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Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1857-1872页

作者： xinlei li Jianfei WANG Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

The structural instability of multi-walled carbon nanotubes(MWCNTs) has captured extensive attention due to the unique characteristic of extremely thin hollow cylinder structure. The previous studies usually focus on the buckling behavior without considering the effects of the wall number and initial pressure. In this paper, the axial buckling behavior of MWCNTs with the length-to-outermost radius ratio less than 20 is investigated within the framework of the Donnell shell theory. The governing equations for the infinitesimal buckling of MWCNTs are established, accounting for the van der Waals(vd W) interaction between layers. The effects of the wall number, initial pressure prior to buckling, and aspect ratio on the critical buckling mode, buckling load, and buckling strain are discussed, respectively. Specially, the four-walled and twenty-walled CNTs are studied in detail, indicating the fact that the buckling instability may occur in other layers besides the outermost layer. The obtained results extend the buckling analysis of the continuum-based model, and provide theoretical support for the application of CNTs.

关键词： multi-walled carbon nanotubes(MWCNTs) buckling load cylindrical shell model instability region buckling mode

Effect of centrifugal counter-gravity casting on solidification microstructure and mechanical properties of A357 aluminum alloy

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China Foundry 2014年第1期11卷 14-19页

作者： li xinlei Hao Qitang Miao Xiaochuan Fan li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an Chaoma Technology Company limited

To investigate the influence of Centrifugal Counter-gravity Casting(C3) process on the solidification microstructure and mechanical properties of the casting, A357 aluminum alloy samples were produced by different process conditions under C3. The results show that C3 has better feeding capacity compared with the vacuum suction casting; and that the mechanical vibration and the convection of melts formed at the centrifugal rotation stage suppress the growth of dendrites, subsequently resulting in the refinement of grains and the improvement of mechanical properties, density and hardness. A finer grain and higher strength can be obtained in the A357 alloy by increasing centrifugal radius and rotational speed. However, casting defects will appear near the rotational axis and the mechanical properties will decrease once the rotational speed exceeds 150 r·min-1.

关键词： centrifugal counter-gravity casting vacuum suction casting rotational speed solidification feeding

An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

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Nano Research 2023年第1期16卷 873-881页

作者： Jinqi li xinlei li Yangfeng Zhang Kun Jin Ye Yuan Ruiqi Ming Yuhua Yang Tongsheng Chen MOE Key Laboratory of Laser life Science&Institute of Laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and *** the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or ***,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood *** the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse *** in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate ***,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire *** concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

China's climate socialization and renewable energy coalition building

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Chinese Journal of Population,Resources and Environment 2019年第3期17卷 203-216页

作者： xinlei li Serafettin Yilmaz(Shifan Yao) School of Political Science and Public Administration Shandong UniversityQingdaoChina

Against the backdrop of a heavy carbon lock-in energy structure,China has made considerable progress in renewable energy(RE)development and become a world leader in this area within a *** existing research suggests that rapid RE growth is mainly due to the convergence of economic growth,green industry competition,and energy security concerns under a unique state-led model,they oversimplify the difficulty inherent in RE policy shifting supported by formerly weak pro-RE actors in China's historical trajectory of a low-carbon *** exploring the interaction between international and domestic actors by means of a socialization-based coalition-building framework,this paper aims at analyzing how the capacity building of the RE coalition gets enhanced via institutional anchoring and resource reallocation in the climate socialization process and how the strengthened RE coalition has spurred transformation in China's RE policy and the challenges they are confronted with.

关键词： Renewable energy(RE) climate socialization coalition-building RE policy change institutional anchoring

Triboelectric‘electrostatic tweezers'for manipulating droplets on lubricated slippery surfaces prepared by femtosecond laser processing

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International Journal of Extreme Manufacturing 2024年第3期6卷 411-426页

作者： Jiale Yong xinlei li Youdi Hu Yubin Peng Zilong Cheng Tianyu Xu Chaowei Wang Dong Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China

The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic ***,we achieve noncontact and multifunctional droplet manipulation on Nepenthes-inspired lubricated slippery surfaces via triboelectric electrostatic tweezers(TETs).The TET manipulation of droplets on a slippery surface has many advantages over electrostatic droplet manipulation on a superhydrophobic *** electrostatic field induces the redistribution of the charges inside the neutral droplet,which causes the triboelectric charged rod to drive the droplet to move forward under the electrostatic *** or negatively charged droplets can also be driven by TET based on electrostatic attraction and *** enables us to manipulate droplets under diverse conditions,including anti-gravity climb,suspended droplets,corrosive liquids,low-surface-tension liquids(*** with a surface tension of 22.3 mN·m^(-1)),different droplet volumes(from 100 nl to 0.5 ml),passing through narrow slits,sliding over damaged areas,on various solid substrates,and even droplets in an enclosed *** droplet-related applications,such as motion guidance,motion switching,droplet-based microreactions,surface cleaning,surface defogging,liquid sorting,and cell labeling,can be easily achieved with TETs.

关键词： triboelectric electrostatic tweezer droplet manipulation slippery surface superhydrophobic surface femtosecond laser

前期干旱寡雨条件下移栽期后移对烤烟碳氮代谢和产质量的影响

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核农学报 2025年第1期39卷 182-190页

作者：罗德香朱奕璟单蕖李鑫磊赵正雄杨志娟欧阳铖人云南农业大学烟草学院云南昆明650201 云南农业大学资源与环境学院云南昆明650201 云南省烟草公司大理州公司大理市分公司云南大理671000

为探究移栽期后移对干旱寡雨条件下烤烟植株生长和烟叶品质的影响,本研究以K326为材料,当地常规移栽期(5月1日,T1)为参照,研究移栽期后移[(5月10日移栽,T2),(5月20日移栽,T3)]条件下烤烟生长、碳氮代谢关键酶活性、烟叶产质量的变化特... 详细信息

为探究移栽期后移对干旱寡雨条件下烤烟植株生长和烟叶品质的影响,本研究以K326为材料,当地常规移栽期(5月1日,T1)为参照,研究移栽期后移[(5月10日移栽,T2),(5月20日移栽,T3)]条件下烤烟生长、碳氮代谢关键酶活性、烟叶产质量的变化特征。结果表明,试验点2022年5至10月的降雨量分别为8.38、53.60、159.87、331.60、452.44、536.55 mm(移栽期呈干旱寡雨特征)。移栽期后移促进了烟株生长,与T1处理相比,T2和T3处理的株高分别提高8.13%和4.42%,茎围分别提高5.10%和17.02%,最大叶宽分别提高1.18%和9.62%。移栽期后移抑制烟株碳、氮代谢,与T1处理相比,T2、T3处理烟株蔗糖合成酶、硝酸还原酶活性降低。与常规移栽期相比,移栽期后移处理烟叶的产量和产值无显著差异,烟叶品质和烟叶感官质量得到提升,不同等级烤烟的常规化学成分(氯、钾、总氮含量和钾氯比)等指标均较满足优质烤烟的化学成分要求。综上,在云南地区前期干旱寡雨条件下,适当后移移栽期(即推迟至5月10日至20日)可以保障烟株的正常生长和烟叶品质。本研究结果为优质烟叶生产提供了理论依据。

关键词：干旱寡雨烤烟移栽期碳氮代谢产量

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Global Clean Energy Transition and China’s Role

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Contemporary World 2023年第3期 40-44页

作者： li xinlei School of Political Science and Public Administration Shandong UniversityChina

The world today is undergoing profound changes unseen in a century.A raft of crises,including climate change,soaring energy price and sluggish economic growth,are dragging behind the achievement of the UN 2030 Sustainable Development *** energy represented by wind,solar,biomass and green hydrogen,as the mainstay of next generation energy economic system.

关键词： Sustainable Clean Transition

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PEP06 polypeptide 30 is a novel clusterdissociating agent inhibiting αv integrin/FAK/Src signaling in oral squamous cell carcinoma cells

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1163-1173页

作者： Gulnara Tuguzbaeva Er Yue Xi Chen lina He xinlei li Jiaming Ju Ying Qin Valentin Pavlov Yanjie Lu Wenting Jia Yunlong Bai Yumei Niu Baofeng Yang Central Laboratory of Scientific Research Bashkir State Medical UniversityUfa 450008Russian Federation Department of Pharmacology(State-Province Key Laboratories of BiomedicineePharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbin 150081China Department of Endodontics the First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Orthopedic Dentistry and Maxillofacial Surgery Bashkir State Medical UniversityUfa 450008Russian Federation

Collectively migrating tumor cells have been recently implicated in enhanced metastasis of epithelial *** oral squamous cell carcinoma(OSCC),av integrin is a crucial mediator of multicellular clustering and collective movement in vitro;however,its contribution to metastatic spread remains to be *** to the emerging therapeutic concept,dissociation of tumor clusters into single cells could significantly suppress metastasis-seeding ability of *** study aimed to investigate the anti-OSCC potential of novel endostatin-derived polypeptide PEP06 as a clusterdissociating therapeutic agent in ***,we found marked enrichment ofαv integrin in collectivelyinvading multicellular clusters in human *** study revealed that metastatic progression of OSCC was associated with augmented immunostaining of av integrin in cancerous *** PEP06treatment,cell clustering on fibronectin,migration,multicellular aggregation,anchorage-independent survival and colony formation of OSCC were significantly ***,PEP06 suppressed av integrin/FAK/Sre signaling in OSCC ***06-induced loss of active Src and E-cadherin from cell-cell contacts contributed to diminished collective migration of OSCC in ***,these results suggest that PEP06 polypeptide 30 inhibiting av integrin/FAK/Src signaling and disrupting E-cadherin-based intercellular junctions possesses anti-metastatic potential in OSCC by acting as a cluster-dissociating therapeutic agent.

关键词： Oral squamous cell carcinoma Tumor cell clusters Collective migration Metastasis αv integrin/FAK/RC signaling RGD

S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission

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Cellular & Molecular Immunology 2022年第11期19卷 1235-1250页

作者： linlu Tian Yongxia Wu Hee-Jin Choi Xiaohui Sui xinlei li M.Hanief Sofi Mohamed Faisal Kassir Xiao Chen Shikhar Mehrotra Besim Ogretmen Xue-zhong Yu Department of Microbiology&Immunology Medical University of South CarolinaCharlestonSCUSA Department of Microbiology&Immunology Medical College of WisconsinMilwaukeeWIUSA Department of Medicine Medical College of WisconsinMilwaukeeWIUSA Department of Biochemistry&Molecular Biology Medical University of South CarolinaCharlestonSCUSA Department of Surgery Medical University of South CarolinaCharlestonSCUSA Hollings Cancer Center Medical University of South CarolinaCharlestonSCUSA The Cancer Center Medical College of WisconsinMilwaukeeWIUSA

Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstrated that recipient sphingosine kinase 1 (Sphk1), but not Sphk2, was required for optimal S1PR1-dependent donor T-cell allogeneic responses by secreting S1P. Using genetic and pharmacologic approaches, we demonstrated that inhibition of Sphk1 or S1PR1 substantially attenuated acute GVHD (aGVHD) while retaining the graft-versus-leukemia (GVL) effect. At the cellular level, the Sphk1/S1P/S1PR1 pathway differentially modulated the alloreactivity of CD4+ and CD8+ T cells;it facilitated T-cell differentiation into Th1/Th17 cells but not Tregs and promoted CD4+ T-cell infiltration into GVHD target organs but was dispensable for the CTL activity of allogeneic CD8+ T cells. At the molecular level, the Sphk1/S1P/S1PR1 pathway augmented mitochondrial fission and increased mitochondrial mass in allogeneic CD4+ but not CD8+ T cells by activating the AMPK/AKT/mTOR/Drp1 pathway, providing a mechanistic basis for GVL maintenance when S1P signaling was inhibited. For translational purposes, we detected the regulatory efficacy of pharmacologic inhibitors of Sphk1 and S1PR1 in GVHD induced by human T cells in a xenograft model. Our study provides novel mechanistic insight into how the Sphk1/S1P/S1PR1 pathway modulates T-cell alloreactivity and validates Sphk1 or S1PR1 as a therapeutic target for the prevention of GVHD and leukemia relapse. This novel strategy may be readily translated into the clinic to benefit patients with hematologic malignancies and disorders.

关键词： Sphk1 S1P S1PR GVHD GVL mitochondrial fission

Asymmetric Total Synthesis of All Four Isomers of 6,7-Dihydroxy-3,7-Dimethyloct-2-enoic Acid, Esters and Their Antifungal Activity

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Asymmetric Total Synthesis of All Four Isomers of 6,7-Dihydr...