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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai Zhang Qimeng li Xuemin Wang Jie Lu ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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吡啶降解菌的筛选及作用机理研究

太原理工大学学报 2008年第5期39卷 490-494页

作者：李叶珺李文英徐英冯杰太原理工大学煤科学与技术教育部和山西省重点实验室山西太原030024

煤中有机氮主要以吡啶、吡咯结构形式存在。为了探索微生物对煤中有机氮的脱除效果，采用平板固体筛选和液体筛选相结合的方法，以模型化合物吡啶作为氮源对降解菌进行筛选，得到吡啶降解能力较高的JH-2菌株。通过分析影响菌种降解能力... 详细信息

煤中有机氮主要以吡啶、吡咯结构形式存在。为了探索微生物对煤中有机氮的脱除效果，采用平板固体筛选和液体筛选相结合的方法，以模型化合物吡啶作为氮源对降解菌进行筛选，得到吡啶降解能力较高的JH-2菌株。通过分析影响菌种降解能力的因素，如培养基种类、接种量、pH值及温度等，获得JH-2菌株降解吡啶的最佳实验条件：以葡萄糖为碳源，温度35～40℃，pH值为7。在此条件下，吡啶降解率可达到40．9％。对JH-2菌株降解吡啶机理的初步研究表明，吡啶中的氮在降解酶的作用下转化为NH4^＋离子，并作为微生物生长代谢过程中的氮源被消耗利用。

关键词：吡啶微生物降解菌种降解机理

Value of sonography in diagnosing breast tumors of different sizes

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Value of sonography in diagnosing breast tumors of different...

中华医学会第十次全国超声医学学术会议

作者： li wen-ying,Chen ya-qing Ultrasonic Department,Xinhua Hospital,Medical College of Shanghai Jiaotong University.

Purpose:The purpose of this study was to evaluate whether tumor size may influence the value of sonographic findings in the diagnosing malignant breast ***:342 patients with 396 breast lesions who were suspicious of breast tumors were examined with gray-scale and color or power Doppler scanning pre-operatively. Samples were divided into three groups by the greatest diameter:Ⅰ(≤1cm),Ⅱ(1.1cm-2cm)

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来源： cnki会议评论

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抑文扬理:日本国立大学课程改革新动向

比较教育研究 2016年第10期38卷 53-58页

作者：李文英陈元元河北大学教育学院河北保定071002

面对经济低迷、少子化、失业率增长、高等教育国际竞争力下降等形势的不断加剧,日本政府开始启动新一轮的国立大学课程改革。改革的主要措施是重组或裁撤人文社科专业,同时扶持与加强理工科专业,并通过适度的财政倾斜保证改革的有效实... 详细信息

面对经济低迷、少子化、失业率增长、高等教育国际竞争力下降等形势的不断加剧,日本政府开始启动新一轮的国立大学课程改革。改革的主要措施是重组或裁撤人文社科专业,同时扶持与加强理工科专业,并通过适度的财政倾斜保证改革的有效实施。此次改革呈现出明显的"抑文扬理"特征。改革的目的在于提升国立大学学术水平,提高国立大学毕业生就业率,促使国立大学由"综合化"向更加"专业化"和"实用性"的方向发展,并促使国立大学将其承担的一部分人文社科功能转交给私立大学,以实现学科布局的合理化。

关键词：抑文扬理课程改革国立大学日本

Pt掺杂Ni/NiAlO_(x)催化菲加氢饱和反应性能研究

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燃料化学学报 2022年第1期50卷 90-97页

作者：刘道诚荆洁颖王九占冯杰李文英太原理工大学省部共建煤基能源清洁高效利用国家重点实验室山西太原030024

本研究选取菲为模型化合物,以强化芳烃吸附为目标,采用等体积浸渍法制备了系列Pt-Ni/NiAlO_(x)催化剂,系统考察了Pt掺杂量对催化剂结构和菲加氢饱和性能的影响。结果表明,当反应温度300℃、氢气压力5 MPa、重时空速52 h^(−1)时,相比Ni/N... 详细信息

本研究选取菲为模型化合物,以强化芳烃吸附为目标,采用等体积浸渍法制备了系列Pt-Ni/NiAlO_(x)催化剂,系统考察了Pt掺杂量对催化剂结构和菲加氢饱和性能的影响。结果表明,当反应温度300℃、氢气压力5 MPa、重时空速52 h^(−1)时,相比Ni/NiAlO_(x)催化剂,掺杂0.5%Pt的0.5Pt-Ni/NiAlO_(x)催化剂上全氢菲选择性在反应8 h后由40%提升至67%,且表观反应速率和转化频率分别由1.53×10^(−3)mol·kg^(−1)·s^(−1)和14.64×10^(−3)s^(−1)提升至1.81×10^(−3)mol·kg^(−1)·s^(−1)和22.16×10^(−3)s^(−1)。这主要归因于金属Pt适宜的掺杂量提高了金属Ni缺电子结构的稳定性,促进芳烃吸附,提升了菲加氢饱和性能。

关键词：菲加氢饱和 Pt-Ni双金属 Pt含量

维普期刊数据库博看期刊

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一种基于深度学习的青铜器铭文识别方法

自动化学报 2018年第11期44卷 2023-2030页

作者：李文英曹斌曹春水黄永祯中国人民大学历史学院北京100872 中国科学院自动化研究所模式识别国家重点实验室北京100190 银河水滴科技(北京)有限公司北京100190

考古出土的青铜器铭文是非常宝贵的文字材料,准确、快速地了解其释义和字形演变源流对考古学、历史学和语言学研究均有重要意义.青铜器铭文的辨识需要综合文字的形、音、义进行研究,其中第一步也是最重要的一步就是分析文字的形体特征.... 详细信息

考古出土的青铜器铭文是非常宝贵的文字材料,准确、快速地了解其释义和字形演变源流对考古学、历史学和语言学研究均有重要意义.青铜器铭文的辨识需要综合文字的形、音、义进行研究,其中第一步也是最重要的一步就是分析文字的形体特征.本文提出一种基于两阶段特征映射的神经网络模型来提取每个文字的形体特征,最后对比目前已知的文字研究成果,如《古文字类编》、《说文解字》,得出识别的结果.通过定性和定量的实验分析,我们发现本文提出的方法可达到较高的识别精度.特别地,在前10个预测类别中(Top-10)准确率达到了94.2%,大幅缩小了考古研究者的搜索推测空间,提高了青铜铭文识别的效率和准确性.

关键词：模式识别青铜器铭文文字识别深度学习深度卷积神经网络

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei Duan Fei Hao wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou Wei Chen Aidong wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics