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Tb(Ⅲ)functionalized MOF based self-calibrating sensor integrated with logic gate operation for efficient epinephrine detection in serum

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Journal of Rare Earths 2024年第5期42卷 987-994,I0006页

作者： Dongsheng Zhao wenqian li Rongmei Wen Wencui li Xin liu Xiutang Zhang liming Fan Shanxi Key Laboratory of Advanced Carbon Electrode Materials Shanxi Coal Mine Water Treatment Technology Innovation CenterSchool of Chemistry and Chemical EngineeringNorth University of ChinaTaiyuan030051China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin300071China

By anchoring Tb^(3+)ions on its free carboxyl groups of the nanocaged NiMOF,a dual-emission self-calibrating sensor of Tb^(3+)@NiMOF was fabricated through coordination post-synthetic modification(PSM)*** Tb^(3+)ions as the secondary fluorescent signal and sensing active sites,Tb^(3+)@NiMOF presents great potentials in visually and efficiently monitoring EPI in serum,with high sensitivity and selectivity,fast response,excellent recyclable,and the low detection limit(LOD,3.06 ng/mL).Furthermore,a tandem combinational logic gate based intelligent detection system was constructed to improve the practicability and convenience of epinephrine(EPI)detection in serum by comparing the light emitted colour with the series standard colour cards preset in the *** work provides a promising approach of developing metal-organic frameworks(MOFs)based self-calibrating sensors for intelligent detection of bioactive molecules.

关键词： Metal-organic framework Post-synthetic modification Self-calibrating sensor Logic gate operation Epinephrine detection Rare earths

Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei Guo wenqian li Ye Guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the *** recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC ***,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the ***,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

Efficient epoxidation of propylene over non-noble nickel-based catalyst promoted by alkali metals

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Science China Chemistry 2024年

作者： wenqian li Wanting li Xinxin Cao Longfei Chen Yibo Qin Yanfeng Zhu Yanfei Zhang Gai Miao lingzhao Kong Jiong li Xinqing Chen State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-carbon Conversion Science and Engineering Shanghai Advanced Research Institute Chinese Academy of Sciences University of Chinese Academy of Sciences School of Environmental Science and Engineering Suzhou University of Science and Technology Shanghai Synchrotron Radiation Facility Zhangjiang National Lab Shanghai Advanced Research Institute Chinese Academy of Sciences

The application of non-noble metal catalysts in the catalytic direct gas-phase epoxidation of propylene with H2and O2to produce propylene oxide is valuable and *** introduction of alkali metal promoters is one of the effective methods to improve the catalytic activity of ***,a series of alkali metal （li,Na,K,Rb,and Cs）-promoted Ni/TS-1 catalysts were prepared to deeply understand the effect of alkali metals on the structure-activity relationship for gas-phase epoxidation of *** them,the Na-Ni/TS-1 catalyst exhibits the highest catalytic activity (propylene conversion of 7.35%and POformation rate of 157.9 g h-1kg-1cat) and the best stability （long-term stability exceeding 140 h at 200°C）.X-ray absorption and photoelectron spectroscopy revealed that the electronic structure of Ni can be tuned by the addition of alkali metal ***3-TPD-MS,CO2-TPD-MS,and C3H6-TPD-MS results indicate that the acidity of the catalyst can also be adjusted by the introduction of alkali metal,whereas the Na-Ni/TS-1 catalyst exhibits the strongest C3H6adsorption ***,the suitable acid-base properties,unique electronic properties of Ni species,and the strongest propylene adsorption capacity resulted in improved propylene gas-phase epoxidation activity of Na-Ni/TS-1 *** study not only provides a new strategy for the practical application of nickel-based catalysts in the gas-phase epoxidation of propylene but also provides insights into the promoting effect of alkali metals.

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“Unveiling the antiviral mechanism of Forsythia suspense: A comprehensive analysis of screening targets and components

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Journal of Chinese Pharmaceutical Sciences 2024年

作者： Na Sun Shuo Ma linxuan Jin Xin Zhang Miao Zhou Huanhuan Yang wenqian li Xinru Wu Yanyan Hou Yuhan Yuan Yu Zhang Penghua Shu Food and Pharmacy College， Xuchang University

list of Supporting InformationTable S1 The PDB ID， Resolution， and ligand of key antiviral target p

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ESG实践对企业价值的影响路径研究——以J公司为例

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市场周刊 2024年第23期37卷 27-29,62页

作者：李汶倩天津科技大学经济与管理学院天津300457

文章以处于汽车行业的J公司为例,通过案例研究,系统归纳并梳理出J公司ESG实践对企业价值的影响路径,发现J公司良好的ESG实践通过提高企业声誉从而扩大销售市场,增加现金流,提高员工工作效率,促使企业加大研发投入力度,进而提升企业效率... 详细信息

文章以处于汽车行业的J公司为例,通过案例研究,系统归纳并梳理出J公司ESG实践对企业价值的影响路径,发现J公司良好的ESG实践通过提高企业声誉从而扩大销售市场,增加现金流,提高员工工作效率,促使企业加大研发投入力度,进而提升企业效率,也会降低企业与投资者之间的信息不对称,减少投资风险,还能够增强投资者信心,拓宽融资渠道,进而缓解融资约束。研究旨在推动ESG理念的发展,激发企业践行ESG的内生动力。

关键词： ESG实践企业价值影响路径

小骨窗神经内镜辅助下血肿清除术联合软通道引流术治疗分隔型慢性硬膜下血肿的临床研究

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系统医学 2024年第14期9卷 118-121页

作者：丁帅利文倩钦州市第二人民医院神经外科广西钦州535000

目的探讨小骨窗神经内镜辅助下血肿清除术联合软通道引流术在分隔型慢性硬膜下血肿中的临床应用价值。方法非随机选取2022年1月—2024年1月钦州市第二人民医院收治的93例分隔型慢性硬膜下血肿患者为研究对象,按照治疗方式的不同分为研究... 详细信息

目的探讨小骨窗神经内镜辅助下血肿清除术联合软通道引流术在分隔型慢性硬膜下血肿中的临床应用价值。方法非随机选取2022年1月—2024年1月钦州市第二人民医院收治的93例分隔型慢性硬膜下血肿患者为研究对象,按照治疗方式的不同分为研究组(n=31)、对照1组(n=31)和对照2组(n=31)。研究组接受小骨窗神经内镜辅助下血肿清除术联合软通道引流术治疗,对照1组单用小骨窗神经内镜辅助下血肿清除术治疗,对照2组单用软通道引流术治疗。比较3组手术情况,以及术后血肿清除率。结果研究组、对照1组的手术时间(65.45±5.68)、(62.36±7.24)min均长于对照2组(44.59±6.13)min,差异有统计学意义(F=96.410,P均<0.05)。研究组引流时间短于对照组2;研究组住院时间短于对照1组和对照2组,对照1组短于对照2组,差异有统计学意义(P均<0.05)。研究组和对照1组血肿清除率均高于对照2组,差异有统计学意义(P均<0.05)。结论小骨窗神经内镜辅助下血肿清除术联合软通道引流术治疗分隔型慢性硬膜下血肿相对于二者单用能更有效地缩短引流时间和住院时间,提高患者术后血肿清除率。

关键词：神经内镜小骨窗血肿清除术软通道引流术慢性硬膜下血肿分隔型

人教版初中生物学教材单元引言的人文素养培育价值

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生物学教学 2024年第3期49卷 76-78页

作者：李雯倩井乐刚张庆岭哈尔滨师范大学生命科学与技术学院哈尔滨150025 哈尔滨师范大学附属中学哈尔滨150080

人教版初中生物学教材中每个单元的引言文辞很精妙,都运用了恰当的词语、简明扼要的成语、种类多样的修辞、关系不同的关联词,小诗也优美含理,具有较高的培养学生文学、美学、道德等人文素养的价值,建议教师充分重视并合理地利用。

关键词：人教版教材单元引言人文素养初中生物学

韧性领导如何影响员工即兴行为?——基于VUCA时代背景的研究

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运筹与模糊学 2024年第3期14卷 834-842页

作者：李文倩鲁虹上海理工大学管理学院上海

随着全球环境的不确定性加剧,企业经营面临挑战。即兴行为在不可预料的情境下产生,与韧性领导一起灵活地应对环境的变化。本文基于资源保存理论,对收集的243份数据利用SPSS以及Amos软件进行分析,探讨韧性领导对员工即兴行为的影响。研... 详细信息

随着全球环境的不确定性加剧,企业经营面临挑战。即兴行为在不可预料的情境下产生,与韧性领导一起灵活地应对环境的变化。本文基于资源保存理论,对收集的243份数据利用SPSS以及Amos软件进行分析,探讨韧性领导对员工即兴行为的影响。研究结果发现:韧性领导对员工即兴行为具有促进作用。韧性领导通过提高员工的心理授权水平进而激发员工即兴行为。并且,在差错管理氛围的调节作用下,韧性领导对员工即兴行为的影响得到加强。研究结论不仅丰富了员工即兴行为的研究,并且为管理者应对多变的环境提供有效思路。

关键词：韧性领导员工即兴行为心理授权差错管理氛围

Potential new applications of immunotherapy for neuroendocrine neoplasms:immune landscape,current status and future perspectives

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Cancer Biology & Medicine 2022年第12期19卷 1649-1661页

作者： Rilan Bai wenqian li Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Neuroendocrine neoplasms(NENs)are a highly heterogeneous class of tumors arising from neuroendocrine cells and peptidergic *** failure of first-line treatment,patients have poor prognosis and limited treatment *** checkpoint inhibitors(ICIs)may be a powerful means of increasing therapeutic efficacy for such patients,but ICIs alone have low response rates and short disease control durations in most NENs and may be effective for only a portion of the *** combined with other immunotherapies,targeted therapies,or cytotoxic drugs have achieved some efficacy in patients with NENs and are worthy of further exploration to assess their benefits to the *** addition,accumulating experimental and clinical evidence supports that the interaction between neuroendocrine and immune systems is essential to maintain homeostasis,and assessment of this broad neuroendocrine-immune correlation is essential for NEN *** this review,we summarize the immune microenvironment characteristics,advances in immunotherapy,predictive biomarkers of ICI efficacy for NENs,and the effects of common endocrine hormones on the immune system,highlighting possible new application areas for this promising treatment in neglected NENs.

关键词： Neuroendocrine neoplasms immunotherapy predictive biomarker hormones