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Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomy.sitis (2022)#

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International Journal of Dermatology.and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui y. Deng D.-q. Gao X.-H. He y.-L. Kang X.-J. Jin H.-Z. li C.-X. li F. li H.-J. liao W.-J. liu X.-M. Lu q.-J. Lu y. Pan M. Pan W.-H. Shu X.-M. Sun q. Tang K.-y. Tao J. Wang y. Xiao T. Zhang F.-R. Zhang H.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomy.sitis, an idiopathic inflammatory.my.pathy. is characterized by.distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by.malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology.Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomy.sitis using Chinese and international literature and expert advice. © 2024 Wolters Kluwer Health. All rights reserved.

关键词： adult clinical protocols dermatomy.sitis diagnosis expert consensus treatment

Evaluation of improved q.ality.of life and therapeutic effect of duragesic on cancerous pain in patients with and advanced tumors

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中国临床康复 2002年第16期6卷 2500-2501页

作者： Fan L. Ren J. Zhang y.-J. y.u X.-H. Sheng R. li y.-q. Xijing Hospital Fourth Military Medical University Xi'an 710032 China

Objective To investigate therapeutic effect of duragesic in the treatment of cancerous pain in patients with advanced tumors,Method Before entering the study.all patients suffered from moderate to sever cancerous pain,All patients were given 5 doses of duragesic within 15 day.,Evaluation was performed every.12 hous,We assessed pain intensity.and pain relief by.using numoral rating scale(NRS).q.ality.of life was also *** Eventual dose was 2.5 mg in 10cases,5 mg in 49 cases.,7.5 mg in 5 cases,10 mg in 3cases,and 12.5 mg in 1 cases,15mg in 1 case complete relief was observed in 13 cases,partial relief observed in 45 cases, effective rate was 84.06%,The therapeutic effect of duragesic was similar to that of MS contin,Therapeutic dffect occurred 48-72house later and became most significant 2-4 day. later,and maintain at constant level,Conclusion By.the special pattern for delivery.via transdermal sy.tem,duragesic produces lasting and stable analgesic effect,In addition,it is characterized by.simple operation,convenient application,insignificant adverse .Hence,duragesic can replace oral strong opiod drugs.

关键词：多瑞吉晚期癌痛镇痛疗效生存质量

轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： li S. Xiao q. y.ng W. y.ng C. Wang y. State Key.Laboratory.of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong University Nanchang 330013 China School of Mechatronics and Vehicle Engineering East China Jiaotong University Nanchang 330013 China Railway.Industry.Key.Laboratory.of Intelligent Operation and Maintenance of Rolling Stock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

Microstructure evolution and shape memory.behaviors of Ni_(47)Ti_(44)Nb_(9)alloy.subjected to multistep thermomechanical loading with different prestrain levels

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Journal of Materials Science & Technology 2024年第4期171卷 80-93页

作者： y.H.Zhang H.li Z.W.y.ng X.liu q.F.Gu State Key.Laboratory.of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key.Laboratory.of High-Performance Precision Forming Technology.and Eq.ipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory.alloy.SMA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory.effect depends on multistep thermomechan-ical loading,viz.,low-temperature deformation and subseq.ent heating to ***-temperature deformation prestrain play. a pivotal role in shape memory.properties tailoring of SMA ***,microstructure evolution and deformation mechanisms of Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory.behaviors of Ni_(47)Ti_(44)Nb_(9)alloy.subjected to multistep thermomechanical loading with prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen exhibits four distinct stages at a maximal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by.the dislocation slip of the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density.of dislocations and further growth of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually.introduced in stageⅣ.Correspondingly.after subseq.ent unloading and heating,a higher density.of{114}austenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new SIMVs,the further growth of existing SIMVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly.associated with the irrecoverable strain by.20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory.alloy Wide transformation hy.teresis Thermomechanical loading Microstructure evolution Shape memory.behaviors Stress-induced martensitic transformation Deformation twinning

Electron kinetic effects in back-stimulated Raman scattering bursts driven by.broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： q.K.liu L.Deng q.Wang X.Zhang F.q.Meng y.P.Wang y.q.Gao H.B.Cai S.P.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Phy.ics and Computational Mathematics Beijing 100094China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of Laser Plasma Shanghai 201800China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of Phy.ics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity.spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity.*** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asy.metry.in the spectrum is *** asy.metry.is amplified and transferred to electron phase space by.high-intensity.broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly.influence the BSRS evolution driven by.broadband lasers.

关键词： scattering kinetic simplified

Genoty.es and Phenoty.es of Uy.ur Children with Xeroderma Pigmentosum: A Case Study.in Xinjiang, China

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International Journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： q.u y. Wang W.-J. liang J.-q. y.key. B. Wang P. Zhang J.-Z. Kang X.-J. Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Laboratory.of Dermatology.Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by.genetic defects of DNA repair. This study.was performed to detect and analy.e the genes of 2 Uy.ur patients with XP and their families and assess the patients' phenoty.es, which may.enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family.members. The patients' DNA was seq.enced and detected by.Sanger seq.encing, and gene mutations were screened. Results: The proband in family.1 presented with brown maculae at the exposure site and sq.amous cell carcinoma secondary.to a facial rash. The proband had a homozy.ous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family. both parents were heterozy.ous, and no similar mutation detected in the sister. In family.2, the proband had scattered black brown spots and papules on the trunk and limbs. and his y.unger sister was also a patient. The proband and his y.unger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain sy.thesis prematurely. All the normal individuals in the two families were heterozy.otes, and homozy.ous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uy.ur population. This study.expanded the mutation spectrum of XP and provided a basis for early.diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, published by.Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

A Hy.rid Signal Processing Method Combining Mathematical Morphology.and Walsh Theory.for Power q.ality.Disturbance Detection and Classification

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CSEE Journal of Power and Energy.Sy.tems 2024年第2期10卷 584-592页

作者： Zhi Ding Tiany.o Ji Mengshi li q.H.Wu School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

In this paper, a novel signal processing method combining mathematical morphology.(MM) and Walsh theory.is proposed, which uses Walsh functions to control the structuring element (SE) and MM operators. Based on the Walsh-MM method, a scheme for power q.ality.disturbances detection and classification is developed, which involves three steps: denoising, feature extraction and morphological clustering. First, various evolution rules of Walsh function are used to generate groups of SEs for the multiscale Walsh-ordered morphological operation, so the original signal can be denoised. Next, the fundamental wave of the denoised signal is suppressed by.Hadamard matrix;thus, disturbances can be extracted. Finally. the Walsh power spectrum of the waveform extracted in the previous step is calculated, and the parameters of which are taken by.morphological clustering to classify.the disturbances. Simulation results reveal the proposed scheme can effectively.detect and classify.disturbances, and the Walsh-MM method is less affected by.noise and only.involves simple calculation, which has a potential to be implemented in hardware and more suitable for real-time application.

关键词： Hadamard matrix mathematical morphology morphological clustering power q.ality.disturbance Walsh theory

“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. q.ao J. Wang C. li H. School of lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy.and fewer off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stability. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological barriers within the body. Herein, we summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. We found that the philosophy.behind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional Chinese culture. Almost all phy.icochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity.and accessibility.should be fully.considered when optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, thereby.aiming to uncover the way. these characteristics influence the NPs’ biological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

Location of Asy.metric Ground Fault Using Virtual Injected Current Ratio and Two-stage Recovery.Strategy.in Distribution Networks

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CSEE Journal of Power and Energy.Sy.tems 2024年第1期10卷 151-161页

作者： Haiting Shan Luliang Zhang q.H.Wu Mengshi li School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

Sparse measurements challenge fault location in distribution *** paper proposes a method for asy.metric ground fault location in distribution networks with limited measurements.A virtual injected current vector is formulated to estimate the fault line,which can be reconstructed from voltage sags measured at a few buses using compressive sensing(CS).The relationship between the virtual injected current ratio(VICR)and fault position is deduced from circuit analy.is to pinpoint the ***,a two-stage recovery.strategy.is proposed for improving reconstruction accuracy.of the current vector,where two different sensing matrixes are utilized to improve the *** proposed method is validated in IEEE 34 node test *** results show asy.metric ground fault ty.e,resistance,fault position and access of distributed generators(DGs)do not significantly.influence performance of our *** addition,it works effectively.under various scenarios of noisy.measurement and line parameter *** on 134 node test feeders prove the proposed method is also suitable for sy.tems with more complex structure.

关键词： Distribution networks fault location reconstruction accuracy two-stage recovery virtual injected current ratio