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IN　SITULASER　RAMAN　SPECTROSCOPY　OF　THERMAL　DECOMPOSITION　OF　AMMONIUM　TUNGSTATE

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Chinese Chemical Letters 1995年第12期6卷 1085-1086页

作者： li, xs Zhu, BZ Wang, L Miao, YF Xin, Q Chinese Acad Sci Dalian Inst Chem Phys State Key Lab Catalysis Dalian 116023 Peoples R China Henan Coll Educ Dept Chem Zhengzhou 450003 Peoples R China

The mechanism of thermal decomposition of ammonium tungstate has been studied by to situ laser Raman spectroscopy (LRS) combined with thermal gravimetric analysis (TG), differental thermal analysis (DTA) and X-ray dif...

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Lateral growth of silicalite-1 crystal membrane on glass slabs

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Chinese Science Bulletin 1997年第1期42卷 37-40页

作者： Cheng, MJ lin, LW Yang, YS Yang, WS Xu, YD li, xs State Key Laboratory of Catalysis. Dalian lnststute of Chemical Physics Chinese Academy of Sciences Dalian China

ZEOliTES and molecular sieves are crystallite materials with well-defined and uniform micropore system that can recognize and discriminate molecules according to their sizes and shapes. Therefore, zeolite and molecular sieve crystals serve as host, organizing organic and inorganic guest atoms, molecules, and supramolecular compounds in their channels or cavities, which results in host-guest materials with novel properties in optical data storage, nonlinear optics, electrochemistry and optoelectronics. The general crystallite size of zeolites and

关键词： zeolite membrane silicalite-1 lateral growth hydrothermal synthesis.

Synthesis of single-walled carbon nanotubes by the vertical floating catalyst method

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Chinese Science Bulletin 2002年第2期47卷 158-161页

作者： Zhu, HW li, xs lijie, C Xu, CL liang, J Wu, DH Tsing Hua Univ Dept Mech Engn State Key Lab Automot Safety & Energy Beijing 100084 Peoples R China

The vertical floating catalyst method is first used to produce single-walled carbon nanotubes (SWNTs) continuously on a large scale by a newly developed technique and pyrolysis of n-hexane. Diameter distributions, micro-structure and purity of the SWNTs film, rope and web are measured by Raman spectroscopy and electron microscope. The results show that SWNTs product has a high degree of orientation, a wide distribution of diameters (0.7-2.0 nm) and high purity of > 80 %.

关键词： single-walled carbon nanotubes (SWNT) vertical floating catalyst method Raman spectroscopy.

Genotoxic effects of low-dose exposure to pirimicarb studied with accelerator mass spectrometry

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Chinese Science Bulletin 1997年第19期42卷 1662-1664页

作者： Shi, JY Wang, HF Wu, XH li, xs liu, YF li, K Lu, XY Wang, JJ liu, KX BEIJING UNIV DEPT TECH PHYSBEIJING 100871PEOPLES R CHINA

SINCE 1990 a few papers presented by researchers at the Lawrence livermore National Labora-tory(LLNL)have shown the great promise of accelerator mass spectrometry(AMS) inthe quantification of biological macromolecular adducts resulting from exposure to the exotictrace chemicals or toxins. For instance, they first successfully detected a carcinogen, 2-amino-3,8-dimethyl-imidazo (4, 5-f) quinoxaline (MeIQx), covalently bound to DNA by AMS.

关键词： pirimicarb DNA adduction accelerator mass spectrometry (AMS).

An easy model for prediction of human renal clear cell carcinoma：curve fitting for three kidney tumors observed for over 10 years

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Chinese Medical Journal 2014年第4期127卷 782-783页

作者： Yao L li xs Zhang L He ZS Zhou LQ Department of Urology Peking University First Hospital Beijing 100034 China Institute of Urology Peking University National Urological Cancer Center Beijing 100034 China

The current researches on natural history of small renal masses show that small renal tumors grow slowly,and few metastasize.1-4 As the length of follow-up is short in these studies （the longest mean follow-up time is 48 months）,changes in tumor size in vivo cannot be observed *** addition,the growth model of tumor is linear,and the average growth rate is used to reflect tumor growth in these ***,most malignant tumor growth curves were not *** may not be correct to assess the growth of tumors by linear models.

关键词： prediction model renal clear cell carcinoma

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两种荧光显微成像系统亚细胞定位的对比

中国组织工程研究与临床康复 2007年第24期11卷 4710-4713页

作者：戴维德李晓松曾晶刘凡光顾瑛卫生部北京医院超声医学科北京市100730 解放军总医院激光医学科北京市100853

目的:应用高分辨率荧光显微成像系统采集细胞器探针图像,并与激光共聚焦显微成像系统进行对比。方法:实验于2003-05/2004-01在解放军总医院完成。①实验材料:鼠肺毛细血管内皮细胞株(1H11)由上海复旦张江生物公司提供;荧光探针Rhodamine... 详细信息

目的:应用高分辨率荧光显微成像系统采集细胞器探针图像,并与激光共聚焦显微成像系统进行对比。方法:实验于2003-05/2004-01在解放军总医院完成。①实验材料:鼠肺毛细血管内皮细胞株(1H11)由上海复旦张江生物公司提供;荧光探针Rhodamine-123,Lucifer Yellow,DiOC6[3],BODIPY(美国Sigma公司)。②细胞培养及荧光探针染色:细胞培养采用含体积分数为0.2胎牛血清的低糖DMEM培养基,密度5×107L-1。选择Rhodamine-123作为细胞线粒体特异性荧光探针,选择DiOC6[3]作为细胞内质网特异性荧光探针,选择BODIPY作为细胞高尔基体特异性荧光探针,选择Lucifer Yellow作为细胞溶酶体探针。前3个探针在完全避光条件下与培养的细胞共同孵育0.5h,后者则共同孵育15h。③高分辨率荧光成像系统的图像采集:线粒体荧光图像采集,选取经Rhodamine-123共孵育完成的细胞,选择激发滤色镜为BP460-490,吸收滤色镜为BA515,分光镜为DM500,另加一绿通道液晶滤光片,激发出Rhodamine-123的荧光。电荷耦合器件采集图像并送入计算机。重复上述步骤,采用DiOC6[3]标记内质网,BODIPY标记高尔基体,Lucifer Yellow标记细胞溶酶体,激发条件同Rhodamine-123。分别采集同一视野靶细胞DiOC6[3]、BODIPY或Lucifer Yellow的荧光图像,完成全部图像采集并储存在计算机中。④激光共聚焦显微成像系统的图像采集:选择经4种探针染色的靶细胞,使用氩离子激光器在488nm激发Rhodamine-123,Rhodamine-123荧光通过配置有530/60-G发射滤光片的通道1探测。重复上述步骤,在488nm激发DiOC6[3]和BODIPY,在457nm激发Lucifer yellow,3种荧光均由通道1探测,后2个探针的发射滤光片的配置为515/30-G,DiOC6[3]选择530/60-G。由光电倍增管接收信号并传输入计算机成像。结果:①高分辨率荧光成像系统所采集图像,靶细胞中由荧光探针Rhodamine-123染色的线粒体呈多个典型的小棒状或卵圆状,聚集在核周;Lucifer yellow染色的溶酶体呈多个非对称球型,在胞浆内随机分布,颗粒尺寸通常大于线粒体;荧光探针DiOC6[3]着色的内质网占据胞浆的很大空间,以囊状聚集为特征;BODIPY特异性地结合在高尔基体上,荧光图像显示围绕在细胞核周围呈条索状。②与高分辨率荧光成像系统比较,激光共聚焦显微成像系统所采集的图像其荧光强度基本相同,但分辨率低、细节显示模糊、胞浆中细胞器的准确分布信息和形态特征显示效果欠佳。结论:两种荧光显微成像系统均可采集到细胞器探针的荧光图像。但高分辨率荧光成像系统采集的荧光图像具有细节清晰、分辨度高、准确显示胞浆中细胞器的分布信息和形态特征等优点。

关键词：细胞器探针荧光显微镜电荷耦合器件

稳定型冠状动脉疾病患者5年死亡风险与肠道微生物代谢产物三甲胺-N-氧化物的关系

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中华高血压杂志 2016年第7期24卷 699-699页

作者： Senthong V Wang Z li xs Fan Y Wu Y Tang WH Hazen SL. 刘莉叶鹏

三甲胺-N-氧化物（trimethylamine-N—oxide，TMAO）是肠道微生物和膳食磷脂酰胆碱的代谢产物，血浆TMAO能否预测稳定型冠状动脉疾病患者5年死亡风险，尚未见报道。该研究旨在确定TMAO在稳定型冠状动脉疾病患者中的临床预后价值。方法... 详细信息

三甲胺-N-氧化物（trimethylamine-N—oxide，TMAO）是肠道微生物和膳食磷脂酰胆碱的代谢产物，血浆TMAO能否预测稳定型冠状动脉疾病患者5年死亡风险，尚未见报道。该研究旨在确定TMAO在稳定型冠状动脉疾病患者中的临床预后价值。方法：连续纳入2235例行选择性冠状动脉造影的稳定型冠状动脉疾病患者，

关键词：稳定型冠状动脉疾病微生物代谢产物 N-氧化物肠道微生物死亡风险三甲胺患者选择性冠状动脉造影

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

P08 Comparing study in self-motivation learning： PBL vs LBL

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中国药理通讯 2006年第2期23卷 18-19页

作者： HG NIE JQ CAI MJ WEI ZG SONG WB JIN JM li xs YU BZ SUN department of pharmacology medical education research center China Medical UniversityLN Shenyang 110001