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C634Y mutation in RET-induced multiple endocrine neoplasia type 2A:A case report

World Journal of Clinical Cases 2024年第15期12卷 2627-2635页

作者： Hui-Fen Zhang Shu-ling Huang wen-li wang Yu-Qing Zhou Jun Jiang Zhuo-Jin Dai Department of Endocrinology Dongguan Hospital of Guangzhou University of Chinese MedicineDongguan 523003Guangdong ProvinceChina Department of Science and Technology Services Beijing Macro and Micro Test Co.Ltd.Beijing 100318China The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina

BACKGROUND Multiple endocrine neoplasia type 2(MEN2)is a rare,autosomal dominant endocrine ***,the RET proto-oncogene is the only gene implicated in MEN2A *** an RET carrier is detected,family members should be screened to enable early detection of medullary thyroid carcinoma,pheochromocytoma,and *** these,medullary thyroid carcinoma is the main factor responsible for patient ***,delineating strategies to inform clinical follow-up and treatment plans based on genes is paramount for clinical *** SUMMARY Herein,we present RET proto-oncogene mutations,clinical characteristics,and treatment strategies in a family with MEN2A.A family study was conducted on patients diagnosed with *** was extracted from the peripheral blood of family members,and first-generation exon sequencing of the RET protooncogene was *** C634Y mutation was identified in three family members spanning three *** patients were sequentially diagnosed with pheochromocytomas and bilateral medullary thyroid carcinomas.A 9-yearold child harboring the gene mutation was diagnosed with medullary thyroid *** resection of the tumors was *** family members were advised to undergo complete genetic testing related to the C634Y mutation,and the corresponding treatments administered based on test results and associated clinical *** Advancements in MEN2A research are important for familial management,assessment of medullary thyroid cancer invasive risk,and deciding surgical timing.

关键词： Multiple endocrine neoplasia type 2A Mutation RET proto-oncogene Medullary thyroid carcinoma Pheochromocytoma Case report

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Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China

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Chinese Journal of Cancer Research 2011年第4期23卷 265-270页

作者： wen-li wang Yang Shen-tu1 Zhi-qiang wang Shanghai Lung Cancer Center Shanghai Chest Hospital School of Medicine Shanghai Jioo Tong University Shanghai 200030 China Center for Chronic Disease School of Medicine University of Queensland Health Sciences Building Royal Brisbane & Women's HospitalHerston QLD 4029 Australia

Objective: To identify clinical and pathologic factors that were associated with the survival of stage IB upper lobe non-small cell lung cancer (NSCLC) patients. Methods: A retrospective study of 147 subjects who had undergone curative resection for stage IB upper lobe NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemotherapy were excluded. Survival function curves were estimated using the Kaplan-Meier procedure. Crude and adjusted hazard ratios (HRs) of potential prognostic factors were estimated using Cox proportional hazards models. Results: Five factors, including age, tumor size, histologic grade of differentiation, number of removed superior mediastinal lymph node stations and presence of visceral pleura invasion, were significantly and independently associated with mortality risk. Adjusted HRs were 2.6 [95% confidence interval (95% CI): 1.1?6.5] and 4.6 (95% CI: 1.9?11) for those aged 58?68 years and those >68 years, respectively, relative to those aged 5 cm (vs ?3.0 cm) were 2.3 (95% CI: 1.1?4.9) and 4.3 (95% CI: 1.9?10), respectively. The presence of visceral pleura invasion also increased the risk of mortality (HR=4.0, 95% CI: 1.3?12). Conclusion: Advanced age, larger tumor size, poorly differentiated histology, smaller number of removed superior mediastinal lymph node stations, and presence of visceral pleura invasion were associated with poor survival of surgically treated stage IB upper lobe NSCLC patients.

关键词： Non-small cell lung cancer Stage IB Prognosis Lymphadenectomy

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High-Sensitive Glucose Biosensor Based on Ionic liquid Doped Polyaniline/Prussian Blue Composite Film

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： Yao Yao Shou-guo Wu Hai-hong Xu li-wen wang Department of Chemistry University of Science and Technology of China Hefei 230026 China Clinical Laboratory Hefei Third People's Hospital Hefei 230022 China

The Prussian blue/ionic liquid-polyaniline/multiwall carbon nanotubes (PB/IL-PANI/MWNTs) composite film was fabricated by using cyclic voltammetry. The ion liquid acting as a lubricating agent, could enhance the electron delocalization degree and reduce the structural defects of the polyaniline. The surface morphology of the composite film revealed that the PB nanoparticles have smaller size than that in pure PB film. Due to the introduction of ion liquid, the PB/IL-PANI/MWNTs composite film showed wonderful synergistic effect which can remarkably enhance sensitivity, expand linear range and broaden acidic adaptability for hydrogen peroxide detection. The composite film demonstrated good stability in neutral solution contrast to pure PB film, with a linear range from 2.5 μmol/L to 0.5 mmol/L and a high sensitivity of 736.8 μA·(mmol/L)?1·cm?2 for H2O2 detection. Based on the composite film, an amperometric glucose biosensor was then fabricated by immobilizing glucose oxidase. Under the optimal conditions, the biosensor also exhibits excellent response to glucose with the linear range from 12.5 μmol/L to 1.75 mmol/L and a high sensitivity of 94.79 μA·(mmol/L)?1·cm?2 for H2O2. The detection limit was estimated 1.1 μmol/L. The resulting biosensor was applied to detect the blood sugar in human serum samples without any pretreatment, and the results were comparatively in agreement with the clinical assay.

关键词： Hydrogen peroxide Prussian blue Ionic liquid Glucose biosensor

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Surgical treatment of severe anterior capsular organized hard core cataract: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7150-7155页

作者： li-wen wang Shi-Feng Fang Department of Ophthalmology The Third People's Hospital of DalianDalian 116000Liaoning ProvinceChina

BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule *** is important to avoid the risk of surgery and improve the surgical skills of *** SUMMARY A 60-year-old man presented with severe cataract and visual *** anterior capsule of the lens was irregularly organized and pulled to the surrounding capsule,and white porcelain organized cord and brown-black lens nucleus were clearly *** phacoemulsification,maintaining the anterior capsule round and intact plays a key role in a successful *** this case,if the conventional capsule treatment method was used,the anterior capsule would be ***,we adopted a segmented anterior capsule treatment method,and a blasting method to release energy when dealing with the lens nucleus,and achieved good surgical *** Complicated cataract surgery is challenging and requires precise *** plans should be made reasonably to predict the risk of surgery,and improve the visual quality of the patients.

关键词： Complex cataract Surgery treatment Hard core cataract Clinical treatment Anterior capsular organized Case report

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Electrochemistry and Electrocatalysis with Hemoglobin in DHP-PDDA Surfactant-Polymer Multibilayer Composite Films

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Chinese Chemical Letters 2001年第3期12卷 269-270页

作者： Nai Fei HU Hong Yun liU li wen wang Department of Chemistry Beijing Normal UniversityBeijing 100875

Polyionic complex DHP-PDDA was prepared by reacting anionic surfactant dihexadecyl phosphate (DHP) with polycationic poly(diallyldimethyl ammonium) (PDDA). Thin films made from DHP-PDDA with incorporated hemoglobin (H... 详细信息

关键词： Hemoglobin dihexadecyl phosphate poly(diallyldimethyl ammonium) multibilayer composite films electrochemistry electrocatalysis

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Synthesis, Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl) phenyl-sulfonamido]phenyl}benzamide

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Chemical Research in Chinese Universities 2008年第3期24卷 295-298页

作者： li wen-ming wang Jian-guo li Zheng-ming SONG Hai-bin Elemento-Organic Chemistry Institute State Key Laboratory of Elemento-Organic Chemistry National Pesticide Engineering Research Center Nankai University Tianjin 300071 P R. China

2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl）phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound（C25H18ClFN2O5S2） belongs to monoclinic, space group P21/n with a=0.7377（3） nm, b=1.2036（5） nm, c=2.6846（11） nm, β=90.895（9）°, V=2.3833（16） nm3, Mr=544.98, Z=4, Dc=1.519 g/cm3, μ=0.385 mm–1, F（000）=1120, R1=0.0632, and wR2=0.1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.

关键词： X-ray diffraction Crystal structure Synthesis Biological activity

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Electrocatalytic Oxidation of Calcium Folinate on Carboxyl Graphene Modified CuxO/Cu Electrode

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Chinese Journal of Chemical Physics 2016年第6期29卷 729-734,I0002页

作者： li-wen wang Shou-guo Wu Tian-yang Shi Wei Wei Pan Pan Departmentol:Chemistry UniversityofScienceandTechnologyofChinaHefei230026China

Carboxyl graphene modified CuxO/Cu electrode was fabricated. The bare copper electrode was firstly anodic polarized in 1.0 mol/L NaOH solution in order to get CuxO nanoparticles, then the carboxyl graphene （CG） was electrodeposited on the CuxO/Cu electrode by cyclic potential sweeping. The electrocatalytic oxidation behaviors of calcium folinate （CF） at the graphene modified CuxO/Cu electrode were investigated by cyclic voltammetry. A positive scan polarization reverse catalytic voltammetry was used to obtain the pure catalytic oxidation current. The graphene modified CuxO/Cu electrode was served as the electrochemical sensor of CF, a highly sensitivity of 22.0μA.（μmol/μL）^-1cm^-2 was achieved, and the current response was linear with increasing CF concentration in the range of 2.0×10^-7 mol/L to 2.0×10^-5 mol/L, which crossed three orders of magnitude, and the detection limit was found 7.6×10^-5 mol/L （S/N=3）. In addition, the proposed sensor was successfully applied in determination of CF in drug sample.

关键词： Calcium folinate Carboxyl graphene CuxO/Cu electrode Chemically modi-fied electrode Positive scan polarization reverse catalytic voltammetry

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-li wang wen-Jun Huang De-li Gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is simplified into three categories according to common mathematical ***,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-wen wang Qiu-wen li li-li Zhang Ai-Zhu wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

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Surface Modification With Zinc and Zn-Ni Alloy Compositionally Modulated Multilayer Coatings

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Journal of Iron and Steel Research International 2006年第4期13卷 61-67页

作者： FEI Jing-yin liANG Guo-zheng XIN wen-li wang Wei-kang Department of Applied Chemistry Northwestern Polytechnical University Xi＇an 710072 Shaanxi China

Zinc and Zn-Ni alloy compositionally modulated multilayer （CMM） coatings were electrodeposited on to a steel substrate by the successive deposition of zinc and Zn-Ni alloy sublayers from dual baths. The coated samples were evaluated in terms of the surface appearance, surface and cross-sectional morphologies, as well as corrosion resistance. The microstructural characteristics that were examined using the field emission gun scanning electron microscopy （FEGSEM） confirmed the layered structure, grain refinement of the zinc and Zn-Ni alloy CMM coatings, and revealed the existence of microcracks caused by the internal stress in the thick Zn-Ni alloy sublayers. The corrosion resistance that was evaluated by means of the salt spray test shows that the zinc and Zn-Ni alloy CMM coatings were more corrosion-resistant than the monolithic coatings of zinc or Zn-Ni alloy of the same thickness. The possible reasons for the better protective performance of Zn-Ni/Zn CMM coatings were given on the basis of the analysis on the micrographic features of zinc and Zn-Ni alloy CMM eoatings after the corrosion test. A probable corrosion mechanism of zinc and Zn-Ni alloy CMM coatings was also proposed.

关键词： electrodeposition compositionally modulated multilayer coating Zn-Ni alloy corrosion resistance

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