs)是一类内源性的非编码的小RNA分子,它们在植物的生长发育和胁迫响应过程中起重要调控作用。本研究对植物miRNAs参与生物和非生物胁迫(盐胁迫,干旱胁迫,温度胁迫,营养胁迫和病原菌生物胁迫)响应过程的研究进展进行了综... 详细信息

microRNAs(miRNAs)是一类内源性的非编码的小RNA分子,它们在植物的生长发育和胁迫响应过程中起重要调控作用。本研究对植物miRNAs参与生物和非生物胁迫(盐胁迫,干旱胁迫,温度胁迫,营养胁迫和病原菌生物胁迫)响应过程的研究进展进行了综述,指出了miRNAs在植物研究过程中存在的问题并对未来发展情况进行了展望,为推动miRNAs在植物逆境胁迫中的研究和应用提供思路和参考。

关键词：植物非生物胁迫生物胁迫 MicroRNA(miRNA)

Comprehensive understanding of glioblastoma molecular phenotypes:classification,characteristics,and transition

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Cancer Biology & Medicine 2024年第5期21卷 363-381页

作者： Can Xu Pengyu Hou Xiang li Menglin Xiao Ziqi Zhang Ziru li Jianglong Xu Guoming liu yanli Tan Chuan Fang School of Clinical Medicine Hebei UniversityDepartment of NeurosurgeryAffiliated Hospital of Hebei UniversityBaoding 07100China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding 071000China School of Basic Medical Sciences Hebei UniversityBaoding 07100China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 07100China

Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality *** high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with *** precision medicine,research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity,as well as the refractory nature of GBM toward *** understanding of the different molecular expression patterns of GBM subtypes is *** have recently proposed tetra fractional or tripartite methods for detecting GBM molecular *** various molecular subtypes of GBM show significant differences in gene expression patterns and biological *** subtypes also exhibit high plasticity in their regulatory pathways,oncogene expression,tumor microenvironment alterations,and differential responses to standard ***,we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each ***,we review the mesenchymal transition mechanisms of GBM under various regulators.

关键词： Glioblastoma molecular phenotype classification characteristic mesenchymal transition

老年男性2型糖尿病患者血糖波动与住院跌倒风险的相关性

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上海护理 2024年第7期24卷 41-44页

作者：缪婕计莹沈琳辉何玉婷曹伟伟李艳莉上海交通大学医学院附属瑞金医院上海200025

目的通过调查了解老年男性2型糖尿病(T2DM)患者血糖波动与跌倒风险间的关系,为临床早期评估及护理提供参考。方法以2020年1月至2021年12月收治于上海交通大学医学院附属瑞金医院老年病科的132例老年男性T2DM住院患者作为调查对象。通过7... 详细信息

目的通过调查了解老年男性2型糖尿病(T2DM)患者血糖波动与跌倒风险间的关系,为临床早期评估及护理提供参考。方法以2020年1月至2021年12月收治于上海交通大学医学院附属瑞金医院老年病科的132例老年男性T2DM住院患者作为调查对象。通过72 h动态血糖监测了解患者血糖波动情况,并采用Morse跌倒评估量表评估其跌倒风险等级。比较跌倒中高风险组及跌倒低风险组患者的血糖波动情况,并通过多元logistic回归分析可能的影响因素。结果①跌倒中高风险组老年男性T2DM患者的餐后2 h血糖水平及使用胰岛素比率均高于低风险组(P0.05)。②与跌倒低风险组患者相比,跌倒中高风险组患者的葡萄糖目标范围内时间(TIR)明显降低[(49.8±5.1)%vs(68.8±6.4)%],而葡萄糖低血糖时间(TBR)[(20.8±3.9)%vs(6.3±1.9)%]、血糖变异率(CV)[(45±3.9)%vs(34±4.5)%]、平均血糖(MAGE)[(5.6±1.8)mmol/L vs(4.1±1.2)mmol/L]明显升高,差异均有统计学意义(P<0.05)。③二分类logistic回归分析结果显示,应用胰岛素、TIR、TBR、CV、MAGE均是老年男性T2DM患者跌倒中高风险的独立危险因素。结论老年男性T2DM患者血糖波动与跌倒中高风险增加密切相关。在临床工作中,护理人员应重视该类患者血糖波动情况,准确评估其跌倒风险并进行早期干预。

关键词： 2型糖尿病老年男性住院血糖波动跌倒风险

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北方春玉米选育方法

耕作与栽培 2024年第1期44卷 135-137页

作者：胡洪林关涛高伟政李艳丽张阔吴成龙王玮黑龙江省农垦科学院黑龙江佳木斯154007 国家现代玉米产业体系佳木斯综合试验站黑龙江佳木斯154007 铁岭市农业科学院辽宁铁岭112001

玉米是中国第一大作物,北方春玉米区是中国玉米生产优势区域,玉米品种市场竞争日趋激烈,却无法满足产业需求。因此,针对北方春玉米区的需求,融合常规育种与单倍体育种方法,注重高产高效、耐逆、抗倒伏、脱水快、宜机收种质创新和品种选... 详细信息

玉米是中国第一大作物,北方春玉米区是中国玉米生产优势区域,玉米品种市场竞争日趋激烈,却无法满足产业需求。因此,针对北方春玉米区的需求,融合常规育种与单倍体育种方法,注重高产高效、耐逆、抗倒伏、脱水快、宜机收种质创新和品种选育。本文概述了选育玉米品种的有效方法,主要有早晚杂交,优系复选,多部抉选等,旨在助力北方春玉米种质资源创新及新品种选育,为中国的粮食安全作出贡献。

关键词：北方春玉米选育方法高产高效

Universal synthesis of metallophthalocyanine covalent organic frameworks as ultra-sensitive multifaceted electrochemical sensor

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Science China Chemistry 2024年第6期67卷 2092-2101页

作者： Qi liu Qiqi Sun Yuming Zhang Hao li Wenmiao Chen Yuexing Zhang Sirong Yu yanli Chen Jianzhuang Jiang School of Materials Science and Engineering China University of Petroleum(East China)Qingdao266580China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China College of Chemistry and Chemical Engineering Dezhou UniversityDezhou253023China

The universal synthesis of highly stable covalent organic frameworks(COFs)for ultra-sensitive and multi-component electrochemical detection in different scenarios remains a great ***,a series of metallophthalocyanine-based twodimensional(2D)dioxin(DXI)-linked metalophthalocyanine(MPc)-n DXI-COFs(M=Ni,Zn;n=1,2)are afforded in high yield(80%-96%)by a facile trace-quinoline assisted one-pot condensation of tetracarbonitrile *** X-ray diffraction and electron microscopy investigations disclose their lamellar texture 2D network with AA stacking *** and calculation results elucidate that the 2DXI-linked MPc-2DXI-COFs provide the stronger built-in electronic field and more electrostatic/hydrogen bonding adsorption sites than DXI-linked MPc-DXI-COFs,and the lower electrode reaction Gibbs free energy and stronger adsorption of analytes at Ni Pc than Zn Pc unit,which grants Ni Pc-2DXI-COF excellent sensing properties for various analytes including neurotransmitters,organic pollutants,and heavy metal ions,with high sensitivity and low detection limit of 0.53 to 25.66 *** in binary and ternary systems and even in real-world conditions,simultaneous multi-component detection could be achieved.

关键词： covalent organic framework metallophthalocyanine 2D materials electrochemical sensors multi-component detection

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