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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan zhou lixia Qin lingyan liang Yichen wei Qingping Zhang Xiaocheng li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Effects of mesoscale gravity waves on sporadic E simulated by a one-dimensional dynamic model

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Earth and Planetary Physics 2025年第1期9卷 1-9页

作者： Xu zhou ZeZhong li XinAn Yue liBo liu Key Laboratory of Earth and Planetary Physics/Heilongjiang Mohe National Geophysical Observatory/Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China

In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively *** this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high *** by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower *** effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the *** mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their *** addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.

关键词： sporadic E ion tidal layer gravity waves numerical simulation

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang li Xingping Quan Jinfen Chen Yan Han li Yang Manfei zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Al阳极氧化及涂膜后处理的微观组织及性能研究

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广西大学学报（自然科学版） 2012年第3期37卷 600-606页

作者：杨剑冰李伟洲陈荣立刘伟广西大学材料科学与工程学院广西南宁530004 广西南南铝业股份有限公司广西南宁530031

为了提高铝的硬度及耐蚀性能,利用硫酸阳极氧化法对铝板材进行表面处理。采用X射线衍射仪、扫描电子显微镜、显微硬度计和滴碱试验等对获得的氧化膜进行观察和性能分析。结果表明,铝硫酸阳极氧化膜具有多孔性,氧化膜主要以非晶态的形式... 详细信息

为了提高铝的硬度及耐蚀性能,利用硫酸阳极氧化法对铝板材进行表面处理。采用X射线衍射仪、扫描电子显微镜、显微硬度计和滴碱试验等对获得的氧化膜进行观察和性能分析。结果表明,铝硫酸阳极氧化膜具有多孔性,氧化膜主要以非晶态的形式存在,膜厚度处于5～19μm。随着阳极氧化时槽电压、电流密度和氧化时间的增加,氧化膜的厚度、耐蚀性和硬度增加;提高电解液温度和浓度,氧化膜的硬度、耐蚀性和厚度则下降。对氧膜化进行PTFE涂膜后处理能有效地改善氧化膜的多孔结构。

关键词：阳极氧化法 PTFE涂膜氧化膜耐蚀性多孔

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Insulin Promotes Proliferative Vitality and Invasive Capability of Pancreatic Cancer Cells via Hypoxia-inducible Factor 1α Pathway

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第3期30卷 349-353页

作者：汪理周伟勾善淼王统玲刘涛王春友 Department of Pancreatic Surgery Union HospitalHuazhong University of Science and Technology

This study examined whether insulin-stimulated hypoxia-inducible factor 1α(HIF-1α) expression plays a crucial role in promoting the proliferative vitality and invasive capability in human pancreatic cancer ***-1 cells were divided into three groups:Control group,insulin group and insulin+YC-1(a pharmacological inhibitor of HIF-1α) group in terms of different *** in the insulin group or insulin+YC-1 group were treated with insulin(0.1,1,10 and 100 nmol/L) alone or combined with 3-(5’-hydroxymethyl-2’-furyl)-1-benzyl indazole(YC-1,0.1,1,10 and 100 μmol/L).HIF-1α mRNA and protein expression in PANC-1 cells was determined by real-time RT-PCR and Western blotting *** proliferation and invasion were measured by using growth curve and invasion assay,*** blot analysis demonstrated that insulin dose-dependently increased the HIF-1α protein expression,and YC-1 could dose-dependently block this ***,neither insulin nor YC-1 altered HIF-1α mRNA levels in PANC-1 ***,insulin could enhance the proliferation and invasion of PANC-1 cells,while YC-1 could weaken this *** was concluded that the malignant proliferation and local invasion of pancreatic cancer cells may be related to high-insulin *** tumor biological behavior change resulting from high-insulin microenvironment may be associated with the increased expression of HIF-1α protein.

关键词： pancreatic cancer cell HIF-1α YC-1 tumor microenvironment proliferation invasion

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铜冶炼制酸污酸高效硫化反应工业试验研究

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中国有色冶金 2017年第2期46卷 61-64页

作者：魏睿阳征会刘克李维舟金川集团股份有限公司甘肃金昌737100 青海铜业有限责任公司青海西宁810008

铜冶炼制酸污酸采用常规硫化法处理后,砷含量一般在100~200 mg/L,中和后产出的石膏渣砷含量有可能超过GB5085.06-2007规定限值。采用新型高效硫化工艺处理高含砷铜冶炼污酸,具有流程短,硫化钠消耗少,砷及重金属离子硫化回收率高(99.9%以... 详细信息

铜冶炼制酸污酸采用常规硫化法处理后,砷含量一般在100~200 mg/L,中和后产出的石膏渣砷含量有可能超过GB5085.06-2007规定限值。采用新型高效硫化工艺处理高含砷铜冶炼污酸,具有流程短,硫化钠消耗少,砷及重金属离子硫化回收率高(99.9%以上),生产环境好,中和后产生的石膏渣砷含量能够满足国际要求等优点。

关键词：铜冶炼污酸硫化法重金属离子石膏渣

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酚妥拉明对重症脓毒症患者血流动力学的影响

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中华医学杂志 2017年第5期97卷 338-342页

作者：杨巍李雪斌周燕莫雪妹南宁市第二人民医院五象医院急诊科广西530012 右江民族医学院附属医院神经内科南宁市红十字会医院重症医学科

目的探讨酚妥拉明对重症脓毒症患者血流动力学的影响。方法2015年1月至2016年8月将南宁市第二人民医院五象医院急诊科和南宁市红十字会医院重症医学科符合入选标准的重症脓毒症患者59例采用数字表法随机分为研究组和对照组。遵照SSC201... 详细信息

目的探讨酚妥拉明对重症脓毒症患者血流动力学的影响。方法2015年1月至2016年8月将南宁市第二人民医院五象医院急诊科和南宁市红十字会医院重症医学科符合入选标准的重症脓毒症患者59例采用数字表法随机分为研究组和对照组。遵照SSC2012指南，两组给予常规治疗，研究组加用酚妥拉明治疗，在患者入院治疗前、治疗后6、12、24、48、72h均应用脉搏指示连续心排血量监测（PiCCO）进行心指数（CI）、胸腔内血容积指数（ITBVI）、血管外肺水指数（EVLWI）、全身血管阻力指数（SVRI）的变化；测量血乳酸、乳酸清除率，比较两组血乳酸、乳酸清除率的变化趋势，观察两组患者的28d生存率以及重症医学科（ICU）住院时间。结果治疗后12、24、48、72h研究组CI、SVRI、ITBVI较对照组明显增高，EVLWI明显下降。研究组的血乳酸水平、乳酸清除率在治疗后的12、24、48、72h时间点改善优于对照组，特别是6h乳酸清除率研究组比较对照组明显增加[（27．2±2．2）mmol／L比（13．9±3．0）mmol／L，t=8．322，P=0．034]。研究组患者ICU的入住时间和28d的病死率明显少于对照组[（9．8±3．6）d比（13．0±4．1）d，P=0．004；（22．6％比35．7％，P=0．021）]。结论联合应用酚妥拉明能显著改善重症脓毒症患者早期血流动力的变化趋势，提高脓毒症患者的生存率。

关键词：脓毒症酚妥拉明乳酸血流动力学

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong wei Jin liu Tao Zhu Cheng zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG li WENKE JIN liFENG WU HUAN WANG XIN XIE wei HUANG BO liU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long zhou wei-Jin Jiang Ji Yu Mao-Jun Yao Yun-Tong li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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