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A New Investigation of Mannich Reaction

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Chinese Chemical Letters 2001年第6期12卷 471-474页

作者： li Yuan MOU Zi Yun liN li ya zhu Xiao Tian liANG Institute of Materia Medica Chinese Academy of Medical Sciencesand Peking Union Medical CollegeBeijing 100050 Center for Biophysical Science and Engineering University of Alabama at Bimingham 90114th street South Birmin ghamAL35294

During the synthesis of the derivatives of styryl ketonic Mannich bases, a side -product IM,other than the normal Mannich base MA, is obtained. Mannich reaction is further studied and the formation mechanism of produc... 详细信息

关键词： Mannich reaction side-product styryl ketonic Mannich bases mechanism

Extreme spring cold spells in North China during 1961–2014 and the evolving processes

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Atmospheric and Oceanic Science Letters 2018年第5期11卷 432-437页

作者： ya-li zhu Hui-Jun WANG Tao WANG Dong GUO Nansen-zhu International Research Centre Chinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology Climate Change Research Centre Chinese Academy of Sciences

This study presents the major features of extreme spring cold spells(ESCS)in North China during 1961–2014 and the evolving *** an ESCS,northern Eurasia is controlled by large-scale positive SLP anomalies and an anomalous anticyclone that continuously transport northern cold air to North China,causing significant,persistent,lower-than-normal daily *** fact,these positive SLP and anticyclonic wind anomalies begin to appear over northwestern Europe about 10 days prior to the *** anticyclonic wind anomalies keep moving southeastward and expand to the west of Lake Baikal until two days before the ***,the center of the anomalous low-level anticyclone moves over Lake Baikal,inducing northerly wind anomalies that transport cold air into North *** the following days,as the positive SLP anomalies weaken,the anomalous anticyclone and related northerly winds appear to wane,and the ESCS gradually comes to an *** results may prove meaningful for the prediction and early warning of ESCSs.

关键词： Spring cold spell North China spring temperature extreme weather

Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

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Neuroscience Bulletin 2020年第10期36卷 1137-1146页

作者： Xiang Feng Hui-Ying Zhao Yu-Jin Shao Hui-Fang Lou li-ya zhu Shumin Duan yan-Qin Yu Department of Neurobiology and Department of Neurology of The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China

Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and *** is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute ***,the effect of acute SDS on sleep/wake behavior in mice varies between *** addition,whether sleep changes in response to stress contribute to anxiety is not well ***,we first investigated the effects of acute SDS on sleep/wake states in the active period in *** results showed that total sleep time(time in rapid eyemovement[REM]and non-REM[NREM]sleep)increased in the active period after acute *** sleep increased mainly during the first 3 h after SDS,while REM sleep increased at a later ***,we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute *** deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state,while in mice with ad libitum sleep the anxiety rapidly faded ***,our findings suggest an anxiolytic effect of NREM sleep,and indicate a potential therapeutic strategy for anxiety.

关键词： Social defeat stress Sleep Sleep deprivation Anxiety Anxiolytic effect

Determination of Ge in Au alloys using sodium hypophosphite and potassium iodate potentiometric titration method

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Rare Metals 2020年第12期39卷 1492-1496页

作者： Shou-li Han Xiao-Tang He Jun-Mei Guo Zhao-Ying Ren li-ya zhu liang-Wei Chen Qing-Nan Shi Jia-Hong Yi School of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Sino-Platinum Metals Resources(Yimen)Co.Ltd.Yimen651100China

This paper presents a new method of determining Ge in AuGe alloys by potassium iodate(KIO3)potentiometric titration when Ge(Ⅱ)and Au(0)are simultaneously reduced from Ge(Ⅳ)and Au(Ⅲ)by sodium hypophosphite rather than by distillation *** influences of such conditions as the reduction acidity,the dosage of sodium hypophosphite and the reduction time on the determination of Ge were *** in AuGe alloys such as AuGe_(12),AuGeNi_(12-2),AuAgGe_(18.8-12.5),and AuAgGeNi_(43.8-6-0.2)was measured with the relative standard deviation(RSD)of 0.10%-0.31%and the recoveries of added standard Ge in sample of 99.40%-100.40%under the conditions of 0.40-0.80 mol·L^(-1)HCl,3.3 mol·L^(-1)H^(3)PO^(4),15 g sodium hypophosphite,and reduction time of40 *** new method presented is of high accuracy in results,good stability and sensibility in end-point,and easy operation and strong selectivity of determination.

关键词： Ge determination AuGe alloy Sodium hypophosphite Potassium iodate Potentiometric titration

Adaptive total variation constraint hypergraph regularized NMF for single-cell RNA-seq data analysis

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Quantitative Biology 2021年第4期9卷 451-462页

作者： ya-li zhu Xiao-Ning Zhang Chuan-Yuan Wang Jin-Xing liu Xiang-Zhen Kong School of Computer Science Qufu Normal UniversityRizhao 276826China

Background:Single-cell RNA sequencing(scRNA-seq)data provides a whole new view to study disease and cell differentiation *** the explosive increment of scRNA-seq data,effective models are demanded for mining the intrinsic biological ***:This paper proposes a novel non-negative matrix factorization(NMF)method for clustering and gene coexpression network analysis,termed Adaptive Total Variation Constraint Hypergraph Regularized NMF(ATV-HNMF).ATV-HNMF can adaptively select the different schemes to denoise the cluster or preserve the cluster boundary information between clusters based on the gradient ***,ATV-HNMF incorporates hypergraph regularization,which can consider high-order relationships between cells to reserve the intrinsic structure of the ***:Experiments show that the performances on clustering outperform other compared methods,and the network construction results are consistent with previous studies,which illustrate that our model is effective and ***:From the clustering results,we can see that ATV-HNMF outperforms other methods,which can help us to understand the *** can discover many disease-related genes from the constructed network,and some are worthy of further clinical exploration.

关键词： adaptive total variation single-cell RNA sequencing network analysis nonnegative matrix factorization hypergraph

A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding ya-Wen Wang Qiu-Wen li li-li Zhang Ai-zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

Stereoselective Total Synthesis of Chrysanthemol

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Chinese Chemical Letters 1998年第10期9卷 929-930页

作者： li Yuan MOU li ya zhu Xiao Tian liANG(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

Chrysanthemol, an active antiinflammatory sesquiterpene from Chrysanthemum indicum L., was synthesized in ten steps from R-(+)-carvone with an overall yield of 2.4%. The analytic data of the synthetic target compound ... 详细信息

关键词： crysanthemol stereoselective total synthesis

SYNTHESIS OF 6-AMINO, 6-METHOXY AND 6-ETHOXY PURINENUCLEOSIDE DERIVATIVES

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Chinese Chemical Letters 1991年第8期2卷 601-604页

作者： li ya zhu Xiao Tian liANG Tai Shun liN Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050 Department of Pharmacology Yale University School of Medicine.New HavenCT 06510 U.S.A.

A convenient route for the conversion of inosine to the corresponding 6-amino, 6-methoxy and 6-ethoxy derivatives is reported. This conversion can be achieved by ammoniation or etherification of the 6-pyridinium intermediate(3) which can be readily produced under mild reaction conditions. The chemistry and characterization of these compounds are presented, A plausible mechanism of the reaction is proposed.

关键词： OCH SYNTHESIS OF 6-AMINO METHOXY AND 6-ETHOXY PURINENUCLEOSIDE DERIVATIVES

Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research International 2024年第2期31卷 389-400页

作者： li-ping Pan ya-wei li Fang-guan Tan Yi-chen Chen yang-fan Xu zhu He Bao-kuan li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress