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Journal of Integrative Agriculture 2022年第2期21卷 486-495页

作者： ZHANG Kai-li PENG Xia ZHANG Sai-xian ZHAN Hui-wen LU Jia-hui XIE Sheng-song ZHAO Shu-hong li xin-yun MA yun-long Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionMinistry of Education/Key Laboratory of Swine Genetics and BreedingMinistry of Agriculture and Rural Affairs/College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070P.R.China

Genotype imputation has become an indispensable part of genomic data analysis. In recent years, imputation based on a multi-breed reference population has received more attention, but the relevant studies are scarce in pigs. In this study, we used the Illumina Porcine SNP50 Bead Chip to investigate the variations of imputation accuracy with various influencing factors and compared the imputation performance of four commonly used imputation software programs. The results indicated that imputation accuracy increased as either the validation population marker density, reference population sample size, or minor allele frequency(MAF) increased. However, the imputation accuracy would have a certain extent of decrease when the pig reference population was a mixed group of multiple breeds or lines. Considering both imputation accuracy and running time, Beagle 4.1 and FImpute are excellent choices among the four software packages tested. This work visually presents the impacts of these influencing factors on imputation and provides a reference for formulating reasonable imputation strategies in actual pig breeding.

关键词： genotype imputation multi-breed reference population imputation accuracy

Synergistic Effect of Zinc and Vitamin A on T Cell Functions

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Biomedical and Environmental Sciences 2007年第2期20卷 131-134页

作者： TING-xin li yun li Department of Nutrition and Food Hygiene Huaxi College of Public Health Sichuan University Chengdu 641000 Sichuan China

Objective To determine whether supplementation of zinc and vitamin A may improve the function of T cells in human PBMC. Methods T cells were separated and cultured in vitro, supplemented with either Zn or vitamin A alone, or both Zn and vitamin A （10^-6 mol/L, 10^-5 mol/L, 10^-4 mol/L）. After harvesting, cell proliferation, cell cycle, apoptosis, expression or function of cell-surface molecules, such as CD^3＋, CD^4＋, and CD^8＋ were detected. Results Higher proliferation level and lower apoptosis level were observed in cells supplemented with both Zn and vitaminA, showing the strongest effect （P〈0.05）. Zn-supplement increased the CD^4＋/CD^3＋ cell percentage, and simultaneously decreased the CD^8＋/CD^3＋ cell population. VA-supplement showed the opposite effect in comparison with Zn-supplement. Conclusion T-cell function can be improved depending on the zinc and/or vitamin A supplemented.

关键词： Vitamin A supplementation Zinc supplementation T cell Immunity

Inducible overexpression of porcine homeobox A10 in the endometrium of transgenic mice

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Journal of Integrative Agriculture 2016年第6期15卷 1338-1344页

作者： liN Rui-yi WU Di ZHAO Chang-zhi CHEN Shang-shang XIAO Qian li xin-yun ZHAO Shu-hong Key Lab of Agricultural Animal Genetics Breeding and Reproduction Ministry of Education/The Cooperative Innovation Center for Sustainable Pig Production Huazhong Agricultural University Wuhan 430070 P.R China College of Animal Science and Technology Northeast Agricultural University Harbin 150030 P.R.China

Homeobox A10 （HOXA 10） is a well-known transcription factor that plays an important role in directing endometrial differ- entiation and establishing the conditions required for implantation. Interestingly, the expression level of HOXAIO may be associated with litter size. To study the effects of the porcine HOXAIO promoter fragment on the expression of HOXAIO gene in vivo, we generated a transgenic mouse model using pronuclear microinjection, and measured the expression of HOXAIO in the endometrium. There was no difference in the expression level of HOXAIO between transgenic and wild- type mice in the absence of hormone stimulation. However, following treatment with progesterone and estradiol benzoate, the expression level of HOXAIO was significantly increased in transgenic mice compared with that of wild-type mice. Fur- thermore, the litter size of transgenic females was larger than that of wild-type females （7.02±1.73 vs. 6.48＋1.85; P=0.14）. Moreover, the difference of litter size was greater in the later parities （7.33±1.62 vs. 6.37±2.02; P=0.08） compared with the first parity （6.76±1.81 vs. 6.61v1.67; P=0.77） between transgenic and wild-type mice. Therefore, our transgenic mouse model provides exciting insights regarding the actions of HOXAIO and its hormone-inducible promoter in vivo. The present study offers valuable proof of principle to develop transgenic pigs with a hormone-inducible promoter regulating HOXAIO to alter litter size.

关键词： porcine HOXA 10 transgenic mice endometrium

Chromosomal imbalances revealed in primary rhabdomyosarcomas by comparative genomic hybridization

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Chinese Medical Journal 2009年第11期122卷 1277-1282页

作者： li Qiao-xin liU Chun-xia CHUN Cai-pu QI Yan CHANG Bin li xin-xia CHEN yun-zhao NONG Wei-xia li Hong-an li Feng Department of Pathology Key Laboratory of Xinjiang Endemic & Ethnic Disease of Ministry of Education Shihezi University School of Medicine Shihezi Xinjiang 832002 China

Background Previous cytogenetic studies revealed rhabdomyosarcoma. We profiled chromosomal imbalances aberrations varied among the three subtypes of n the different subtypes and investigated the relationships between clinical parameters and genomic aberrations. Methods Comparative genomic hybridization was used to investigate genomic imbalances in 25 cases of primary rhabdomyosarcomas and two rhabdomyosarcoma cell lines. Specimens were reviewed to determine histological type, pathological grading and clinical staging. Results Changes involving one or more regions of the genome were seen in all rhabdomyosarcomal patients. For rhabdomyosarcoma, DNA sequence gains were most frequently （〉30%） seen in chromosomes 2p, 12q, 6p, 9q, 10q, lp, 2q, 6q, 8q, 15q and 18q; losses from 3p, 11p and 6p. In aggressive alveolar rhabdomyosarcoma, frequent gains were seen on chromosomes 12q, 2p, 6p, 2q, 4q, 10q and 15q; losses from 3p, 6p, lq and 5q. For embryonic rhabdomyosarcoma, frequent gains were on 7p, 9q, 2p, 18q, lp and 8q; losses only from 11p. Frequently gained chromosome arms of translocation associated with rhabdomyosarcoma were 12q, 2, 6, 10q, 4q and 15q; losses from 3p, 6p and 5q. The frequently gained chromosome arms of nontranslocation associated with rhabdomyosarcoma were 2p, 9q and 18q, while 11p and 14q were the frequently lost chromosome arms. Gains on chromosome 12q were significantly correlated with translocation type. Gains on chromosome 9q were significantly correlated with clinical staging. Conclusions Gains on chromosomes 2p, 12q, 6p, 9q, 10q, lp, 2q, 6q, 8q, 15q and 18q and losses on chromosomes 3p, 11p and 6p may be related to rhabdomyosarcomal carcinogenesis. Furthermore, gains on chromosome 12q may be correlated with translocation and gains on chromosome 9q with the early stages of rhabdomyosarcoma.

关键词： rhabdomyosarcoma fusion gene comparative genomic hybridization

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong liu li Ma xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

中国城镇化进程中社会冲突发生机理与过程分析

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中国人口·资源与环境 2015年第2期25卷 57-65页

作者：李云新中南财经政法大学公共管理学院湖北武汉430073

城镇化的快速推进导致资源价值结构和经济机会水平发生了重大改变,模糊的制度规则未能及时、有效调整以反映新的资源价值和经济机会,争夺资源价值和经济机会的社会冲突频发,而地方政府的介入及其凭借强制力对资源价值和经济机会进行的... 详细信息

城镇化的快速推进导致资源价值结构和经济机会水平发生了重大改变,模糊的制度规则未能及时、有效调整以反映新的资源价值和经济机会,争夺资源价值和经济机会的社会冲突频发,而地方政府的介入及其凭借强制力对资源价值和经济机会进行的策略性分配使得冲突变得更加复杂与剧烈。本文用简单的博弈论模型来展示城镇化利益分配的基本情境、利益分割中的不对等博弈以及谈判破裂后的抗争策略选择博弈,并在此基础上结合现实情境进行了延展分析。研究表明:关键行为者为获得城镇化利益而展开争夺,他们围绕城镇化利益分配存在着根本性利益冲突。通过利用制度规则模糊性提供的机会,地方政府和强势利益团体,在短期利益的驱动下,日益严重地侵犯农民等弱势群体的权利边界,利益攫取和成本转嫁越来越厉害。在城镇化的利益分割严重不对等和公共权利非均等覆盖的情况下,弱势群体也不愿意忍气吞声,运用"弱者的武器"进行抗争成为他们的理性选择。在制度规则形同虚设的情况下,现有体制鼓励了极端抗争行为和事件的发生,地方政府往往陷入越维越乱的维稳怪圈,社会冲突呈现出燃点低、爆点多、不断蔓延的特征。

关键词：快速城镇化社会冲突制度模糊性利益分配成本转嫁

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制度模糊性下中国城镇化进程中的社会冲突

中国人口·资源与环境 2014年第6期24卷 1-8页

作者：李云新中南财经政法大学公共管理学院湖北武汉430073

我国快速城镇化进程中社会冲突频发并呈现出迅速累积和扩散的趋势。制度模糊性为政府和强势集团对城镇化利益进行策略性分配提供了行为空间,成为城镇化利益分配冲突的制度根源。在城镇化进程中,作为主导力量的地方政府具有强烈的获利机... 详细信息

我国快速城镇化进程中社会冲突频发并呈现出迅速累积和扩散的趋势。制度模糊性为政府和强势集团对城镇化利益进行策略性分配提供了行为空间,成为城镇化利益分配冲突的制度根源。在城镇化进程中,作为主导力量的地方政府具有强烈的获利机会进行城镇化运动的动机,成为积极谋取城镇化净收益的"第一行动集团"。由于委托代理机制的失灵,中央政府对城镇化发展的目标定位、利益诉求都会落空。在信息高度不对称的情况下,地方政府、资本投资者等利益主体有着采取策略性行为的动机和能力。由于他们在城镇化运动中存在着狭隘的共容利益,他们更容易在城镇化推进过程中形成非正式的利益联盟,来谋取城镇化收益而转嫁成本。因此,社会冲突的有效治理需要加速制度变迁以促进制度系统与城镇化的有效调适,明晰制度规则以压缩强势集团策略性分配城镇化利益的行为空间,减少地方政府对城镇化的过度干预以促进城乡社会的自然融合,建立社会安全阀制度实现社会冲突的动态治理。

关键词：快速城镇化制度模糊性策略性分配社会冲突

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我国区域低碳发展指标体系及定量评估研究

江西财经大学学报 2013年第5期 5-14页

作者：李新运山东财经大学管理科学与工程学院山东济南250014

如何对区域低碳发展状况进行系统评估,是管理部门和理论界普遍关注的热点问题。通过对区域低碳发展系统的分析,以此为基础构建区域低碳发展概念模型,建立区域低碳发展指标体系并分配指标权重。采用综合评价和模糊聚类方法对我国各省级... 详细信息

如何对区域低碳发展状况进行系统评估,是管理部门和理论界普遍关注的热点问题。通过对区域低碳发展系统的分析,以此为基础构建区域低碳发展概念模型,建立区域低碳发展指标体系并分配指标权重。采用综合评价和模糊聚类方法对我国各省级区域的低碳发展进行定量评价和聚类分析,将我国低碳发展分为三个类型区,并针对各类型区的低碳发展特征提出相应的对策建议。

关键词：区域低碳发展综合评价模糊聚类

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从生态批评视角解读流散文学

山东社会科学 2009年第12期 50-53页

作者：李新云山东大学外国语学院山东济南250100

流散文学在新世纪的世界文学领域发挥了举足轻重的作用,它体现了本土与异国之间的一种文化张力:相互对抗又相互渗透。生态批评的兴起对流散文学研究提供了多方面的理论启示,人类中心主义批判,征服与控制自然观批判与生态批评整体性地提... 详细信息

流散文学在新世纪的世界文学领域发挥了举足轻重的作用,它体现了本土与异国之间的一种文化张力:相互对抗又相互渗透。生态批评的兴起对流散文学研究提供了多方面的理论启示,人类中心主义批判,征服与控制自然观批判与生态批评整体性地提出对于解构西方文化霸权,构建良好的文化生态以及实现流散文学、民族文学与世界文学的和谐发展和良性进化指明了方向。

关键词：流散文学人类中心主义批判征服与控制自然观批判生态批评的整体性